Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0094 | 1 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0018 | 0.0018 |
Plasmodium falciparum | importin beta, putative | 0.0032 | 0.0064 | 0.0064 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0094 | 1 |
Schistosoma mansoni | importin beta-1 | 0.0032 | 0.0064 | 0.0175 |
Echinococcus granulosus | snurportin 1 | 0.0341 | 0.2412 | 0.6579 |
Entamoeba histolytica | hypothetical protein | 0.0026 | 0.0018 | 0.0018 |
Onchocerca volvulus | 0.0036 | 0.0094 | 0.0938 | |
Loa Loa (eye worm) | TAR-binding protein | 0.0126 | 0.0778 | 0.0778 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0036 | 0.0094 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0094 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0752 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0048 | 0.0188 | 0.0512 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0094 | 0.0094 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.052 | 0.1419 |
Leishmania major | importin beta-1 subunit, putative | 0.0026 | 0.0018 | 0.0018 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0571 | 0.0571 |
Schistosoma mansoni | hypothetical protein | 0.0341 | 0.2412 | 0.6579 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0027 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0094 | 0.0094 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0778 | 0.2121 |
Schistosoma mansoni | lamin | 0.0027 | 0.0026 | 0.0071 |
Echinococcus multilocularis | snurportin 1 | 0.0341 | 0.2412 | 0.6579 |
Plasmodium vivax | macrophage migration inhibitory factor, putative | 0.1339 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0094 | 0.0094 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0027 | 0.0026 | 0.0026 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0094 | 0.0257 |
Echinococcus granulosus | geminin | 0.0506 | 0.3666 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0094 | 0.0094 |
Echinococcus multilocularis | tar DNA binding protein | 0.0126 | 0.0778 | 0.2121 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | intermediate filament protein | 0.0027 | 0.0026 | 0.0026 |
Onchocerca volvulus | 0.0099 | 0.0571 | 0.7502 | |
Schistosoma mansoni | hypothetical protein | 0.0506 | 0.3666 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.052 | 0.052 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0636 | 0.4659 | 0.4659 |
Schistosoma mansoni | survival motor neuron protein | 0.0048 | 0.0188 | 0.0512 |
Echinococcus granulosus | intermediate filament protein | 0.0027 | 0.0026 | 0.0071 |
Plasmodium vivax | importin-beta 2, putative | 0.0032 | 0.0064 | 0.0064 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.0099 | 0.0571 | 0.0571 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0341 | 0.2412 | 0.2412 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.1339 | 1 | 1 |
Onchocerca volvulus | Huntingtin homolog | 0.0122 | 0.0752 | 1 |
Schistosoma mansoni | lamin | 0.0027 | 0.0026 | 0.0071 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0778 | 0.2121 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0064 | 0.0064 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0094 | 0.0094 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.052 | 0.1419 |
Trichomonas vaginalis | Importin beta-1 subunit, putative | 0.0026 | 0.0018 | 0.0018 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0236 | 0.1617 | 0.4411 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0094 | 0.0257 |
Schistosoma mansoni | hypothetical protein | 0.0506 | 0.3666 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0571 | 0.0571 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1339 | 1 | 1 |
Trichomonas vaginalis | macrophage migration inhibitory factor, mif, putative | 0.1339 | 1 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0036 | 0.0094 | 0.0094 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0094 | 0.0094 |
Giardia lamblia | Macrophage migration inhibitory factor | 0.1339 | 1 | 1 |
Entamoeba histolytica | macrophage migration inhibitory factor-like protein | 0.1339 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.052 | 0.1419 |
Brugia malayi | hypothetical protein | 0.0236 | 0.1617 | 0.1617 |
Brugia malayi | hypothetical protein | 0.0122 | 0.0752 | 0.0752 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.052 | 0.052 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0048 | 0.0188 | 0.0188 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0571 | 0.0571 |
Trichomonas vaginalis | importin beta-1, putative | 0.0026 | 0.0018 | 0.0018 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0094 | 0.0094 |
Brugia malayi | RNA, U transporter 1 | 0.0091 | 0.0512 | 0.0512 |
Mycobacterium ulcerans | beta-lactamase | 0.0036 | 0.0094 | 0.5 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0094 | 0.0094 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0032 | 0.0064 | 0.0175 |
Onchocerca volvulus | 0.0099 | 0.0571 | 0.7502 | |
Onchocerca volvulus | 0.0048 | 0.0188 | 0.2226 | |
Loa Loa (eye worm) | RNA binding protein | 0.0126 | 0.0778 | 0.0778 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0094 | 0.0094 |
Onchocerca volvulus | 0.0099 | 0.0571 | 0.7502 | |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0094 | 0.0094 |
Echinococcus multilocularis | lamin | 0.0027 | 0.0026 | 0.0071 |
Loa Loa (eye worm) | thyroglobulin type-1 repeat family protein | 0.0099 | 0.0571 | 0.0571 |
Brugia malayi | intermediate filament protein | 0.0027 | 0.0026 | 0.0026 |
Echinococcus granulosus | lamin | 0.0027 | 0.0026 | 0.0071 |
Toxoplasma gondii | macrophage migration inhibitory factor, putative | 0.1339 | 1 | 1 |
Trypanosoma cruzi | importin beta-1 subunit, putative | 0.0026 | 0.0018 | 0.1929 |
Plasmodium falciparum | macrophage migration inhibitory factor | 0.1339 | 1 | 1 |
Echinococcus granulosus | importin subunit beta 1 | 0.0032 | 0.0064 | 0.0175 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0092 | 0.052 | 0.1419 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0126 | 0.0778 | 0.0778 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0778 | 0.2121 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0064 | 0.6799 |
Echinococcus multilocularis | geminin | 0.0506 | 0.3666 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0094 | 0.0257 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0778 | 0.2121 |
Echinococcus granulosus | lamin dm0 | 0.0027 | 0.0026 | 0.0071 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0094 | 0.5 |
Loa Loa (eye worm) | macrophage migration inhibitory factor | 0.1339 | 1 | 1 |
Brugia malayi | Importin beta-1 subunit | 0.0032 | 0.0064 | 0.0064 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.052 | 0.1419 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0026 | 0.0026 |
Brugia malayi | TAR-binding protein | 0.0126 | 0.0778 | 0.0778 |
Mycobacterium ulcerans | hypothetical protein | 0.0036 | 0.0094 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0126 | 0.0778 | 0.2121 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0571 | 0.0571 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.0099 | 0.0571 | 0.0571 |
Schistosoma mansoni | intermediate filament proteins | 0.0027 | 0.0026 | 0.0071 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0032 | 0.0064 | 0.0064 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0236 | 0.1617 | 0.4411 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0094 | 0.0257 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0092 | 0.052 | 0.1419 |
Brugia malayi | Thyroglobulin type-1 repeat family protein | 0.0099 | 0.0571 | 0.0571 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0126 | 0.0778 | 0.0778 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0094 | 0.0094 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0094 | 0.0094 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0092 | 0.052 | 0.1419 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.1617 | 0.1617 |
Mycobacterium ulcerans | lipase LipD | 0.0036 | 0.0094 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0752 | 0.0752 |
Loa Loa (eye worm) | thyroglobulin type-1 repeat family protein | 0.0099 | 0.0571 | 0.0571 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0022 | 0.0022 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | macrophage migration inhibitory factor 2 | 0.0636 | 0.4659 | 0.4659 |
Echinococcus multilocularis | lamin dm0 | 0.0027 | 0.0026 | 0.0071 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0032 | 0.0064 | 0.6799 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0094 | 0.5 |
Brugia malayi | RNA binding protein | 0.0126 | 0.0778 | 0.0778 |
Leishmania major | macrophage migration inhibitory factor-like protein | 0.1339 | 1 | 1 |
Onchocerca volvulus | 0.0099 | 0.0571 | 0.7502 | |
Onchocerca volvulus | 0.0036 | 0.0094 | 0.0938 | |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0094 | 0.0094 |
Echinococcus multilocularis | musashi | 0.0027 | 0.0026 | 0.0071 |
Loa Loa (eye worm) | hypothetical protein | 0.0122 | 0.0752 | 0.0752 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0229 | 0.1565 | 1 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0094 | 0.0094 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.0099 | 0.0571 | 0.0571 |
Schistosoma mansoni | tar DNA-binding protein | 0.0126 | 0.0778 | 0.2121 |
Onchocerca volvulus | 0.0036 | 0.0094 | 0.0938 | |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0036 | 0.0094 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Spont activity (functional) | = 49 Counts 10min-1 | Evaluated for reduction in spontaneous locomotor activity in mice, at a dose of 0 mg/Kg | ChEMBL. | 2158563 |
Spont activity (functional) | = 54 Counts 10min-1 | Evaluated for reduction in spontaneous locomotor activity in mice at a dose of 10 mg/Kg | ChEMBL. | 2158563 |
Tail flick latency (functional) | = 0.5 s | Tail-flick latency was determined at a concentration of 0 mg/Kg. | ChEMBL. | 2158563 |
Tail flick latency (functional) | < 2.6 s | Tail-flick latency was determined at a concentration of 10 mg/Kg. | ChEMBL. | 2158563 |
Temperature (functional) | < -3.8 degrees C | Evaluated for hypothermic activity in mice at a dose of 10 mg/Kg. | ChEMBL. | 2158563 |
Temperature (functional) | = -1.8 degrees C | Evaluated for hypothermic activity in mice at a dose of 0 mg/Kg. | ChEMBL. | 2158563 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.