TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 442.528 | Formula: C27H27FN4O
H donors: 1 H acceptors: 2 LogP: 4.41 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Fc1ccc2c(c1)nc([nH]2)c1ccc(cc1)c1cccc(c1)CN1CCC(C1)N(C(=O)C)C
InChi: 1S/C27H27FN4O/c1-18(33)31(2)24-12-13-32(17-24)16-19-4-3-5-22(14-19)20-6-8-21(9-7-20)27-29-25-11-10-23(28)15-26(25)30-27/h3-11,14-15,24H,12-13,16-17H2,1-2H3,(H,29,30)
InChiKey: IKQCEUSIFNIATQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0621	0.1151
Leishmania major	glucose transporter, lmgt2	0.0033	0.0621	0.6168
Trypanosoma cruzi	hexose transporter, putative	0.0018	0.0286	0.2838
Toxoplasma gondii	sugar transporter ST3	0.0015	0.0217	0.0327
Treponema pallidum	NADH oxidase	0.0017	0.0271	0.8162
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Echinococcus granulosus	dihydrolipoamide dehydrogenase	0.0017	0.0271	0.0656
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Schistosoma mansoni	hypothetical protein	0.018	0.3913	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Mycobacterium leprae	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase)	0.0006	0.0016	0.0057
Leishmania major	trypanothione reductase	0.005	0.1007	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0115	0.2448	0.8953
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0329	0.0314
Plasmodium vivax	CDK-related protein kinase 6, putative	0.0453	1	1
Chlamydia trachomatis	lysine--tRNA ligase	0.0024	0.0414	1
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0271	0.0543
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0115	0.2448	0.8953
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.002	0.0329	0.1203
Toxoplasma gondii	NADPH-glutathione reductase	0.0017	0.0271	0.041
Toxoplasma gondii	cell-cycle-associated protein kinase MAPK, putative	0.0172	0.3734	0.5643
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0271	0.2696
Echinococcus multilocularis	synaptic vesicle 2 protein	0.0015	0.0217	0.0516
Plasmodium falciparum	dihydrolipoyl dehydrogenase, apicoplast	0.0017	0.0271	0.0256
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Brugia malayi	Muscleblind-like protein	0.0159	0.3436	0.7265
Entamoeba histolytica	hypothetical protein	0.0024	0.0414	0.6679
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Schistosoma mansoni	dihydrolipoamide dehydrogenase	0.0017	0.0271	0.0656
Leishmania major	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0155
Plasmodium vivax	thioredoxin reductase, putative	0.005	0.1007	0.0993
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0621	0.1151
Plasmodium vivax	calcium-dependent protein kinase 1, putative	0.0033	0.0612	0.0597
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0516
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Trichomonas vaginalis	glucose transporter, putative	0.0015	0.0217	0.0402
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.1529
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0414	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.1234
Trypanosoma brucei	dihydrolipoyl dehydrogenase	0.0017	0.0271	0.2696
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.4724	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.002	0.0329	0.3268
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0576	0.1438
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0576	0.087
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0427
Brugia malayi	major facilitator superfamily protein	0.0015	0.0217	0.0427
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Trichomonas vaginalis	mercuric reductase, putative	0.0017	0.0271	0.0503
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Leishmania major	acetoin dehydrogenase e3 component-like protein	0.0017	0.0271	0.2696
Echinococcus granulosus	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0597	0.1491
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0115	0.2448	0.8953
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0329	0.061
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.1529
Loa Loa (eye worm)	bifunctional aminoacyl-tRNA synthetase	0.0013	0.0175	0.0339
Mycobacterium tuberculosis	Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter)	0.0015	0.0217	0.0792
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0271	0.8162
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0115	0.2448	0.8953
Plasmodium falciparum	thioredoxin reductase	0.0017	0.0271	0.0256
Mycobacterium ulcerans	fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT	0.0015	0.0217	0.5239
Brugia malayi	lysyl-tRNA synthetase	0.0024	0.0414	0.0845
Schistosoma mansoni	serine/threonine protein kinase	0.0033	0.0611	0.1529
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.002	0.0329	0.7954
Leishmania major	hypothetical protein, conserved	0.0015	0.0217	0.2153
Mycobacterium leprae	Possible lysyl-tRNA synthetase 2 LysX	0.0024	0.0414	0.1513
Toxoplasma gondii	calcium-dependent protein kinase CDPK2A	0.0033	0.0612	0.0925
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.1529
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.6168
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0017	0.0271	0.6426
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.6168
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0414	0.0845
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.002	0.0329	0.3268
Mycobacterium tuberculosis	Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot	0.0017	0.0271	0.0992
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0715	0.7105
Plasmodium falciparum	calcium-dependent protein kinase 3	0.0033	0.0612	0.0597
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.6168
Plasmodium falciparum	calcium-dependent protein kinase 2	0.0033	0.0612	0.0597
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0516
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Toxoplasma gondii	threonyl-tRNA synthetase family protein	0.0006	0.0016	0.0024
Mycobacterium leprae	Probable prolyl tRNA synthetase ProS	0.0032	0.0597	0.2182
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0271	0.2696
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0621	0.6168
Brugia malayi	exodeoxyribonuclease III family protein	0.002	0.0329	0.0666
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0516
Treponema pallidum	exodeoxyribonuclease (exoA)	0.002	0.0329	1
Leishmania major	myo-inositol/proton symporter (MIT)	0.0015	0.0217	0.2153
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0597	0.1234
Toxoplasma gondii	thioredoxin reductase	0.005	0.1007	0.1521
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.002	0.0329	0.0666
Mycobacterium ulcerans	threonyl-tRNA synthetase	0.0006	0.0016	0.0377
Echinococcus granulosus	General substrate transporter	0.0092	0.193	0.4912
Plasmodium vivax	sugar transporter, putative	0.0015	0.0217	0.0201
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2266	0.5772
Mycobacterium ulcerans	lysyl-tRNA synthetase	0.0024	0.0414	1
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0115	0.2448	0.8953
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.055	0.1372
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0576	0.1438
Leishmania major	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.4109
Echinococcus multilocularis	geminin	0.018	0.3913	1
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.6168
Trypanosoma brucei	bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0715	0.7105
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0115	0.2448	0.8953
Trichomonas vaginalis	set domain proteins, putative	0.0247	0.5393	1
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.002	0.0329	0.5259
Toxoplasma gondii	exonuclease III APE	0.002	0.0329	0.0497
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0128	0.2734	1
Mycobacterium tuberculosis	Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase)	0.0006	0.0016	0.0057
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0155
Trichomonas vaginalis	prolyl-tRNA synthetase, putative	0.0032	0.0597	0.1107
Treponema pallidum	prolyl-tRNA synthetase	0.0011	0.0134	0.3782
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0271	0.2696
Toxoplasma gondii	glycyl-tRNA synthetase	0.0006	0.0016	0.0024
Echinococcus granulosus	Sugar transporter ERD6 protein	0.0015	0.0217	0.0516
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0576	0.1438
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0621	0.1151
Trypanosoma brucei	glucose transporter 1E	0.0033	0.0621	0.6168
Schistosoma mansoni	ap endonuclease	0.002	0.0329	0.0804
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Echinococcus multilocularis	lysyl tRNA synthetase	0.0024	0.0414	0.1021
Mycobacterium ulcerans	integral membrane transport protein	0.0015	0.0217	0.5239
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Plasmodium vivax	calcium-dependent protein kinase, putative	0.0033	0.0612	0.0597
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0427
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0217	0.0427
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0402
Plasmodium falciparum	calcium-dependent protein kinase 4	0.0033	0.0612	0.0597
Trypanosoma brucei	sugar transporter, putative	0.0015	0.0217	0.2153
Plasmodium falciparum	protein kinase 7	0.0301	0.6617	0.6612
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2266	0.5772
Trichomonas vaginalis	ap endonuclease, putative	0.002	0.0329	0.061
Plasmodium vivax	dihydrolipoyl dehydrogenase, apicoplast, putative	0.0017	0.0271	0.0256
Echinococcus multilocularis	glutamyl tRNA synthetase cytoplasmic	0.0032	0.0597	0.1491
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0516
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0516
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0621	0.6168
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0271	0.2696
Echinococcus granulosus	muscleblind protein	0.0159	0.3436	0.8775
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0516
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Echinococcus multilocularis	calcium dependent protein kinase	0.0031	0.0566	0.1413
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Onchocerca volvulus		0.0247	0.5393	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Trypanosoma cruzi	dihydrolipoyl dehydrogenase, putative	0.0017	0.0271	0.2696
Schistosoma mansoni	glucose transport protein	0.0107	0.2266	0.5772
Brugia malayi	Calcium/calmodulin-dependent protein kinase type II alpha chain	0.0033	0.0611	0.1266
Echinococcus multilocularis	General substrate transporter	0.0092	0.193	0.4912
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0597	0.1491
Trypanosoma cruzi	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.4109
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0715	0.7105
Toxoplasma gondii	calcium-dependent protein kinase CDPK2B	0.0033	0.0612	0.0925
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Mycobacterium tuberculosis	Probable conserved integral membrane transport protein	0.0015	0.0217	0.0792
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2266	0.5772
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0271	0.2696
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0414	0.1021
Trypanosoma brucei	glycyl-tRNA synthetase, putative	0.0006	0.0016	0.0155
Echinococcus granulosus	calcium dependent protein kinase	0.0031	0.0566	0.1413
Echinococcus granulosus	thioredoxin glutathione reductase	0.005	0.1007	0.2542
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2266	0.5772
Schistosoma mansoni	glucose transport protein	0.0107	0.2266	0.5772
Leishmania major	glucose transporter, lmgt1	0.0033	0.0621	0.6168
Trypanosoma cruzi	hexose transporter, putative	0.0015	0.0217	0.2153
Plasmodium falciparum	calcium-dependent protein kinase 5	0.0033	0.0612	0.0597
Leishmania major	glucose transporter, lmgt3	0.0033	0.0621	0.6168
Chlamydia trachomatis	proline--tRNA ligase	0.0011	0.0134	0.2978
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0427
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type 1	0.0033	0.0611	0.1529
Trypanosoma brucei	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0155
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0402
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Schistosoma mansoni	protein kinase	0.0033	0.0611	0.1529
Echinococcus multilocularis	Sugar transporter ERD6 protein	0.0015	0.0217	0.0516
Giardia lamblia	Sugar-proton symporter	0.0015	0.0217	0.346
Loa Loa (eye worm)	sugar transporter	0.0107	0.2266	0.4779
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase	0.0017	0.0271	0.6561
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.002	0.0329	0.0804
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.002	0.0329	1
Plasmodium falciparum	hexose transporter	0.0107	0.2266	0.2253
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0621	0.6168
Plasmodium vivax	dihydrolipoyl dehydrogenase, mitochondrial, putative	0.0017	0.0271	0.0256
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0271	0.4401
Schistosoma mansoni	glucose transporter	0.0015	0.0217	0.0516
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.6168
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.002	0.0329	0.3268
Plasmodium vivax	proline--tRNA ligase, putative	0.0037	0.0715	0.0701
Brugia malayi	Thioredoxin reductase	0.005	0.1007	0.2105
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0271	0.2696
Trypanosoma brucei	dihydrolipoamide dehydrogenase, point mutation	0.0017	0.0271	0.2696
Trichomonas vaginalis	glucose transporter, putative	0.0033	0.0621	0.1151
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0576	0.1438
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0621	0.1151
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0463	0.0949
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Echinococcus granulosus	lysyl tRNA synthetase	0.0024	0.0414	0.1021
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0128	0.2734	1
Brugia malayi	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein	0.0013	0.0168	0.0323
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2266	0.5772
Plasmodium falciparum	glutathione reductase	0.005	0.1007	0.0993
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.6168
Trypanosoma cruzi	trypanothione reductase, putative	0.005	0.1007	1
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.002	0.0329	0.5393
Toxoplasma gondii	lysine-tRNA ligase	0.0024	0.0414	0.0625
Loa Loa (eye worm)	thioredoxin reductase	0.005	0.1007	0.2105
Mycobacterium ulcerans	dihydrolipoamide dehydrogenase, LpdB	0.0017	0.0271	0.6561
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0516
Trypanosoma cruzi	trypanothione reductase, putative	0.0017	0.0271	0.2696
Echinococcus granulosus	synaptic vesicle 2 protein	0.0015	0.0217	0.0516
Trypanosoma brucei	myo-inositol/proton symporter (MIT)	0.0015	0.0217	0.2153
Giardia lamblia	Lysyl-tRNA synthetase	0.0024	0.0414	0.6849
Mycobacterium ulcerans	sugar-transport integral membrane protein SugI	0.0015	0.0217	0.5239
Schistosoma mansoni	protein kinase	0.0033	0.0611	0.1529
Trypanosoma cruzi	glucose transporter, putative	0.0015	0.0217	0.2153
Toxoplasma gondii	sugar transporter ST1	0.0015	0.0217	0.0327
Plasmodium falciparum	thioredoxin reductase	0.005	0.1007	0.0993
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.6168
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0621	0.6168
Trypanosoma cruzi	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0155
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Trypanosoma cruzi	hexose transporter	0.0033	0.0621	0.6168
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Plasmodium falciparum	dihydrolipoyl dehydrogenase, mitochondrial	0.0017	0.0271	0.0256
Leishmania major	protein kinase, putative	0.0033	0.0611	0.6075
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Brugia malayi	bifunctional aminoacyl-tRNA synthetase	0.0032	0.0597	0.1234
Loa Loa (eye worm)	CAMK/CAMK2 protein kinase	0.0033	0.0611	0.1266
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.1529
Trypanosoma brucei	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.4109
Trichomonas vaginalis	conserved hypothetical protein	0.0033	0.0621	0.1151
Trypanosoma cruzi	sugar transporter, putative	0.0015	0.0217	0.2153
Echinococcus multilocularis	solute carrier family 22	0.0015	0.0217	0.0516
Plasmodium vivax	calcium-dependent protein kinase 3, putative	0.0033	0.0612	0.0597
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.002	0.0329	0.3268
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0271	0.2696
Entamoeba histolytica	prolyl-tRNA synthetase, putative	0.0032	0.0597	0.9752
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0576	0.1438
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 2 LysX	0.002	0.0333	0.1219
Trichomonas vaginalis	CAMK family protein kinase	0.0033	0.0611	0.1134
Brugia malayi	Cam kinase protein 1	0.0033	0.0611	0.1266
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3436	0.7265
Plasmodium vivax	SET domain protein, putative	0.0031	0.0576	0.0561
Mycobacterium ulcerans	flavoprotein disulfide reductase	0.0017	0.0271	0.6561
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0576	0.1438
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0427
Brugia malayi	Major Facilitator Superfamily protein	0.0015	0.0217	0.0427
Loa Loa (eye worm)	glutathione reductase	0.005	0.1007	0.2105
Toxoplasma gondii	transporter, major facilitator family protein	0.0015	0.0217	0.0327
Schistosoma mansoni	glucose transport protein	0.0107	0.2266	0.5772
Plasmodium falciparum	lysine--tRNA ligase	0.0024	0.0414	0.0399
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Schistosoma mansoni	ap endonuclease	0.002	0.0329	0.0804
Leishmania major	2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein	0.0017	0.0271	0.2696
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Toxoplasma gondii	calcium-dependent protein kinase CDPK3	0.0033	0.0612	0.0925
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Brugia malayi	hypothetical protein	0.0015	0.0217	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Mycobacterium tuberculosis	Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0333	0.1219
Brugia malayi	Sugar transporter family protein	0.0107	0.2266	0.4779
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Trichomonas vaginalis	myo-inositol transporter, putative	0.0015	0.0217	0.0402
Schistosoma mansoni	hypothetical protein	0.018	0.3913	1
Echinococcus multilocularis	muscleblind protein	0.0159	0.3436	0.8775
Plasmodium vivax	glutathione reductase, putative	0.005	0.1007	0.0993
Schistosoma mansoni	hypothetical protein	0.0107	0.2266	0.5772
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.002	0.0329	0.0804
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.002	0.0329	0.0314
Echinococcus multilocularis	solute carrier family 2, facilitated glucose	0.0107	0.2266	0.5772
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.005	0.1007	0.3681
Echinococcus multilocularis	solute carrier family 2 facilitated glucose	0.0107	0.2266	0.5772
Toxoplasma gondii	protein kinase, putative	0.0301	0.6617	1
Echinococcus granulosus	geminin	0.018	0.3913	1
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Plasmodium falciparum	mitogen-activated protein kinase 2	0.0172	0.3734	0.3724
Loa Loa (eye worm)	calcium/calmodulin-dependent protein kinase ID	0.0033	0.0611	0.1266
Brugia malayi	glutathione reductase	0.005	0.1007	0.2105
Wolbachia endosymbiont of Brugia malayi	major facilitator superfamily permease	0.0015	0.0217	0.6417
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0021	0.0348	0.0645
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0402
Loa Loa (eye worm)	major facilitator superfamily transporter	0.0015	0.0217	0.0427
Schistosoma mansoni	nuclear transcription factor X-box binding 1 (nfx1)	0.0015	0.0217	0.0516
Trypanosoma brucei	dihydrolipoamide dehydrogenase	0.0017	0.0271	0.2696
Brugia malayi	alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase	0.0013	0.0168	0.0323
Toxoplasma gondii	facilitative glucose transporter GT1	0.0107	0.2266	0.3424
Schistosoma mansoni	glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs)	0.0032	0.0597	0.1491
Giardia lamblia	Prolyl-tRNA synthetase	0.0032	0.0597	1
Loa Loa (eye worm)	hypothetical protein	0.0159	0.3436	0.7265
Mycobacterium leprae	Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase)	0.002	0.0333	0.1219
Echinococcus multilocularis	dihydrolipoamide dehydrogenase	0.0017	0.0271	0.0656
Toxoplasma gondii	prolyl-tRNA synthetase (ProRS)	0.0037	0.0715	0.1081
Plasmodium falciparum	calcium-dependent protein kinase 1	0.0033	0.0612	0.0597
Echinococcus multilocularis	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.1529
Trypanosoma brucei	trypanothione reductase	0.005	0.1007	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0576	0.1438
Loa Loa (eye worm)	sugar transporter	0.0015	0.0217	0.0427
Plasmodium vivax	mitogen-activated protein kinase 2, putative	0.0172	0.3734	0.3724
Plasmodium falciparum	proline--tRNA ligase	0.0037	0.0715	0.0701
Trypanosoma cruzi	prolyl-tRNA synthetase, putative	0.0037	0.0715	0.7105
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0402
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0017	0.0271	0.8162
Brugia malayi	Pre-SET motif family protein	0.0031	0.0576	0.119
Mycobacterium ulcerans	sugar transporter	0.0015	0.0217	0.5239
Trichomonas vaginalis	sugar transporter, putative	0.0033	0.0621	0.1151
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.1529
Trichomonas vaginalis	glutathione reductase, putative	0.0017	0.0271	0.0503
Leishmania major	dihydrolipoamide dehydrogenase, putative	0.0017	0.0271	0.2696
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0576	0.119
Toxoplasma gondii	pyruvate dehydrogenase complex subunit PDH-E3II	0.0017	0.0271	0.041
Plasmodium vivax	lysine--tRNA ligase, putative	0.0024	0.0414	0.0399
Schistosoma mansoni	sugar transporter	0.0015	0.0217	0.0516
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Echinococcus granulosus	calcium:calmodulin dependent protein kinase type	0.0033	0.0611	0.1529
Trichomonas vaginalis	sugar transport protein, putative	0.0015	0.0217	0.0402
Echinococcus granulosus	solute carrier family 2 facilitated glucose	0.0107	0.2266	0.5772
Brugia malayi	Pre-SET motif family protein	0.0217	0.4724	1
Toxoplasma gondii	sugar transporter ST2	0.0015	0.0217	0.0327
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0516
Echinococcus granulosus	solute carrier family 22	0.0015	0.0217	0.0516
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0128	0.2734	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Echinococcus multilocularis	muscleblind protein 1	0.0159	0.3436	0.8775
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Trypanosoma brucei	glucose transporter 2A	0.0033	0.0621	0.6168
Plasmodium vivax	hexose transporter	0.0107	0.2266	0.2253
Onchocerca volvulus		0.0031	0.0576	0.0694
Brugia malayi	Sugar transporter family protein	0.0015	0.0217	0.0427
Entamoeba histolytica	protein kinase, putative	0.0033	0.0611	1
Trypanosoma cruzi	hexose transporter, putative	0.0033	0.0621	0.6168
Plasmodium falciparum	glutathione reductase	0.0017	0.0271	0.0256
Schistosoma mansoni	lysyl-tRNA synthetase	0.0024	0.0414	0.1021
Trichomonas vaginalis	threonyl-tRNA synthetase, putative	0.0006	0.0016	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0217	0.0427
Giardia lamblia	Hexose transporter	0.0015	0.0217	0.346
Trichomonas vaginalis	conserved hypothetical protein	0.0107	0.2266	0.4201
Brugia malayi	major facilitator superfamily protein	0.0015	0.0217	0.0427
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0271	0.2696
Plasmodium falciparum	major facilitator superfamily domain-containing protein, putative	0.0015	0.0217	0.0201
Trichomonas vaginalis	lysyl-tRNA synthetase, putative	0.0024	0.0414	0.0767
Trypanosoma cruzi	dihydrolipoamide dehydrogenase, putative	0.0017	0.0271	0.2696
Trichomonas vaginalis	conserved hypothetical protein	0.0015	0.0217	0.0402
Brugia malayi	Bifunctional aminoacyl-tRNA synthetase	0.0032	0.0597	0.1234
Mycobacterium ulcerans	prolyl-tRNA synthetase	0.0011	0.0134	0.3243
Mycobacterium tuberculosis	Probable oxidoreductase	0.0128	0.2734	1
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Leishmania major	prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative	0.0037	0.0715	0.7105
Trichomonas vaginalis	sugar transporter, putative	0.0015	0.0217	0.0402
Entamoeba histolytica	protein kinase, putative	0.0033	0.0611	1
Trypanosoma brucei	calcium/calmodulin-dependent protein kinase, putative	0.0033	0.0611	0.6075
Mycobacterium ulcerans	glycyl-tRNA synthetase	0.0006	0.0016	0.0377
Trypanosoma brucei	THT1 - hexose transporter, putative	0.0033	0.0621	0.6168
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0611	0.1266
Schistosoma mansoni	protein kinase	0.0033	0.0611	0.1529
Mycobacterium tuberculosis	Probable reductase	0.0115	0.2448	0.8953
Echinococcus multilocularis	thioredoxin glutathione reductase	0.005	0.1007	0.2542
Plasmodium vivax	calcium-dependent protein kinase 4, putative	0.0033	0.0612	0.0597
Leishmania major	glucose transporter/membrane transporter D2, putative	0.0033	0.0621	0.6168
Trypanosoma brucei	glucose transporter, putative	0.0033	0.0621	0.6168
Brugia malayi	Sugar transporter family protein	0.0015	0.0217	0.0427

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL525101

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1023585