Detailed information for compound 1032747

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 385.458 | Formula: C24H23N3O2
  • H donors: 2 H acceptors: 3 LogP: 5.69 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Nc1nc(O)c2c(n1)cccc2)Cc1ccc(cc1)OCc1ccccc1
  • InChi: 1S/C24H23N3O2/c1-17(25-24-26-22-10-6-5-9-21(22)23(28)27-24)15-18-11-13-20(14-12-18)29-16-19-7-3-2-4-8-19/h2-14,17H,15-16H2,1H3,(H2,25,26,27,28)
  • InChiKey: PQCHHTHUJUFNNZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus intermediate filament protein 0.0202 0.1178 0.1178
Loa Loa (eye worm) hypothetical protein 0.0105 0.0545 0.0958
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0153 0.0712
Brugia malayi polk-prov protein 0.0034 0.0082 0.0144
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0156 0.0876 0.4338
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0138 0.076 0.1336
Brugia malayi MH2 domain containing protein 0.0061 0.0258 0.0454
Echinococcus multilocularis thyroid hormone receptor alpha 0.0287 0.1729 0.1729
Echinococcus multilocularis lamin 0.0202 0.1178 0.1178
Loa Loa (eye worm) hypothetical protein 0.0133 0.0728 0.128
Schistosoma mansoni glutaminase 0.0274 0.1644 0.1644
Echinococcus multilocularis microtubule associated protein 2 0.1559 1 1
Brugia malayi beta-lactamase family protein 0.0228 0.1344 0.2362
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0163 0.0054
Loa Loa (eye worm) hypothetical protein 0.0228 0.1344 0.2362
Leishmania major mitochondrial DNA polymerase beta 0.033 0.2005 1
Echinococcus granulosus tumor protein p63 0.0719 0.4535 0.4535
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0163 0.0762
Brugia malayi MH1 domain containing protein 0.0061 0.0258 0.0454
Leishmania major cathepsin L-like protease 0.0065 0.0281 0.1357
Loa Loa (eye worm) hypothetical protein 0.0228 0.1344 0.2362
Brugia malayi latrophilin 2 splice variant baaae 0.0288 0.1734 0.3048
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0245 0.0498
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0364 0.1414
Trypanosoma brucei PAB1-binding protein , putative 0.0055 0.022 0.1051
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0364 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.022 0.5654
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0153 0.0712
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0281 0.0695
Mycobacterium tuberculosis Probable esterase LipL 0.0228 0.1344 0.143
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0228 0.1344 0.7987
Brugia malayi MH1 domain containing protein 0.0061 0.0258 0.0454
Brugia malayi beta-lactamase family protein 0.0228 0.1344 0.2362
Schistosoma mansoni thyroid hormone receptor 0.0287 0.1729 0.1729
Echinococcus granulosus GPCR family 2 0.0133 0.0728 0.0728
Schistosoma mansoni lamin 0.0202 0.1178 0.1178
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0138 0.076 0.1336
Schistosoma mansoni tar DNA-binding protein 0.0546 0.3409 0.3409
Echinococcus granulosus mothers against decapentaplegic 6 0.0027 0.0039 0.0039
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Trichomonas vaginalis D-aminoacylase, putative 0.0228 0.1344 0.7987
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0163 0.0054
Schistosoma mansoni hypothetical protein 0.0133 0.0728 0.0728
Entamoeba histolytica hypothetical protein 0.0267 0.1596 1
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0281 0.0695
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0153 0.0712
Echinococcus multilocularis mothers against decapentaplegic 6 0.0027 0.0039 0.0039
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0039 0.0068
Schistosoma mansoni Smad4 0.0027 0.0039 0.0039
Plasmodium vivax ataxin-2 like protein, putative 0.0055 0.022 0.1422
Echinococcus multilocularis Smad4 0.0061 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0148 0.0821 0.1443
Trypanosoma brucei DNA polymerase IV, putative 0.0038 0.0106 0.0477
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0077 0.0364 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0228 0.1344 0.7987
Mycobacterium tuberculosis Conserved protein 0.0228 0.1344 0.143
Schistosoma mansoni tar DNA-binding protein 0.0546 0.3409 0.3409
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Loa Loa (eye worm) hypothetical protein 0.0228 0.1344 0.2362
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0228 0.1344 0.2362
Loa Loa (eye worm) hypothetical protein 0.0148 0.0821 0.1443
Brugia malayi N-terminal motif family protein 0.0178 0.1021 0.1795
Loa Loa (eye worm) transcription factor SMAD2 0.0896 0.569 1
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0077 0.0364 0.0364
Onchocerca volvulus 0.0228 0.1344 1
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.2005 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0364 0.2515
Loa Loa (eye worm) hypothetical protein 0.0077 0.0364 0.0639
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0267 0.1596 0.1596
Trypanosoma cruzi hypothetical protein, conserved 0.0228 0.1344 0.6431
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0133 0.0728 0.0728
Echinococcus granulosus mothers against decapentaplegic 5 0.0061 0.0258 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.0228 0.1344 0.7987
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Trichomonas vaginalis esterase, putative 0.0228 0.1344 0.7987
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0228 0.1344 0.143
Onchocerca volvulus 0.0105 0.0545 0.4057
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0153 0.0153
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.076 0.3758
Schistosoma mansoni smad1 5 8 and 0.0061 0.0258 0.0258
Trypanosoma brucei unspecified product 0.0038 0.0106 0.0477
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Giardia lamblia DINP protein human, muc B family 0.0023 0.0011 0.5
Brugia malayi MH1 domain containing protein 0.0034 0.0081 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0153 0.0712
Mycobacterium tuberculosis Conserved protein 0.0228 0.1344 0.143
Loa Loa (eye worm) hypothetical protein 0.0094 0.0473 0.0831
Schistosoma mansoni smad 0.0027 0.0039 0.0039
Onchocerca volvulus 0.0202 0.1178 0.8766
Trichomonas vaginalis penicillin-binding protein, putative 0.0228 0.1344 0.7987
Leishmania major cathepsin L-like protease 0.0065 0.0281 0.1357
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0077 0.0364 0.2515
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0364 0.5
Loa Loa (eye worm) hypothetical protein 0.0288 0.1734 0.3048
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0153 0.0712
Schistosoma mansoni lamin 0.0202 0.1178 0.1178
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0228 0.1344 0.143
Brugia malayi RNA recognition motif domain containing protein 0.0546 0.3409 0.5991
Toxoplasma gondii ABC1 family protein 0.0228 0.1344 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0039 0.0068
Echinococcus multilocularis tumor protein p63 0.0719 0.4535 0.4535
Echinococcus granulosus lamin 0.0202 0.1178 0.1178
Onchocerca volvulus 0.0228 0.1344 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.076 0.328
Loa Loa (eye worm) RNA binding protein 0.0546 0.3409 0.5991
Echinococcus granulosus mothers against decapentaplegic 2 0.0027 0.0039 0.0039
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0138 0.076 0.076
Mycobacterium ulcerans beta-lactamase 0.0228 0.1344 0.7987
Echinococcus granulosus lamin dm0 0.0202 0.1178 0.1178
Brugia malayi Probable ClpP-like protease 0.0077 0.0364 0.0639
Loa Loa (eye worm) nuclear factor I 0.0034 0.0081 0.0142
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0267 0.1596 0.1596
Loa Loa (eye worm) glutaminase 0.0274 0.1644 0.289
Entamoeba histolytica hypothetical protein 0.0267 0.1596 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0546 0.3409 0.5991
Schistosoma mansoni transcription factor LCR-F1 0.0267 0.1596 0.1596
Brugia malayi Muscleblind-like protein 0.0148 0.0821 0.1443
Mycobacterium ulcerans hypothetical protein 0.0228 0.1344 0.7987
Echinococcus granulosus tar DNA binding protein 0.0546 0.3409 0.3409
Schistosoma mansoni Smad4 0.0027 0.0039 0.0039
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0098 0.0497 0.0497
Loa Loa (eye worm) hypothetical protein 0.0421 0.2601 0.4571
Brugia malayi MH2 domain containing protein 0.0061 0.0258 0.0454
Echinococcus multilocularis transcription factor Dp 1 0.008 0.0382 0.0382
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0153 0.0712
Schistosoma mansoni hypothetical protein 0.0266 0.1591 0.1591
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.022 0.0366
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0191 0.0191
Mycobacterium ulcerans lipase LipD 0.0228 0.1344 0.7987
Trichomonas vaginalis D-aminoacylase, putative 0.0228 0.1344 0.7987
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0153 0.0712
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Echinococcus multilocularis musashi 0.0202 0.1178 0.1178
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Schistosoma mansoni peptidase Clp (S14 family) 0.0077 0.0364 0.0364
Schistosoma mansoni tar DNA-binding protein 0.0546 0.3409 0.3409
Echinococcus granulosus beta LACTamase domain containing family member 0.0228 0.1344 0.1344
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0153 0.0712
Brugia malayi MH2 domain containing protein 0.0027 0.0039 0.0068
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0077 0.0364 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0138 0.076 0.3758
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0108 0.0567 0.0996
Echinococcus multilocularis smad 0.0061 0.0258 0.0258
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0077 0.0364 0.0364
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0229 0.041
Onchocerca volvulus 0.0202 0.1178 0.8766
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0191 0.0209
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0077 0.0364 0.5
Trypanosoma cruzi cruzipain precursor, putative 0.0065 0.0281 0.0695
Leishmania major hypothetical protein, conserved 0.0055 0.022 0.1051
Brugia malayi hypothetical protein 0.0267 0.1596 0.2804
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0191 0.1193
Brugia malayi beta-lactamase 0.0228 0.1344 0.2362
Toxoplasma gondii LsmAD domain-containing protein 0.0055 0.022 0.1422
Brugia malayi intermediate filament protein 0.0202 0.1178 0.2071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0228 0.1344 0.2362
Echinococcus multilocularis lamin dm0 0.0202 0.1178 0.1178
Onchocerca volvulus 0.0228 0.1344 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0081 0.0142
Loa Loa (eye worm) MH2 domain-containing protein 0.0061 0.0258 0.0454
Schistosoma mansoni tar DNA-binding protein 0.0546 0.3409 0.3409
Trypanosoma brucei mitochondrial DNA polymerase beta 0.033 0.2005 1
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0191 0.0191
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0077 0.0364 0.2515
Echinococcus granulosus TGF beta signal transducer SmadC 0.0061 0.0258 0.0258
Echinococcus multilocularis beta LACTamase domain containing family member 0.0228 0.1344 0.1344
Schistosoma mansoni hypothetical protein 0.0133 0.0728 0.0728
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.0876 0.3904
Echinococcus multilocularis mothers against decapentaplegic 2 0.0027 0.0039 0.0039
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0138 0.076 0.328
Loa Loa (eye worm) hypothetical protein 0.0228 0.1344 0.2362
Loa Loa (eye worm) hypothetical protein 0.0027 0.0039 0.0068
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0133 0.0728 0.0728
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0022 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.0065 0.0281 0.0695
Loa Loa (eye worm) Smad1 0.0061 0.0258 0.0454
Mycobacterium ulcerans hypothetical protein 0.0174 0.0991 0.5617
Mycobacterium ulcerans glutaminase 0.0274 0.1644 1
Schistosoma mansoni intermediate filament proteins 0.0202 0.1178 0.1178
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0077 0.0364 0.2515
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0133 0.0728 0.0728
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0082 0.0356
Echinococcus multilocularis GPCR, family 2 0.0133 0.0728 0.0728
Echinococcus granulosus muscleblind protein 0.0148 0.0821 0.0821
Mycobacterium leprae conserved hypothetical protein 0.0228 0.1344 1
Brugia malayi hypothetical protein 0.0055 0.022 0.0387
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0133 0.0728 0.128
Loa Loa (eye worm) TAR-binding protein 0.0546 0.3409 0.5991
Trypanosoma cruzi PAB1-binding protein , putative 0.0055 0.022 0.0366
Schistosoma mansoni hypothetical protein 0.0025 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0202 0.1178 0.2071
Brugia malayi glutaminase DH11.1 0.0274 0.1644 0.289
Brugia malayi MH1 domain containing protein 0.0034 0.0081 0.0142
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0133 0.0728 0.0728
Echinococcus multilocularis muscleblind protein 0.0148 0.0821 0.0821
Loa Loa (eye worm) hypothetical protein 0.0094 0.0473 0.0831
Entamoeba histolytica hypothetical protein 0.0267 0.1596 1
Mycobacterium tuberculosis Probable hydrolase 0.0228 0.1344 0.143
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.033 0.2005 1
Brugia malayi Intermediate filament tail domain containing protein 0.0202 0.1178 0.2071
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0202 0.1178 0.2071
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0191 0.0193
Mycobacterium leprae Probable lipase LipE 0.0228 0.1344 1
Leishmania major hypothetical protein, conserved 0.0228 0.1344 0.6685
Schistosoma mansoni smad1 5 8 and 0.0061 0.0258 0.0258
Echinococcus multilocularis mothers against decapentaplegic 5 0.0061 0.0258 0.0258
Trypanosoma brucei hypothetical protein, conserved 0.0228 0.1344 0.6685
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0228 0.1344 0.1344
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0228 0.1344 0.143
Trichomonas vaginalis glutaminase, putative 0.0274 0.1644 1
Echinococcus granulosus dna polymerase kappa 0.0045 0.0153 0.0153
Loa Loa (eye worm) MH1 domain-containing protein 0.0061 0.0258 0.0454
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0163 0.0054
Loa Loa (eye worm) beta-lactamase 0.0228 0.1344 0.2362
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0266 0.1591 0.1591
Schistosoma mansoni tar DNA-binding protein 0.0546 0.3409 0.3409
Schistosoma mansoni Smad4 0.0061 0.0258 0.0258
Entamoeba histolytica hypothetical protein 0.0267 0.1596 1
Echinococcus multilocularis muscleblind protein 1 0.0148 0.0821 0.0821
Brugia malayi mothers against decapentaplegic homolog 3 0.0027 0.0039 0.0068
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0098 0.0497 0.0497
Loa Loa (eye worm) intermediate filament protein 0.0202 0.1178 0.2071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Schistosoma mansoni hypothetical protein 0.0288 0.1734 0.1734
Loa Loa (eye worm) MH2 domain-containing protein 0.0896 0.569 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0153 0.0712
Mycobacterium tuberculosis Conserved protein 0.0228 0.1344 0.143
Schistosoma mansoni hypothetical protein 0.0133 0.0728 0.0728
Schistosoma mansoni smad 0.0061 0.0258 0.0258
Brugia malayi Smad1 0.0061 0.0258 0.0454
Schistosoma mansoni smad1 5 8 and 0.0061 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0034 0.0082 0.0144
Schistosoma mansoni hypothetical protein 0.0267 0.1596 0.1596
Brugia malayi TAR-binding protein 0.0546 0.3409 0.5991
Brugia malayi RNA binding protein 0.0546 0.3409 0.5991
Mycobacterium tuberculosis Conserved hypothetical protein 0.0174 0.0991 0.1051
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0077 0.0364 0.1414
Brugia malayi cytoplasmic intermediate filament protein 0.0108 0.0567 0.0996
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0061 0.0258 0.0258
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0191 0.0193
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.0545 0.0545
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0061 0.0258 0.0258
Loa Loa (eye worm) hypothetical protein 0.0098 0.0497 0.0873
Echinococcus granulosus smad 0.0061 0.0258 0.0258
Plasmodium falciparum ataxin-2 like protein, putative 0.0055 0.022 0.5654
Echinococcus granulosus Smad4 0.0061 0.0258 0.0258
Loa Loa (eye worm) latrophilin receptor protein 2 0.0133 0.0728 0.128
Mycobacterium tuberculosis Probable lipase LipD 0.0228 0.1344 0.143
Mycobacterium tuberculosis Probable lipase LipE 0.0228 0.1344 0.143
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Loa Loa (eye worm) hypothetical protein 0.0228 0.1344 0.2362
Brugia malayi Calcitonin receptor-like protein seb-1 0.0421 0.2601 0.4571
Loa Loa (eye worm) hypothetical protein 0.0199 0.1154 0.2028
Loa Loa (eye worm) hypothetical protein 0.0228 0.1344 0.2362
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0022 0.0022
Brugia malayi hypothetical protein 0.0036 0.0093 0.0164
Mycobacterium ulcerans esterase/lipase LipP 0.0228 0.1344 0.7987
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0156 0.0876 0.4338
Loa Loa (eye worm) hypothetical protein 0.0055 0.022 0.0387
Echinococcus multilocularis tar DNA binding protein 0.0546 0.3409 0.3409
Loa Loa (eye worm) hypothetical protein 0.0178 0.1021 0.1795
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1457 0.9335 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0065 0.0281 0.1357
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0421 0.2601 0.4571
Trypanosoma brucei DNA polymerase kappa, putative 0.0034 0.0082 0.0356
Schistosoma mansoni thyroid hormone receptor 0.0287 0.1729 0.1729
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0153 0.0712
Toxoplasma gondii hypothetical protein 0.0053 0.0207 0.1319
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0138 0.076 0.076
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0027 0.0039 0.0288
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0153 0.0712
Echinococcus granulosus transcription factor Dp 1 0.008 0.0382 0.0382
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0228 0.1344 0.1344
Brugia malayi Latrophilin receptor protein 2 0.0133 0.0728 0.128
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0266 0.1591 0.1591
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0138 0.076 0.076
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0421 0.2601 0.4571
Loa Loa (eye worm) glutaminase 2 0.0274 0.1644 0.289
Brugia malayi MH2 domain containing protein 0.0896 0.569 1
Plasmodium vivax hypothetical protein, conserved 0.0228 0.1344 1
Trypanosoma cruzi hypothetical protein, conserved 0.0228 0.1344 0.6431
Schistosoma mansoni hypothetical protein 0.0133 0.0728 0.0728
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.1021 0.7597
Leishmania major cathepsin L-like protease 0.0065 0.0281 0.1357
Schistosoma mansoni microtubule-associated protein tau 0.1559 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.