Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1043 | 0.1197 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.1592 | 0.2471 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0044 | 0.0538 | 0.231 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0377 | 0.0235 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0663 | 0.0754 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0248 | 0.0288 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0173 | 0.453 | 0.7073 |
Brugia malayi | Heterochromatin protein 1 | 0.0078 | 0.1592 | 0.1836 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0377 | 0.0235 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0377 | 0.0235 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0173 | 0.453 | 0.5263 |
Onchocerca volvulus | 0.0034 | 0.0248 | 0.1027 | |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0538 | 0.0398 |
Brugia malayi | MH2 domain containing protein | 0.0143 | 0.3608 | 0.4182 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.1043 | 1 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0377 | 0.0235 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0038 | 0.0377 | 0.0439 |
Trichomonas vaginalis | glutaminase, putative | 0.0305 | 0.8606 | 0.8585 |
Trypanosoma brucei | glucosidase, putative | 0.0038 | 0.0377 | 0.5 |
Loa Loa (eye worm) | glutaminase | 0.0305 | 0.8606 | 1 |
Schistosoma mansoni | alpha glucosidase | 0.0038 | 0.0377 | 0.0422 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0173 | 0.453 | 0.5255 |
Trichomonas vaginalis | maltase-glucoamylase, putative | 0.0038 | 0.0377 | 0.0235 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.1043 | 0.1611 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6398 | 0.7434 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.1592 | 0.1836 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0015 | 0.0017 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0143 | 0.3608 | 0.4192 |
Schistosoma mansoni | alpha-glucosidase | 0.0149 | 0.3787 | 0.439 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0038 | 0.0377 | 0.0422 |
Onchocerca volvulus | 0.01 | 0.228 | 1 | |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.064 | 0.0502 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0015 | 0.0017 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0663 | 0.0754 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0233 | 0.6398 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0044 | 0.0538 | 0.0609 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0171 | 0.4472 | 0.4534 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0047 | 0.064 | 0.2761 |
Trichomonas vaginalis | sucrase-isomaltase, putative | 0.0038 | 0.0377 | 0.0235 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0044 | 0.0538 | 0.0398 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0173 | 0.453 | 0.7073 |
Schistosoma mansoni | alpha-glucosidase | 0.0149 | 0.3787 | 0.439 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.1592 | 0.1468 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0143 | 0.3608 | 0.4192 |
Loa Loa (eye worm) | glutaminase 2 | 0.0305 | 0.8606 | 1 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0377 | 0.0235 |
Trichomonas vaginalis | neutral alpha-glucosidase ab precursor, putative | 0.0038 | 0.0377 | 0.0235 |
Brugia malayi | hypothetical protein | 0.0233 | 0.6398 | 0.743 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0078 | 0.1592 | 0.185 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0377 | 0.5 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0663 | 0.0754 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0233 | 0.6398 | 1 |
Echinococcus multilocularis | chromobox protein 1 | 0.0078 | 0.1592 | 0.2471 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0038 | 0.0377 | 0.0568 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0171 | 0.4472 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.1592 | 0.2471 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.1043 | 0.1611 |
Mycobacterium ulcerans | glutaminase | 0.0305 | 0.8606 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0078 | 0.1592 | 0.1468 |
Trichomonas vaginalis | alpha-glucosidase, putative | 0.0038 | 0.0377 | 0.0235 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0038 | 0.0377 | 0.0568 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0538 | 0.0625 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0171 | 0.4472 | 1 |
Onchocerca volvulus | 0.0048 | 0.0663 | 0.2861 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.1043 | 0.1197 |
Trichomonas vaginalis | chromobox protein, putative | 0.0047 | 0.064 | 0.0502 |
Schistosoma mansoni | chromobox protein | 0.0078 | 0.1592 | 0.1836 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.1043 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0377 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0305 | 0.8606 | 1 |
Schistosoma mansoni | glutaminase | 0.0305 | 0.8606 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0173 | 0.453 | 0.7073 |
Echinococcus granulosus | chromobox protein 1 | 0.0078 | 0.1592 | 0.2471 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Activation of human Gi protein alpha1 subunit expressed in Escherichia coli assessed as protein bound [35S]GTPgammaS levels by scintillation spectroscopy | ChEMBL. | 19289280 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.