TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 384.427 | Formula: C24H20N2O3
H donors: 0 H acceptors: 2 LogP: 3.72 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=c1cc(oc2c1cccc2c1cccc(c1)c1ccccn1)N1CCOCC1
InChi: 1S/C24H20N2O3/c27-22-16-23(26-11-13-28-14-12-26)29-24-19(7-4-8-20(22)24)17-5-3-6-18(15-17)21-9-1-2-10-25-21/h1-10,15-16H,11-14H2
InChiKey: RZXHAHWHWMPFDL-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	protein kinase, DNA-activated, catalytic polypeptide	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	Get druggable targets OG5_132688	All targets in OG5_132688

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	RNA binding protein	0.0064	0.1926	1
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0186	0.0135
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0558	0.0456
Brugia malayi	nuclear hormone receptor	0.0022	0.0558	0.2243
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Trypanosoma cruzi	hypothetical protein, conserved	0.011	0.3403	1
Brugia malayi	Nuclear hormone receptor E75	0.001	0.0186	0.0135
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0022	0.0561	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Schistosoma mansoni	nuclear receptor	0.001	0.0186	0.0924
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0022	0.0558	0.277
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0012	0.0253	0.0414
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0872	0.4025
Schistosoma mansoni	coup transcription factor	0.0022	0.0558	0.277
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1926	0.9564
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0014	0.0298	0.4484
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0558	0.2243
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0561	0.1352
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0022	0.0561	0.0459
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0253	0.3528
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0022	0.0558	0.2243
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0022	0.0558	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0226	0.0603
Giardia lamblia	GTOR	0.0022	0.0561	0.5
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0022	0.0558	0.277
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.005	0.1476	0.7512
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0022	0.0558	0.277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.001	0.0186	0.0924
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0226	0.0603
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1476	0.7328
Trichomonas vaginalis	conserved hypothetical protein	0.0008	0.0117	0.0672
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0022	0.0561	0.2785
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1476	0.7328
Echinococcus granulosus	serine protein kinase ATM	0.0012	0.0253	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0558	0.2439
Echinococcus multilocularis	serine protein kinase ATM	0.0012	0.0253	0.0147
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0022	0.0558	0.0456
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0186	0.0924
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0022	0.0558	0.2243
Trypanosoma cruzi	target of rapamycin kinase 3	0.0022	0.0561	0.1352
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0186	0.008
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0022	0.0561	0.1352
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1476	0.1383
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0022	0.0558	0.0456
Echinococcus granulosus	ecdysone induced protein 78C	0.0022	0.0558	0.0456
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0022	0.0561	0.1352
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.001	0.0186	0.0135
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0022	0.0561	0.2785
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0022	0.0558	0.0456
Loa Loa (eye worm)	histone methyltransferase	0.001	0.0169	0.0289
Loa Loa (eye worm)	hypothetical protein	0.001	0.0162	0.0252
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0313	1	1
Brugia malayi	nuclear receptor NHR-88	0.001	0.0186	0.0135
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0022	0.0558	0.2243
Brugia malayi	TAR-binding protein	0.0064	0.1926	1
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0022	0.0561	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0022	0.0558	0.2243
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0022	0.0558	0.0456
Loa Loa (eye worm)	DR-78	0.001	0.0186	0.0383
Echinococcus multilocularis	nuclear receptor nhr 48	0.001	0.0186	0.008
Loa Loa (eye worm)	nuclear receptor NHR-67	0.001	0.0186	0.0383
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0558	0.2243
Brugia malayi	nuclear receptor RXR	0.001	0.0186	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0558	0.2439
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0008	0.0107	0.0531
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0011	0.0226	0.012
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0022	0.0561	0.0459
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1926	0.9564
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Schistosoma mansoni	cpg binding protein	0.0033	0.093	0.4619
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0253	0.0513
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0169	0.0063
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0872	0.4176
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1476	0.1383
Loa Loa (eye worm)	hypothetical protein	0.0014	0.0298	0.1004
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0558	0.277
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0022	0.0561	0.0459
Brugia malayi	hypothetical protein	0.0011	0.0226	0.0361
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0011	0.0226	0.1122
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0186	0.008
Schistosoma mansoni	cpg binding protein	0.0031	0.0872	0.4331
Onchocerca volvulus		0.0031	0.0872	1
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.001	0.0162	0.0056
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0558	0.2439
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0253	0.3528
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0253	0.3528
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0011	0.0226	0.012
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0022	0.0558	0.0456
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0064	0.1926	1
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.001	0.0186	0.0924
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0022	0.0558	0.0456
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0022	0.0561	1
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.001	0.0162	0.0056
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.005	0.1476	0.7447
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Brugia malayi	hypothetical protein	0.0011	0.0226	0.0361
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0226	0.0603
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0561	0.2455
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0253	0.3528
Brugia malayi	ecdysteroid receptor	0.0022	0.0558	0.2243
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0022	0.0558	0.2243
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.001	0.0186	0.008
Onchocerca volvulus	Protein ultraspiracle homolog	0.0022	0.0558	0.542
Schistosoma mansoni	RAR-like nuclear receptor	0.0022	0.0558	0.277
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0558	0.2439
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0022	0.0558	0.2439
Echinococcus granulosus	cpg binding protein	0.0033	0.093	0.0832
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0253	0.0752
Brugia malayi	tailless protein	0.001	0.0186	0.0135
Echinococcus granulosus	thyroid hormone receptor alpha	0.001	0.0186	0.008
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0558	0.2439
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Schistosoma mansoni	nuclear hormone receptor	0.0022	0.0558	0.277
Brugia malayi	nuclear hormone receptor family member nhr-6	0.001	0.0186	0.0135
Trichomonas vaginalis	conserved hypothetical protein	0.001	0.0162	0.1628
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0014	0.0298	0.1478
Loa Loa (eye worm)	phosphatidylinositol 3	0.0022	0.0561	0.2455
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0561	0.2261
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.001	0.0186	0.008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Onchocerca volvulus	Bile acid receptor homolog	0.0022	0.0558	0.542
Brugia malayi	Steroid receptor seven-up type 2	0.0022	0.0558	0.2243
Schistosoma mansoni	nuclear hormone receptor	0.001	0.0186	0.0924
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.001	0.0186	0.0383
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0558	0.2439
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0022	0.0558	0.2439
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0022	0.0558	0.2439
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.005	0.1476	0.1383
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0022	0.0558	0.2439
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0022	0.0561	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.005	0.1476	0.7328
Brugia malayi	nuclear hormone receptor family member odr-7	0.001	0.0186	0.0135
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0226	0.0361
Brugia malayi	hypothetical protein	0.001	0.0186	0.0135
Schistosoma mansoni	retinoic acid receptor RXR	0.0022	0.0558	0.277
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0022	0.0561	0.1352
Echinococcus multilocularis	tar DNA binding protein	0.0064	0.1926	0.1838
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0022	0.0561	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0558	0.2243
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1926	0.9564
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0022	0.0558	0.2243
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0253	0.3528
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0022	0.0561	0.2014
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0022	0.0558	0.277
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0022	0.0558	0.2243
Loa Loa (eye worm)	steroid hormone receptor	0.0022	0.0558	0.2439
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.001	0.0186	0.008
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0012	0.0253	0.0414
Brugia malayi	nuclear receptor NHR-67	0.001	0.0186	0.0135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0022	0.0558	0.2243
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0022	0.0558	0.0456
Schistosoma mansoni	thyroid hormone receptor	0.0022	0.0558	0.277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Schistosoma mansoni	nuclear receptor nhr-48	0.001	0.0186	0.0924
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0022	0.0558	0.2243
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0022	0.0558	0.2439
Brugia malayi	orphan nuclear receptor NR2E1	0.001	0.0186	0.0135
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0012	0.0253	0.0513
Brugia malayi	nuclear hormone receptor	0.001	0.0186	0.0135
Schistosoma mansoni	cpg binding protein	0.0033	0.093	0.4619
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0169	0.0063
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1926	0.9564
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0558	0.2439
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0558	0.0456
Echinococcus multilocularis	FTZ F1 alpha	0.0022	0.0558	0.0456
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0011	0.0226	0.0603
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0022	0.0561	0.0459
Brugia malayi	F/Y-rich N-terminus family protein	0.001	0.0165	0.0016
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0022	0.0558	0.0456
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.2013	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0012	0.0253	0.1255
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0022	0.0558	0.0456
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.0561	0.2261
Schistosoma mansoni	zinc finger protein	0.001	0.0186	0.0924
Trichomonas vaginalis	conserved hypothetical protein	0.0014	0.0298	0.4484
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Brugia malayi	hypothetical protein	0.001	0.0186	0.0135
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0022	0.0558	0.542
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Brugia malayi	ecdysone receptor	0.001	0.0186	0.0135
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0022	0.0558	0.0456
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0253	0.3528
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0558	0.2439
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.005	0.1476	0.1383
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.001	0.0186	0.008
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0014	0.0298	0.0298
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0022	0.0558	0.2243
Echinococcus granulosus	FTZ F1 alpha	0.0022	0.0558	0.0456
Echinococcus granulosus	tar DNA binding protein	0.0064	0.1926	0.1838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0253	0.3528
Brugia malayi	Nuclear hormone receptor-like 1	0.0022	0.0558	0.2243
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.001	0.0186	0.008
Echinococcus multilocularis	cpg binding protein	0.0033	0.093	0.0832
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0008	0.0117	0.0672
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0022	0.0558	0.0456
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0226	0.0603
Echinococcus granulosus	Nuclear hormone receptor HR96	0.001	0.0186	0.008
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.1783	1
Echinococcus granulosus	nuclear receptor nhr 48	0.001	0.0186	0.008
Schistosoma mansoni	tar DNA-binding protein	0.0064	0.1926	0.9564
Loa Loa (eye worm)	TAR-binding protein	0.0064	0.1926	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0022	0.0558	0.277
Brugia malayi	photoreceptor-specific nuclear receptor	0.0022	0.0558	0.2243
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0022	0.0558	0.277
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0012	0.0253	0.3528
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Brugia malayi	Nuclear hormone receptor-like 1	0.0011	0.0226	0.0361
Onchocerca volvulus		0.0022	0.0558	0.542
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0226	0.0603
Brugia malayi	nuclear receptor RXR	0.0011	0.0226	0.0361
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0022	0.0558	0.2439
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0012	0.0253	0.0147
Loa Loa (eye worm)	RNA binding protein	0.0064	0.1926	1
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0011	0.0226	0.1122
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0022	0.0558	0.2439
Schistosoma mansoni	nuclear receptor	0.001	0.0186	0.0924
Schistosoma mansoni	hypothetical protein	0.001	0.0162	0.0806
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0022	0.0558	0.277
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.001	0.0186	0.008
Brugia malayi	nuclear receptor NHR-88	0.0022	0.0558	0.2243
Brugia malayi	conserved hypotetical protein	0.001	0.0186	0.0135
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Brugia malayi	RNA recognition motif domain containing protein	0.0064	0.1926	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0012	0.0253	0.0147
Loa Loa (eye worm)	nuclear hormone receptor	0.001	0.0186	0.0383
Loa Loa (eye worm)	hypothetical protein	0.001	0.0186	0.0383
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0022	0.0561	1
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0022	0.0561	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0022	0.0558	0.0456
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0012	0.0253	0.1255
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0022	0.0561	1
Leishmania major	hypothetical protein, conserved	0.0114	0.3539	1
Brugia malayi	steroid hormone receptor	0.0022	0.0558	0.2243

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.88 uM	Inhibition of DNA-dependent protein kinase	ChEMBL.	18678488

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL529668

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1027283