Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Entamoeba histolytica | cysteine protease, putative | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Echinococcus granulosus | eukaryotic initiation factor 4A III | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0026 | 0.1244 | 0.1244 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.0889 | 0.0889 |
Leishmania major | cysteine peptidase A (CPA) | 0.0023 | 0.0889 | 0.0669 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0018 | 0.0236 | 0.0236 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Toxoplasma gondii | cathepsin CPL | 0.0023 | 0.0889 | 0.0669 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Onchocerca volvulus | 0.0023 | 0.0889 | 0.0889 | |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0889 | 0.0669 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 1 | 1 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.0102 | 1 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0023 | 0.0889 | 0.0889 |
Leishmania major | cytochrome p450-like protein | 0.0026 | 0.1244 | 0.1033 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0889 | 0.0669 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Onchocerca volvulus | Cathepsin F homolog | 0.0023 | 0.0889 | 0.0889 |
Onchocerca volvulus | 0.0023 | 0.0889 | 0.0889 | |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0889 | 0.0669 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma cruzi | cytochrome p450-like protein, putative | 0.0018 | 0.0236 | 0.0236 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.0889 | 0.0889 | |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0023 | 0.0889 | 0.0889 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0889 | 0.0889 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0018 | 0.0236 | 0.0236 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0889 | 0.0889 |
Brugia malayi | Cytochrome P450 family protein | 0.0018 | 0.0236 | 0.0236 |
Onchocerca volvulus | 0.0023 | 0.0889 | 0.0889 | |
Echinococcus granulosus | cathepsin l1 | 0.0023 | 0.0889 | 0.0889 |
Echinococcus multilocularis | cysteine protease | 0.0023 | 0.0889 | 0.0669 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.1244 | 0.1244 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0889 | 0.0669 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Onchocerca volvulus | 0.0023 | 0.0889 | 0.0889 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.1244 | 0.1244 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0018 | 0.0236 | 0.5 |
Echinococcus granulosus | eukaryotic initiation factor 4A | 0.0102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0026 | 0.1244 | 0.1244 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0889 | 0.0889 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0889 | 0.0669 |
Schistosoma mansoni | DEAD box ATP-dependent RNA helicase | 0.0102 | 1 | 1 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0889 | 0.0669 |
Loa Loa (eye worm) | fibroinase | 0.0023 | 0.0889 | 0.0889 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0023 | 0.0889 | 0.0669 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 1 | 1 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Toxoplasma gondii | eukaryotic initiation factor-4A, putative | 0.0102 | 1 | 1 |
Schistosoma mansoni | cytochrome P450 | 0.0018 | 0.0236 | 0.0236 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0889 | 0.0889 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.0102 | 1 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma cruzi | Eukaryotic initiation factor 4A-1 | 0.0102 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0023 | 0.0889 | 0.0669 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.1244 | 0.1244 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0889 | 0.0889 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.0102 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma brucei | cytochrome P450, putative | 0.0026 | 0.1244 | 0.1033 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0056 | 0.4627 | 0.4627 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.0102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma cruzi | Lanosterol 14-alpha demethylase | 0.0018 | 0.0236 | 0.0236 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0026 | 0.1244 | 0.1244 |
Plasmodium vivax | RNA helicase-1, putative | 0.0102 | 1 | 1 |
Echinococcus multilocularis | eukaryotic initiation factor 4A III | 0.0102 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0056 | 0.4627 | 0.4627 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0889 | 0.0889 |
Loa Loa (eye worm) | cytochrome P450 | 0.0018 | 0.0236 | 0.0236 |
Treponema pallidum | ATP-dependent RNA helicase | 0.0102 | 1 | 0.5 |
Brugia malayi | cytochrome P450 | 0.0018 | 0.0236 | 0.0236 |
Mycobacterium leprae | putative cytochrome p450 | 0.0018 | 0.0236 | 0.5 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0023 | 0.0889 | 0.0669 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Loa Loa (eye worm) | ctsf protein | 0.0023 | 0.0889 | 0.0889 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0023 | 0.0889 | 0.0669 |
Echinococcus multilocularis | cysteine protease | 0.0023 | 0.0889 | 0.0669 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Echinococcus multilocularis | eukaryotic initiation factor 4A | 0.0102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.0102 | 1 | 1 |
Onchocerca volvulus | 0.0023 | 0.0889 | 0.0889 | |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.0102 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0023 | 0.0889 | 0.0889 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.0102 | 1 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0023 | 0.0889 | 0.0889 |
Onchocerca volvulus | Eukaryotic initiation factor 4A homolog | 0.0102 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Loa Loa (eye worm) | cysteine protease | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0889 | 0.0669 |
Brugia malayi | Cytochrome P450 family protein | 0.0026 | 0.1244 | 0.1244 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0023 | 0.0889 | 0.0669 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0023 | 0.0889 | 0.0889 |
Onchocerca volvulus | 0.0023 | 0.0889 | 0.0889 | |
Schistosoma mansoni | hypothetical protein | 0.0018 | 0.0236 | 0.0236 |
Brugia malayi | Cathepsin L-like precursor | 0.0023 | 0.0889 | 0.0889 |
Leishmania major | cathepsin L-like protease | 0.0023 | 0.0889 | 0.0669 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0026 | 0.1244 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change in Tm (ADMET) | = 8.4 | Compound was evaluated for the change in Tm of isolated helical DNA in solution. | ChEMBL. | 3761325 |
ED50 (functional) | = 0.37 uM | Compound was evaluated for the 50% inhibition of the incorporation of [3H]- thymidine in the RNA (inhibition of synthesis in leukemia L1210 cells) | ChEMBL. | 3761325 |
ED50 (functional) | = 0.37 uM | Compound was evaluated for the 50% inhibition of the incorporation of [3H]- thymidine in the RNA (inhibition of synthesis in leukemia L1210 cells) | ChEMBL. | 3761325 |
ED50 (functional) | = 1.3 uM | Compound was evaluated for the 50% inhibition of the incorporation of [3H]- thymidine in the DNA (inhibition of synthesis in leukemia L1210 cells) | ChEMBL. | 3761325 |
ED50 (functional) | = 1.3 uM | Compound was evaluated for the 50% inhibition of the incorporation of [3H]- thymidine in the DNA (inhibition of synthesis in leukemia L1210 cells) | ChEMBL. | 3761325 |
logD | = 2.04 | Partition coefficient of the compound in octanol-phosphate buffer at pH 7.4 | ChEMBL. | 3761325 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.