Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0533 |
Brugia malayi | Pre-B cell enhancing factor precursor | 0.0334 | 0.4143 | 1 |
Schistosoma mansoni | cytochrome b | 0.0312 | 0.3861 | 0.4542 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0042 | 0.0466 | 0.1208 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Echinococcus granulosus | expressed conserved protein | 0.0091 | 0.1085 | 0.1252 |
Brugia malayi | acetyl-Coenzyme A synthetase 2 | 0.0007 | 0.0024 | 0.003 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0232 | 1 |
Echinococcus multilocularis | bloom syndrome protein | 0.0024 | 0.0235 | 0.0212 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0042 | 0.0466 | 0.6379 |
Schistosoma mansoni | patched 1 | 0.0042 | 0.0462 | 0.0543 |
Trichomonas vaginalis | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0024 | 0.0235 | 0.3049 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0024 | 0.017 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.0232 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase | 0.0062 | 0.0717 | 0.0844 |
Loa Loa (eye worm) | oxidoreductase | 0.0007 | 0.0024 | 0.003 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0156 |
Echinococcus granulosus | bloom syndrome protein | 0.0024 | 0.0235 | 0.025 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.0232 | 1 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.0157 | 0.0379 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0042 | 0.0462 | 0.6312 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0024 | 0.017 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0024 | 0.0235 | 0.3049 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0042 | 0.0466 | 0.1182 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.001 | 0.006 | 0.0037 |
Schistosoma mansoni | cytochrome b | 0.0312 | 0.3861 | 0.4542 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0097 | 0.1159 | 0.1138 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.0157 | 0.6421 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0097 | 0.1159 | 0.2778 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0156 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.0232 | 0.3115 |
Plasmodium falciparum | cytochrome b | 0.0312 | 0.3861 | 1 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.0232 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0119 | 0.1437 | 0.345 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.0232 | 0.1998 |
Echinococcus granulosus | cytochrome B | 0.0312 | 0.3861 | 0.4527 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0533 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.0232 | 1 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0042 | 0.0462 | 0.0517 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.0157 | 0.0379 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Loa Loa (eye worm) | RecQ helicase | 0.0024 | 0.0235 | 0.0542 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0042 | 0.0466 | 0.6379 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0024 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0096 | 0.1049 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0312 | 0.3861 | 0.5 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.001 | 0.006 | 0.0037 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.001 | 0.006 | 0.0127 |
Plasmodium falciparum | acetyl-CoA synthetase, putative | 0.0007 | 0.0024 | 0.0032 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.0157 | 0.2061 |
Trypanosoma cruzi | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0007 | 0.0024 | 0.003 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0024 | 0.017 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0024 | 0.017 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0533 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0099 | 0.1178 | 0.1386 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.0232 | 0.3115 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0042 | 0.0462 | 0.109 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0232 | 0.0533 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0017 | 0.0145 | 0.1891 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.001 | 0.006 | 0.0043 |
Plasmodium vivax | cytochrome b | 0.0312 | 0.3861 | 1 |
Onchocerca volvulus | 0.0023 | 0.0232 | 1 | |
Trypanosoma brucei | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Schistosoma mansoni | acetyl-CoA synthetase | 0.0007 | 0.0024 | 0.0028 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0139 | 0.1683 | 0.1958 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0042 | 0.0462 | 0.0517 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0024 | 0.017 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0024 | 0.017 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0533 |
Toxoplasma gondii | patched family protein | 0.0006 | 0.0011 | 0.003 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0016 | 0.0136 | 0.0353 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0118 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0232 | 0.0533 |
Toxoplasma gondii | propionate-CoA ligase | 0.0007 | 0.0024 | 0.0061 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0143 | 0.1736 | 0.4174 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.0232 | 1 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0042 | 0.0466 | 0.0522 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.001 | 0.006 | 0.0118 |
Toxoplasma gondii | cytochrome b | 0.0312 | 0.3861 | 1 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0097 | 0.1159 | 0.1339 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.006 | 0.0118 |
Brugia malayi | cytochrome b | 0.0312 | 0.3861 | 0.9317 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.2996 |
Loa Loa (eye worm) | pre-B cell enhancing factor | 0.0334 | 0.4143 | 1 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB1 | 0.0062 | 0.0717 | 1 |
Plasmodium falciparum | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 0.1834 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.0199 | 0.0487 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Toxoplasma gondii | hypothetical protein | 0.0006 | 0.0011 | 0.003 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0097 | 0.1159 | 1 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0232 | 0.1998 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0042 | 0.0466 | 0.1208 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0024 | 0.003 |
Leishmania major | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0681 | 0.8501 | 0.8497 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0062 | 0.0717 | 0.0844 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.2996 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0139 | 0.1685 | 0.196 |
Plasmodium vivax | acetyl-CoA synthetase, putative | 0.0007 | 0.0024 | 0.0032 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0462 | 0.109 |
Schistosoma mansoni | nicotinate phosphoribosyltransferase related pre-B cell enhancing factor | 0.0334 | 0.4143 | 0.4874 |
Echinococcus granulosus | nicotinamide phosphoribosyltransferase | 0.0334 | 0.4143 | 0.486 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0681 | 0.8501 | 1 |
Entamoeba histolytica | long-chain-fatty-acid--CoA ligase, putative | 0.0007 | 0.0024 | 0.0205 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0016 | 0.0139 | 0.0331 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0019 | 0.0173 | 0.0203 |
Toxoplasma gondii | apocytochrome b, putative | 0.0312 | 0.3861 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.001 | 0.006 | 0.0071 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0096 | 0.1049 |
Loa Loa (eye worm) | cytochrome b | 0.0312 | 0.3861 | 0.9317 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0024 | 0.003 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0013 | 0.0096 | 0.1049 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0039 | 0.0422 | 1 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.0232 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.001 | 0.006 | 0.0071 |
Entamoeba histolytica | recQ family helicase, putative | 0.0013 | 0.0096 | 0.0832 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Echinococcus multilocularis | expressed conserved protein | 0.0091 | 0.1085 | 0.1064 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0157 | 0.0353 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.0232 | 0.1998 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.0157 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1159 | 0.2778 |
Treponema pallidum | nicotinate phosphoribosyltransferase | 0.0062 | 0.0717 | 0.5 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0024 | 0.0235 | 0.0542 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.0232 | 0.2996 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.058 | 0.1375 |
Brugia malayi | AMP-binding enzyme family protein | 0.0007 | 0.0024 | 0.003 |
Loa Loa (eye worm) | acetyltransferase | 0.0143 | 0.1736 | 0.4174 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0039 | 0.0422 | 0.3642 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0139 | 0.1683 | 0.1664 |
Echinococcus multilocularis | protein dispatched 1 | 0.0048 | 0.0536 | 0.0513 |
Toxoplasma gondii | AMP-binding enzyme domain-containing protein | 0.0007 | 0.0024 | 0.0061 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0681 | 0.8501 | 1 |
Echinococcus multilocularis | protein patched | 0.0042 | 0.0462 | 0.0439 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0143 | 0.1736 | 0.1716 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0143 | 0.1736 | 0.2042 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0024 | 0.017 |
Mycobacterium tuberculosis | Nicotinic acid phosphoribosyltransferase PncB2 | 0.0062 | 0.0717 | 1 |
Entamoeba histolytica | nicotinate phosphoribosyltransferase, putative | 0.0062 | 0.0717 | 0.619 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0039 | 0.0422 | 0.1067 |
Echinococcus multilocularis | nicotinamide phosphoribosyltransferase | 0.0334 | 0.4143 | 0.4129 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.001 | 0.006 | 0.0118 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.001 | 0.006 | 0.0043 |
Onchocerca volvulus | 0.0007 | 0.0024 | 0.0559 | |
Toxoplasma gondii | Acetyl-coenzyme A synthetase 2, putative | 0.0007 | 0.0024 | 0.0061 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0013 | 0.0096 | 0.1049 |
Brugia malayi | CHE-14 protein | 0.0042 | 0.0462 | 0.109 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.0443 | 0.0521 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0042 | 0.0462 | 0.0439 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.