Detailed information for compound 1039494

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 293.404 | Formula: C16H27N3O2
  • H donors: 2 H acceptors: 2 LogP: 3.93 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O/N=C(/c1cccnc1OCC(C)(C)C)\NC(CC)(C)C
  • InChi: 1S/C16H27N3O2/c1-7-16(5,6)18-13(19-20)12-9-8-10-17-14(12)21-11-15(2,3)4/h8-10,20H,7,11H2,1-6H3,(H,18,19)
  • InChiKey: JXPIHIRUNILZAR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) inositol-1 0.0042 0.0038 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0139 0.0383
Echinococcus granulosus Chromobox protein 3 0.0047 0.0054 0.0285
Echinococcus granulosus lysine specific demethylase 6a 0.0076 0.0136 0.0733
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.013 0.0878
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0077 0.0141 0.0759
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0113 0.0606
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0073 0.0067
Brugia malayi hypothetical protein 0.0074 0.013 0.018
Brugia malayi M-phase phosphoprotein, mpp8 0.0047 0.0054 0.0074
Brugia malayi AF-10 protein 0.006 0.009 0.0125
Plasmodium falciparum 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0055 0.0075 0.0278
Echinococcus granulosus chromobox protein 1 0.0289 0.0757 0.4103
Echinococcus granulosus GPCR family 2 0.0068 0.0113 0.0606
Schistosoma mansoni transient receptor potential channel 0.0063 0.0099 0.0668
Mycobacterium tuberculosis Conserved protein 0.0077 0.0139 0.0863
Mycobacterium tuberculosis Conserved protein 0.0077 0.0139 0.0863
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0038 0.014
Schistosoma mansoni hypothetical protein 0.0146 0.0341 0.2298
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0226 0.0575 0.3113
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0019 0.0026
Brugia malayi hypothetical protein 0.0152 0.0358 0.0494
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0047 0.0054 0.0074
Mycobacterium ulcerans 5'-3' exonuclease 0.0055 0.0075 0.0297
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0072 0.0065
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.0231 0.0731
Echinococcus multilocularis chromobox protein 1 0.0289 0.0757 0.4103
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.019 0.1028
Brugia malayi Protein cec-1. 0.0047 0.0054 0.0074
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0072 0.0127
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0049 0.0058 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0388 0.0686
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.1572 0.4497 1
Plasmodium vivax heterochromatin protein 1, putative 0.0047 0.0054 0.0197
Echinococcus multilocularis cpg binding protein 0.003 0.0005 0.002
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0047 0.0054 0.0361
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0072 0.0065
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0119
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0072 0.0384
Echinococcus granulosus jumonji domain containing 1A 0.0076 0.0136 0.0733
Echinococcus multilocularis dnaJ subfamily B 0.0411 0.1113 0.6036
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0054 0.003
Toxoplasma gondii PHD-finger domain-containing protein 0.0183 0.045 0.168
Schistosoma mansoni inositol monophosphatase 0.0042 0.0038 0.0259
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0051 0.0064 0.005
Onchocerca volvulus 0.0047 0.0054 0.0054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0226 0.0575 0.3871
Brugia malayi beta-lactamase 0.0077 0.0139 0.0192
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0038 0.0203
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0231 0.0378
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0047 0.0054 0.0197
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0047 0.0054 0.0197
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.0193 0.1299
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0072 0.0127
Toxoplasma gondii RNA-directed DNA polymerase 0.0945 0.267 1
Plasmodium falciparum heterochromatin protein 1 0.0047 0.0054 0.0197
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0054 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0047 0.0054 0.003
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0055 0.0075 0.014
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0119
Entamoeba histolytica hypothetical protein 0.0074 0.013 0.0344
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0054 0.003
Loa Loa (eye worm) hypothetical protein 0.0095 0.0193 0.0429
Toxoplasma gondii ABC1 family protein 0.0077 0.0139 0.0518
Plasmodium vivax hypothetical protein, conserved 0.0183 0.045 0.168
Entamoeba histolytica hypothetical protein 0.0047 0.0054 0.0057
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0958 0.2707 0.524
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0054 0.0197
Onchocerca volvulus 0.0127 0.0286 0.0286
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0113 0.0606
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0136 0.0303
Plasmodium vivax telomerase reverse transcriptase, putative 0.0945 0.267 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.0825 0.1834
Schistosoma mansoni chromobox protein 0.0289 0.0757 0.5101
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.0313 0.1695
Trypanosoma brucei polo-like protein kinase 0.0108 0.0231 0.086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0958 0.2707 0.524
Echinococcus granulosus chromobox protein 2 0.0047 0.0054 0.0285
Schistosoma mansoni hypothetical protein 0.0189 0.0465 0.3135
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0313 0.2112
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0108 0.0231 0.0731
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0076 0.0136 0.0371
Brugia malayi Importin beta-1 subunit 0.0029 0.0001 0.0002
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0047 0.0054 0.0197
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0139 0.0198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0073 0.0067
Entamoeba histolytica hypothetical protein 0.0047 0.0054 0.0057
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0038 0.0203
Loa Loa (eye worm) beta-lactamase 0.0077 0.0139 0.031
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0113 0.0606
Leishmania major hypothetical protein, conserved 0.0077 0.0139 0.0383
Loa Loa (eye worm) hypothetical protein 0.0077 0.0139 0.031
Schistosoma mansoni transient receptor potential channel 0.0095 0.0193 0.1299
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0139 0.0198
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0099 0.0368
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0072 0.0127
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.0312 0.0694
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.0184 0.0991
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.019 0.1028
Mycobacterium ulcerans lipase LipD 0.0077 0.0139 0.0812
Loa Loa (eye worm) jmjC domain-containing protein 0.0378 0.1018 0.2263
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0054 0.003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0113 0.0156
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.0184 0.0991
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0073 0.0067
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.0341 0.0471
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.006 0.009 0.0334
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.013 0.0701
Giardia lamblia PHD finger protein 15 0.0183 0.045 0.1434
Echinococcus multilocularis peregrin 0.0183 0.045 0.2434
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.019 0.1283
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.0313 0.2185
Trypanosoma brucei protein kinase, putative 0.0053 0.0072 0.0265
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0054 0.0073 0.0067
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0072 0.016
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.076
Echinococcus granulosus PHD finger protein rhinoceros 0.0183 0.045 0.2434
Brugia malayi Heterochromatin protein 1 0.0289 0.0757 0.1045
Echinococcus granulosus jumonji domain containing protein 0.0255 0.0659 0.3568
Mycobacterium tuberculosis Probable DNA polymerase I PolA 0.0077 0.014 0.087
Mycobacterium ulcerans hypothetical protein 0.0077 0.0139 0.0812
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0113 0.0606
Brugia malayi PHD-finger family protein 0.0183 0.045 0.062
Trichomonas vaginalis chromobox protein, putative 0.0289 0.0757 0.1412
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0662 0.1844 1
Loa Loa (eye worm) hypothetical protein 0.033 0.0879 0.1954
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0313 0.2216
Chlamydia trachomatis DNA polymerase I 0.0077 0.014 0.5
Mycobacterium tuberculosis Probable 5'-3' exonuclease 0.0055 0.0075 0.0377
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0945 0.267 1
Trichomonas vaginalis conserved hypothetical protein 0.0162 0.0388 0.0686
Brugia malayi hypothetical protein 0.0047 0.0054 0.0074
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0072 0.0065
Entamoeba histolytica hypothetical protein 0.0074 0.013 0.0344
Onchocerca volvulus 0.1789 0.513 0.513
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0231 0.0378
Loa Loa (eye worm) hypothetical protein 0.0032 0.001 0.0022
Echinococcus granulosus cpg binding protein 0.003 0.0005 0.002
Brugia malayi MAP kinase sur-1 0.0053 0.0072 0.0099
Brugia malayi Pre-SET motif family protein 0.1572 0.4497 0.6207
Loa Loa (eye worm) hypothetical protein 0.0076 0.0136 0.0303
Brugia malayi serine/threonine-protein kinase plk-2 0.0108 0.0231 0.0318
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0139 0.0812
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0099 0.0532
Trypanosoma brucei telomerase reverse transcriptase 0.0945 0.267 1
Mycobacterium leprae PROBABLE DNA POLYMERASE I POLA 0.0077 0.014 0.0914
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0958 0.2707 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0313 0.2216
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0139 0.0863
Schistosoma mansoni hypothetical protein 0.0047 0.0054 0.0361
Echinococcus multilocularis JmjC domain containing protein 4 0.0076 0.0136 0.0733
Trypanosoma brucei mitochondrial structure specific endonuclease I (SSE-1), putative 0.0055 0.0075 0.0278
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0139 0.0863
Schistosoma mansoni jumonji/arid domain-containing protein 0.0285 0.0747 0.503
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0054 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0054 0.003
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0072 0.0265
Schistosoma mansoni hypothetical protein 0.0183 0.045 0.3028
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.0118 0.0798
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0468 0.1279 0.9518
Plasmodium vivax SET domain protein, putative 0.0226 0.0575 0.2149
Schistosoma mansoni chromobox protein 0.0047 0.0054 0.0361
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0047 0.0054 0.0285
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0136 0.0303
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.019 0.1283
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0047 0.0054 0.0285
Loa Loa (eye worm) hypothetical protein 0.0077 0.0139 0.031
Onchocerca volvulus 0.0077 0.0139 0.0139
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0072 0.0067
Brugia malayi MH2 domain containing protein 0.0136 0.0312 0.0431
Wolbachia endosymbiont of Brugia malayi DNA polymerase I 0.0077 0.014 1
Trichomonas vaginalis chromobox protein, putative 0.0289 0.0757 0.1412
Loa Loa (eye worm) hypothetical protein 0.0077 0.0139 0.031
Leishmania major telomerase reverse transcriptase, putative 0.0945 0.267 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0001 0.0002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0073 0.0067
Trichomonas vaginalis hypothetical protein 0.0047 0.0054 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0054 0.003
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0139 0.0518
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0231 0.0378
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.019 0.1028
Plasmodium falciparum phd finger protein, putative 0.0183 0.045 0.168
Onchocerca volvulus 0.0047 0.0054 0.0054
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0468 0.1279 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0072 0.0127
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0119
Schistosoma mansoni phosphatidylserine receptor 0.0076 0.0136 0.0917
Brugia malayi Associated with TFs and helicases family protein 0.0047 0.0054 0.0074
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0062 0.0095 0.0354
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0047 0.0054 0.0361
Schistosoma mansoni phd/f-box containing protein 0.0076 0.0136 0.0917
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0054 0.003
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0072 0.0067
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0139 0.0906
Echinococcus granulosus Chromo domain 0.0047 0.0054 0.0285
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.0313 0.1695
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0662 0.1844 1
Brugia malayi jmjC domain containing protein 0.0285 0.0747 0.1031
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0072 0.0384
Schistosoma mansoni chromobox protein 0.0047 0.0054 0.0361
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.006 0.009 0.0334
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0958 0.2707 0.524
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0072 0.0384
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0162 0.0388 0.0388
Brugia malayi Valyl-tRNA synthetase 0.0047 0.0054 0.0074
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0213 0.0538 0.1196
Schistosoma mansoni jumonji domain containing protein 0.0538 0.1485 1
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.0193 0.1041
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0038 0.014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0139 0.0938
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0049 0.0058 0.0311
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0072 0.0065
Brugia malayi Bromodomain containing protein 0.0183 0.045 0.062
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0054 0.003
Echinococcus multilocularis geminin 0.0189 0.0465 0.252
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0217 0.0549 0.2972
Echinococcus granulosus JmjC domain containing protein 4 0.0076 0.0136 0.0733
Echinococcus multilocularis chromobox protein 1 0.0289 0.0757 0.4103
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0139 0.0863
Echinococcus multilocularis Chromobox protein 3 0.0047 0.0054 0.0285
Schistosoma mansoni protein phosphatase 2C 0.0076 0.0136 0.0917
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0108 0.0231 0.1246
Schistosoma mansoni hypothetical protein 0.0074 0.013 0.0878
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0054 0.0057
Trypanosoma cruzi mitochondrial structure specific endonuclease I (SSE-1), putative 0.0055 0.0075 0.014
Loa Loa (eye worm) hypothetical protein 0.0226 0.0575 0.1278
Brugia malayi F/Y-rich N-terminus family protein 0.0077 0.014 0.0193
Treponema pallidum fructose-bisphosphate aldolase 0.0958 0.2707 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0139 0.031
Schistosoma mansoni cpg binding protein 0.003 0.0005 0.0032
Echinococcus multilocularis phd:f box containing protein 0.0076 0.0136 0.0733
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0049 0.0058 0.0311
Echinococcus multilocularis lysine specific demethylase 5A 0.0283 0.0742 0.4021
Brugia malayi jmjC domain containing protein 0.0076 0.0136 0.0188
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0076 0.0136 0.0506
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0958 0.2707 0.524
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0139 0.075
Plasmodium vivax JmjC domain containing protein 0.0076 0.0136 0.0506
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0072 0.0127
Trichomonas vaginalis esterase, putative 0.0077 0.0139 0.0198
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0139 0.0812
Entamoeba histolytica hypothetical protein 0.0047 0.0054 0.0057
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0054 0.0073 0.0067
Trichomonas vaginalis chromobox protein, putative 0.0174 0.0423 0.0756
Brugia malayi Inositol-1 0.0042 0.0038 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0958 0.2707 0.524
Giardia lamblia Kinase, PLK 0.0108 0.0231 0.0603
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.019 0.0423
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0099 0.0532
Leishmania major mitochondrial structure specific endonuclease I (SSE-1), putative 0.0055 0.0075 0.014
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0072 0.0484
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0108 0.0231 0.1246
Onchocerca volvulus 0.0273 0.0712 0.0712
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.0193 0.1041
Giardia lamblia Fructose-bisphosphate aldolase 0.0958 0.2707 1
Onchocerca volvulus 0.0077 0.0139 0.0139
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0136 0.0303
Brugia malayi jmjC domain containing protein 0.0076 0.0136 0.0188
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0072 0.0127
Brugia malayi SET domain containing protein 0.0056 0.008 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0313 0.2216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0226 0.0575 0.3871
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0047 0.0054 0.0197
Schistosoma mansoni serine/threonine protein kinase 0.0108 0.0231 0.1554
Echinococcus granulosus phd:f box containing protein 0.0076 0.0136 0.0733
Giardia lamblia Telomerase catalytic subunit 0.0945 0.267 0.9862
Loa Loa (eye worm) PHD-finger family protein 0.0183 0.045 0.1
Echinococcus granulosus chromobox protein 1 0.0289 0.0757 0.4103
Onchocerca volvulus Alhambra homolog 0.0183 0.045 0.045
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0273 0.0712 0.4798
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0113 0.0251
Onchocerca volvulus 0.0077 0.0139 0.0139
Loa Loa (eye worm) CHromoDomain protein family member 0.0049 0.0058 0.013
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0076 0.0136 0.0506
Mycobacterium leprae Probable lipase LipE 0.0077 0.0139 0.0906
Brugia malayi chromobox protein homolog 3 0.0162 0.0388 0.0535
Schistosoma mansoni hypothetical protein 0.0411 0.1113 0.7499
Echinococcus granulosus dnaJ subfamily B 0.0411 0.1113 0.6036
Loa Loa (eye worm) hypothetical protein 0.0061 0.0095 0.0212
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0958 0.2707 0.524
Loa Loa (eye worm) hypothetical protein 0.0068 0.0113 0.0251
Schistosoma mansoni inositol monophosphatase 0.0042 0.0038 0.0259
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.019 0.0263
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0958 0.2707 1
Echinococcus multilocularis jumonji domain containing protein 0.0255 0.0659 0.3568
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.025 0.0415
Echinococcus multilocularis Chromo domain 0.0047 0.0054 0.0285
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0139 0.0863
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.0313 0.1045
Schistosoma mansoni hypothetical protein 0.006 0.009 0.0609
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.019 0.1283
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0135 0.0912
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0119
Onchocerca volvulus 0.0152 0.0358 0.0358
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0231 0.0378
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0099 0.0532
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0047 0.0054 0.0361
Loa Loa (eye worm) hypothetical protein 0.006 0.009 0.02
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0139 0.0863
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0213 0.0538 0.0743
Echinococcus multilocularis lysine specific demethylase 6a 0.0076 0.0136 0.0733
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0076 0.0136 0.0371
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0226 0.0575 0.3871
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0072 0.0384
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0054 0.0057
Loa Loa (eye worm) hypothetical protein 0.0146 0.0341 0.0759
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0077 0.0141 0.0759
Schistosoma mansoni kinase 0.0055 0.0077 0.0516
Brugia malayi jmjC domain containing protein 0.0076 0.0136 0.0188
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0139 0.0198
Echinococcus multilocularis PHD finger protein rhinoceros 0.0183 0.045 0.2434
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0958 0.2707 0.524
Loa Loa (eye worm) hypothetical protein 0.0183 0.045 0.1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0139 0.0192
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.0945 0.267 1
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0095 0.0354
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0139 0.031
Entamoeba histolytica hypothetical protein 0.0074 0.013 0.0344
Schistosoma mansoni chromobox protein 0.0289 0.0757 0.5101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0073 0.0067
Brugia malayi jmjC domain containing protein 0.0662 0.1844 0.2545
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0139 0.0938
Brugia malayi CHD4 protein 0.0049 0.0058 0.0081
Echinococcus granulosus geminin 0.0189 0.0465 0.252
Schistosoma mansoni jumonji/arid domain-containing protein 0.0285 0.0747 0.503
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0119
Echinococcus multilocularis jumonji domain containing 1A 0.0076 0.0136 0.0733
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0231 0.0378
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0108 0.0231 0.0513
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0139 0.0863
Plasmodium falciparum telomerase reverse transcriptase 0.0945 0.267 1
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.025 0.0415
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0019 0.0097
Entamoeba histolytica serine/threonine protein kinase, putative 0.0108 0.0231 0.0721
Onchocerca volvulus Serine\/threonine kinase homolog 0.0108 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0035 0.0019 0.0042
Schistosoma mansoni transient receptor potential channel 0.0063 0.0099 0.0668
Plasmodium vivax hypothetical protein, conserved 0.0047 0.0054 0.0197
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0099 0.0532
Brugia malayi jmjC domain containing protein 0.0076 0.0136 0.0188
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0231 0.0378
Brugia malayi RNA, U transporter 1 0.0083 0.0158 0.0218
Loa Loa (eye worm) helicase 0.0047 0.0054 0.0119
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.005 0.0062 0.0047
Trichomonas vaginalis CAMK family protein kinase 0.0108 0.0231 0.0378
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.013 0.0701
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0139 0.075
Loa Loa (eye worm) hypothetical protein 0.0213 0.0538 0.1196
Brugia malayi Telomerase reverse transcriptase 0.2515 0.7246 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0183 0.045 0.168
Toxoplasma gondii PHD-finger domain-containing protein 0.006 0.009 0.0334
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0072 0.0265
Loa Loa (eye worm) hypothetical protein 0.0047 0.0054 0.0119
Trichomonas vaginalis set domain proteins, putative 0.1789 0.513 1
Plasmodium falciparum JmjC domain-containing protein, putative 0.0076 0.0136 0.0506
Schistosoma mansoni importin beta-1 0.0029 0.0001 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0139 0.0198
Mycobacterium ulcerans DNA polymerase I 0.0077 0.014 0.082
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0054 0.003
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.076
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0139 0.0863
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.0312 0.0694
Echinococcus granulosus snurportin 1 0.0312 0.0825 0.4472
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0054 0.0057
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0019 0.0097
Mycobacterium tuberculosis Conserved protein 0.0077 0.0139 0.0863
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0139 0.0383
Brugia malayi PHD-finger family protein 0.0061 0.0095 0.0131
Loa Loa (eye worm) hypothetical protein 0.0127 0.0286 0.0635
Trypanosoma cruzi polo-like protein kinase, putative 0.0108 0.0231 0.0731
Loa Loa (eye worm) jmjC domain-containing protein 0.0285 0.0747 0.166
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0468 0.1279 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0958 0.2707 0.524
Echinococcus granulosus histone lysine methyltransferase setb 0.0226 0.0575 0.3113
Loa Loa (eye worm) hypothetical protein 0.0152 0.0358 0.0797
Trichomonas vaginalis Heterochromatin protein, putative 0.0047 0.0054 0.003
Echinococcus granulosus peregrin 0.0183 0.045 0.2434
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0064 0.005
Loa Loa (eye worm) hypothetical protein 0.0077 0.0139 0.031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.019 0.1028
Loa Loa (eye worm) hypothetical protein 0.0076 0.0136 0.0303
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0076 0.0136 0.0917
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0113 0.0156
Schistosoma mansoni hypothetical protein 0.0312 0.0825 0.5558
Echinococcus granulosus lysine specific demethylase 5A 0.0285 0.0747 0.4047
Echinococcus multilocularis snurportin 1 0.0312 0.0825 0.4472
Entamoeba histolytica hypothetical protein 0.0074 0.013 0.0344
Mycobacterium ulcerans beta-lactamase 0.0077 0.0139 0.0812
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0183 0.045 0.3028
Brugia malayi beta-lactamase family protein 0.0077 0.0139 0.0192
Brugia malayi Pre-SET motif family protein 0.0226 0.0575 0.0793
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.076
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0139 0.0198
Brugia malayi Calcitonin receptor-like protein seb-1 0.0213 0.0538 0.0743
Loa Loa (eye worm) hypothetical protein 0.0162 0.0388 0.0862
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0226 0.0575 0.2149
Trichomonas vaginalis chromobox protein, putative 0.0174 0.0423 0.0756
Loa Loa (eye worm) heterochromatin protein 1 0.0289 0.0757 0.1684
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0174 0.0423 0.0423
Echinococcus multilocularis chromobox protein 2 0.0047 0.0054 0.0285
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0136 0.0917
Schistosoma mansoni hypothetical protein 0.0189 0.0465 0.3135
Leishmania major hypothetical protein, conserved 0.0076 0.0136 0.0371
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.0313 0.117
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0054 0.003
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.006 0.009 0.0334
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0313 0.2112
Schistosoma mansoni cpg binding protein 0.003 0.0005 0.0032
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0139 0.0518
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0047 0.0054 0.0197
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0054 0.003
Brugia malayi beta-lactamase family protein 0.0077 0.0139 0.0192
Schistosoma mansoni hypothetical protein 0.0068 0.0113 0.076
Echinococcus multilocularis GPCR, family 2 0.0068 0.0113 0.0606
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0054 0.0073 0.0067
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.1343 1
Loa Loa (eye worm) hypothetical protein 0.0077 0.0139 0.031
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0047 0.0054 0.003
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0076 0.0136 0.0506
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0226 0.0575 0.3113
Plasmodium vivax 5'-3' exonuclease, N-terminal resolvase-like domain, putative 0.0055 0.0075 0.0278

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 11 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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