Detailed information for compound 1028823

Basic information

Technical information
  • TDR Targets ID: 1028823
  • Name: 4-(aminomethyl)pyridin-3-amine dihydrochlorid e
  • MW: 196.078 | Formula: C6H11Cl2N3
  • H donors: 2 H acceptors: 1 LogP: 1.18 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCc1ccncc1N.Cl.Cl
  • InChi: 1S/C6H9N3.2ClH/c7-3-5-1-2-9-4-6(5)8;;/h1-2,4H,3,7-8H2;2*1H
  • InChiKey: HREWBDQQRCHSNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(aminomethyl)-3-pyridinamine dihydrochloride
  • (3-amino-4-pyridyl)methylamine dihydrochloride

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens amine oxidase, copper containing 1 Starlite/ChEMBL References
Homo sapiens amine oxidase, copper containing 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127171 All targets in OG5_127171
Cryptosporidium parvum extracellular protein with a signal peptide sequence, MAM domain and a Cu amine oxidase domain Get druggable targets OG5_127171 All targets in OG5_127171
Toxoplasma gondii hypothetical protein Get druggable targets OG5_127171 All targets in OG5_127171
Candida albicans one of two likely copper amine oxidase genes Get druggable targets OG5_127171 All targets in OG5_127171
Schistosoma japonicum IPR000269,Copper amine oxidase,domain-containing Get druggable targets OG5_127171 All targets in OG5_127171
Candida albicans one of two likely peroxisomal copper amine oxidase genes Get druggable targets OG5_127171 All targets in OG5_127171
Cryptosporidium hominis amiloride binding protein 1 Get druggable targets OG5_127171 All targets in OG5_127171
Candida albicans one of two likely peroxisomal copper amine oxidase genes Get druggable targets OG5_127171 All targets in OG5_127171
Candida albicans one of two likely copper amine oxidase genes Get druggable targets OG5_127171 All targets in OG5_127171
Echinococcus multilocularis amiloride sensitive amine oxidase Get druggable targets OG5_127171 All targets in OG5_127171
Neospora caninum hypothetical protein Get druggable targets OG5_127171 All targets in OG5_127171
Schistosoma japonicum ko:K00276 copper amine oxidase [EC1.4.3.6], putative Get druggable targets OG5_127171 All targets in OG5_127171
Schistosoma mansoni copper/topaquinone oxidase Get druggable targets OG5_127171 All targets in OG5_127171
Echinococcus granulosus amiloride sensitive amine oxidase Get druggable targets OG5_127171 All targets in OG5_127171
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0067 0.1479 0.1479
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0553 0.5
Echinococcus multilocularis amiloride sensitive amine oxidase 0.0206 0.5785 0.5785
Brugia malayi G protein-coupled receptor F59B2.13 0.0067 0.1479 0.1523
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0553 0.0569
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.1479 0.1479
Loa Loa (eye worm) TYRA-2 protein 0.0067 0.1479 0.1523
Schistosoma mansoni ap endonuclease 0.0037 0.0558 0.0558
Schistosoma mansoni thyroid hormone receptor 0.002 0.0031 0.0031
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0558 0.0558
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0067 0.1479 0.1523
Schistosoma mansoni hypothetical protein 0.0342 1 1
Mycobacterium ulcerans beta-lactamase 0.0037 0.0553 0.4281
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.2487 0.2563
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0067 0.1479 0.1479
Brugia malayi Dopamine receptor protein 2 0.0067 0.1479 0.1523
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.1429 0.1472
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.1479 0.1479
Leishmania major hypothetical protein, conserved 0.0037 0.0553 0.1851
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1291 0.1291
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0031 0.0032
Echinococcus multilocularis muscleblind protein 1 0.015 0.4054 0.4054
Echinococcus granulosus protein quaking 0.0028 0.0271 0.0271
Echinococcus granulosus transcription factor eb 0.0106 0.2692 0.2692
Schistosoma mansoni neuropeptide f receptor 76f 0.0067 0.1479 0.1479
Echinococcus granulosus orexin receptor type 2 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.015 0.4054 0.4176
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0032
Schistosoma mansoni amine GPCR 0.0067 0.1479 0.1479
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1291 0.1291
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0558 0.187
Mycobacterium ulcerans lipase LipD 0.0037 0.0553 0.4281
Schistosoma mansoni alpha-1 adrenergic receptor 0.0067 0.1479 0.1479
Brugia malayi Tachykinin-like peptides receptor 99D 0.0067 0.1479 0.1523
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0553 0.1851
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0553 0.0816
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.1479 0.1479
Schistosoma mansoni neuropeptide receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0031 0.0031
Echinococcus multilocularis allatostatin A receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0031 0.0031
Brugia malayi nuclear hormone receptor 0.002 0.0031 0.0032
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0558 0.0575
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0067 0.1479 0.1523
Mycobacterium tuberculosis Conserved protein 0.0037 0.0553 0.0816
Onchocerca volvulus 0.0037 0.0553 0.075
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1429 0.1429
Loa Loa (eye worm) hypothetical protein 0.0106 0.2676 0.2756
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0116 0.2986 1
Toxoplasma gondii ABC1 family protein 0.0037 0.0553 0.0869
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.1479 0.1479
Echinococcus granulosus neuropeptide receptor 0.0067 0.1479 0.1479
Echinococcus granulosus alpha 1A adrenergic receptor 0.0067 0.1479 0.1479
Echinococcus granulosus g-protein coupled receptor 0.0067 0.1479 0.1479
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0558 0.187
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0553 0.1851
Echinococcus multilocularis g protein coupled receptor 0.0067 0.1479 0.1479
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0031 0.0031
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.2986 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0067 0.1479 0.1479
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0067 0.1479 0.1479
Schistosoma mansoni neuropeptide receptor 0.0067 0.1479 0.1479
Toxoplasma gondii hypothetical protein 0.0104 0.2624 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0553 0.0816
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.1479 0.1523
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0553 0.9716
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Schistosoma mansoni coup transcription factor 0.002 0.0031 0.0031
Echinococcus multilocularis geminin 0.0342 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0553 0.0553
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1479 0.1479
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0116 0.2986 1
Brugia malayi AKH receptor 0.0067 0.1479 0.1523
Echinococcus multilocularis fmrfamide receptor 0.0067 0.1479 0.1479
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0238 0.6772 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0031 0.0032
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.1479 0.1479
Brugia malayi neuropeptide F receptor 0.0067 0.1479 0.1523
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0067 0.1479 0.1523
Echinococcus granulosus hypothetical protein 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0028 0.0271 0.0279
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Echinococcus multilocularis g protein coupled receptor 0.0067 0.1479 0.1479
Schistosoma mansoni hypothetical protein 0.0068 0.151 0.151
Brugia malayi G-protein coupled receptor 0.0067 0.1479 0.1523
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0116 0.2986 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus g protein coupled receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0031 0.0032
Brugia malayi beta-lactamase 0.0037 0.0553 0.0569
Schistosoma mansoni biogenic amine receptor 0.0067 0.1479 0.1479
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0067 0.1479 0.208
Echinococcus multilocularis tar DNA binding protein 0.0066 0.1429 0.1429
Echinococcus multilocularis g-protein coupled receptor 0.0067 0.1479 0.1479
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0553 0.1851
Echinococcus granulosus dro:myosuppressin receptor 0.0067 0.1479 0.1479
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0116 0.2986 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0031 0.0032
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0067 0.1479 0.1479
Brugia malayi G-protein coupled receptor 0.0067 0.1479 0.1523
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0116 0.2986 1
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus fmrfamide receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis neuropeptide receptor A26 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus muscleblind protein 0.015 0.4054 0.4054
Brugia malayi Pre-SET motif family protein 0.0215 0.607 0.6253
Echinococcus granulosus g protein coupled receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Brugia malayi Temporarily assigned gene name protein 44 0.0028 0.0271 0.0279
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus neuropeptide FF receptor 2 0.0067 0.1479 0.1479
Brugia malayi RE15519p 0.0067 0.1479 0.1523
Onchocerca volvulus 0.0067 0.1479 0.208
Schistosoma mansoni hypothetical protein 0.0032 0.0376 0.0376
Echinococcus multilocularis G protein coupled receptor 139 0.0067 0.1479 0.1479
Loa Loa (eye worm) melatonin receptor type 1A 0.0067 0.1479 0.1523
Echinococcus multilocularis transcription factor eb 0.0106 0.2692 0.2692
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0553 0.0569
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.1479 0.1523
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1429 0.1429
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.1479 0.1479
Schistosoma mansoni histamine h1 receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) G-protein coupled receptor 0.0067 0.1479 0.1523
Echinococcus granulosus neuropeptide s receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.3041 0.3133
Schistosoma mansoni copper/topaquinone oxidase 0.0206 0.5785 0.5785
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1291 0.1906
Brugia malayi GnHR receptor homolog 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0807 0.0807
Echinococcus multilocularis neuropeptide receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.1479 0.1479
Brugia malayi G protein-coupled receptor 0.0067 0.1479 0.1523
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0067 0.1479 0.1479
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0067 0.1479 0.1479
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni amine GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1479 0.1479
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0067 0.1479 0.1523
Schistosoma mansoni amine GPCR 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Onchocerca volvulus 0.0067 0.1479 0.208
Brugia malayi nuclear receptor NHR-88 0.002 0.0031 0.0032
Echinococcus granulosus amiloride sensitive amine oxidase 0.0206 0.5785 0.5785
Echinococcus multilocularis orexin receptor type 2 0.0067 0.1479 0.1479
Brugia malayi steroid hormone receptor 0.002 0.0031 0.0032
Brugia malayi Dopamine receptor protein 1 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus GPCR family 2 0.0032 0.0376 0.0376
Brugia malayi tumor suppressor. 0.0333 0.9707 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0031 0.0031
Schistosoma mansoni biogenic amine receptor 0.0067 0.1479 0.1479
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0553 0.079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0355 0.0355
Mycobacterium tuberculosis Conserved protein 0.0037 0.0553 0.0816
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0569
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0553 0.0816
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0031 0.0032
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0553 0.4281
Echinococcus multilocularis neuropeptide FF receptor 2 0.0067 0.1479 0.1479
Onchocerca volvulus 0.0067 0.1479 0.208
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0031 0.0032
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0067 0.1479 0.1523
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.151 0.1556
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.1479 0.1479
Entamoeba histolytica hypothetical protein 0.0073 0.1649 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.032 0.032
Onchocerca volvulus 0.0067 0.1479 0.208
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0376 0.0387
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1429 0.1429
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0067 0.1479 0.1523
Brugia malayi beta-lactamase family protein 0.0037 0.0553 0.0569
Schistosoma mansoni hypothetical protein 0.0073 0.1649 0.1649
Schistosoma mansoni ap endonuclease 0.0037 0.0558 0.0558
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0031 0.0031
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0116 0.2986 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0376 0.0376
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0031 0.0031
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) tumor suppressor 0.0333 0.9707 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0355 0.0366
Trichomonas vaginalis set domain proteins, putative 0.0245 0.6992 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0067 0.1479 0.1479
Echinococcus granulosus 7tm_1 domain containing protein 0.0067 0.1479 0.1479
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0031 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0376 0.0376
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0807 0.0832
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0553 0.0553
Onchocerca volvulus 0.0067 0.1479 0.208
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0116 0.2986 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.3041 0.3133
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni hypothetical protein 0.0028 0.0271 0.0271
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus neuropeptide receptor 0.0067 0.1479 0.1479
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0558 0.0558
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0031 0.0031
Brugia malayi hypothetical protein 0.0073 0.1649 0.1699
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0553 0.4281
Trichomonas vaginalis esterase, putative 0.0037 0.0553 0.079
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0031 0.0032
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0067 0.1479 0.1479
Brugia malayi Dopamine receptor 0.0067 0.1479 0.1523
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1479 0.1479
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.2986 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Brugia malayi Muscleblind-like protein 0.015 0.4054 0.4176
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0031 0.0031
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0031 0.0032
Echinococcus multilocularis neuropeptide receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.1479 0.1479
Onchocerca volvulus 0.0067 0.1479 0.208
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0558 0.187
Echinococcus granulosus 7TM GPCR rhodopsin 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0569
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0031 0.0031
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0067 0.1479 0.1523
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Brugia malayi RNA binding protein 0.0066 0.1429 0.1472
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0376 0.0376
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0031 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0558 0.187
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.2487 0.2563
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.2986 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0067 0.1479 0.1479
Onchocerca volvulus 0.0067 0.1479 0.208
Brugia malayi Serotonin receptor 0.0067 0.1479 0.1523
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.1429 0.1472
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0807 0.0807
Onchocerca volvulus 0.0245 0.6992 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0558 0.4326
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Brugia malayi follicle stimulating hormone receptor 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Schistosoma mansoni opsin-like receptor 0.0067 0.1479 0.1479
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0068 0.151 0.1556
Onchocerca volvulus 0.0067 0.1479 0.208
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0031 0.0031
Echinococcus multilocularis neuropeptides capa receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0376 0.0387
Echinococcus multilocularis sex peptide receptor 0.0067 0.1479 0.1479
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0031 0.0032
Schistosoma mansoni biogenic amine (5HT) receptor 0.0067 0.1479 0.1479
Echinococcus granulosus somatostatin receptor 0.0067 0.1479 0.1479
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.1649 0.1649
Entamoeba histolytica hypothetical protein 0.0073 0.1649 1
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0553 0.0816
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0116 0.2986 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0067 0.1479 0.1479
Schistosoma mansoni hypothetical protein 0.0342 1 1
Schistosoma mansoni hypothetical protein 0.0067 0.1479 0.1479
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.1649 0.1649
Loa Loa (eye worm) hypothetical protein 0.01 0.2487 0.2563
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.2986 1
Brugia malayi Serotonin receptor 0.0067 0.1479 0.1523
Schistosoma mansoni hypothetical protein 0.0067 0.1479 0.1479
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0067 0.1479 0.1479
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0807 0.0807
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0553 0.079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.1479 0.1479
Schistosoma mansoni hypothetical protein 0.0032 0.0376 0.0376
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0032
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0031 0.0032
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1429 0.1429
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0553 0.079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0031 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0031 0.0032
Schistosoma mansoni nuclear hormone receptor 0.002 0.0031 0.0031
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0558 0.0825
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0032
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0067 0.1479 0.1479
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.1479 0.1479
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Echinococcus multilocularis GPCR, family 2 0.0032 0.0376 0.0376
Schistosoma mansoni tar DNA-binding protein 0.0066 0.1429 0.1429
Schistosoma mansoni hypothetical protein 0.0206 0.5785 0.5785
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0031 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni thyroid hormone receptor 0.002 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0031 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0067 0.1479 0.1479
Brugia malayi larval opioid receptor 0.0067 0.1479 0.1523
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0031 0.0031
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0067 0.1479 0.1479
Schistosoma mansoni neuropeptide F-like receptor 0.0067 0.1479 0.1479
Echinococcus granulosus allatostatin A receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis serotonin receptor 0.0067 0.1479 0.1479
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0558 0.0799
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0558 0.5
Echinococcus granulosus peptide allatostatin:somatostatin 0.0067 0.1479 0.1479
Loa Loa (eye worm) neuropeptide F receptor 0.0067 0.1479 0.1523
Onchocerca volvulus 0.0067 0.1479 0.208
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.2487 0.2563
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0031 0.0032
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.1479 0.1479
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0355 0.0355
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1291 0.4324
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0106 0.2692 0.2773
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0067 0.1479 0.1479
Echinococcus granulosus neuropeptide Y receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0067 0.1479 0.1479
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0807 0.0807
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0031 0.0031
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0031 0.0031
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0355 0.0355
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0067 0.1479 0.1523
Brugia malayi MH2 domain containing protein 0.0118 0.3041 0.3133
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0031 0.0031
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0558 0.5
Onchocerca volvulus 0.0067 0.1479 0.208
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1291 0.1291
Echinococcus multilocularis fmrfamide receptor 0.0067 0.1479 0.1479
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0067 0.1479 0.1523
Schistosoma mansoni biogenic amine receptor 0.0067 0.1479 0.1479
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0032
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0031 0.0032
Schistosoma mansoni myosin xvIII 0.0067 0.1479 0.1479
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0031 0.0032
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0553 0.079
Onchocerca volvulus 0.0067 0.1479 0.208
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0031 0.0031
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0558 1
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0553 0.0816
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0553 0.0816
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0032
Loa Loa (eye worm) hypothetical protein 0.015 0.4054 0.4176
Brugia malayi ecdysteroid receptor 0.002 0.0031 0.0032
Echinococcus granulosus tar DNA binding protein 0.0066 0.1429 0.1429
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0558 1
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0553 0.0816
Brugia malayi Pre-SET motif family protein 0.0031 0.0355 0.0366
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0031 0.0032
Echinococcus granulosus tm gpcr rhodopsin 0.0067 0.1479 0.1479
Onchocerca volvulus 0.0067 0.1479 0.208
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.1649 0.1649
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0031 0.0032
Brugia malayi TAR-binding protein 0.0066 0.1429 0.1472
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.1479 0.1479
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0067 0.1479 0.1523
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni adenoreceptor 0.0067 0.1479 0.1479
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0569
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0558 0.3386
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus multilocularis neuropeptide s receptor 0.0067 0.1479 0.1479
Trypanosoma brucei hypothetical protein 0.0116 0.2986 1
Echinococcus granulosus serotonin receptor 0.0067 0.1479 0.1479
Echinococcus granulosus neuropeptide receptor A26 0.0067 0.1479 0.1479
Trypanosoma brucei calpain-like protein, putative 0.0116 0.2986 1
Entamoeba histolytica hypothetical protein 0.0073 0.1649 1
Echinococcus granulosus G protein coupled receptor 139 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0569
Echinococcus granulosus FTZ F1 alpha 0.002 0.0031 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0031 0.0031
Loa Loa (eye worm) beta-lactamase 0.0037 0.0553 0.0569
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0355 0.0355
Schistosoma mansoni neuropeptide receptor 0.0067 0.1479 0.1479
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0807 0.0807
Loa Loa (eye worm) hypothetical protein 0.0032 0.0376 0.0387
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0031 0.0031
Loa Loa (eye worm) RNA binding protein 0.0066 0.1429 0.1472
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0067 0.1479 0.1479
Onchocerca volvulus 0.0067 0.1479 0.208
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0376 0.0376
Mycobacterium leprae Probable lipase LipE 0.0037 0.0553 0.5
Schistosoma mansoni opsin-like receptor 0.0067 0.1479 0.1479
Schistosoma mansoni amine GPCR 0.0067 0.1479 0.1479
Onchocerca volvulus 0.0037 0.0553 0.075
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni hypothetical protein 0.0067 0.1479 0.1479
Brugia malayi beta-lactamase family protein 0.0037 0.0553 0.0569
Echinococcus multilocularis dro:myosuppressin receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) TAR-binding protein 0.0066 0.1429 0.1472
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus g protein coupled receptor 0.0067 0.1479 0.1479
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0553 0.079
Onchocerca volvulus Neuropeptide F receptor homolog 0.0067 0.1479 0.208
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1291 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1291 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Onchocerca volvulus 0.0067 0.1479 0.208
Onchocerca volvulus 0.0067 0.1479 0.208
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0031 0.0032
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0116 0.2986 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0553 0.0553
Trypanosoma brucei calpain, putative 0.0116 0.2986 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0355 0.0355
Schistosoma mansoni neuropeptide receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.1479 0.1479
Onchocerca volvulus 0.0067 0.1479 0.208
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1291 0.1291
Schistosoma mansoni hypothetical protein 0.0032 0.0376 0.0376
Echinococcus granulosus rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Toxoplasma gondii exonuclease III APE 0.0037 0.0558 0.0895
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus granulosus neuropeptides capa receptor 0.0067 0.1479 0.1479
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0376 0.0387
Mycobacterium tuberculosis Conserved protein 0.0037 0.0553 0.0816
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0569
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0553 0.0553
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0558 0.5
Echinococcus multilocularis g protein coupled receptor 0.0067 0.1479 0.1479
Schistosoma mansoni amine GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni hypothetical protein 0.0028 0.0271 0.0271
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0031 0.0032
Schistosoma mansoni hypothetical protein 0.0032 0.0376 0.0376
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0807 0.0807
Mycobacterium ulcerans hypothetical protein 0.0037 0.0553 0.4281
Schistosoma mansoni opsin-like receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0067 0.1479 0.1479
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.607 0.6253
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1291 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0067 0.1479 0.1479
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0807 0.0807
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0355 0.0355
Loa Loa (eye worm) hypothetical protein 0.0037 0.0553 0.0569
Brugia malayi sulfakinin receptor protein 0.0067 0.1479 0.1523
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0116 0.2986 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0807 0.0832
Onchocerca volvulus 0.0037 0.0553 0.075
Echinococcus granulosus sex peptide receptor 0.0067 0.1479 0.1479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1479 0.1479
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1291 0.4123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0067 0.1479 0.1479
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0031 0.0031
Echinococcus multilocularis neuropeptide Y receptor 0.0067 0.1479 0.1479
Echinococcus granulosus biogenic amine 5HT receptor 0.0067 0.1479 0.1479
Echinococcus multilocularis somatostatin receptor 0.0067 0.1479 0.1479
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0031 0.0032
Echinococcus multilocularis muscleblind protein 0.015 0.4054 0.4054
Brugia malayi neuropeptide F receptor 0.0067 0.1479 0.1523
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0355 0.0355
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0067 0.1479 0.1479
Brugia malayi hypothetical protein 0.0028 0.0271 0.0279
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0116 0.2986 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1479 0.1479
Brugia malayi hypothetical protein 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.002 0.0031 0.0032
Onchocerca volvulus 0.0067 0.1479 0.208
Brugia malayi putative neuropeptide receptor 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Onchocerca volvulus 0.0031 0.0355 0.0466
Echinococcus multilocularis rhodopsin orphan GPCR 0.0067 0.1479 0.1479
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0067 0.1479 0.1479
Brugia malayi putative neuropeptide receptor NPR1 0.0067 0.1479 0.1523
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0558 0.0575
Loa Loa (eye worm) hypothetical protein 0.0067 0.1479 0.1523
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0558 0.0799
Echinococcus multilocularis protein quaking 0.0028 0.0271 0.0271
Entamoeba histolytica hypothetical protein 0.0073 0.1649 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0067 0.1479 0.1479
Brugia malayi Melatonin receptor type 1A 0.0067 0.1479 0.1523
Echinococcus multilocularis serotonin receptor 0.0067 0.1479 0.1479
Echinococcus granulosus hypothetical protein 0.0028 0.0271 0.0271
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0106 0.2676 0.2756
Brugia malayi ORL1-like opioid receptor 0.0067 0.1479 0.1523

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.0000003 M Inhibition of putrescine binding to against Diamine oxidase of porcine kidney ChEMBL. 15689151
IC50 (binding) = 0.000016 M Inhibition of benzylamine binding to Benzylamine oxidase of porcine serum ChEMBL. 15689151
IC50 (binding) > 0.002 M Inhibitory concentration for rat liver Monoamine oxidase B using beta-phenylethylamine ChEMBL. 15689151
IC50 (binding) > 0.002 M Inhibitory concentration for rat liver Monoamine oxidase A using 5-hydroxytryptamine ChEMBL. 15689151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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