Detailed information for compound 1020758

Basic information

Technical information
  • TDR Targets ID: 1020758
  • Name: 3-[(E)-3-[[4-[(carboxymethylcarbamoylamino)me thyl]phenyl]amino]-3-oxoprop-1-enyl]-4,6-dich loro-1H-indole-2-carboxylic acid
  • MW: 505.308 | Formula: C22H18Cl2N4O6
  • H donors: 6 H acceptors: 6 LogP: 2.96 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=C(NCc1ccc(cc1)NC(=O)/C=C/c1c([nH]c2c1c(Cl)cc(c2)Cl)C(=O)O)NCC(=O)O
  • InChi: 1S/C22H18Cl2N4O6/c23-12-7-15(24)19-14(20(21(32)33)28-16(19)8-12)5-6-17(29)27-13-3-1-11(2-4-13)9-25-22(34)26-10-18(30)31/h1-8,28H,9-10H2,(H,27,29)(H,30,31)(H,32,33)(H2,25,26,34)/b6-5+
  • InChiKey: QRDYOSMXKQJZCG-AATRIKPKSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[(E)-3-[[4-[(carboxymethylcarbamoylamino)methyl]phenyl]amino]-3-oxo-prop-1-enyl]-4,6-dichloro-1H-indole-2-carboxylic acid
  • 3-[(E)-3-[[4-[[[(carboxymethylamino)-oxomethyl]amino]methyl]phenyl]amino]-3-oxoprop-1-enyl]-4,6-dichloro-1H-indole-2-carboxylic acid
  • 3-[(E)-3-[[4-[(carboxymethylcarbamoylamino)methyl]phenyl]amino]-3-keto-prop-1-enyl]-4,6-dichloro-1H-indole-2-carboxylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis roundabout 2 0.0005 0.0001 0.0001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0149 0.0158 0.0304
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0006 0.0006
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0009
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.2103 0.2297 0.4417
Schistosoma mansoni septate junction protein 0.0005 0.0001 0.0001
Schistosoma mansoni ap endonuclease 0.002 0.0017 0.0017
Schistosoma mansoni tyrosine kinase 0.0006 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0009
Onchocerca volvulus 0.001 0.0006 0.0393
Schistosoma mansoni cell adhesion molecule 0.0005 0.0001 0.0001
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.3953 0.4322 0.7612
Loa Loa (eye worm) hypothetical protein 0.0158 0.0168 0.0323
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0006 0.0011
Brugia malayi Fibronectin type III domain containing protein 0.0009 0.0005 0.0009
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.4755 0.5201 0.5201
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.3953 0.4322 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0009
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0012 0.0023
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.007 0.0072 0.0055
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.007 0.0072 0.0072
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0006 0.0006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0017 0.002
Schistosoma mansoni ap endonuclease 0.002 0.0017 0.0017
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0005 0.0001 0.0001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0006 0.0006
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0006 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0006 0.0011
Schistosoma mansoni nephrin 0.0005 0.0001 0.0001
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0005 0.0001 0.0001
Echinococcus multilocularis roundabout 2 0.0005 0.0001 0.0001
Schistosoma mansoni cpg binding protein 0.0032 0.003 0.003
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0001 0.0001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0017 0.0009
Echinococcus multilocularis hemicentin 1 0.0005 0.0001 0.0001
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0006 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0006 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0001 0.0001
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0005 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0006 0.0011
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0011
Echinococcus multilocularis hemicentin 1 0.0005 0.0001 0.0001
Schistosoma mansoni nephrin 0.0012 0.0008 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0017 0.0009
Echinococcus granulosus carbonic anhydrase 0.2103 0.2297 0.4417
Brugia malayi CXXC zinc finger family protein 0.003 0.0029 0.0054
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0006 0.001
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0005 0.0001 0.0045
Echinococcus granulosus lachesin 0.0005 0.0001 0.0001
Echinococcus multilocularis cpg binding protein 0.0032 0.003 0.0058
Echinococcus multilocularis carbonic anhydrase 0.2103 0.2297 0.4417
Echinococcus multilocularis muscleblind protein 1 0.0158 0.0168 0.0323
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0011
Schistosoma mansoni carbonic anhydrase 0.914 1 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0005 0.0001 0.0001
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0005 0.0001 0.0001
Schistosoma mansoni carbonic anhydrase-related 0.2103 0.2297 0.2297
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0006 0.0011
Echinococcus granulosus transcription factor Dp 1 0.004 0.004 0.0075
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0003 0.0006
Brugia malayi hypothetical protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0012 0.0023
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0023
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0005 0.0001 0.0001
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0006 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0006 0.0011
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0017 0.5
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0005 0.0001 0.0001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0001 0.0001
Echinococcus granulosus Immunoglobulin 0.0009 0.0005 0.0009
Echinococcus multilocularis muscleblind protein 0.0158 0.0168 0.0323
Schistosoma mansoni vesicular amine transporter 0.0009 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.003 0.0029 0.0029
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0009 0.0005 0.0009
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0006 0.0011
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0006 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0011
Echinococcus granulosus hemicentin 1 0.0005 0.0001 0.0001
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0006 0.0393
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Echinococcus multilocularis tyrosine protein kinase otk 0.0005 0.0001 0.0001
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0017 0.0032
Echinococcus granulosus roundabout 2 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0021
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0072 0.0114
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0011
Echinococcus granulosus neuroglian 0.0005 0.0001 0.0001
Onchocerca volvulus 0.003 0.0029 0.191
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0149 0.0158 0.0304
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0009 0.0016
Echinococcus multilocularis roundabout 2 0.0015 0.0011 0.0021
Brugia malayi hypothetical protein 0.0009 0.0005 0.0009
Toxoplasma gondii hypothetical protein 0.2103 0.2297 1
Schistosoma mansoni coup transcription factor 0.001 0.0006 0.0006
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.2103 0.2297 0.4417
Echinococcus granulosus twitchin 0.0012 0.0008 0.0014
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.4755 0.5201 0.5201
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0023
Schistosoma mansoni hypothetical protein 0.2103 0.2297 0.2297
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0006 0.0011
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0006 0.001
Brugia malayi Putative carbonic anhydrase 5 precursor 0.4755 0.5201 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0072 0.0114
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Echinococcus multilocularis neuroglian 0.0012 0.0008 0.0014
Echinococcus multilocularis Immunoglobulin 0.0009 0.0005 0.0009
Echinococcus granulosus roundabout 2 0.0005 0.0001 0.0001
Echinococcus granulosus defective proboscis extension response 0.0009 0.0005 0.0009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0006 0.0006
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0006 0.0011
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.007 0.0072 0.0114
Schistosoma mansoni cell adhesion molecule 0.0012 0.0009 0.0009
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0006 0.0393
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.4755 0.5201 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0005 0.0001 0.0001
Echinococcus multilocularis peroxidasin 0.0005 0.0001 0.0001
Brugia malayi steroid hormone receptor 0.001 0.0006 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0011
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.2103 0.2297 0.4417
Echinococcus granulosus neuroglian 0.0012 0.0008 0.0014
Brugia malayi nuclear hormone receptor 0.001 0.0006 0.0011
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0012 0.0009 0.0016
Schistosoma mansoni neuroglian 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0009
Trypanosoma brucei carbonic anhydrase-like protein 0.4755 0.5201 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0006 0.0011
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0006 0.0393
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0006 0.0006
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.2103 0.2297 0.4417
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0005 0.0001 0.0001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0006 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Brugia malayi hypothetical protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0005 0.0001 0.0001
Schistosoma mansoni roundabout 0.0005 0.0001 0.0001
Brugia malayi ecdysteroid receptor 0.001 0.0006 0.0011
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0006 0.0011
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0005 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0006 0.0011
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0017 0.5
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0005 0.0001 0.0001
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0017 0.5
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Echinococcus multilocularis carbonic anhydrase 0.2103 0.2297 0.4417
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0001 0.0001
Echinococcus granulosus muscleblind protein 0.0158 0.0168 0.0323
Echinococcus granulosus carbonic anhydrase 0.2103 0.2297 0.4417
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.5188 0.5674 1
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0017 0.0032
Brugia malayi Nuclear hormone receptor-like 1 0.0005 0.0001 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0006 0.0011
Schistosoma mansoni carbonic anhydrase-related 0.2103 0.2297 0.2297
Mycobacterium ulcerans carbonic anhydrase 0.914 1 1
Loa Loa (eye worm) hypothetical protein 0.2103 0.2297 0.4417
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.2103 0.2297 0.4417
Brugia malayi Muscleblind-like protein 0.0158 0.0168 0.0323
Echinococcus granulosus peroxidasin 0.0005 0.0001 0.0001
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.4755 0.5201 1
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.914 1 0.5
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.007 0.0072 0.0137
Leishmania major carbonic anhydrase family protein, putative 0.914 1 1
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0009 0.0005 0.0005
Schistosoma mansoni septate junction protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Brugia malayi nuclear receptor RXR 0.0005 0.0001 0.0001
Echinococcus multilocularis carbonic anhydrase II 0.4755 0.5201 1
Schistosoma mansoni titin 0.0005 0.0001 0.0001
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0012 0.0023
Echinococcus granulosus FTZ F1 alpha 0.001 0.0006 0.0011
Echinococcus granulosus carbonic anhydrase II 0.4755 0.5201 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0012 0.0023
Echinococcus granulosus contactin 0.0005 0.0001 0.0001
Echinococcus granulosus carbonic anhydrase 0.2103 0.2297 0.4417
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Echinococcus multilocularis lachesin 0.0005 0.0001 0.0001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0006 0.0011
Schistosoma mansoni carbonic anhydrase-related 0.2103 0.2297 0.2297
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0012 0.0012
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0006 0.0011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0058 0.0201
Loa Loa (eye worm) hypothetical protein 0.0158 0.0168 0.0323
Schistosoma mansoni cell adhesion molecule 0.0005 0.0001 0.0001
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0006
Echinococcus multilocularis neuroglian 0.0005 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0006 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.3953 0.4322 1
Echinococcus granulosus tyrosine protein kinase otk 0.0005 0.0001 0.0001
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.007 0.0072 0.0059
Plasmodium falciparum carbonic anhydrase 0.2103 0.2297 1
Echinococcus multilocularis transcription factor Dp 1 0.004 0.004 0.0075
Mycobacterium ulcerans carbonic anhydrase 0.3953 0.4322 0.4312
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.2103 0.2297 0.4417
Schistosoma mansoni nuclear hormone receptor 0.001 0.0006 0.0006
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0001 0.0001
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.4755 0.5201 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0001 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0006 0.0011
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0006 0.0011
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.007 0.0072 0.0137
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0066 0.0066
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.007 0.0072 0.0137
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.4755 0.5201 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0005 0.0009
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0003 0.0006
Loa Loa (eye worm) carbonic anhydrase 3 0.4755 0.5201 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0001 0.0001
Schistosoma mansoni thyroid hormone receptor 0.001 0.0006 0.0006
Onchocerca volvulus Tyrosine kinase homolog 0.0139 0.0148 1
Schistosoma mansoni cell adhesion molecule 0.0005 0.0001 0.0001
Brugia malayi Peroxidasin 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.2103 0.2297 0.4417
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0021
Echinococcus granulosus cpg binding protein 0.0032 0.003 0.0058
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.007 0.0072 0.0137
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0001 0.0001
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0005 0.0001 0.0001
Schistosoma mansoni carbonic anhydrase 0.2103 0.2297 0.2297
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0017 0.0033
Brugia malayi isocitrate dehydrogenase 0.0016 0.0012 0.0023
Toxoplasma gondii exonuclease III APE 0.002 0.0017 0.002
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0006 0.0011
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0017 0.0032
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.2103 0.2297 0.4417
Schistosoma mansoni cpg binding protein 0.0032 0.003 0.003
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0006 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0006 0.0011
Brugia malayi nuclear receptor NHR-88 0.001 0.0006 0.0011
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0005 0.0001 0.0001
Leishmania major carbonic anhydrase-like protein 0.4755 0.5201 0.5195
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Echinococcus multilocularis Immunoglobulin 0.0009 0.0005 0.0009
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0017 0.0033
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0005 0.0001 0.0001
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0017 0.0008
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0017 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0006 0.0011
Brugia malayi Immunoglobulin I-set domain containing protein 0.0009 0.0005 0.0009
Loa Loa (eye worm) hypothetical protein 0.0005 0.0001 0.0001
Brugia malayi Prion-like- 0.0005 0.0001 0.0001
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0006 0.0011
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0029 0.0054
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0006 0.0006
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0009 0.0005 0.0005
Echinococcus granulosus roundabout 2 0.0015 0.0011 0.0021
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0006 0.0011
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0006 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0006 0.0011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0003 0.0006
Onchocerca volvulus 0.0136 0.0144 0.9764
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0017 0.0032
Echinococcus multilocularis carbonic anhydrase 0.2103 0.2297 0.4417
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0017 0.0005
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0017 0.0009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0005 0.0001 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0012 0.0023

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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