TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 264.195 | Formula: C11H19Cl2N3
H donors: 2 H acceptors: 1 LogP: 3.12 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: NCc1ccncc1NC1CCCC1.Cl.Cl
InChi: 1S/C11H17N3.2ClH/c12-7-9-5-6-13-8-11(9)14-10-3-1-2-4-10;;/h5-6,8,10,14H,1-4,7,12H2;2*1H
InChiKey: YNBSFGYHEBSHMR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	amine oxidase, copper containing 1	Starlite/ChEMBL	References
Homo sapiens	amine oxidase, copper containing 3	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	amiloride sensitive amine oxidase	Get druggable targets OG5_127171	All targets in OG5_127171
Neospora caninum	hypothetical protein	Get druggable targets OG5_127171	All targets in OG5_127171
Schistosoma mansoni	copper/topaquinone oxidase	Get druggable targets OG5_127171	All targets in OG5_127171
Schistosoma japonicum	IPR000269,Copper amine oxidase,domain-containing	Get druggable targets OG5_127171	All targets in OG5_127171
Echinococcus multilocularis	amiloride sensitive amine oxidase	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	one of two likely copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Cryptosporidium hominis	amiloride binding protein 1	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	one of two likely peroxisomal copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	one of two likely peroxisomal copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Schistosoma japonicum	ko:K00276 copper amine oxidase [EC1.4.3.6], putative	Get druggable targets OG5_127171	All targets in OG5_127171
Schistosoma mansoni	hypothetical protein	Get druggable targets OG5_127171	All targets in OG5_127171
Cryptosporidium parvum	extracellular protein with a signal peptide sequence, MAM domain and a Cu amine oxidase domain	Get druggable targets OG5_127171	All targets in OG5_127171
Candida albicans	one of two likely copper amine oxidase genes	Get druggable targets OG5_127171	All targets in OG5_127171
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_127171	All targets in OG5_127171

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	protein kinase, putative	0.0058	0.0128	0.1248
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.001	0.0102
Schistosoma mansoni	malate dehydrogenase	0.0343	0.1024	0.1024
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0064	0.0147	0.1439
Echinococcus granulosus	amiloride sensitive amine oxidase	0.0206	0.0593	0.2178
Entamoeba histolytica	malate dehydrogenase,cytoplasmic, putative	0.0343	0.1024	0.3753
Trypanosoma brucei	unspecified product	0.0021	0.001	0.0102
Trypanosoma brucei	DNA polymerase eta, putative	0.0049	0.0098	0.0952
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0235	0.0685	0.2515
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0019	0.0004	0.0015
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0058	0.0128	0.047
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0249	0.0915
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.0128	0.1248
Echinococcus multilocularis	dna polymerase kappa	0.0021	0.001	0.0038
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0058	0.0128	0.1248
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0058	0.0128	0.047
Echinococcus multilocularis	L lactate dehydrogenase	0.054	0.1643	0.6034
Echinococcus multilocularis	neuropeptide s receptor	0.0467	0.1413	0.5191
Brugia malayi	MAP kinase sur-1	0.0058	0.0128	0.047
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0058	0.0128	0.047
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0055	0.0533
Plasmodium falciparum	glutathione reductase	0.0051	0.0105	0.0384
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0116	0.031	0.2632
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0055	0.0055
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0055	0.0055
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0018	0.0001	0.0002
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0056	0.0122	0.0447
Mycobacterium ulcerans	malate dehydrogenase	0.0343	0.1024	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0004	0.0039
Toxoplasma gondii	lactate dehydrogenase LDH2	0.0883	0.2722	1
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0036	0.0058	0.0562
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0019	0.0004	0.0039
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0055	0.0199
Giardia lamblia	DINP protein human, muc B family	0.0021	0.001	0.0102
Toxoplasma gondii	lactate dehydrogenase LDH1	0.0883	0.2722	1
Mycobacterium ulcerans	phytoene synthase, CrtB	0.0084	0.0209	0.2042
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0021	0.001	0.001
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.0105	0.1022
Loa Loa (eye worm)	glutathione reductase	0.0051	0.0105	0.0383
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0058	0.0128	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0055	0.0199
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0055	0.0533
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0249	0.0249
Leishmania major	DNA polymerase kappa, putative	0.0021	0.001	0.0038
Loa Loa (eye worm)	MH2 domain-containing protein	0.0129	0.0349	0.128
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0019	0.0004	0.0039
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0055	0.0533
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.0105	0.1022
Echinococcus multilocularis	muscleblind protein	0.0148	0.0409	0.1501
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0055	0.0533
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0058	0.0128	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0055	0.0199
Schistosoma mansoni	ap endonuclease	0.0019	0.0004	0.0004
Brugia malayi	ImpB/MucB/SamB family protein	0.0049	0.0098	0.0358
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0018	0.0001	0.0002
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0055	0.0201
Mycobacterium leprae	PROBABLE MALATE DEHYDROGENASE MDH	0.0343	0.1024	1
Echinococcus granulosus	mitogen activated protein kinase 3	0.0058	0.0128	0.047
Leishmania major	malate dehydrogenase	0.0343	0.1024	0.3763
Brugia malayi	Latrophilin receptor protein 2	0.0018	0.0001	0.0002
Leishmania major	cytosolic malate dehydrogenase	0.0343	0.1024	0.3763
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0343	0.1024	1
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0343	0.1024	1
Plasmodium vivax	lactate dehydrogenase	0.0883	0.2722	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0018	0.0001	0.0002
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0052	0.0191
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0116	0.031	0.3025
Leishmania major	hypothetical protein, conserved	0.0028	0.0034	0.0125
Trypanosoma brucei	mitochondrial malate dehydrogenase	0.0343	0.1024	1
Schistosoma mansoni	L-lactate dehydrogenase	0.0883	0.2722	0.2722
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0249	0.0249
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0021	0.001	0.0102
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0129	0.0351	0.3053
Trichomonas vaginalis	esterase, putative	0.0035	0.0055	0.0533
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Loa Loa (eye worm)	malate dehydrogenase	0.0343	0.1024	0.3761
Schistosoma mansoni	hypothetical protein	0.0206	0.0593	0.0593
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0098	0.0356
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0019	0.0004	0.0015
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0116	0.031	0.3025
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.001	0.0102
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0055	0.0533
Trichomonas vaginalis	DNA polymerase eta, putative	0.0021	0.001	0.0102
Plasmodium falciparum	lactate dehydrogenase, putative	0.0343	0.1024	0.3763
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Trypanosoma brucei	malate dehydrogenase-related	0.0343	0.1024	1
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0128	0.1248
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0055	0.0533
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0064	0.0147	0.0541
Trypanosoma brucei	cytosolic malate dehydrogenase	0.0343	0.1024	1
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Mycobacterium tuberculosis	Probable reductase	0.0116	0.031	0.3025
Toxoplasma gondii	ABC1 family protein	0.0035	0.0055	0.0201
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0019	0.0004	1
Echinococcus granulosus	L lactate dehydrogenase	0.054	0.1643	0.6034
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0209	0.0766
Trypanosoma cruzi	malate dehydrogenase, putative	0.0343	0.1024	1
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0021	0.001	0.001
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0055	0.0533
Schistosoma mansoni	L-lactate dehydrogenase	0.0343	0.1024	0.1024
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0055	0.0533
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0064	0.0147	0.0541
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.0052	0.0508
Trypanosoma cruzi	DNA polymerase eta, putative	0.0049	0.0098	0.0952
Trichomonas vaginalis	conserved hypothetical protein	0.0036	0.0058	0.0562
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0019	0.0004	0.0039
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0147	0.0147
Leishmania major	hypothetical protein, conserved	0.0035	0.0055	0.0201
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0055	0.0533
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0343	0.1024	1
Toxoplasma gondii	aldehyde dehydrogenase	0.0064	0.0147	0.0541
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0058	0.0562
Echinococcus granulosus	mitogen activated protein kinase	0.0058	0.0128	0.047
Leishmania major	malate dehydrogenase, putative	0.0343	0.1024	0.3763
Brugia malayi	beta-lactamase	0.0035	0.0055	0.0201
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0058	0.0562
Loa Loa (eye worm)	hypothetical protein	0.0883	0.2722	1
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0058	0.0128	0.047
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0055	0.0533
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0034	0.0125
Echinococcus multilocularis	geminin	0.0707	0.2167	0.7961
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0021	0.001	0.0102
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.001	0.0102
Schistosoma mansoni	hypothetical protein	0.0707	0.2167	0.2167
Entamoeba histolytica	malate dehydrogenase, putative	0.0343	0.1024	0.3753
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0064	0.0147	0.0541
Leishmania major	hypothetical protein, conserved	0.0084	0.0209	0.0768
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0343	0.1024	0.3763
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0055	0.0533
Leishmania major	malate dehydrogenase, putative	0.0883	0.2722	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Schistosoma mansoni	copper/topaquinone oxidase	0.0206	0.0593	0.0593
Echinococcus multilocularis	L lactate dehydrogenase B chain	0.0883	0.2722	1
Brugia malayi	Muscleblind-like protein	0.0148	0.0409	0.1501
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.001	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0409	0.1499
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0036	0.0058	0.0211
Echinococcus granulosus	cytosolic malate dehydrogenase	0.0343	0.1024	0.3763
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0128	0.1248
Mycobacterium tuberculosis	Probable phytoene synthase PhyA	0.0084	0.0209	0.2042
Schistosoma mansoni	hypothetical protein	0.0707	0.2167	0.2167
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0058	0.0211
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0055	0.0201
Schistosoma mansoni	hypothetical protein	0.0018	0.0001	0.0001
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0058	0.0128	0.0468
Brugia malayi	glutathione reductase	0.0051	0.0105	0.0384
Schistosoma mansoni	hypothetical protein	0.0018	0.0001	0.0001
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0021	0.001	0.0036
Echinococcus granulosus	dna polymerase kappa	0.0021	0.001	0.0038
Echinococcus granulosus	GPCR family 2	0.0018	0.0001	0.0002
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0343	0.1024	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0021	0.001	0.0038
Echinococcus multilocularis	lactate dehydrogenase a	0.0883	0.2722	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0097	0.0249	0.0915
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0004	0.0039
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0018	0.0001	0.0002
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0249	0.0915
Echinococcus granulosus	lactate dehydrogenase a	0.0883	0.2722	1
Brugia malayi	hypothetical protein	0.0018	0.0002	0.0009
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0058	0.0211
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0036	0.0058	0.0211
Toxoplasma gondii	malate dehydrogenase MDH	0.0883	0.2722	1
Echinococcus granulosus	neuropeptide s receptor	0.0467	0.1413	0.5191
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0019	0.0004	0.0013
Loa Loa (eye worm)	transcription factor SMAD2	0.0129	0.0349	0.128
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0343	0.1024	0.3763
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0034	0.0333
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0147	0.1439
Toxoplasma gondii	hypothetical protein	0.0104	0.0272	0.1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0129	0.0351	0.3423
Echinococcus multilocularis	cytosolic malate dehydrogenase	0.0343	0.1024	0.3763
Leishmania major	mitochondrial malate dehydrogenase	0.0343	0.1024	0.3763
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0147	0.1439
Brugia malayi	exodeoxyribonuclease III family protein	0.0019	0.0004	0.0015
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0019	0.0004	0.0039
Trypanosoma cruzi	glycosomal malate dehydrogenase, putative	0.0343	0.1024	1
Echinococcus granulosus	neuropeptide receptor A26	0.0467	0.1413	0.5191
Echinococcus granulosus	lactate dehydrogenase a	0.0883	0.2722	1
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0036	0.0058	0.0058
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0343	0.1024	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0066	0.0066
Brugia malayi	follicle stimulating hormone receptor	0.0235	0.0685	0.2516
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0019	0.0004	0.0039
Brugia malayi	Malate dehydrogenase, cytoplasmic	0.0343	0.1024	0.3763
Trypanosoma cruzi	squalene synthase, putative	0.027	0.0794	0.7747
Mycobacterium tuberculosis	Probable malate dehydrogenase Mdh	0.0343	0.1024	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0021	0.001	0.0038
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0036	0.0058	0.0211
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0066	0.0239
Schistosoma mansoni	ap endonuclease	0.0019	0.0004	0.0004
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0058	0.0209
Brugia malayi	ImpB/MucB/SamB family protein	0.0021	0.001	0.0038
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0055	0.0199
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0034	0.0125
Trypanosoma cruzi	malate dehydrogenase, putative	0.0343	0.1024	1
Leishmania major	DNA polymerase eta, putative	0.0034	0.0052	0.0191
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0034	0.0125
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0034	0.0125
Schistosoma mansoni	malate dehydrogenase	0.0343	0.1024	0.1024
Echinococcus multilocularis	neuropeptide receptor A26	0.0467	0.1413	0.5191
Schistosoma mansoni	hypothetical protein	0.0018	0.0001	0.0001
Brugia malayi	latrophilin 2 splice variant baaae	0.0039	0.0066	0.0241
Echinococcus multilocularis	lactate dehydrogenase a	0.0883	0.2722	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0034	0.0333
Toxoplasma gondii	thioredoxin reductase	0.0051	0.0105	0.0384
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Giardia lamblia	Malate dehydrogenase	0.0343	0.1024	1
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0055	0.0533
Echinococcus multilocularis	muscleblind protein 1	0.0148	0.0409	0.1501
Echinococcus granulosus	lactate dehydrogenase protein	0.0883	0.2722	1
Brugia malayi	MH2 domain containing protein	0.0129	0.0349	0.1282
Echinococcus multilocularis	amiloride sensitive amine oxidase	0.0206	0.0593	0.2178
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0055	0.0533
Echinococcus granulosus	malate dehydrogenase	0.0343	0.1024	0.3763
Echinococcus granulosus	Squalene phytoene synthase	0.0084	0.0209	0.0768
Schistosoma mansoni	malate dehydrogenase	0.0883	0.2722	0.2722
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Trichomonas vaginalis	malate dehydrogenase, putative	0.0167	0.0471	0.4594
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0116	0.031	0.3025
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0097	0.0249	0.0914
Schistosoma mansoni	hypothetical protein	0.0018	0.0001	0.0001
Echinococcus granulosus	malate dehydrogenase	0.0343	0.1024	0.3763
Giardia lamblia	Kinase, CMGC MAPK	0.0058	0.0128	0.1248
Toxoplasma gondii	exonuclease III APE	0.0019	0.0004	0.0015
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Brugia malayi	hypothetical protein	0.0028	0.0034	0.0125
Trypanosoma brucei	DNA polymerase IV, putative	0.0021	0.001	0.0102
Brugia malayi	beta-lactamase family protein	0.0035	0.0055	0.0201
Entamoeba histolytica	malate dehydrogenase, putative	0.0883	0.2722	1
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Echinococcus granulosus	dna polymerase eta	0.0049	0.0098	0.0358
Plasmodium falciparum	thioredoxin reductase	0.0051	0.0105	0.0384
Loa Loa (eye worm)	malate dehydrogenase	0.0343	0.1024	0.3761
Mycobacterium ulcerans	lipase LipD	0.0035	0.0055	0.0533
Leishmania major	squalene synthase, putative	0.027	0.0794	0.2915
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0004	0.0015
Echinococcus multilocularis	GPCR, family 2	0.0018	0.0001	0.0002
Plasmodium vivax	malate dehydrogenase, putative	0.0883	0.2722	1
Echinococcus granulosus	L lactate dehydrogenase B chain	0.0883	0.2722	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0055	0.0533
Schistosoma mansoni	serine/threonine protein kinase	0.0058	0.0128	0.0128
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.0105	0.0384
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0036	0.0058	0.0058
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Leishmania major	DNA polymerase eta, putative	0.0049	0.0098	0.0358
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0056	0.0122	0.0445
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0224	0.0648	0.6325
Plasmodium falciparum	malate dehydrogenase	0.0883	0.2722	1
Echinococcus multilocularis	lactate dehydrogenase protein	0.0883	0.2722	1
Trypanosoma brucei	glycosomal malate dehydrogenase	0.0343	0.1024	1
Trypanosoma cruzi	squalene synthase, putative	0.027	0.0794	0.7747
Leishmania major	glycosomal malate dehydrogenase	0.0343	0.1024	0.3763
Echinococcus multilocularis	mitogen activated protein kinase	0.0058	0.0128	0.047
Plasmodium vivax	glutathione reductase, putative	0.0051	0.0105	0.0384
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.0105	0.0384
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0116	0.031	0.3025
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.0105	0.0383
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0019	0.0004	0.0015
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0036	0.0058	0.0562
Schistosoma mansoni	malate dehydrogenase	0.0343	0.1024	0.1024
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0055	0.0199
Schistosoma mansoni	hypothetical protein	0.0084	0.0209	0.0209
Loa Loa (eye worm)	hypothetical protein	0.0148	0.0409	0.1499
Wolbachia endosymbiont of Brugia malayi	malate dehydrogenase	0.0883	0.2722	1
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Trichomonas vaginalis	ap endonuclease, putative	0.0019	0.0004	0.0039
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0055	0.0533
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0128	0.1248
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0122	0.0445
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0056	0.0122	0.0447
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0129	0.0351	0.3423
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0055	0.0533
Trichomonas vaginalis	malate dehydrogenase, putative	0.0343	0.1024	1
Trichomonas vaginalis	malate and lactate dehydrogenase, putative	0.0343	0.1024	1
Trypanosoma cruzi	phytoene synthase, putative	0.0084	0.0209	0.2042
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0055	0.0533
Plasmodium vivax	lactate/malate dehydrogenase, putative	0.0343	0.1024	0.3763
Entamoeba histolytica	deoxycytidyl transferase, putative	0.0021	0.001	0.0024
Trypanosoma brucei	squalene synthase, putative	0.027	0.0794	0.7747
Schistosoma mansoni	aldehyde dehydrogenase	0.0064	0.0147	0.0147
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0058	0.0562
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0055	0.0201
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0055	0.0199
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0019	0.0004	0.0015
Trypanosoma brucei	trypanothione reductase	0.0051	0.0105	0.1022
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0055	0.0533
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0036	0.0058	0.0562
Brugia malayi	lactate dehydrogenase.	0.0883	0.2722	1
Brugia malayi	Probable malate dehydrogenase, mitochondrial precursor	0.0343	0.1024	0.3763
Trichomonas vaginalis	CMGC family protein kinase	0.0058	0.0128	0.1248
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0097	0.0249	0.0915
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0036	0.0058	0.0197
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0018	0.0001	0.0002
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0055	0.0533
Echinococcus multilocularis	dna polymerase eta	0.0049	0.0098	0.0358
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0034	0.0123
Leishmania major	trypanothione reductase	0.0051	0.0105	0.0384
Echinococcus granulosus	muscleblind protein	0.0148	0.0409	0.1501
Mycobacterium ulcerans	DNA polymerase IV	0.0021	0.001	0.0102
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0019	0.0004	0.0015
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0036	0.0058	0.0211
Echinococcus multilocularis	malate dehydrogenase	0.0343	0.1024	0.3763
Echinococcus multilocularis	lactate dehydrogenase a	0.0883	0.2722	1
Trypanosoma cruzi	cytosolic malate dehydrogenase, putative	0.0343	0.1024	1
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0055	0.0533
Brugia malayi	beta-lactamase family protein	0.0035	0.0055	0.0201
Trypanosoma cruzi	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Trypanosoma brucei	DNA polymerase kappa, putative	0.0021	0.001	0.0102
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0581	0.1773	0.1773
Echinococcus multilocularis	Squalene phytoene synthase	0.0084	0.0209	0.0768
Echinococcus granulosus	ubiquitin specific protease 41	0.0036	0.0058	0.0211
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0058	0.0128	0.1248
Plasmodium falciparum	L-lactate dehydrogenase	0.0883	0.2722	1
Chlamydia trachomatis	malate dehydrogenase	0.0343	0.1024	1
Brugia malayi	Thioredoxin reductase	0.0051	0.0105	0.0384
Mycobacterium tuberculosis	Probable dehydrogenase	0.0116	0.031	0.3025
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.0105	0.0384
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0097	0.0249	0.0249
Echinococcus multilocularis	malate dehydrogenase	0.0343	0.1024	0.3763
Trypanosoma cruzi	mitochondrial malate dehydrogenase, putative	0.0343	0.1024	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0036	0.0058	0.0211
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0129	0.0351	0.3423
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0034	0.0333
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0055	0.0533
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0097	0.0249	0.0915
Echinococcus granulosus	geminin	0.0707	0.2167	0.7961
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0055	0.0201
Trichomonas vaginalis	malate dehydrogenase, putative	0.0167	0.0471	0.4594
Onchocerca volvulus	NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 homolog	0.0084	0.0209	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0055	0.0199
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0055	0.0533
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0055	0.0199
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0064	0.0147	0.1439
Schistosoma mansoni	DNA polymerase eta	0.0049	0.0098	0.0098
Leishmania major	DNA polymerase kappa, putative,DNA polymerase IV, putative	0.0021	0.001	0.0038

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.000016 M	Inhibition of benzylamine binding to Benzylamine oxidase of porcine serum	ChEMBL.	15689151
IC50 (binding)	= 0.000019 M	Inhibition of putrescine binding to against Diamine oxidase of porcine kidney	ChEMBL.	15689151
IC50 (binding)	> 0.0001 M	Inhibitory concentration for rat liver Monoamine oxidase A using 5-hydroxytryptamine	ChEMBL.	15689151
IC50 (binding)	> 0.0001 M	Inhibitory concentration for rat liver Monoamine oxidase B using beta-phenylethylamine	ChEMBL.	15689151
IC50 (binding)	= 0.0007 M	Inhibition of beta-phenylethylamine binding to Hansenula polymorpha amine oxidase	ChEMBL.	15689151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL537402

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1031592