TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 281.327 | Formula: C17H16FN3
H donors: 2 H acceptors: 1 LogP: 4.18 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)C(CCC2)Nc1nc2c([nH]1)cccc2
InChi: 1S/C17H16FN3/c18-12-9-8-11-4-3-7-14(13(11)10-12)19-17-20-15-5-1-2-6-16(15)21-17/h1-2,5-6,8-10,14H,3-4,7H2,(H2,19,20,21)
InChiKey: PJRHYQKKJIKFHE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Small conductance calcium-activated potassium channel protein 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	small conductance calcium activated potassium	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	expressed protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	IPR011996,SK channel region,domain-containing	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	Small conductance calcium-activated potassium channel protein, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	Small conductance calcium-activated potassium channel protein, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	ko:K01047 phospholipase A2 [EC3.1.1.4], putative	Get druggable targets OG5_130097	All targets in OG5_130097
Echinococcus multilocularis	small conductance calcium activated potassium	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma mansoni	calcium-activated potassium channel	Get druggable targets OG5_130097	All targets in OG5_130097
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097
Schistosoma japonicum	ko:K04942 potassium intermediate/small conductance calcium-activated channel,, putative	Get druggable targets OG5_130097	All targets in OG5_130097
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130097	All targets in OG5_130097

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	geminin	0.035	0.4874	0.487
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0213	0.0089
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0142	0.1863	0.4319
Onchocerca volvulus		0.0309	0.4276	1
Mycobacterium tuberculosis	Probable reductase	0.0084	0.1028	0.2858
Echinococcus granulosus	thioredoxin glutathione reductase	0.0037	0.0354	0.0347
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0142	0.1863	0.1857
Schistosoma mansoni	transcription factor LCR-F1	0.0108	0.1374	0.1265
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0021	0.0125	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0206	0.0478
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0024	0.0165	0.2892
Loa Loa (eye worm)	hypothetical protein	0.0029	0.0236	0.0548
Mycobacterium ulcerans	esterase/lipase LipP	0.0039	0.0382	1
Echinococcus granulosus	intermediate filament protein	0.0028	0.0213	0.0206
Echinococcus multilocularis	geminin	0.035	0.4874	0.487
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0165	0.1555
Schistosoma mansoni	hypothetical protein	0.0048	0.0512	0.0392
Echinococcus granulosus	beta LACTamase domain containing family member	0.0039	0.0382	0.0375
Entamoeba histolytica	hypothetical protein	0.0024	0.0157	0.0252
Brugia malayi	hypothetical protein	0.0028	0.0221	0.0454
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0033	0.0287	0.0164
Toxoplasma gondii	isocitrate dehydrogenase	0.0033	0.0287	0.6286
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0024	0.0165	0.2892
Trichomonas vaginalis	esterase, putative	0.0039	0.0382	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0142	0.1863	0.1857
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0152	0.2016	0.4679
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0033	0.0287	0.7786
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0033	0.0287	0.0665
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0033	0.0287	0.028
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0084	0.1028	0.2858
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0033	0.0287	0.6286
Brugia malayi	beta-lactamase	0.0039	0.0382	0.0834
Onchocerca volvulus		0.0039	0.0382	0.0529
Echinococcus granulosus	lamin dm0	0.0028	0.0213	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0382	0.0887
Schistosoma mansoni	lamin	0.0028	0.0213	0.0089
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0382	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0084	0.1028	0.2858
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0084	0.1028	0.2858
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0024	0.0165	0.0304
Entamoeba histolytica	hypothetical protein	0.0108	0.1374	1
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0093	0.1163	0.3258
Brugia malayi	glutathione reductase	0.0037	0.0347	0.0749
Brugia malayi	hypothetical protein	0.0309	0.4276	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0142	0.1863	0.1857
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0382	1
Loa Loa (eye worm)	beta-lactamase	0.0039	0.0382	0.0887
Leishmania major	trypanothione reductase	0.0037	0.0347	0.8608
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0039	0.0382	0.0375
Mycobacterium ulcerans	hypothetical protein	0.0039	0.0382	1
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0033	0.0287	0.6286
Loa Loa (eye worm)	hypothetical protein	0.0104	0.132	0.3063
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0015	0.0028	0.0066
Mycobacterium ulcerans	lipase LipD	0.0039	0.0382	1
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0165	0.0322
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0236	0.4319
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0251	0.3439	1
Plasmodium falciparum	thioredoxin reductase	0.0037	0.0347	1
Echinococcus multilocularis	importin subunit beta 1	0.0029	0.0236	0.0229
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0512	0.0505
Leishmania major	importin beta-1 subunit, putative	0.0024	0.0157	0.1225
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0077	0.0178
Echinococcus granulosus	importin subunit beta 1	0.0029	0.0236	0.0229
Mycobacterium ulcerans	hypothetical protein	0.0024	0.0165	0.2892
Entamoeba histolytica	hypothetical protein	0.0108	0.1374	1
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0512	0.1187
Echinococcus multilocularis	snurportin 1	0.0311	0.431	0.4306
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0512	0.1138
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0213	0.0495
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0382	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0024	0.0165	0.2892
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0382	1
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0165	0.0383
Toxoplasma gondii	ABC1 family protein	0.0039	0.0382	1
Echinococcus multilocularis	lamin dm0	0.0028	0.0213	0.0206
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0221	0.5359
Schistosoma mansoni	hypothetical protein	0.0048	0.0512	0.0392
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0382	0.0887
Schistosoma mansoni	hypothetical protein	0.0049	0.0519	0.0399
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.1863	0.176
Plasmodium vivax	hypothetical protein, conserved	0.0039	0.0382	1
Loa Loa (eye worm)	hypothetical protein	0.021	0.2851	0.6616
Echinococcus multilocularis	microtubule associated protein 2	0.0705	1	1
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0512	0.1187
Schistosoma mansoni	hypothetical protein	0.0108	0.1374	0.1265
Brugia malayi	beta-lactamase family protein	0.0039	0.0382	0.0834
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.1863	0.176
Loa Loa (eye worm)	hypothetical protein	0.0309	0.4276	0.992
Brugia malayi	latrophilin 2 splice variant baaae	0.0104	0.132	0.3041
Echinococcus granulosus	GPCR family 2	0.0048	0.0512	0.0505
Schistosoma mansoni	hypothetical protein	0.0048	0.0512	0.0392
Onchocerca volvulus		0.0049	0.0519	0.0862
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0084	0.1028	0.2858
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0512	0.0505
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0033	0.0287	0.6286
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0077	0.0178
Toxoplasma gondii	isocitrate dehydrogenase	0.0033	0.0287	0.6286
Echinococcus multilocularis	lamin	0.0028	0.0213	0.0206
Brugia malayi	Isocitrate dehydrogenase	0.0033	0.0287	0.0609
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0021	0.0125	0.1583
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0213	0.0495
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0382	0.0887
Mycobacterium leprae	Probable lipase LipE	0.0039	0.0382	0.2179
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0382	0.0261
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0039	0.0382	0.0834
Onchocerca volvulus		0.0039	0.0382	0.0529
Brugia malayi	beta-lactamase family protein	0.0039	0.0382	0.0834
Trypanosoma brucei	trypanothione reductase	0.0037	0.0347	0.8608
Loa Loa (eye worm)	hypothetical protein	0.0239	0.3268	0.7583
Entamoeba histolytica	hypothetical protein	0.0108	0.1374	1
Onchocerca volvulus		0.0039	0.0382	0.0529
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0165	0.2892
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0165	0.2892
Echinococcus granulosus	survival motor neuron protein 1	0.0239	0.3268	0.3263
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0221	0.374
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0039	0.0382	0.0948
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0033	0.0287	0.028
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0039	0.0382	1
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0213	0.0495
Schistosoma mansoni	hypothetical protein	0.0104	0.132	0.121
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0093	0.1163	0.3258
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0221	0.374
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.0157	0.1225
Echinococcus multilocularis	musashi	0.0028	0.0213	0.0206
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0077	0.0178
Brugia malayi	Thioredoxin reductase	0.0037	0.0347	0.0749
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0037	0.0354	0.0347
Schistosoma mansoni	hypothetical protein	0.021	0.2851	0.2761
Plasmodium vivax	importin-beta 2, putative	0.0029	0.0236	0.5218
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0084	0.1028	0.2858
Echinococcus multilocularis	isocitrate dehydrogenase	0.0033	0.0287	0.028
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0382	0.0887
Brugia malayi	RNA, U transporter 1	0.0083	0.1013	0.2317
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0021	0.0125	0.0118
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.0018	0.0077	0.5
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0165	0.1555
Schistosoma mansoni	survival motor neuron protein	0.0049	0.0519	0.0399
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0021	0.0125	0.0228
Loa Loa (eye worm)	hypothetical protein	0.0152	0.2016	0.4679
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0152	0.2016	0.4681
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0742	0.1721
Loa Loa (eye worm)	thioredoxin reductase	0.0037	0.0347	0.0804
Brugia malayi	MH2 domain containing protein	0.0122	0.1577	0.3647
Brugia malayi	hypothetical protein	0.0018	0.0077	0.0115
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0049	0.0519	0.1156
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0165	0.0383
Echinococcus multilocularis	survival motor neuron protein 1	0.0239	0.3268	0.3263
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0033	0.0287	0.6286
Trypanosoma brucei	importin beta-1 subunit, putative	0.0029	0.0236	0.4319
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0077	0.0178
Entamoeba histolytica	acyl-coA synthetase, putative	0.0024	0.0165	0.0321
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0039	0.0382	0.0948
Brugia malayi	Importin beta-1 subunit	0.0029	0.0236	0.0489
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0512	0.0505
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0021	0.0125	0.029
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0033	0.0287	0.6874
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0033	0.0287	0.0666
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0165	0.0322
Trichomonas vaginalis	D-aminoacylase, putative	0.0039	0.0382	1
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0382	0.0948
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0142	0.1863	0.1857
Trypanosoma cruzi	trypanothione reductase, putative	0.0037	0.0347	0.8608
Mycobacterium tuberculosis	Probable hydrolase	0.0039	0.0382	0.0948
Brugia malayi	follicle stimulating hormone receptor	0.0234	0.3197	0.7461
Onchocerca volvulus		0.0028	0.0213	0.0117
Brugia malayi	AMP-binding enzyme family protein	0.0024	0.0165	0.0322
Plasmodium vivax	glutathione reductase, putative	0.0037	0.0347	0.8829
Leishmania major	4-coumarate:coa ligase-like protein	0.0024	0.0165	0.1555
Mycobacterium ulcerans	acyl-CoA synthetase	0.0024	0.0165	0.2892
Loa Loa (eye worm)	transcription factor SMAD2	0.0122	0.1577	0.3659
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0213	0.0435
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0792	0.1837
Mycobacterium leprae	conserved hypothetical protein	0.0039	0.0382	0.2179
Brugia malayi	intermediate filament protein	0.0028	0.0213	0.0435
Echinococcus granulosus	lamin	0.0028	0.0213	0.0206
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0157	0.1225
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0033	0.0287	0.6286
Schistosoma mansoni	hypothetical protein	0.0048	0.0512	0.0392
Mycobacterium tuberculosis	Probable oxidoreductase	0.0093	0.1163	0.3258
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0512	0.0505
Schistosoma mansoni	hypothetical protein	0.0311	0.431	0.4238
Brugia malayi	hypothetical protein	0.0239	0.3268	0.7628
Brugia malayi	hypothetical protein	0.0108	0.1374	0.3168
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0033	0.0287	0.028
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0382	0.0887
Plasmodium vivax	thioredoxin reductase, putative	0.0037	0.0347	0.8829
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0142	0.1863	0.4322
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0039	0.0382	0.0948
Plasmodium falciparum	importin beta, putative	0.0029	0.0236	0.5911
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0221	0.0514
Entamoeba histolytica	hypothetical protein	0.0108	0.1374	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0221	0.374
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0033	0.0287	0.028
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0007	0.0017
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0024	0.0165	0.2892
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0039	0.0382	0.0887
Toxoplasma gondii	thioredoxin reductase	0.0037	0.0347	0.8608
Loa Loa (eye worm)	glutathione reductase	0.0037	0.0347	0.0804
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0093	0.1163	1
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0021	0.0125	0.1794
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0039	0.0382	0.0261
Echinococcus multilocularis	small conductance calcium activated potassium	0.021	0.2851	0.2846
Mycobacterium tuberculosis	Probable esterase LipL	0.0039	0.0382	0.0948
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0077	0.0178
Trichomonas vaginalis	penicillin-binding protein, putative	0.0039	0.0382	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0142	0.1863	0.176
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.0157	0.1225
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0165	0.0321
Schistosoma mansoni	hypothetical protein	0.035	0.4874	0.4809
Schistosoma mansoni	hypothetical protein	0.035	0.4874	0.4809
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0165	0.0383
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0108	0.1374	0.1368
Mycobacterium tuberculosis	Probable lipase LipD	0.0039	0.0382	0.0948
Leishmania major	hypothetical protein, conserved	0.0039	0.0382	1
Echinococcus granulosus	snurportin 1	0.0311	0.431	0.4306
Mycobacterium ulcerans	beta-lactamase	0.0039	0.0382	1
Onchocerca volvulus		0.0028	0.0213	0.0117
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0221	0.374
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0512	0.0505
Trypanosoma brucei	hypothetical protein, conserved	0.0039	0.0382	1
Schistosoma mansoni	microtubule-associated protein tau	0.0705	1	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0024	0.0165	0.0321
Brugia malayi	isocitrate dehydrogenase	0.0033	0.0287	0.0609
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0108	0.1374	0.1368
Schistosoma mansoni	calcium-activated potassium channel	0.0136	0.1774	0.167
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0152	0.2016	0.4681
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0037	0.0347	0.0842
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0512	0.1138
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0024	0.0165	0.0304
Toxoplasma gondii	HEAT repeat-containing protein	0.0029	0.0236	0.4319
Loa Loa (eye worm)	MH2 domain-containing protein	0.0122	0.1577	0.3659
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0033	0.0287	0.028
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0311	0.431	1
Schistosoma mansoni	calcium-activated potassium channel	0.021	0.2851	0.2761
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0382	0.0948
Schistosoma mansoni	importin beta-1	0.0029	0.0236	0.0113
Leishmania major	hypothetical protein, conserved	0.0028	0.0221	0.374
Plasmodium falciparum	glutathione reductase	0.0037	0.0347	1
Schistosoma mansoni	lamin	0.0028	0.0213	0.0089
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0221	0.4731
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0382	0.0887
Echinococcus granulosus	small conductance calcium activated potassium	0.021	0.2851	0.2846
Mycobacterium tuberculosis	Probable lipase LipE	0.0039	0.0382	0.0948
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0221	0.5359
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0021	0.0125	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.0848	0.1967
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0234	0.3197	0.7418
Mycobacterium tuberculosis	Conserved protein	0.0039	0.0382	0.0948
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.0157	0.1225
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0084	0.1028	0.8644
Trypanosoma cruzi	hypothetical protein, conserved	0.0039	0.0382	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0018	0.0077	0.0042

Activities

Activity type	Activity value	Assay description	Source	Reference
Kd (binding)	= 0.034 uM	Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique	ChEMBL.	18998663

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL511681

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1011276