TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 252.266 | Formula: C12H16N2O4
H donors: 3 H acceptors: 4 LogP: -1.63 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)[C@H](CC1=CCCC(c2c1c(O)no2)C)N
InChi: 1S/C12H16N2O4/c1-6-3-2-4-7(5-8(13)12(16)17)9-10(6)18-14-11(9)15/h4,6,8H,2-3,5,13H2,1H3,(H,14,15)(H,16,17)/t6?,8-/m0/s1
InChiKey: OGDYFTNOLZTFCD-XDKWHASVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Glutamate receptor ionotropic, AMPA 1	Starlite/ChEMBL	References
Rattus norvegicus	Glutamate receptor ionotropic kainate 3	Starlite/ChEMBL	References
Rattus norvegicus	Glutamate receptor ionotropic, AMPA 2	Starlite/ChEMBL	References
Rattus norvegicus	Glutamate receptor ionotropic kainate 1	Starlite/ChEMBL	References
Rattus norvegicus	Glutamate receptor ionotropic, AMPA 3	Starlite/ChEMBL	References
Rattus norvegicus	Glutamate receptor ionotropic, AMPA 4	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Brugia malayi	Glutamate receptor 1 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	NMDA receptor	Get druggable targets OG5_127034	All targets in OG5_127034
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Schistosoma mansoni	glutamate receptor kainate	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Brugia malayi	Glutamate receptor 2 precursor	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	Get druggable targets OG5_127034	All targets in OG5_127034
Schistosoma mansoni	glutamate receptor kainate	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor ionotropic kainate	Get druggable targets OG5_127034	All targets in OG5_127034
Schistosoma japonicum	Glutamate receptor, ionotropic kainate 1 precursor, putative	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	glutamate receptor subunit protein glur	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	Get druggable targets OG5_127034	All targets in OG5_127034
Schistosoma japonicum	Glutamate receptor, ionotropic kainate 3 precursor, putative	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Schistosoma japonicum	expressed protein	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Get druggable targets OG5_127034	All targets in OG5_127034
Loa Loa (eye worm)	glutamate receptor 1	Get druggable targets OG5_128645	All targets in OG5_128645
Schistosoma japonicum	Glutamate receptor delta-2 subunit precursor, putative	Get druggable targets OG5_127034	All targets in OG5_127034
Echinococcus granulosus	glutamate receptor 2	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor 4	Get druggable targets OG5_128645	All targets in OG5_128645
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	Get druggable targets OG5_128645	All targets in OG5_128645
Echinococcus multilocularis	glutamate receptor ionotropic kainate	Get druggable targets OG5_127034	All targets in OG5_127034

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	glutamate receptor kainate	Glutamate receptor ionotropic, AMPA 4	902 aa	745 aa	32.9 %
Drosophila melanogaster	NMDA receptor 2	Glutamate receptor ionotropic, AMPA 4	902 aa	779 aa	23.4 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA 4	902 aa	817 aa	33.0 %
Onchocerca volvulus		Glutamate receptor ionotropic, AMPA 4	902 aa	876 aa	38.9 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA 4	902 aa	817 aa	32.8 %
Onchocerca volvulus	Putative 39S ribosomal protein L45, mitochondrial	Glutamate receptor ionotropic, AMPA 4	902 aa	853 aa	35.4 %
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	Glutamate receptor ionotropic kainate 3	919 aa	969 aa	27.6 %
Drosophila melanogaster	Glutamate receptor IA	Glutamate receptor ionotropic kainate 1	949 aa	913 aa	34.5 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA 4	902 aa	857 aa	34.0 %
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	Glutamate receptor ionotropic, AMPA 4	902 aa	906 aa	34.3 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA 4	902 aa	921 aa	34.5 %
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	Glutamate receptor ionotropic, AMPA 4	902 aa	856 aa	33.6 %
Drosophila melanogaster	Glutamate receptor IIB	Glutamate receptor ionotropic, AMPA 4	902 aa	856 aa	26.4 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	RNA, U transporter 1	0.0089	0.0653	0.0653
Brugia malayi	Glutamate receptor 1 precursor	0.0367	0.3893	0.3893
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1104	0.1993
Brugia malayi	Receptor family ligand binding region containing protein	0.0034	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0232	0.2319	0.2319
Echinococcus multilocularis	NMDA receptor	0.0142	0.1269	0.2268
Brugia malayi	RNA binding protein	0.0128	0.1104	0.1104
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0272	0.2784	0.5011
Schistosoma mansoni	hypothetical protein	0.0067	0.0398	0.0718
Schistosoma mansoni	glutamate receptor kainate	0.0163	0.1511	0.2727
Brugia malayi	Guanylyl cyclase protein 23	0.0034	0.0015	0.0015
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0233	0.2331	1
Brugia malayi	Glutamate receptor 2 precursor	0.0367	0.3893	0.3893
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.0703	0.0703
Echinococcus granulosus	glutamate receptor 1	0.0204	0.1994	0.3581
Schistosoma mansoni	metabotropic glutamate receptor	0.0034	0.0015	0.0027
Echinococcus granulosus	geminin	0.0508	0.5541	1
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0165	0.0165
Brugia malayi	Receptor family ligand binding region containing protein	0.0034	0.0015	0.0015
Brugia malayi	hypothetical protein	0.0034	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0038	0.0038
Mycobacterium leprae	conserved hypothetical protein	0.0036	0.0038	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0179	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Echinococcus granulosus	survival motor neuron protein 1	0.0232	0.2319	0.4168
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0703	0.1245
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0271	0.2779	0.5002
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.089	1	1
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0036	0.0038	0.5
Schistosoma mansoni	glutamate receptor kainate	0.0237	0.2382	0.4299
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0335	0.3517	0.3517
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0036	0.0038	0.0038
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0165	0.0297
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0034	0.0015	0.0015
Loa Loa (eye worm)	glutamate receptor	0.0034	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0204	0.1994	0.1994
Echinococcus granulosus	glutamate receptor 2	0.0334	0.351	0.6325
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0034	0.0015	0.0015
Onchocerca volvulus	Huntingtin homolog	0.012	0.1015	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0703	0.1245
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Loa Loa (eye worm)	TAR-binding protein	0.0128	0.1104	0.1104
Echinococcus granulosus	nmda type glutamate receptor	0.0096	0.0733	0.1299
Onchocerca volvulus		0.0036	0.0038	0.0232
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0703	0.1269
Schistosoma mansoni	protein kinase	0.0034	0.0015	0.0027
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1104	0.1993
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0272	0.2784	0.5011
Schistosoma mansoni	glutamate receptor NMDA	0.0163	0.1511	0.2727
Schistosoma mansoni	ATP-binding cassette transporter	0.0163	0.1511	0.2727
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1104	0.1993
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0204	0.1994	0.1994
Mycobacterium ulcerans	hypothetical protein	0.0036	0.0038	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1104	0.1993
Schistosoma mansoni	metabotropic glutamate receptor	0.0034	0.0015	0.0027
Leishmania major	macrophage migration inhibitory factor-like protein	0.089	1	1
Echinococcus granulosus	beta LACTamase domain containing family member	0.0036	0.0038	0.0042
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.089	1	1
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0142	0.1269	0.2268
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0036	0.0038	0.0038
Echinococcus multilocularis	glutamate receptor 2	0.0334	0.351	0.6325
Trypanosoma brucei	hypothetical protein, conserved	0.0036	0.0038	0.5
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0272	0.2784	0.5011
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0179	0.0179
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0401	0.4295	0.7745
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.089	1	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0038	1
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0067	0.0398	0.0692
Echinococcus multilocularis	snurportin 1	0.0335	0.3517	0.6337
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0038	0.0038
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0163	0.1511	0.2707
Leishmania major	hypothetical protein, conserved	0.0036	0.0038	0.0023
Echinococcus multilocularis	nmda type glutamate receptor	0.0096	0.0733	0.1299
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0272	0.2784	0.5011
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0034	0.0015	0.0015
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0271	0.2779	0.5002
Brugia malayi	beta-lactamase	0.0036	0.0038	0.0038
Schistosoma mansoni	glutamate receptor NMDA	0.0197	0.1914	0.3453
Echinococcus multilocularis	glutamate receptor 4	0.0204	0.1994	0.3581
Onchocerca volvulus		0.0036	0.0038	0.0232
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Mycobacterium ulcerans	esterase/lipase LipP	0.0036	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0204	0.1994	0.1994
Schistosoma mansoni	glutamate receptor kainate	0.0237	0.2382	0.4299
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Schistosoma mansoni	tyrosine kinase	0.0034	0.0015	0.0027
Echinococcus multilocularis	glutamate receptor 2	0.0401	0.4295	0.7745
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.089	1	1
Echinococcus granulosus	snurportin 1	0.0335	0.3517	0.6337
Brugia malayi	beta-lactamase family protein	0.0036	0.0038	0.0038
Onchocerca volvulus		0.0036	0.0038	0.0232
Schistosoma mansoni	hypothetical protein	0.0047	0.0165	0.0297
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0034	0.0015	0.0015
Mycobacterium ulcerans	lipase LipD	0.0036	0.0038	0.5
Schistosoma mansoni	glutamate receptor AMPA	0.0163	0.1511	0.2727
Schistosoma mansoni	hypothetical protein	0.0508	0.5541	1
Onchocerca volvulus	Huntingtin homolog	0.012	0.1015	1
Echinococcus multilocularis	glutamate receptor 2	0.0367	0.3893	0.7017
Loa Loa (eye worm)	glutamate receptor 2	0.0163	0.1511	0.1511
Loa Loa (eye worm)	RNA binding protein	0.0128	0.1104	0.1104
Trichomonas vaginalis	conserved hypothetical protein	0.089	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.089	1	1
Schistosoma mansoni	tar DNA-binding protein	0.0128	0.1104	0.1993
Loa Loa (eye worm)	hypothetical protein	0.012	0.1015	0.1015
Schistosoma mansoni	tyrosine kinase	0.0034	0.0015	0.0027
Giardia lamblia	Macrophage migration inhibitory factor	0.089	1	0.5
Loa Loa (eye worm)	glutamate receptor 1	0.0367	0.3893	0.3893
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0142	0.1269	0.2268
Leishmania major	macrophage migration inhibitory factor-like protein	0.089	1	1
Echinococcus multilocularis	tar DNA binding protein	0.0128	0.1104	0.1971
Schistosoma mansoni	glutamate receptor AMPA	0.0163	0.1511	0.2727
Echinococcus multilocularis	survival motor neuron protein 1	0.0232	0.2319	0.4168
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0703	0.1269
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0038	0.0038
Echinococcus granulosus	glutamate receptor 4	0.0204	0.1994	0.3581
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0703	0.1245
Mycobacterium leprae	Probable lipase LipE	0.0036	0.0038	0.5
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0034	0.0015	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0038	0.0038
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0703	0.1245
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.04	0.4278	0.4278
Brugia malayi	beta-lactamase family protein	0.0036	0.0038	0.0038
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0272	0.2784	0.5011
Brugia malayi	TAR-binding protein	0.0128	0.1104	0.1104
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0038	0.0069
Brugia malayi	hypothetical protein	0.012	0.1015	0.1015
Brugia malayi	hypothetical protein	0.0232	0.2319	0.2319
Brugia malayi	RNA recognition motif domain containing protein	0.0128	0.1104	0.1104
Loa Loa (eye worm)	hypothetical protein	0.012	0.1015	0.1015
Brugia malayi	metabotropic glutamate receptor type 2	0.0034	0.0015	0.0015
Echinococcus granulosus	tar DNA binding protein	0.0128	0.1104	0.1971
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.0703	0.0703
Mycobacterium ulcerans	beta-lactamase	0.0036	0.0038	0.5
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0034	0.0015	0.0015
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0163	0.1511	0.2707
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0036	0.0038	0.0069
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.04	0.4278	0.4278
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0034	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.0335	0.3517	0.6347
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0179	0.0179
Echinococcus granulosus	glutamate receptor 2	0.0401	0.4295	0.7745
Plasmodium falciparum	macrophage migration inhibitory factor	0.089	1	0.5
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0036	0.0038	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0179	0.0179
Loa Loa (eye worm)	beta-lactamase	0.0036	0.0038	0.0038
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0272	0.2784	0.5011
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0703	0.1269
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0401	0.4295	0.7745
Trypanosoma cruzi	hypothetical protein, conserved	0.0036	0.0038	1
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0034	0.0015	0.0015
Onchocerca volvulus		0.0047	0.0165	0.1496
Echinococcus multilocularis	geminin	0.0508	0.5541	1
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0067	0.0398	0.0692
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0171	0.1604	0.2875
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0015	0.0015
Schistosoma mansoni	hypothetical protein	0.0508	0.5541	1
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0128	0.1104	0.1104
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0142	0.1269	0.2268
Loa Loa (eye worm)	hypothetical protein	0.0036	0.0038	0.0038

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 11 %	Agonist activity at rat recombinant GluR2(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay relative to glutamic acid	ChEMBL.	19588945
Activity (functional)	= 29 %	Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay relative to glutamic acid	ChEMBL.	19588945
Activity (functional)	= 46 %	Agonist activity at rat recombinant GluR3 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay relative to glutamic acid	ChEMBL.	19588945
Activity (functional)	= 68 %	Agonist activity at rat recombinant GluR4 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay relative to glutamic acid	ChEMBL.	19588945
Activity (functional)	= 147 %	Agonist activity at rat recombinant GluR5(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay relative to glutamic acid	ChEMBL.	19588945
EC50 (functional)	= 3.8	Agonist activity at rat recombinant GluR2(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	= 3.8	Agonist activity at rat recombinant GluR4 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	= 4.2	Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	= 4.2	Agonist activity at rat recombinant GluR3 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	= 6.1	Agonist activity at rat recombinant GluR5(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	= 0.66 uM	Agonist activity at ConA-treated rat GluR5(Q) RNA-edited isoform expressed in Xenopus laevis oocytes assessed as glutamic acid-induced maximal current by two-electrode voltage clamp method	ChEMBL.	19588945
EC50 (functional)	= 0.86 uM	Agonist activity at rat recombinant GluR5(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	= 35 uM	Agonist activity at rat recombinant GluR4 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	= 48 uM	Agonist activity at rat recombinant GluR3 flip isomer expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	= 62 uM	Agonist activity at ConA-treated rat GluR1 flip isoform expressed in Xenopus laevis oocytes assessed as glutamic acid-induced maximal current by two-electrode voltage clamp method	ChEMBL.	19588945
EC50 (functional)	= 70 uM	Agonist activity at rat recombinant GluR1 flip isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	= 160 uM	Agonist activity at rat recombinant GluR2(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	> 1000 uM	Agonist activity at rat recombinant GluR6(Q) RNA-edited isoform expressed in HEK293 cells assessed as increase in intracellular calcium level by Fluo-4/AM assay	ChEMBL.	19588945
EC50 (functional)	> 1000 uM	Agonist activity at ConA-treated rat NR1/NR2A expressed in Xenopus laevis oocytes assessed as glycine-induced maximal current by two-electrode voltage clamp method	ChEMBL.	19588945
Ki (binding)	= 5.08 nM	Displacement of [3H]SYM from rat recombinant GluR5(Q) RNA-edited isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
Ki (binding)	= 1110 nM	Displacement of [3H]AMPA from rat recombinant GluR3 flop isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
Ki (binding)	= 1380 nM	Displacement of [3H]SYM from rat recombinant GluR7A expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
Ki (binding)	= 1550 nM	Displacement of [3H]AMPA from rat recombinant GluR1 flop isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
Ki (binding)	= 2200 nM	Displacement of [3H]AMPA from rat recombinant GluR4 flop isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
Ki (binding)	= 6310 nM	Displacement of [3H]AMPA from rat recombinant GluR2(R) RNA-edited flop isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
Ki (binding)	> 100000 nM	Displacement of [3H]KA from rat recombinant GluR6(VCR) RNA-edited isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
Ki (binding)	> 100 uM	Displacement of [3H]CGP from NMDA receptor in rat cortical synaptosomes	ChEMBL.	19588945
pKi (binding)	= 0.696 nM	Displacement of [3H]SYM from rat recombinant GluR5(Q) RNA-edited isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
pKi (binding)	= 3.024 nM	Displacement of [3H]AMPA from rat recombinant GluR3 flop isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
pKi (binding)	= 3.113 nM	Displacement of [3H]SYM from rat recombinant GluR7A expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
pKi (binding)	= 3.177 nM	Displacement of [3H]AMPA from rat recombinant GluR1 flop isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
pKi (binding)	= 3.338 nM	Displacement of [3H]AMPA from rat recombinant GluR4 flop isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945
pKi (binding)	= 3.782 nM	Displacement of [3H]AMPA from rat recombinant GluR2(R) RNA-edited flop isoform expressed in baculovirus infected Sf9 cells	ChEMBL.	19588945

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL553028

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1047890