Target list

Search results for query: Wes VV TB Prioritized Targets: Structure, Enzyme, <600AA, essential, curated, not in human

  • Score for genes in query #58 (TB w/ solved structures): 30
  • Score for genes in query #60 (TB known essentials): 35
  • Score for genes in query #63 (TB not in human): 10
  • Score for genes in query #61 (TB E coli essentials): 20
  • Score for genes in query #59 (TB with Modeled structures): 20
  • Score for genes in query #52 (TB enzymes (any EC #)): 35
  • Score for genes in query #54 (TB < 600 AA): 25
  • Score for genes in query #48 (TB curated): 50
  • Score for genes in query #62 (TB essential in any species): 10

Convert this list of targets into a list of drugs:

Compounds have been manually associated with targets based on literature curation (Curated), and transitively associated with known druggable homologs or direct orthologs (predicted). Network derived target prioritizations also allows to convert any gene list into a drug list by making use of gene-drug indirect relationships within the repurposing network. All associations are done with true positives (known druggable targets), but predicted interactions are by no means tested or experimentally validated.

Retrieve:

2250 records found | Showing page 3 of 90 (records 51-75) | Number of records to display | Find orthologs in

  Organism   Name     Ortholog group   Product Weight
M. tuberculosis   Rv0902c   OG5_127115   Two component sensor histidine kinase PrrB 150
M. tuberculosis   Rv1311   OG5_127404   Probable ATP synthase epsilon chain AtpC 145
M. tuberculosis   Rv1092c   OG5_141174   Probable pantothenate kinase CoaA (pantothenic acid kinase) 145
M. tuberculosis   Rv1631   OG5_127254   Probable dephospho-CoA kinase CoaE (dephosphocoenzyme a kinase) 145
M. tuberculosis   Rv0429c   OG5_128237   Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 145
M. tuberculosis   Rv2447c   OG5_126889   Probable folylpolyglutamate synthase protein FolC (folylpoly-gamma-glutamate syn ... 145
M. tuberculosis   Rv3609c   OG5_127507   GTP cyclohydrolase I FolE (GTP-ch-I) 145
M. tuberculosis   Rv0989c     No group Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthet ... 145
M. tuberculosis   Rv1300   OG5_128078   Probable HemK protein homolog HemK 145
M. tuberculosis   Rv1485   OG5_127510   Ferrochelatase HemZ (protoheme ferro-lyase) (heme synthetase) 145
M. tuberculosis   Rv2121c   OG5_129102   ATP phosphoribosyltransferase HisG 145
M. tuberculosis   Rv1437   OG5_126776   Probable phosphoglycerate kinase Pgk 145
M. tuberculosis   Rv1822   OG5_127373   Probable CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsA ... 145
M. tuberculosis   Rv2746c   OG5_127373   Probable PGP synthase PgsA3 (CDP-diacylglycerol--glycerol-3-phosphate 3- phospha ... 145
M. tuberculosis   Rv1649   OG5_127036   Probable phenylalanyl-tRNA synthetase, alpha chain PheS 145
M. tuberculosis   Rv0500   OG5_126801   Probable pyrroline-5-carboxylate reductase ProC (P5CR) (P5C reductase) 145
M. tuberculosis   Rv2182c   OG5_126904   1-acylglycerol-3-phosphate O-acyltransferase 145
M. tuberculosis   Rv3336c   OG5_127531   Probable tryptophanyl-tRNA synthetase TrpS (tryptophan--tRNA ligase) (TRPRS) (tr ... 145
M. tuberculosis   Rv3913   OG5_127532   Probable thioredoxin reductase TrxB2 (TRXR) (TR) 145
M. tuberculosis   Rv1689   OG5_127413   Probable tyrosyl-tRNA synthase TyrS (TYRRS) 145
M. tuberculosis   Rv1568   OG5_128068   Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 140
M. tuberculosis   Rv2882c   OG5_127647   Ribosome recycling factor Frr (ribosome releasing factor) (RRF) 140
M. tuberculosis   Rv0440   OG5_126788   60 kDa chaperonin 2 GroEL2 (protein CPN60-2) (GroEL protein 2) (65 kDa antigen) ... 140
M. tuberculosis   Rv2861c   OG5_126721   Methionine aminopeptidase MapB (map) (peptidase M) 140
M. tuberculosis   Rv3566c   OG5_131280   Arylamine N-acetyltransferase Nat (arylamine acetylase) 140

Showing page 3 (records 51-75) of 90