Detailed information for compound 1016527

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 367.415 | Formula: C16H14FNO4S2
  • H donors: 1 H acceptors: 4 LogP: 2.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)NS(=O)(=O)c1ccc(cc1)F)CSC(=O)C
  • InChi: 1S/C16H14FNO4S2/c1-11(19)23-10-16(20)12-2-6-14(7-3-12)18-24(21,22)15-8-4-13(17)5-9-15/h2-9,18H,10H2,1H3
  • InChiKey: WXVXAQVVGXIQOQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens histone deacetylase 9 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium knowlesi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei gambiense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Toxoplasma gondii histone deacetylase HDAC1 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Brugia malayi Histone deacetylase family protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase 2 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 4, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma cruzi histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium vivax histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Neospora caninum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Candida albicans strong similarity to S. cerevisiae HDA1 (YNL021W) class II histone deacetylase HDA1 complex subunit Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania major histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase 4 5 Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 3 Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma brucei histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania donovani histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus granulosus histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 7 Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium berghei histone deacetylase 2, putative Get druggable targets OG5_126654 All targets in OG5_126654
Cryptosporidium parvum histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium yoelii Histone deacetylase family, putative Get druggable targets OG5_126654 All targets in OG5_126654
Trypanosoma congolense histone deacetylase 4 Get druggable targets OG5_126654 All targets in OG5_126654
Theileria parva histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 10, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum Histone deacetylase 6, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania braziliensis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Plasmodium falciparum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Babesia bovis histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma mansoni histone deacetylase hda2 Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania infantum histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Leishmania mexicana histone deacetylase, putative Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase Get druggable targets OG5_126654 All targets in OG5_126654
Echinococcus multilocularis histone deacetylase 6 Get druggable targets OG5_126654 All targets in OG5_126654
Schistosoma japonicum IPR000286,Histone deacetylase superfamily;IPR013838,Beta tubulin, autoregulation binding site,domain-containing Get druggable targets OG5_126654 All targets in OG5_126654
Loa Loa (eye worm) histone deacetylase 7A Get druggable targets OG5_126654 All targets in OG5_126654
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable hydrolase 0.0081 0.0684 0.0788
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1314 0.3068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.2079 0.2057
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0186 0.2079 0.3187
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0291 0.0627
Loa Loa (eye worm) hypothetical protein 0.0051 0.0291 0.0446
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0081 0.0684 0.1048
Schistosoma mansoni histone deacetylase 4 5 0.0051 0.0291 0.0627
Brugia malayi Pre-SET motif family protein 0.0031 0.0028 0.0043
Echinococcus granulosus geminin 0.0347 0.4221 0.6463
Schistosoma mansoni hypothetical protein 0.0106 0.1024 0.2375
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0125 0.1267 0.1941
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0217 0.2496 0.3826
Schistosoma mansoni alpha-glucosidase 0.0303 0.3629 0.8587
Brugia malayi Pre-SET motif family protein 0.0217 0.2496 0.3826
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0404 0.062
Schistosoma mansoni alpha glucosidase 0.0078 0.0649 0.1482
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0515 0.6444 1
Trypanosoma brucei histone deacetylase 3 0.0051 0.0291 0.4257
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0191 0.0163
Echinococcus granulosus histone deacetylase 6 0.0051 0.0291 0.0427
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0404 0.062
Loa Loa (eye worm) hypothetical protein 0.006 0.0404 0.062
Mycobacterium tuberculosis Conserved protein 0.0081 0.0684 0.0788
Brugia malayi Histone deacetylase family protein 0.0051 0.0291 0.0446
Loa Loa (eye worm) histone deacetylase 7A 0.0051 0.0291 0.0446
Mycobacterium ulcerans beta-lactamase 0.0081 0.0684 0.1418
Loa Loa (eye worm) hypothetical protein 0.0081 0.0684 0.1048
Brugia malayi beta-lactamase 0.0081 0.0684 0.1048
Loa Loa (eye worm) hypothetical protein 0.0521 0.6524 1
Entamoeba histolytica hypothetical protein 0.0109 0.1054 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0291 0.0446
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0649 0.9501
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0106 0.1024 0.1569
Toxoplasma gondii aldehyde dehydrogenase 0.0128 0.1314 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2079 0.4892
Schistosoma mansoni hypothetical protein 0.0109 0.1054 0.2448
Loa Loa (eye worm) RNA binding protein 0.0125 0.1267 0.1941
Echinococcus multilocularis survival motor neuron protein 1 0.0521 0.6524 0.6515
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0352 0.4278 0.6557
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0649 0.1771
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1267 0.2954
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0081 0.0684 0.0788
Brugia malayi hypothetical protein 0.0521 0.6524 1
Echinococcus multilocularis histone deacetylase 0.0051 0.0291 0.0264
Onchocerca volvulus 0.0081 0.0684 0.2362
Echinococcus multilocularis geminin 0.0347 0.4221 0.4205
Echinococcus granulosus Aminotransferase class III 0.0043 0.0191 0.0273
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.0649 0.9501
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0109 0.1054 0.16
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0649 0.1771
Loa Loa (eye worm) beta-lactamase 0.0081 0.0684 0.1048
Onchocerca volvulus 0.0081 0.0684 0.2362
Plasmodium vivax histone deacetylase 2, putative 0.0051 0.0291 0.4012
Echinococcus multilocularis lysosomal alpha glucosidase 0.0352 0.4278 0.4262
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1314 0.3233
Leishmania major histone deacetylase, putative 0.0051 0.0291 0.2214
Mycobacterium tuberculosis Probable lipase LipD 0.0081 0.0684 0.0788
Trypanosoma brucei glucosidase, putative 0.0078 0.0649 0.9501
Loa Loa (eye worm) hypothetical protein 0.0041 0.0155 0.0237
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0028 0.0023
Echinococcus granulosus survival motor neuron protein 1 0.0521 0.6524 1
Entamoeba histolytica hypothetical protein 0.0109 0.1054 1
Entamoeba histolytica hypothetical protein 0.0109 0.1054 1
Mycobacterium tuberculosis Probable lipase LipE 0.0081 0.0684 0.0788
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1314 0.3233
Loa Loa (eye worm) hypothetical protein 0.0081 0.0684 0.1048
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0155 0.0237
Echinococcus granulosus histone deacetylase 7 0.0051 0.0291 0.0427
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1267 0.2954
Mycobacterium ulcerans aldehyde dehydrogenase 0.0128 0.1314 0.3233
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0291 0.4257
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0186 0.2079 0.3187
Loa Loa (eye worm) glutaminase 2 0.0276 0.3268 0.5009
Echinococcus multilocularis beta LACTamase domain containing family member 0.0081 0.0684 0.0657
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0684 0.1864
Echinococcus multilocularis Aminotransferase class III 0.0043 0.0191 0.0163
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0128 0.1314 0.1999
Onchocerca volvulus 0.0247 0.2894 1
Mycobacterium ulcerans esterase/lipase LipP 0.0081 0.0684 0.1418
Loa Loa (eye worm) hypothetical protein 0.0081 0.0684 0.1048
Toxoplasma gondii histone deacetylase HDAC1 0.0051 0.0291 0.2045
Plasmodium falciparum histone deacetylase 2 0.0051 0.0291 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0684 0.1564
Echinococcus multilocularis histone deacetylase 7 0.0051 0.0291 0.0264
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0078 0.0649 0.4832
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0081 0.0684 0.1048
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0404 0.062
Mycobacterium ulcerans lipase LipD 0.0081 0.0684 0.1418
Schistosoma mansoni glutaminase 0.0276 0.3268 0.7726
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0128 0.1314 1
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0043 0.0191 0.5
Echinococcus granulosus tar DNA binding protein 0.0125 0.1267 0.1926
Leishmania major hypothetical protein, conserved 0.0081 0.0684 0.5201
Schistosoma mansoni hypothetical protein 0.0347 0.4221 1
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0306 0.3666 0.5558
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0291 0.0264
Onchocerca volvulus 0.0081 0.0684 0.2362
Mycobacterium ulcerans glutaminase 0.0276 0.3268 0.8853
Brugia malayi Glycosyl hydrolases family 31 protein 0.0352 0.4278 0.6557
Trypanosoma brucei histone deacetylase 4 0.0051 0.0291 0.4257
Trypanosoma brucei histone deacetylase, putative 0.0051 0.0291 0.4257
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0081 0.0684 0.1564
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0291 0.0264
Mycobacterium leprae Probable lipase LipE 0.0081 0.0684 0.1418
Plasmodium vivax ornithine aminotransferase, putative 0.0043 0.0191 0.2482
Schistosoma mansoni alpha-glucosidase 0.0303 0.3629 0.8587
Echinococcus granulosus beta LACTamase domain containing family member 0.0081 0.0684 0.103
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0291 0.4257
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0186 0.2079 0.2057
Onchocerca volvulus 0.0106 0.1024 0.3538
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2079 0.4892
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0109 0.1054 0.1029
Brugia malayi hypothetical protein 0.0109 0.1054 0.1616
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0649 0.1771
Trypanosoma cruzi histone deacetylase, putative 0.0051 0.0291 0.4257
Loa Loa (eye worm) hypothetical protein 0.0081 0.0684 0.1048
Echinococcus granulosus lysosomal alpha glucosidase 0.0352 0.4278 0.655
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0043 0.0191 0.0292
Mycobacterium tuberculosis Probable esterase LipL 0.0081 0.0684 0.0788
Leishmania major alpha glucosidase II subunit, putative 0.0078 0.0649 0.4941
Echinococcus multilocularis lysosomal alpha glucosidase 0.0352 0.4278 0.4262
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0649 0.1771
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0306 0.3666 1
Brugia malayi RNA binding protein 0.0125 0.1267 0.1941
Brugia malayi RNA recognition motif domain containing protein 0.0125 0.1267 0.1941
Echinococcus granulosus histone deacetylase 6 0.0051 0.0291 0.0427
Echinococcus multilocularis ornithine aminotransferase 0.0043 0.0191 0.0163
Brugia malayi glutaminase DH11.1 0.0276 0.3268 0.5009
Echinococcus multilocularis histone deacetylase 6 0.0051 0.0291 0.0264
Brugia malayi Glycosyl hydrolases family 31 protein 0.0078 0.0649 0.0995
Plasmodium vivax hypothetical protein, conserved 0.0081 0.0684 1
Mycobacterium tuberculosis Probable aminotransferase 0.0306 0.3666 0.5558
Brugia malayi TAR-binding protein 0.0125 0.1267 0.1941
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0043 0.0191 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0186 0.2079 0.4892
Mycobacterium tuberculosis Conserved protein 0.0081 0.0684 0.0788
Loa Loa (eye worm) TAR-binding protein 0.0125 0.1267 0.1941
Plasmodium falciparum histone deacetylase, putative 0.0051 0.0291 1
Entamoeba histolytica hypothetical protein 0.0109 0.1054 1
Echinococcus granulosus histone deacetylase 6 0.0051 0.0291 0.0427
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1267 0.2954
Schistosoma mansoni histone deacetylase hda2 0.0051 0.0291 0.0627
Trichomonas vaginalis glutaminase, putative 0.0276 0.3268 0.8913
Loa Loa (eye worm) hypothetical protein 0.0081 0.0684 0.1048
Echinococcus granulosus histone deacetylase 0.0051 0.0291 0.0427
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0649 0.6159
Schistosoma mansoni aldehyde dehydrogenase 0.0128 0.1314 0.3068
Plasmodium vivax histone deacetylase, putative 0.0051 0.0291 0.4012
Echinococcus granulosus neutral alpha glucosidase AB 0.0078 0.0649 0.0978
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.2079 0.3174
Schistosoma mansoni survival motor neuron protein 0.0106 0.1024 0.2375
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1267 0.2954
Mycobacterium ulcerans hypothetical protein 0.0306 0.3666 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0186 0.2079 0.3174
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0078 0.0649 0.0995
Trichomonas vaginalis maltase-glucoamylase, putative 0.0078 0.0649 0.1771
Echinococcus multilocularis neutral alpha glucosidase AB 0.0078 0.0649 0.0623
Echinococcus multilocularis tar DNA binding protein 0.0125 0.1267 0.1242
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0128 0.1314 0.129
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0306 0.3666 1
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0684 0.1864
Mycobacterium leprae conserved hypothetical protein 0.0081 0.0684 0.1418
Trichomonas vaginalis alpha-glucosidase, putative 0.0078 0.0649 0.1771
Trichomonas vaginalis set domain proteins, putative 0.0247 0.2894 0.7894
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0081 0.0684 0.1418
Trichomonas vaginalis esterase, putative 0.0081 0.0684 0.1864
Brugia malayi beta-lactamase family protein 0.0081 0.0684 0.1048
Schistosoma mansoni transcription factor LCR-F1 0.0109 0.1054 0.2448
Loa Loa (eye worm) glutaminase 0.0276 0.3268 0.5009
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0684 0.1864
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0081 0.0684 0.0788
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0306 0.3666 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0028 0.0043
Loa Loa (eye worm) histone deacetylase 0.0051 0.0291 0.0446
Mycobacterium tuberculosis Conserved protein 0.0081 0.0684 0.0788
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0684 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0078 0.0649 0.1771
Brugia malayi beta-lactamase family protein 0.0081 0.0684 0.1048
Trichomonas vaginalis D-aminoacylase, putative 0.0081 0.0684 0.1864
Trypanosoma brucei hypothetical protein, conserved 0.0081 0.0684 1
Trypanosoma cruzi hypothetical protein, conserved 0.0081 0.0684 1
Schistosoma mansoni hypothetical protein 0.0347 0.4221 1
Onchocerca volvulus 0.0031 0.0028 0.0096
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0649 0.1771
Brugia malayi Histone deacetylase family protein 0.0051 0.0291 0.0446
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0078 0.0649 0.6159
Echinococcus granulosus ornithine aminotransferase 0.0043 0.0191 0.0273
Leishmania major histone deacetylase, putative 0.0051 0.0291 0.2214
Loa Loa (eye worm) hypothetical protein 0.0081 0.0684 0.1048
Onchocerca volvulus 0.0203 0.2312 0.7988
Trichomonas vaginalis penicillin-binding protein, putative 0.0081 0.0684 0.1864
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0043 0.0191 0.0388
Schistosoma mansoni tar DNA-binding protein 0.0125 0.1267 0.2954
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0128 0.1314 0.1797
Schistosoma mansoni hypothetical protein 0.0041 0.0155 0.0302
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0043 0.0191 0.1265
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0078 0.0649 0.1771
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0081 0.0684 0.0788
Mycobacterium ulcerans hypothetical protein 0.0081 0.0684 0.1418
Toxoplasma gondii ABC1 family protein 0.0081 0.0684 0.5097

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 0.95 uM Inhibition of histone deacetylase in human HeLa cells assessed as induction of histone H3 hyperacetylation ChEMBL. 18954984

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.