TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 583.072 | Formula: C31H35ClN2O7
H donors: 1 H acceptors: 2 LogP: 5.96 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: COc1cc(cc(c1O)OC)[C@H]1[C@H]2C(=O)OCC2[C@@H](c2c1cc1OCOc1c2)CCN(N(c1ccccc1)C)C.Cl
InChi: 1S/C31H34N2O7.ClH/c1-32(33(2)19-8-6-5-7-9-19)11-10-20-21-14-24-25(40-17-39-24)15-22(21)28(29-23(20)16-38-31(29)35)18-12-26(36-3)30(34)27(13-18)37-4;/h5-9,12-15,20,23,28-29,34H,10-11,16-17H2,1-4H3;1H/t20-,23?,28-,29+;/m1./s1
InChiKey: WQTVCOAPNUWJII-WCSCJQKSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	non-receptor protein-tyrosine phosphatase	0.0348	0.027	0.0239
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Mycobacterium tuberculosis	Two component sensory transduction histidine kinase MtrB	0.0245	0.0179	0.5
Plasmodium falciparum	DNA topoisomerase VI, b subunit, putative	0.0245	0.0179	0.5
Onchocerca volvulus		0.0348	0.027	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Brugia malayi	Endoplasmin precursor	0.0245	0.0179	0.0129
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.0348	0.027	0.0239
Schistosoma mansoni	heat shock protein	0.0245	0.0179	0.0147
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0348	0.027	0.0239
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Onchocerca volvulus		0.0348	0.027	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Mycobacterium ulcerans	two component sensor histidine kinase PrrB	0.0245	0.0179	0.5
Schistosoma mansoni	endoplasmin	0.0245	0.0179	0.0147
Trypanosoma cruzi	developmentally regulated phosphoprotein, putative	0.4403	0.3858	1
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.4403	0.3858	0.3858
Echinococcus granulosus	DNA topoisomerase 2 alpha	0.0245	0.0179	0.0179
Loa Loa (eye worm)	protein-tyrosine phosphatase	1.1344	1	1
Loa Loa (eye worm)	heat shock protein 90	0.0245	0.0179	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Mycobacterium ulcerans	two component regulator - sensor kinase	0.0245	0.0179	0.5
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Treponema pallidum	DNA gyrase, subunit B (gyrB)	0.0245	0.0179	0.5
Onchocerca volvulus		0.0348	0.027	1
Echinococcus granulosus	heat shock protein	0.0245	0.0179	0.0179
Schistosoma mansoni	heat shock protein	0.0245	0.0179	0.0147
Schistosoma mansoni	pyruvate dehydrogenase	0.4158	0.3641	0.3621
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Onchocerca volvulus		0.0348	0.027	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0348	0.027	0.0239
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Leishmania major	pyruvate dehydrogenase (lipoamide) kinase, putative	0.1539	0.1324	0.3113
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0348	0.027	0.027
Trichomonas vaginalis	pten, drome, putative	0.0348	0.027	1
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0099	0.0051	0.0051
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0348	0.027	0.027
Chlamydia trachomatis	two component regulatory system sensor histidine kinase	0.0245	0.0179	0.5
Leishmania major	protein-tyrosine phosphatase 1-like protein	0.0348	0.027	0.0247
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	1.1344	1	1
Mycobacterium tuberculosis	Two component sensor histidine kinase PrrB	0.0245	0.0179	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0348	0.027	0.027
Onchocerca volvulus		0.0348	0.027	1
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0348	0.027	0.027
Echinococcus multilocularis	heat shock protein	0.0245	0.0179	0.0179
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Brugia malayi	hypothetical protein	0.0348	0.027	0.0221
Plasmodium falciparum	DNA topoisomerase 2	0.0245	0.0179	0.5
Mycobacterium ulcerans	two component system membrane associated sensor kinase	0.0245	0.0179	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0348	0.027	0.0239
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0348	0.027	0.027
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Loa Loa (eye worm)	dual specificity protein phosphatase CDC14B	0.0348	0.027	0.0262
Schistosoma mansoni	pyruvate dehydrogenase	0.4403	0.3858	0.3838
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Plasmodium vivax	heat shock protein 86, putative	0.0245	0.0179	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Schistosoma mansoni	protein-tyrosine phosphatase non-receptor type nt5	0.0348	0.027	0.0239
Echinococcus multilocularis		0.0348	0.027	0.027
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Leishmania major	developmentally regulated phosphoprotein-like protein	0.4403	0.3858	1
Loa Loa (eye worm)	hypothetical protein	0.4403	0.3858	0.3853
Onchocerca volvulus		0.0348	0.027	1
Plasmodium falciparum	heat shock protein 90	0.0245	0.0179	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0348	0.027	0.027
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	1.1344	1	1
Mycobacterium tuberculosis	Two component sensor histidine kinase TrcS	0.0245	0.0179	0.5
Brugia malayi	DNA gyrase/topoisomerase IV, A subunit family protein	0.0245	0.0179	0.0129
Brugia malayi	hypothetical protein	0.0348	0.027	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Schistosoma mansoni	protein tyrosine phosphatase	0.0348	0.027	0.0239
Onchocerca volvulus		0.0348	0.027	1
Trypanosoma cruzi	pyruvate dehydrogenase (lipoamide) kinase, putative	0.1539	0.1324	0.3113
Mycobacterium tuberculosis	DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase)	0.0245	0.0179	0.5
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0348	0.027	0.0247
Mycobacterium ulcerans	two component sensor histidine kinase SenX3	0.0245	0.0179	0.5
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0348	0.027	0.0239
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0348	0.027	1
Echinococcus granulosus	heat shock protein 90	0.0245	0.0179	0.0179
Mycobacterium ulcerans	two component sensor histidine kinase DevS	0.0245	0.0179	0.5
Mycobacterium tuberculosis	Possible two component sensor kinase TcrY	0.0245	0.0179	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0348	0.027	0.027
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0348	0.027	0.027
Mycobacterium ulcerans	DNA gyrase subunit B	0.0245	0.0179	0.5
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.0348	0.027	0.0262
Brugia malayi	heat shock protein 90	0.0245	0.0179	0.0129
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Schistosoma mansoni	protein tyrosine phosphatase	0.0348	0.027	0.0239
Echinococcus granulosus	protein tyrosine phosphatase n9	0.0348	0.027	0.027
Loa Loa (eye worm)	protein-tyrosine phosphatase 1	0.0348	0.027	0.0262
Schistosoma mansoni	receptor protein tyrosine phosphatase n (ia2)	0.0348	0.027	0.0239
Loa Loa (eye worm)	protein tyrosine phosphatase	0.0348	0.027	0.0262
Schistosoma mansoni	pyruvate dehydrogenase	0.4158	0.3641	0.3621
Schistosoma mansoni	rgs-gaip interacting protein gipc	0.0348	0.027	0.0239
Mycobacterium ulcerans	two component system response phosphate sensor kinase, PhoR	0.0245	0.0179	0.5
Schistosoma mansoni	receptor protein tyrosine phosphatase r (pcptp1)	0.0348	0.027	0.0239
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Brugia malayi	Probable DNA topoisomerase II	0.0245	0.0179	0.0129
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Echinococcus multilocularis	hypothetical protein	0.0348	0.027	0.027
Echinococcus multilocularis	protein tyrosine phosphatase n9	0.0348	0.027	0.027
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.0348	0.027	0.027
Mycobacterium tuberculosis	Two component sensor kinase MprB	0.0245	0.0179	0.5
Mycobacterium ulcerans	putative regultory protein	0.0245	0.0179	0.5
Brugia malayi	Protein-tyrosine phosphatase	0.0348	0.027	0.0221
Echinococcus multilocularis	DNA topoisomerase 2 alpha	0.0245	0.0179	0.0179
Mycobacterium leprae	Probable two-component sensor kinase	0.0245	0.0179	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Mycobacterium tuberculosis	Two component sensor histidine kinase DevS	0.0245	0.0179	0.5
Onchocerca volvulus		0.0348	0.027	1
Schistosoma mansoni	endoplasmin	0.0245	0.0179	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Entamoeba histolytica	protein tyrosine phosphatase, putative	0.0348	0.027	1
Chlamydia trachomatis	DNA gyrase subunit B	0.0245	0.0179	0.5
Schistosoma mansoni	protein tyrosine phosphatase non-receptor type nt1	1.1344	1	1
Toxoplasma gondii	ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein	0.1784	0.1541	1
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Chlamydia trachomatis	DNA gyrase subunit B	0.0245	0.0179	0.5
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Mycobacterium tuberculosis	Possible two component system response sensor kinase membrane associated PhoR	0.0245	0.0179	0.5
Mycobacterium leprae	TWO COMPONENT SENSOR HISTIDINE KINASE PRRB	0.0245	0.0179	0.5
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Onchocerca volvulus		0.0348	0.027	1
Mycobacterium ulcerans	sensor kinase from two component regulatory system	0.0245	0.0179	0.5
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0179	0.0171
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0348	0.027	0.027
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0348	0.027	0.027
Plasmodium vivax	hypothetical protein, conserved	0.0245	0.0179	0.5
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Treponema pallidum	chemotaxis histidine kinase (cheA)	0.0245	0.0179	0.5
Toxoplasma gondii	pyruvate dehydrogenase kinase, putative	0.1539	0.1324	0.8409
Brugia malayi	kinase, mitochondrial precursor	0.4403	0.3858	0.3827
Schistosoma mansoni	pcd6 interacting protein-related	0.0348	0.027	0.0239
Mycobacterium ulcerans	two component sensor kinase MprB	0.0245	0.0179	0.5
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Onchocerca volvulus	4.1 G protein, putative homolog	0.0348	0.027	1
Mycobacterium tuberculosis	Two component sensor histidine kinase DosT	0.0245	0.0179	0.5
Plasmodium vivax	endoplasmin, putative	0.0245	0.0179	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0348	0.027	0.0239
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Echinococcus granulosus	Receptor type tyrosine protein phosphatase O	0.0348	0.027	0.027
Brugia malayi	Dual specificity protein phosphatase CDC14B	0.0348	0.027	0.0221
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0348	0.027	0.027
Mycobacterium tuberculosis	Probable sensor protein KdpD	0.0245	0.0179	0.5
Plasmodium vivax	DNA gyrase subunit B, putative	0.0245	0.0179	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase H	0.0348	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.0348	0.027	0.027
Wolbachia endosymbiont of Brugia malayi	DNA gyrase, topoisomerase II, B subunit, GyrB	0.0245	0.0179	0.5
Onchocerca volvulus		0.0348	0.027	1
Mycobacterium ulcerans	two component sensor histidine kinase TrcS	0.0245	0.0179	0.5
Plasmodium falciparum	endoplasmin, putative	0.0245	0.0179	0.5
Mycobacterium tuberculosis	Possible two component sensor kinase	0.0245	0.0179	0.5
Trypanosoma brucei	developmentally regulated phosphoprotein	0.4403	0.3858	1
Mycobacterium tuberculosis	Two component sensor kinase [second part]	0.0245	0.0179	0.5
Loa Loa (eye worm)	hypothetical protein	0.0245	0.0179	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0348	0.027	0.027
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Brugia malayi	hypothetical protein	0.0348	0.027	0.0221
Brugia malayi	hypothetical protein	0.0348	0.027	0.0221
Trypanosoma brucei	pyruvate dehydrogenase (lipoamide) kinase, putative	0.1539	0.1324	0.3113
Onchocerca volvulus		0.0348	0.027	1
Onchocerca volvulus		0.0348	0.027	1
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0348	0.027	0.0239
Schistosoma mansoni	protein tyrosine phosphatase	0.0348	0.027	0.0239
Echinococcus multilocularis	Pyruvate dehydrogenase (lipoamide) kinase	0.4403	0.3858	0.3858
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Echinococcus granulosus	Pyruvate dehydrogenase lipoamide kinase	0.4403	0.3858	0.3858
Onchocerca volvulus		0.0348	0.027	1
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Mycobacterium leprae	Probable two component sensor kinase MprB	0.0245	0.0179	0.5
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0348	0.027	0.027
Loa Loa (eye worm)	endoplasmin	0.0245	0.0179	0.0171
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Brugia malayi	DNA topoisomerase II, alpha isozyme	0.0245	0.0179	0.0129
Mycobacterium leprae	PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3	0.0245	0.0179	0.5
Schistosoma mansoni	protein-tyrosine phosphatase n9	0.0348	0.027	0.0239
Schistosoma mansoni	DNA topoisomerase II	0.0245	0.0179	0.0147
Brugia malayi	hypothetical protein	0.0348	0.027	0.0221
Wolbachia endosymbiont of Brugia malayi	signal transduction histidine kinase and receiver	0.0245	0.0179	0.5
Plasmodium falciparum	DNA gyrase subunit B	0.0245	0.0179	0.5
Leishmania major	tyrosine specific protein phosphatase, putative	0.0348	0.027	0.0247
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0348	0.027	0.027
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0348	0.027	0.027
Loa Loa (eye worm)	protein-tyrosine-phosphatase	0.0348	0.027	0.0262
Trypanosoma brucei	protein tyrosine phosphatase 1	0.0348	0.027	0.0247
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.0348	0.027	0.027
Onchocerca volvulus		0.0348	0.027	1
Entamoeba histolytica	Pten 3-phosphoinositide phosphatase, putative	0.0348	0.027	1
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0348	0.027	0.027
Mycobacterium tuberculosis	Probable two component sensor kinase	0.0245	0.0179	0.5
Onchocerca volvulus		0.0348	0.027	1
Wolbachia endosymbiont of Brugia malayi	membrane associated signal transduction histidine kinase	0.0245	0.0179	0.5
Onchocerca volvulus		0.0348	0.027	1
Onchocerca volvulus		0.0348	0.027	1
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.0348	0.027	0.027
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Mycobacterium tuberculosis	Conserved protein	0.0245	0.0179	0.5
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0348	0.027	0.0247
Giardia lamblia	Protein tyrosine phosphatase	0.0348	0.027	1
Onchocerca volvulus		0.0348	0.027	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0348	0.027	0.027
Brugia malayi	Protein-tyrosine phosphatase	0.0348	0.027	0.0221
Onchocerca volvulus		0.0348	0.027	1
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0099	0.0051	0.0051
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Plasmodium vivax	DNA topoisomerase II, putative	0.0245	0.0179	0.5
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0348	0.027	0.0239
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0348	0.027	0.027
Onchocerca volvulus		0.0348	0.027	1
Loa Loa (eye worm)	jmjC domain-containing protein	0.0063	0.0018	0.0009
Onchocerca volvulus		0.0348	0.027	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Onchocerca volvulus		0.0348	0.027	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.0348	0.027	0.0221
Brugia malayi	Protein-tyrosine phosphatase 1	0.0348	0.027	0.0221
Echinococcus multilocularis	heat shock protein 90	0.0245	0.0179	0.0179
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0348	0.027	0.0262
Onchocerca volvulus		0.0348	0.027	1
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0348	0.027	0.0221
Mycobacterium ulcerans	two component sensory transduction histidine kinase MtrB	0.0245	0.0179	0.5
Loa Loa (eye worm)	TOPoisomerase family member	0.0245	0.0179	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0348	0.027	0.0262
Trypanosoma cruzi	tyrosine specific protein phosphatase, putative	0.0348	0.027	0.0247

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 0.000001 M	Cytotoxicity against P388 leukemia	ChEMBL.	8389875

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Mus musculus	ChEMBL23	8389875

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL541290

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1036620