Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | T-complex protein 1, beta subunit | 0.0028 | 0.0793 | 0.107 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0042 | 0.1321 | 0.2058 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1321 | 0.2058 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0045 | 0.1454 | 1 |
Brugia malayi | beta-lactamase | 0.0042 | 0.1321 | 0.2058 |
Loa Loa (eye worm) | phosphoenolpyruvate carboxykinase cytosolic family member | 0.0045 | 0.1454 | 0.2307 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0222 | 0.1526 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1321 | 0.2058 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.1321 | 0.2058 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0029 | 0.0815 | 0.1111 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0151 | 0.5563 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.1454 | 0.2307 |
Echinococcus granulosus | phosphoenolpyruvate carboxykinase | 0.0045 | 0.1454 | 1 |
Brugia malayi | phosphoenolpyruvate carboxykinase [GTP] | 0.0045 | 0.1454 | 0.2307 |
Mycobacterium leprae | PROBABLE IRON-REGULATED PHOSPHOENOLPYRUVATE CARBOXYKINASE [GTP] PCKA (PHOSPHOENOLPYRUVATE CARBOXYLASE) (PEPCK)(PEP CARBOXYKINASE | 0.0045 | 0.1454 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0013 | 0.0222 | 0.1052 |
Leishmania major | hypothetical protein, conserved | 0.0042 | 0.1321 | 1 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0045 | 0.1454 | 1 |
Giardia lamblia | Phosphoenolpyruvate carboxykinase | 0.0045 | 0.1454 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0042 | 0.1327 | 0.2068 |
Plasmodium falciparum | T-complex protein 1 subunit beta | 0.0028 | 0.0793 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0013 | 0.0222 | 0.1052 |
Echinococcus multilocularis | chaperonin containing TCP1, subunit 2 (beta) | 0.0028 | 0.0793 | 0.5202 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0028 | 0.0793 | 0.5456 |
Echinococcus multilocularis | phosphoenolpyruvate carboxykinase | 0.0045 | 0.1454 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.1321 | 0.8249 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0528 | 0.0573 |
Brugia malayi | phosphoenolpyruvate carboxykinase [GTP] | 0.0045 | 0.1454 | 0.2307 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0222 | 0.1526 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0042 | 0.1327 | 0.2068 |
Brugia malayi | hypothetical protein | 0.0015 | 0.0304 | 0.0154 |
Mycobacterium ulcerans | phosphoenolpyruvate carboxykinase | 0.0045 | 0.1454 | 1 |
Brugia malayi | T-complex protein 1, beta subunit | 0.0028 | 0.0793 | 0.107 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0028 | 0.0793 | 0.5456 |
Plasmodium vivax | T-complex protein 1 subunit beta, putative | 0.0028 | 0.0793 | 0.3348 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0042 | 0.1327 | 0.2068 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.1321 | 0.9086 |
Trichomonas vaginalis | chaperonin, putative | 0.0028 | 0.0793 | 0.1299 |
Loa Loa (eye worm) | T-complex protein 1 | 0.0028 | 0.0793 | 0.107 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0045 | 0.1454 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.1321 | 1 |
Entamoeba histolytica | T-complex protein 1 beta subunit, putative | 0.0028 | 0.0793 | 0.5 |
Brugia malayi | hypothetical protein | 0.0021 | 0.0528 | 0.0573 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1327 | 0.2068 |
Schistosoma mansoni | hypothetical protein | 0.0009 | 0.0077 | 0.053 |
Mycobacterium tuberculosis | Probable iron-regulated phosphoenolpyruvate carboxykinase [GTP] PckA (phosphoenolpyruvate carboxylase) (PEPCK)(pep carboxykinase | 0.0045 | 0.1454 | 0.0153 |
Loa Loa (eye worm) | hypothetical protein | 0.0151 | 0.5563 | 1 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0035 | 0.1064 | 0.4857 |
Toxoplasma gondii | ABC1 family protein | 0.0042 | 0.1321 | 1 |
Brugia malayi | MH2 domain containing protein | 0.01 | 0.3581 | 0.6289 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0042 | 0.1321 | 0.2058 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1321 | 0.2058 |
Schistosoma mansoni | hypothetical protein | 0.0029 | 0.0815 | 0.5608 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0042 | 0.1321 | 1 |
Trypanosoma brucei | T-complex protein 1, beta subunit, putative | 0.0028 | 0.0793 | 0.3348 |
Trichomonas vaginalis | esterase, putative | 0.0042 | 0.1321 | 0.8249 |
Onchocerca volvulus | 0.0042 | 0.1321 | 0.0572 | |
Schistosoma mansoni | phosphoenolpyruvate carboxykinase | 0.0045 | 0.1454 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0222 | 0.1526 |
Echinococcus multilocularis | GPCR, family 2 | 0.0013 | 0.0222 | 0.1052 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0042 | 0.1321 | 0.9086 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1321 | 0.2058 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0013 | 0.0222 | 0.1052 |
Echinococcus granulosus | GPCR family 2 | 0.0013 | 0.0222 | 0.1052 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.01 | 0.3581 | 0.6289 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1321 | 0.2058 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0042 | 0.1321 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1321 | 0.2058 |
Echinococcus granulosus | chaperonin containing TCP1 subunit 2 beta | 0.0028 | 0.0793 | 0.5202 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0042 | 0.1321 | 0.9034 |
Brugia malayi | N-terminal motif family protein | 0.0151 | 0.5563 | 1 |
Chlamydia trachomatis | phosphoenolpyruvate carboxykinase | 0.0045 | 0.1454 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.01 | 0.3581 | 0.6289 |
Loa Loa (eye worm) | beta-lactamase | 0.0042 | 0.1321 | 0.2058 |
Leishmania major | T-complex protein 1, beta subunit, putative | 0.0028 | 0.0793 | 0.3348 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.1321 | 0.8249 |
Plasmodium vivax | hypothetical protein, conserved | 0.0042 | 0.1321 | 1 |
Brugia malayi | beta-lactamase family protein | 0.0042 | 0.1321 | 0.2058 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0045 | 0.1454 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.1321 | 0.8249 |
Brugia malayi | hypothetical protein | 0.0014 | 0.0238 | 0.003 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0042 | 0.1321 | 0.8249 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0042 | 0.1321 | 0.9034 |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0045 | 0.1454 | 1 |
Schistosoma mansoni | chaperonin containing t-complex protein 1 beta subunit tcpb | 0.0028 | 0.0793 | 0.5456 |
Treponema pallidum | phosphoenolpyruvate carboxykinase | 0.0045 | 0.1454 | 0.5 |
Onchocerca volvulus | 0.0042 | 0.1321 | 0.0572 | |
Toxoplasma gondii | t-complex protein beta subunit | 0.0028 | 0.0793 | 0.3348 |
Trypanosoma cruzi | T-complex protein 1, beta subunit, putative | 0.0028 | 0.0793 | 0.3348 |
Schistosoma mansoni | hypothetical protein | 0.0013 | 0.0222 | 0.1526 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0815 | 0.1111 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0013 | 0.0222 | 0.1052 |
Loa Loa (eye worm) | phosphoenolpyruvate carboxykinase | 0.0045 | 0.1454 | 0.2307 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0042 | 0.1321 | 0.8249 |
Trichomonas vaginalis | chaperonin-60kD, ch60, putative | 0.0028 | 0.0793 | 0.1299 |
Onchocerca volvulus | 0.0042 | 0.1321 | 0.0572 | |
Trichomonas vaginalis | phosphoenolpyruvate carboxykinase, putative | 0.0035 | 0.1064 | 0.4857 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 145 nmol/ml | Antimicrobial activity against Escherichia coli B3704 after overnight incubation by microdilution broth susceptibility assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.