Detailed information for compound 1043211

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 334.2 | Formula: C16H13Cl2N3O
  • H donors: 1 H acceptors: 2 LogP: 3.08 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(c(c1)Cl)c1occ(n1)CNCc1cccnc1
  • InChi: 1S/C16H13Cl2N3O/c17-12-3-4-14(15(18)6-12)16-21-13(10-22-16)9-20-8-11-2-1-5-19-7-11/h1-7,10,20H,8-9H2
  • InChiKey: TZCVXBRRILPVPI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis neuropeptide receptor A26 0.0554 0.2807 0.2805
Echinococcus granulosus o acyltransferase membrane bound domain 0.0023 0.0044 0.0096
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0047 0.0096
Schistosoma mansoni lamin 0.0032 0.009 0.0197
Brugia malayi SH2 domain containing protein 0.0047 0.0168 0.0992
Brugia malayi SH2 domain containing protein 0.006 0.0237 0.1418
Echinococcus granulosus caspase 2 0.0037 0.0113 0.026
Echinococcus granulosus tyrosine protein kinase shark 0.006 0.0237 0.0553
Brugia malayi cytokine inducible SH2-containing protein 5 0.0047 0.0168 0.0992
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0047 0.0105
Echinococcus multilocularis c src tyrosine kinase 0.006 0.0237 0.0234
Onchocerca volvulus 0.0047 0.0168 0.1203
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0047 0.0096
Echinococcus granulosus c src tyrosine kinase 0.006 0.0237 0.0553
Loa Loa (eye worm) hhat protein 0.0023 0.0044 0.0267
Echinococcus granulosus sterol O acyltransferase 1 0.0239 0.1167 0.2756
Echinococcus granulosus neuropeptide receptor A26 0.0554 0.2807 0.6638
Onchocerca volvulus 0.006 0.0237 0.1871
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.006 0.0237 0.0234
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0047 0.025
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0325 0.1614 0.4547
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0047 0.0292
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0292
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0047 0.0168 0.039
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0325 0.1614 0.4547
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0047 0.025
Mycobacterium ulcerans glutaminase 0.0327 0.1628 0.882
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0016 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0047 0.025
Brugia malayi Protein kinase domain containing protein 0.006 0.0237 0.1418
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0023 0.0044 0.0087
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0047 0.0168 0.0381
Loa Loa (eye worm) hypothetical protein 0.0239 0.1167 0.7173
Loa Loa (eye worm) intermediate filament protein 0.0032 0.009 0.0554
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0047 0.025
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.006 0.0237 0.0553
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0292
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0047 0.025
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0047 0.025
Schistosoma mansoni adapter molecule crk 0.0047 0.0168 0.0381
Schistosoma mansoni tensin 0.0047 0.0168 0.0381
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0047 0.0096
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0047 0.025
Loa Loa (eye worm) MBOAT family protein 0.0023 0.0044 0.0267
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0047 0.0044
Echinococcus granulosus tensin 0.0047 0.0168 0.039
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0237 0.0234
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0097 0.0425 0.1103
Loa Loa (eye worm) transcription factor SMAD2 0.0143 0.0667 0.4097
Onchocerca volvulus 0.006 0.0237 0.1871
Loa Loa (eye worm) MBOAT family protein 0.0023 0.0044 0.0267
Echinococcus granulosus tyrosine protein kinase Fyn 0.006 0.0237 0.0553
Loa Loa (eye worm) TK protein kinase 0.006 0.0237 0.1454
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Echinococcus multilocularis lamin dm0 0.0032 0.009 0.0087
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0047 0.0292
Brugia malayi Protein kinase domain containing protein 0.006 0.0237 0.1418
Echinococcus granulosus suppressor of cytokine signaling 6 0.0047 0.0168 0.039
Brugia malayi nuclear hormone receptor 0.0024 0.0047 0.025
Brugia malayi Variant SH3 domain containing protein 0.0047 0.0168 0.0992
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0023 0.0044 0.004
Echinococcus multilocularis geminin 0.0203 0.0979 0.0976
Loa Loa (eye worm) SH2 domain-containing protein 0.0047 0.0168 0.103
Echinococcus granulosus tyrosine kinase 0.006 0.0237 0.0553
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0023 0.0044 0.004
Brugia malayi steroid hormone receptor 0.0024 0.0047 0.025
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0135 0.0787
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0298 0.0689
Schistosoma mansoni tensin-related 0.0047 0.0168 0.0381
Schistosoma mansoni coup transcription factor 0.0024 0.0047 0.0096
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.006 0.0237 0.0234
Echinococcus multilocularis SH2 domain containing protein 7 0.0047 0.0168 0.0165
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0207 0.0483
Schistosoma mansoni suppressor of cytokine signaling 0.0047 0.0168 0.0381
Brugia malayi Protein kinase domain containing protein 0.006 0.0237 0.1418
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Echinococcus granulosus tyrosine protein kinase Lyn 0.006 0.0237 0.0553
Echinococcus multilocularis pol protein 0.0989 0.5073 0.5072
Loa Loa (eye worm) MH2 domain-containing protein 0.0143 0.0667 0.4097
Echinococcus multilocularis tyrosine kinase 0.006 0.0237 0.0234
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0047 0.025
Brugia malayi MBOAT family protein 0.0023 0.0044 0.0226
Entamoeba histolytica hypothetical protein 0.0043 0.0146 0.5323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0047 0.0292
Loa Loa (eye worm) hhat protein 0.0023 0.0044 0.0267
Echinococcus granulosus GPCR family 2 0.0019 0.002 0.0041
Schistosoma mansoni tyrosine kinase 0.006 0.0237 0.0544
Schistosoma mansoni SH2A 0.0047 0.0168 0.0381
Echinococcus granulosus tyrosine protein kinase Src64B 0.006 0.0237 0.0553
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.002 0.0082
Echinococcus granulosus N chimaerin 0.0047 0.0168 0.039
Brugia malayi tRNA modification GTPase TrmE family protein 0.0047 0.0168 0.0992
Toxoplasma gondii aldehyde dehydrogenase 0.0072 0.0298 0.5584
Brugia malayi SH2 domain containing protein 0.0047 0.0168 0.0992
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0233 0.1431
Echinococcus multilocularis tyrosine protein kinase ABL1 0.006 0.0237 0.0234
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.006 0.0237 0.0234
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0047 0.0096
Echinococcus multilocularis tyrosine protein kinase Blk 0.006 0.0237 0.0234
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.006 0.0237 0.0553
Echinococcus multilocularis microtubule associated protein 2 0.0826 0.4228 0.4226
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0237 0.0234
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0047 0.0105
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Schistosoma mansoni tyrosine kinase 0.006 0.0237 0.0544
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0207 0.0475
Brugia malayi Latrophilin receptor protein 2 0.0019 0.002 0.0082
Echinococcus granulosus voltage gated potassium channel 0.0016 0.0007 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0047 0.0096
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0047 0.0168 0.0165
Loa Loa (eye worm) SH2 domain-containing protein 0.0047 0.0168 0.103
Echinococcus multilocularis SHC transforming protein 3 0.0047 0.0168 0.0165
Entamoeba histolytica protein kinase, putative 0.0047 0.0168 0.6427
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0237 0.0234
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0118 0.0535 0.1422
Brugia malayi Protein kinase domain containing protein 0.006 0.0237 0.1418
Schistosoma mansoni hypothetical protein 0.0023 0.0044 0.0087
Toxoplasma gondii hypothetical protein 0.0111 0.0499 1
Echinococcus multilocularis musashi 0.0032 0.009 0.0087
Schistosoma mansoni glutaminase 0.0327 0.1628 0.384
Brugia malayi Tyrosine-protein kinase abl-1 0.006 0.0237 0.1418
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0686 0.3498 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0695
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0267
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0023 0.0044 0.004
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0047 0.0168 0.0165
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0023 0.0044 0.5
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0292
Onchocerca volvulus 0.0047 0.0168 0.1203
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0047 0.0096
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0175 0.0399
Schistosoma mansoni tyrosine kinase 0.006 0.0237 0.0544
Echinococcus multilocularis tyrosine protein kinase Srms 0.006 0.0237 0.0234
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0207 0.0483
Onchocerca volvulus 0.0047 0.0168 0.1203
Brugia malayi SH2 domain containing protein 0.0047 0.0168 0.0992
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0023 0.0044 0.0087
Echinococcus granulosus SH2 motif 0.0047 0.0168 0.039
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Brugia malayi protein-tyrosine kinase 0.006 0.0237 0.1418
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0146 0.0143
Echinococcus multilocularis sterol O acyltransferase 1 0.0239 0.1167 0.1165
Echinococcus multilocularis pol protein 0.0989 0.5073 0.5072
Echinococcus granulosus apoptotic protease activating factor 1 0.0037 0.0113 0.026
Echinococcus multilocularis SH2 motif 0.0047 0.0168 0.0165
Leishmania major mitochondrial DNA polymerase beta 0.0686 0.3498 1
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0047 0.0168 0.0165
Brugia malayi hypothetical protein 0.0043 0.0146 0.086
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0686 0.3498 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.002 0.0125
Loa Loa (eye worm) MBOAT family protein 0.0023 0.0044 0.0267
Schistosoma mansoni tensin-related 0.0047 0.0168 0.0381
Schistosoma mansoni hypothetical protein 0.0041 0.0135 0.0302
Schistosoma mansoni signal transduction protein lnk-related 0.0047 0.0168 0.0381
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0023 0.0044 0.004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0032 0.009 0.0554
Brugia malayi Variant SH3 domain containing protein 0.0047 0.0168 0.0992
Echinococcus multilocularis signal transduction protein lnk realted 0.0047 0.0168 0.0165
Brugia malayi MH2 domain containing protein 0.0143 0.0667 0.4071
Brugia malayi ecdysteroid receptor 0.0024 0.0047 0.025
Onchocerca volvulus 0.006 0.0237 0.1871
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0023 0.0044 0.0087
Schistosoma mansoni tensin 0.0047 0.0168 0.0381
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0023 0.0044 0.004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.002 0.0125
Brugia malayi Hhat protein 0.0023 0.0044 0.0226
Onchocerca volvulus 0.006 0.0237 0.1871
Onchocerca volvulus Cell death protein 3 homolog 0.0037 0.0113 0.0674
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0047 0.025
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0047 0.0168 0.0165
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.0168 0.0381
Brugia malayi hypothetical protein 0.0037 0.0113 0.0655
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0047 0.0044
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0292
Schistosoma mansoni hypothetical protein 0.0037 0.0113 0.0251
Loa Loa (eye worm) glutaminase 2 0.0327 0.1628 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0087 0.0535
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0156 0.0362
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0156 0.092
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0047 0.0168 0.0165
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0047 0.0168 0.039
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0047 0.0038
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0047 0.0168 0.6427
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Echinococcus multilocularis N chimaerin 0.0047 0.0168 0.0165
Echinococcus multilocularis tensin 0.0047 0.0168 0.0165
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0012 0.0031
Onchocerca volvulus 0.0047 0.0168 0.1203
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0047 0.0292
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0142 0.0623
Echinococcus granulosus SH2 motif 0.0047 0.0168 0.039
Brugia malayi Cell death protein 3 precursor 0.0037 0.0113 0.0655
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0207 0.0475
Treponema pallidum alginate O-acetylation protein (algI) 0.0023 0.0044 0.5
Loa Loa (eye worm) SRC-1 0.006 0.0237 0.1454
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0047 0.0105
Echinococcus multilocularis tyrosine protein kinase Src42A 0.006 0.0237 0.0234
Echinococcus multilocularis NCK adaptor protein 0.0047 0.0168 0.0165
Brugia malayi Intermediate filament tail domain containing protein 0.0032 0.009 0.0513
Echinococcus multilocularis GPCR, family 2 0.0019 0.002 0.0017
Echinococcus granulosus geminin 0.0203 0.0979 0.2311
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0207 0.0204
Schistosoma mansoni caspase-7 (C14 family) 0.0037 0.0113 0.0251
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0146 0.033
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0047 0.0168 0.103
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0156 0.0153
Entamoeba histolytica SH2 domain containing protein 0.0047 0.0168 0.6427
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0047 0.0105
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Brugia malayi glutaminase DH11.1 0.0327 0.1628 1
Schistosoma mansoni nck2/grb4 0.0047 0.0168 0.0381
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0047 0.0105
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0023 0.0044 0.0267
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0047 0.0292
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0097 0.0425 0.1103
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0023 0.0044 0.5
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0047 0.0292
Brugia malayi MBOAT family protein 0.0023 0.0044 0.0226
Brugia malayi hypothetical protein 0.006 0.0237 0.1418
Mycobacterium ulcerans hypothetical protein 0.0362 0.1805 1
Brugia malayi hypothetical protein 0.0047 0.0168 0.0992
Schistosoma mansoni hypothetical protein 0.0043 0.0146 0.033
Echinococcus multilocularis 0.0047 0.0168 0.0165
Brugia malayi SH2 domain containing protein 0.0047 0.0168 0.0992
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0012 0.0074
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0047 0.025
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0292
Schistosoma mansoni hypothetical protein 0.0047 0.0168 0.0381
Brugia malayi SH2 domain containing protein 0.0047 0.0168 0.0992
Echinococcus granulosus tyrosine protein kinase Src42A 0.006 0.0237 0.0553
Echinococcus granulosus tyrosine protein kinase Fyn 0.006 0.0237 0.0553
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.006 0.0237 0.0234
Echinococcus granulosus o acyltransferase membrane bound domain 0.0023 0.0044 0.0096
Echinococcus multilocularis pol protein 0.0989 0.5073 0.5072
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0267
Brugia malayi N-terminal motif family protein 0.0222 0.1076 0.6597
Schistosoma mansoni suppressor of cytokine signaling 0.0047 0.0168 0.0381
Loa Loa (eye worm) hypothetical protein 0.0041 0.0135 0.0826
Loa Loa (eye worm) hypothetical protein 0.0222 0.1076 0.6611
Entamoeba histolytica hypothetical protein 0.0043 0.0146 0.5323
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0047 0.0168 0.1203
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0047 0.0168 0.0165
Brugia malayi MBOAT family protein 0.0023 0.0044 0.0226
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0047 0.0096
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0019
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0267
Brugia malayi MBOAT family protein 0.0023 0.0044 0.0226
Schistosoma mansoni hypothetical protein 0.0029 0.0073 0.0156
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0023 0.0044 0.0096
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0047 0.0168 0.039
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.0032
Echinococcus multilocularis lamin 0.0032 0.009 0.0087
Schistosoma mansoni vav2 0.0047 0.0168 0.0381
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0047 0.025
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0207 0.1274
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0072 0.0298 0.0295
Schistosoma mansoni tyrosine kinase 0.006 0.0237 0.0544
Brugia malayi STAT protein, DNA binding domain containing protein 0.0047 0.0168 0.0992
Schistosoma mansoni aldehyde dehydrogenase 0.0072 0.0298 0.0689
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0047 0.0168 0.039
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0292
Schistosoma mansoni tyrosine kinase 0.006 0.0237 0.0544
Echinococcus multilocularis tyrosine protein kinase Abl 0.006 0.0237 0.0234
Echinococcus granulosus lamin dm0 0.0032 0.009 0.0206
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0047 0.0044
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0047 0.0168 0.039
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Echinococcus granulosus suppressor of cytokine signaling 7 0.0047 0.0168 0.039
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.0032
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0047 0.0168 0.103
Echinococcus multilocularis tyrosine protein kinase Fgr 0.006 0.0237 0.0234
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0325 0.1614 0.4547
Brugia malayi Sex muscle abnormal protein 5 0.0047 0.0168 0.0992
Entamoeba histolytica SH2-protein kinase domain containing protein 0.006 0.0237 1
Schistosoma mansoni voltage-gated potassium channel 0.0049 0.0175 0.0399
Loa Loa (eye worm) hypothetical protein 0.0035 0.0104 0.0639
Entamoeba histolytica hypothetical protein 0.0043 0.0146 0.5323
Schistosoma mansoni zinc finger protein 0.0023 0.0044 0.0087
Brugia malayi Variant SH3 domain containing protein 0.0047 0.0168 0.0992
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.002 0.0017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0072 0.0298 0.0697
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.006 0.0237 0.0544
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0047 0.0168 0.0165
Echinococcus multilocularis tyrosine protein kinase Fyn 0.006 0.0237 0.0234
Echinococcus multilocularis tyrosine protein kinase shark 0.006 0.0237 0.0234
Schistosoma mansoni hypothetical protein 0.0203 0.0979 0.2303
Loa Loa (eye worm) hypothetical protein 0.0016 0.0007 0.0043
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0047 0.0168 0.0165
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0047 0.0044
Echinococcus granulosus growth factor receptor bound protein 2 0.0047 0.0168 0.039
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0207 0.0475
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0047 0.0168 0.0165
Echinococcus multilocularis neuropeptide s receptor 0.0554 0.2807 0.2805
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0222 0.1076 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0047 0.025
Onchocerca volvulus 0.0032 0.009 0.0451
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Onchocerca volvulus 0.0047 0.0168 0.1203
Loa Loa (eye worm) hypothetical protein 0.0216 0.1046 0.6425
Onchocerca volvulus 0.006 0.0237 0.1871
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0047 0.0168 0.0992
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.002 0.0041
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.006 0.0237 0.0553
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.002 0.0041
Echinococcus granulosus SHC transforming protein 3 0.0047 0.0168 0.039
Loa Loa (eye worm) hypothetical protein 0.006 0.0237 0.1454
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0047 0.0096
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0047 0.0168 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0047 0.025
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0023 0.0044 0.0096
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0207 0.0204
Schistosoma mansoni tyrosine kinase 0.006 0.0237 0.0544
Echinococcus multilocularis caspase 2 0.0037 0.0113 0.011
Echinococcus granulosus tyrosine protein kinase Src42A 0.0047 0.0168 0.039
Echinococcus multilocularis voltage gated potassium channel 0.0016 0.0007 0.0004
Brugia malayi nuclear receptor NHR-88 0.0024 0.0047 0.025
Loa Loa (eye worm) hypothetical protein 0.0037 0.0113 0.0695
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0233 0.1394
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.006 0.0237 0.0234
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0047 0.0168 0.0381
Echinococcus multilocularis tensin 0.0047 0.0168 0.0165
Echinococcus granulosus o acyltransferase membrane bound domain 0.0023 0.0044 0.0096
Schistosoma mansoni intermediate filament proteins 0.0032 0.009 0.0197
Brugia malayi SH2 domain containing protein 0.006 0.0237 0.1418
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Onchocerca volvulus 0.0032 0.009 0.0451
Echinococcus granulosus tyrosine protein kinase Fps85D 0.006 0.0237 0.0553
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.0032
Echinococcus granulosus lamin 0.0032 0.009 0.0206
Loa Loa (eye worm) TK/ABL protein kinase 0.006 0.0237 0.1454
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0233 0.1394
Brugia malayi RhoGAP domain containing protein 0.0047 0.0168 0.0992
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0047 0.0168 0.103
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0047 0.0044
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0686 0.3498 1
Schistosoma mansoni hypothetical protein 0.0047 0.0168 0.0381
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0047 0.0044
Echinococcus granulosus tyrosine protein kinase ABL1 0.006 0.0237 0.0553
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0047 0.0038
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0047 0.0096
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0047 0.0105
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0292
Onchocerca volvulus 0.0024 0.0047 0.0038
Brugia malayi diacylglycerol acyltransferase 0.0023 0.0044 0.0226
Echinococcus granulosus tyrosine protein kinase Btk29A 0.006 0.0237 0.0553
Schistosoma mansoni tensin 0.0047 0.0168 0.0381
Mycobacterium tuberculosis Conserved hypothetical protein 0.0362 0.1805 1
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0023 0.0044 0.0096
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0023 0.0044 0.004
Loa Loa (eye worm) hypothetical protein 0.0032 0.009 0.0554
Echinococcus granulosus SH2 domain containing adapter protein F 0.0047 0.0168 0.039
Echinococcus granulosus signal transduction protein lnk realted 0.0047 0.0168 0.039
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0023 0.0044 0.0087
Echinococcus granulosus tyrosine kinase 0.006 0.0237 0.0553
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0047 0.025
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0047 0.0044
Echinococcus multilocularis pol protein 0.0989 0.5073 0.5072
Loa Loa (eye worm) glutaminase 0.0327 0.1628 1
Echinococcus granulosus intermediate filament protein 0.0032 0.009 0.0206
Brugia malayi SH2 domain containing protein 0.0047 0.0168 0.0992
Brugia malayi Tensin 0.0047 0.0168 0.0992
Echinococcus granulosus tyrosine protein kinase Srms 0.006 0.0237 0.0553
Schistosoma mansoni GTPase activating protein 0.0047 0.0168 0.0381
Loa Loa (eye worm) hypothetical protein 0.0024 0.0047 0.0292
Schistosoma mansoni lamin 0.0032 0.009 0.0197
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0142 0.0623
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Schistosoma mansoni hypothetical protein 0.0019 0.002 0.0032
Onchocerca volvulus 0.006 0.0237 0.1871
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0023 0.0044 0.0087
Schistosoma mansoni growth factor receptor-bound protein 0.0047 0.0168 0.0381
Loa Loa (eye worm) SH2 domain-containing protein 0.0047 0.0168 0.103
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0207 0.1236
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0047 0.0096
Brugia malayi Protein kinase domain containing protein 0.006 0.0237 0.1418
Echinococcus granulosus microtubule associated protein 2 0.0826 0.4228 1
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0047 0.0105
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0047 0.0292
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0072 0.0298 0.0736
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0047 0.0168 0.103
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0023 0.0044 0.004
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0016 0.0007 0.0004
Echinococcus multilocularis apoptotic protease activating factor 1 0.0037 0.0113 0.011
Brugia malayi Variant SH3 domain containing protein 0.0047 0.0168 0.0992
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0097 0.0425 0.1103
Echinococcus granulosus neuropeptide s receptor 0.0554 0.2807 0.6638
Schistosoma mansoni growth factor receptor-bound protein 0.0047 0.0168 0.0381
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0023 0.0044 0.0096
Echinococcus multilocularis tyrosine protein kinase Src64B 0.006 0.0237 0.0234
Loa Loa (eye worm) STAT protein 0.0047 0.0168 0.103
Schistosoma mansoni sterol O-acyltransferase 1 0.0239 0.1167 0.2749
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Echinococcus granulosus SH2 domain containing protein 7 0.0047 0.0168 0.039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0146 0.0339
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0047 0.0168 0.1203
Trichomonas vaginalis glutaminase, putative 0.0327 0.1628 1
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0047 0.0096
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Schistosoma mansoni shc transforming protein 0.0047 0.0168 0.0381
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0047 0.025
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0047 0.0168 0.103
Brugia malayi SH2 domain containing protein 0.0047 0.0168 0.0992
Schistosoma mansoni hypothetical protein 0.0203 0.0979 0.2303
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0047 0.0105
Echinococcus granulosus expressed conserved protein 0.0047 0.0168 0.039
Echinococcus multilocularis SH2 motif 0.0047 0.0168 0.0165
Onchocerca volvulus 0.0037 0.0113 0.0674
Echinococcus multilocularis SH2 motif 0.0047 0.0168 0.0165
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0047 0.0096
Onchocerca volvulus 0.0047 0.0168 0.1203
Echinococcus granulosus tyrosine protein kinase Fyn 0.006 0.0237 0.0553
Brugia malayi intermediate filament protein 0.0032 0.009 0.0513
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0047 0.0292
Loa Loa (eye worm) hypothetical protein 0.0047 0.0168 0.103
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0023 0.0044 0.0087
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0047 0.0168 0.103
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0023 0.0044 0.0267
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0047 0.0038
Loa Loa (eye worm) hypothetical protein 0.006 0.0233 0.1431
Brugia malayi SRC-1 0.006 0.0237 0.1418
Brugia malayi MBOAT family protein 0.0023 0.0044 0.0226
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0047 0.0168 0.0381
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0097 0.0425 0.1103
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0047 0.0105
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.002 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.006 0.0237 0.1454
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0156 0.0959
Echinococcus granulosus tyrosine protein kinase Blk 0.006 0.0237 0.0553
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0047 0.025
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0023 0.0044 0.0096
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0023 0.0044 0.004
Echinococcus granulosus NCK adaptor protein 0.0047 0.0168 0.039
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0047 0.0044
Entamoeba histolytica hypothetical protein 0.0043 0.0146 0.5323
Schistosoma mansoni microtubule-associated protein tau 0.0826 0.4228 1
Echinococcus multilocularis growth factor receptor bound protein 2 0.0047 0.0168 0.0165
Echinococcus granulosus hypothetical protein 0.0047 0.0168 0.039

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = -4 % DNDI: Inhibition of Human African Trypanosomiasis, SBRI 427, in vitro at 2 ug.mL-1 ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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