Detailed information for compound 1076714

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 475.97 | Formula: C26H26ClN5O2
  • H donors: 4 H acceptors: 4 LogP: 4.77 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC[C@H](c1cccc(c1)Cl)NC(=O)c1[nH]cc(c1)c1nc(ncc1C)Nc1ccccc1CC
  • InChi: 1S/C26H26ClN5O2/c1-3-17-7-4-5-10-21(17)31-26-29-13-16(2)24(32-26)19-12-22(28-14-19)25(34)30-23(15-33)18-8-6-9-20(27)11-18/h4-14,23,28,33H,3,15H2,1-2H3,(H,30,34)(H,29,31,32)/t23-/m1/s1
  • InChiKey: SJOKPCUBKAMNFF-HSZRJFAPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens aurora kinase A Starlite/ChEMBL References
Homo sapiens mitogen-activated protein kinase 1 Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania donovani mitogen activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi MAP kinase sur-1 Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440,map kinase Get druggable targets OG5_126781 All targets in OG5_126781
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi mitogen activated protein kinase 2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma japonicum ko:K04371 extracellular signal-regulated kinase 1/2, putative Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium parvum MAPK, putative Get druggable targets OG5_126781 All targets in OG5_126781
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense mitogen-activated protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans MAP kinase implicated in PKC1-controlled signalling pathway Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus mitogen activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC MAPK Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei mitogen activated protein kinase 4, putative Get druggable targets OG5_126781 All targets in OG5_126781
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana mitogen-activated protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis mitogen activated protein kinase 3 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative,tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania braziliensis mitogen activated protein kinase, putative,map kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase Get druggable targets OG5_126781 All targets in OG5_126781
Candida albicans Serine/threonine protein kinase of MAP kinase family Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Mitogen-activated protein kinase 3, putative Get druggable targets OG5_126781 All targets in OG5_126781
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani mitogen-activated protein kinase 4 Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense tyrosine protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans MAP kinase-like orf Get druggable targets OG5_126781 All targets in OG5_126781
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126781 All targets in OG5_126781
Trypanosoma cruzi mitogen-activated protein kinase 11, putative Get druggable targets OG5_126781 All targets in OG5_126781
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 1 360 aa 361 aa 33.2 %
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Protein kinase domain containing protein 0.0053 0.4031 0.3948
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.4031 0.6276
Echinococcus granulosus cyclin dependent kinase 0.0053 0.4031 0.3948
Echinococcus multilocularis cyclin dependent kinase 0.0053 0.4031 0.3948
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0063 0.5439 0.8468
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0053 0.4031 0.3948
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.4031 0.6195
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.6423 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0053 0.4031 0.3948
Echinococcus granulosus cyclin dependent kinase 1 0.0053 0.4031 0.3948
Entamoeba histolytica cell division protein kinase 2, putative 0.0053 0.4031 0.6276
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.5439 0.8434
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.6423 1
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.6423 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.4031 0.3948
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.4031 0.3948
Trichomonas vaginalis AGC family protein kinase 0.0069 0.6423 1
Giardia lamblia Kinase, CMGC MAPK 0.0063 0.5439 0.8434
Schistosoma mansoni serine/threonine protein kinase 0.0063 0.5439 0.5375
Trypanosoma brucei cdc2-related kinase 1 0.0053 0.4031 0.6276
Echinococcus multilocularis cyclin dependent kinase 1 0.0053 0.4031 0.3948
Trypanosoma cruzi cdc2-related kinase 3 0.0053 0.4031 0.6195
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0063 0.5439 0.8434
Entamoeba histolytica protein kinase, putative 0.0069 0.6423 1
Toxoplasma gondii aurora kinase 0.0069 0.6423 1
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.4031 0.3948
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0063 0.5439 0.8468
Echinococcus multilocularis mitogen activated protein kinase 3 0.0063 0.5439 0.5375
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.6423 0.6373
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0063 0.5439 0.8468
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0138 0.0214
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0063 0.5439 0.8468
Brugia malayi serine/threonine kinase 12 0.0069 0.6423 0.6373
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0063 0.5439 0.5375
Giardia lamblia Kinase, CMGC CDK 0.0053 0.4031 0.6195
Entamoeba histolytica protein kinase, putative 0.0069 0.6423 1
Loa Loa (eye worm) AUR protein kinase 0.0069 0.6423 0.6373
Leishmania major protein kinase, putative 0.0069 0.6423 1
Echinococcus multilocularis aurora kinase A 0.0069 0.6423 0.6373
Trichomonas vaginalis AGC family protein kinase 0.0069 0.6423 1
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.4031 0.6195
Echinococcus granulosus aurora kinase A 0.0069 0.6423 0.6373
Loa Loa (eye worm) AUR protein kinase 0.0069 0.6423 0.6373
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.4031 0.6195
Echinococcus multilocularis mitogen activated protein kinase 0.0063 0.5439 0.5375
Plasmodium falciparum protein kinase 5 0.0053 0.4031 0.6276
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.6423 0.6373
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.4031 0.3948
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0053 0.4031 0.6276
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.5439 0.8434
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.6423 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0053 0.4031 0.3948
Loa Loa (eye worm) hypothetical protein 0.0052 0.3782 0.3695
Trypanosoma brucei aurora B kinase 0.0069 0.6423 1
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0138 0.0214
Echinococcus granulosus mitogen activated protein kinase 0.0063 0.5439 0.5375
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0053 0.4031 0.6276
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.6423 0.6373
Plasmodium vivax protein kinase Crk2 0.0053 0.4031 0.6276
Entamoeba histolytica protein kinase , putative 0.0069 0.6423 1
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.6423 1
Echinococcus granulosus cyclin dependent kinase 5 0.0053 0.4031 0.3948
Brugia malayi cell division control protein 2 homolog 0.0053 0.4031 0.3948
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0053 0.4031 0.6276
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0138 0.0214
Brugia malayi serine/threonine protein kinase 6 0.0069 0.6423 0.6373
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.6423 1
Trypanosoma brucei cdc2-related kinase 3 0.0053 0.4031 0.6276
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.5439 0.8434
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.4031 0.6195
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0138 0.0214
Brugia malayi MAP kinase sur-1 0.0063 0.5439 0.5375
Echinococcus granulosus mitogen activated protein kinase 3 0.0063 0.5439 0.5375
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0138 0.0214
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0138 0.0214
Loa Loa (eye worm) AUR protein kinase 0.0069 0.6423 0.6373
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0053 0.4031 0.3948
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0063 0.5439 0.8434
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.5439 0.8434
Giardia lamblia Kinase, CMGC CDK 0.0053 0.4031 0.6195
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.6423 1
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.6423 0.6373
Giardia lamblia Aurora kinase 0.0069 0.6423 1
Trichomonas vaginalis AGC family protein kinase 0.0069 0.6423 1
Trichomonas vaginalis CMGC family protein kinase 0.0063 0.5439 0.8434
Trypanosoma cruzi cdc2-related kinase 1 0.0053 0.4031 0.6195
Schistosoma mansoni protein kinase 0.0069 0.6423 0.6373
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.4031 0.6195
Trypanosoma brucei protein kinase, putative 0.0063 0.5439 0.8468
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0063 0.5439 0.8434
Trichomonas vaginalis AGC family protein kinase 0.0069 0.6423 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 39 nM Antiproliferative activity against human HT-29 cells ChEMBL. 19827834
Ki (binding) < 2 nM Inhibition of ERK2 after 10 mins by spectrophotometric coupled-enzyme assay ChEMBL. 19827834
Ki (binding) = 450 nM Inhibition of CDK2 ChEMBL. 19827834
Ki (binding) = 720 nM Inhibition of AURA ChEMBL. 19827834

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 19827834

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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