TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 487.541 | Formula: C23H37NO10
H donors: 2 H acceptors: 2 LogP: -0.12 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: CO[C@@H]1C2OCOC([C@@H]2O[C@H]2[C@H]1OC(C)(C)OC2)NC(=O)[C@H]([C@@]1(OC)O[C@@H](C)[C@H](C(=C)C1)C)O
InChi: 1S/C23H37NO10/c1-11-8-23(28-7,33-13(3)12(11)2)19(25)20(26)24-21-18-17(29-10-30-21)16(27-6)15-14(32-18)9-31-22(4,5)34-15/h12-19,21,25H,1,8-10H2,2-7H3,(H,24,26)/t12-,13-,14-,15-,16+,17?,18+,19-,21?,23-/m1/s1
InChiKey: ZWMAIXIBZBVFJZ-UDGZVGLPSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	AKH receptor	0.0009	0.0002	0.0002
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0008	0.0006
Trichomonas vaginalis	histone deacetylase, putative	0.0333	0.0706	1
Echinococcus multilocularis	DNA methyltransferase 2, putative	0.002	0.0025	0.025
Loa Loa (eye worm)	TAR-binding protein	0.0065	0.0122	0.0122
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0009	0.0002	0.0002
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0002	0.0001
Leishmania major	N-acetyl-D-acetylglucosaminylphosphatidylinositol deacetylase	0.0046	0.0082	0.0074
Echinococcus multilocularis	u4:u6.u5 tri snrnp associated protein 2	0.0012	0.0008	0.0082
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus multilocularis	histone deacetylase 7	0.0333	0.0707	0.726
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0085	0.0166	0.2265
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0122	0.1647
Brugia malayi	histone deacetylase 11	0.0151	0.031	0.031
Trichomonas vaginalis	histone deacetylase, putative	0.0333	0.0706	1
Brugia malayi	hypothetical protein	0.0012	0.0008	0.0008
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0009	0.0002	0.0002
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0002	0.0014
Brugia malayi	BRCA1-associated protein 2 containing protein	0.0012	0.0008	0.0008
Plasmodium falciparum	cysteine repeat modular protein 1	0.0017	0.0019	0.0154
Leishmania major	histone deacetylase, putative	0.0333	0.0707	0.07
Loa Loa (eye worm)	hypothetical protein	0.2352	0.5102	0.5102
Echinococcus granulosus	histone deacetylase 6	0.0333	0.0707	0.726
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0078	0.08
Trypanosoma cruzi	C-8 sterol isomerase, putative	0.4603	1	1
Echinococcus granulosus	DNA methyltransferase 2, putative	0.002	0.0025	0.025
Onchocerca volvulus		0.0012	0.0008	0.0182
Trypanosoma cruzi	histone deacetylase, putative	0.0333	0.0707	0.07
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0151	0.031	0.031
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0078	0.1045
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 22	0.0012	0.0008	0.0082
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.034	0.4754
Schistosoma mansoni	histone deacetylase hda2	0.0346	0.0734	1
Schistosoma mansoni	histone deacetylase 4 5	0.0333	0.0707	0.9635
Toxoplasma gondii	histone deacetylase HDAC1	0.0333	0.0707	1
Loa Loa (eye worm)	histone deacetylase 7A	0.0333	0.0707	0.0707
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0002	0.0014
Loa Loa (eye worm)	UDP galactose 4'-epimerase	0.0052	0.0094	0.0094
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0002	0.0014
Brugia malayi	neuropeptide F receptor	0.0009	0.0002	0.0002
Plasmodium vivax	histone deacetylase, putative	0.0151	0.031	0.4322
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0002	0.0014
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0009	0.0002	0.0014
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0008	0.0008
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0008	0.0008
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0002	0.0014
Schistosoma mansoni	histone deacetylase 4 5	0.0333	0.0707	0.9635
Schistosoma mansoni	brca1-associated protein (brap2)	0.0012	0.0008	0.0089
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 5	0.0012	0.0008	0.0082
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0009	0.0002	0.0001
Entamoeba histolytica	N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase, putative	0.0046	0.0082	0.1053
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Toxoplasma gondii	N-acetylglucosaminylphosphatidylinositol deacetylase	0.0046	0.0082	0.1056
Echinococcus multilocularis	somatostatin receptor	0.0009	0.0002	0.0014
Echinococcus granulosus	histone deacetylase 1	0.0333	0.0706	0.7245
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Trichomonas vaginalis	BRCA1-associated protein, putative	0.0012	0.0008	0.0006
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.034	0.4754
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.003
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0002	0.0014
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0012	0.0008	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Loa Loa (eye worm)	histone deacetylase	0.0333	0.0707	0.0707
Toxoplasma gondii	UBA/TS-N domain-containing protein	0.0012	0.0008	0.0006
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Echinococcus granulosus	histone deacetylase 8	0.0151	0.031	0.3182
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.0046	0.0082	0.0074
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0009	0.0002	0.0002
Echinococcus multilocularis	dro:myosuppressin receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0009	0.0002	0.0001
Schistosoma mansoni	hypothetical protein	0.0017	0.0019	0.0231
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus granulosus	neuropeptide FF receptor 2	0.0009	0.0002	0.0014
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0044	0.0078	0.08
Schistosoma mansoni	cytosol alanyl aminopeptidase (M01 family)	0.0034	0.0056	0.0746
Trichomonas vaginalis	histone deacetylase, putative	0.0333	0.0706	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0009	0.0002	0.0014
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0008	0.0008
Echinococcus multilocularis	tar DNA binding protein	0.0065	0.0122	0.1253
Brugia malayi	sulfakinin receptor protein	0.0009	0.0002	0.0002
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0008	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0019	0.0018
Trypanosoma cruzi	histone deacetylase, putative	0.0333	0.0707	0.07
Leishmania major	modification methylase-like protein	0.002	0.0025	0.0017
Echinococcus granulosus	disco interacting protein 2	0.0039	0.0066	0.0671
Brugia malayi	Serotonin receptor	0.0009	0.0002	0.0002
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0008	0.0008
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0012	0.0008	0.0008
Plasmodium vivax	N-acetylglucosaminylphosphatidylinositol deacetylase, putative	0.0046	0.0082	0.1056
Trichomonas vaginalis	glucosamine-6-phosphate isomerase, putative	0.0046	0.0082	0.1059
Echinococcus multilocularis	histone deacetylase 1	0.0333	0.0706	0.7245
Schistosoma mansoni	UDP-glucose 4-epimerase	0.0052	0.0094	0.1265
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0009	0.0002	0.0014
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Onchocerca volvulus	Histone deacetylase 10 homolog	0.0151	0.031	0.9126
Echinococcus granulosus	sex peptide receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	phosphatidylinositol glycan anchor biosynthesis protein	0.0046	0.0082	0.0081
Trichomonas vaginalis	histone deacetylase, putative	0.0333	0.0706	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.0359	0.5031
Loa Loa (eye worm)	histone deacetylase 11	0.0151	0.031	0.031
Brugia malayi	TATA binding protein associated factor	0.0012	0.0008	0.0008
Echinococcus granulosus	BRCA1 associated protein	0.0012	0.0008	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Leishmania major	udp-glc 4-epimerase, putative	0.005	0.009	0.0083
Loa Loa (eye worm)	TK/ROR protein kinase	0.0017	0.0019	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Brugia malayi	G-protein coupled receptor	0.0009	0.0002	0.0002
Echinococcus granulosus	UDP glucose 4 epimerase	0.0052	0.0094	0.0966
Brugia malayi	Peptidase family M1 containing protein	0.0117	0.0236	0.0236
Plasmodium vivax	ubiquitin carboxyl-terminal hydrolase 13, putative	0.0012	0.0008	0.0006
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0122	0.1647
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0066	0.0065
Echinococcus multilocularis	disco interacting protein 2	0.0039	0.0066	0.0671
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0333	0.0706	1
Brugia malayi	Kringle domain containing protein	0.0017	0.0019	0.0019
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus granulosus	N acetylglucosaminyl phosphatidylinositol	0.0046	0.0082	0.0836
Leishmania major	histone deacetylase, putative	0.0333	0.0706	0.0698
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0056	0.0575
Entamoeba histolytica	DNA (cytosine-5)-methyltransferase, putative	0.002	0.0025	0.0235
Schistosoma mansoni	aminopeptidase A (M01 family)	0.0012	0.0008	0.0084
Plasmodium falciparum	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.0012	0.0008	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Onchocerca volvulus		0.0017	0.0019	0.05
Brugia malayi	Uncharacterized LmbE-like protein, COG2120 containing protein	0.0046	0.0082	0.0082
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0009	0.0002	0.0014
Schistosoma mansoni	cpg binding protein	0.0063	0.0119	0.16
Toxoplasma gondii	UDP-glucose 4-epimerase	0.0052	0.0094	0.1237
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0056	0.0575
Brugia malayi	Histone deacetylase family protein	0.0333	0.0707	0.0707
Toxoplasma gondii	histone deacetylase HDAC5	0.0151	0.031	0.4322
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus granulosus	g-protein coupled receptor	0.0009	0.0002	0.0014
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.0056	0.0575
Loa Loa (eye worm)	aminopeptidase N	0.0034	0.0056	0.0056
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Trypanosoma cruzi	histone deacetylase, putative	0.0151	0.031	0.0302
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0527	0.7444
Loa Loa (eye worm)	hypothetical protein	0.4603	1	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0009	0.0002	0.0014
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.034	0.4754
Echinococcus granulosus	neuropeptide s receptor	0.0456	0.0974	1
Plasmodium falciparum	N-acetylglucosaminylphosphatidylinositol deacetylase, putative	0.0046	0.0082	0.1056
Echinococcus multilocularis	neuropeptide s receptor	0.0456	0.0974	1
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0002	0.0014
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0008	0.0006
Echinococcus multilocularis	cpg binding protein	0.0063	0.0119	0.1217
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0061	0.0115	0.0115
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0017	0.0019	0.0154
Mycobacterium tuberculosis	Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase)	0.4046	0.8788	1
Entamoeba histolytica	aminopeptidase, putative	0.0034	0.0056	0.069
Loa Loa (eye worm)	ubiquitin carboxyl-terminal hydrolase	0.0012	0.0008	0.0008
Schistosoma mansoni	histone deacetylase hda2	0.0151	0.031	0.4212
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase 13, putative	0.0012	0.0008	0.0006
Trypanosoma cruzi	UDP-galactose 4-epimerase, putative	0.0052	0.0094	0.0087
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0527	0.7444
Loa Loa (eye worm)	hypothetical protein	0.0182	0.0379	0.0378
Trypanosoma brucei	N-acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase	0.0046	0.0082	0.0074
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0009	0.0002	0.0014
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.034	0.4754
Trypanosoma cruzi	N-Acetyl-D-glucosaminylphosphatidylinositol de-N-acetylase, putative	0.0046	0.0082	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Brugia malayi	Serotonin receptor	0.0009	0.0002	0.0002
Loa Loa (eye worm)	G-protein coupled receptor	0.0009	0.0002	0.0001
Echinococcus multilocularis	N acetylglucosaminyl phosphatidylinositol	0.0046	0.0082	0.0836
Brugia malayi	histone deacetylase 3 (HD3)	0.0333	0.0706	0.0706
Echinococcus granulosus	histone deacetylase 6	0.0346	0.0734	0.7535
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0002	0.0001
Schistosoma mansoni	N-acetylglucosaminyl-phosphatidylinositol de-n-acetylase	0.0046	0.0082	0.1093
Echinococcus granulosus	histone deacetylase 3	0.0333	0.0706	0.7245
Loa Loa (eye worm)	hypothetical protein	0.0333	0.0706	0.0705
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0078	0.08
Entamoeba histolytica	glucosamine-6-phosphate isomerase, putative	0.0046	0.0082	0.1053
Echinococcus granulosus	G protein coupled receptor 139	0.0009	0.0002	0.0014
Plasmodium vivax	histone deacetylase, putative	0.0333	0.0707	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus granulosus	tissue type plasminogen activator	0.0017	0.0019	0.0188
Brugia malayi	UDP galactose 4'-epimerase	0.0052	0.0094	0.0094
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 22	0.0012	0.0008	0.0082
Onchocerca volvulus	Glucosylceramidase homolog	0.0165	0.034	1
Brugia malayi	GnHR receptor homolog	0.0009	0.0002	0.0002
Echinococcus multilocularis	Peptidase M1, membrane alanine aminopeptidase, N terminal	0.0034	0.0056	0.0575
Echinococcus multilocularis	neuropeptide receptor A26	0.0456	0.0974	1
Giardia lamblia	Glucosamine-6-phosphate isomerase, putative	0.0046	0.0082	0.1053
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0056	0.0575
Echinococcus granulosus	neuropeptide receptor A26	0.0456	0.0974	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0009	0.0002	0.0014
Loa Loa (eye worm)	melatonin receptor type 1A	0.0009	0.0002	0.0001
Echinococcus multilocularis	histone deacetylase 8	0.0151	0.031	0.3182
Brugia malayi	G protein-coupled receptor F59B2.13	0.0009	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus multilocularis	histone deacetylase 6	0.0333	0.0707	0.726
Brugia malayi	G protein-coupled receptor	0.0009	0.0002	0.0002
Echinococcus granulosus	7tm_1 domain containing protein	0.0009	0.0002	0.0014
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus granulosus	tar DNA binding protein	0.0065	0.0122	0.1253
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0044	0.0078	0.0078
Trypanosoma cruzi	Aminopeptidase M1, putative	0.0034	0.0056	0.0049
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Brugia malayi	Peptidase family M1 containing protein	0.0012	0.0008	0.0008
Loa Loa (eye worm)	TATA binding protein associated factor	0.0012	0.0008	0.0008
Toxoplasma gondii	hypothetical protein	0.0085	0.0166	0.2265
Trypanosoma cruzi	histone deacetylase, putative	0.0151	0.031	0.0302
Plasmodium falciparum	histone deacetylase 2	0.0333	0.0707	1
Trypanosoma cruzi	histone deacetylase 1, putative	0.0333	0.0706	0.0698
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0009	0.0002	0.0002
Plasmodium falciparum	DNA (cytosine-5)-methyltransferase	0.002	0.0025	0.024
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Brugia malayi	neuropeptide F receptor	0.0009	0.0002	0.0002
Brugia malayi	RNA binding protein	0.0065	0.0122	0.0122
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0002	0.0014
Echinococcus multilocularis	neuropeptides capa receptor	0.0009	0.0002	0.0014
Brugia malayi	larval opioid receptor	0.0009	0.0002	0.0002
Echinococcus granulosus	histone deacetylase	0.0333	0.0707	0.726
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0002	0.0014
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0251	0.0527	0.0527
Schistosoma mansoni	disco-interacting protein 2 (dip2)	0.0039	0.0066	0.0873
Trypanosoma brucei	C-8 sterol isomerase, putative	0.4603	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0078	0.1045
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0009	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Leishmania major	histone deacetylase, putative	0.0333	0.0707	0.07
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0009	0.0002	0.0001
Echinococcus granulosus	histone deacetylase 7	0.0333	0.0707	0.726
Echinococcus granulosus	histone deacetylase 6	0.0333	0.0707	0.726
Toxoplasma gondii	DNA methyltransferase 2, putative	0.002	0.0025	0.024
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Toxoplasma gondii	C-5 cytosine-specific DNA methylase superfamily protein	0.002	0.0025	0.024
Mycobacterium leprae	Mycothiol conjugate amidase Mca (Mycothiol S-conjugate amidase)	0.4092	0.8889	1
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0333	0.0706	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0002	0.0014
Echinococcus multilocularis	serotonin receptor	0.0009	0.0002	0.0014
Mycobacterium ulcerans	mycothiol conjugate amidase Mca	0.4092	0.8889	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0009	0.0002	0.0001
Brugia malayi	CXXC zinc finger family protein	0.0061	0.0115	0.0115
Brugia malayi	Histone deacetylase 1	0.0333	0.0706	0.0706
Trypanosoma brucei	Aminopeptidase M1, putative	0.0034	0.0056	0.0049
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.0056	0.0575
Loa Loa (eye worm)	BRCA1-associated protein 2 containing protein	0.0012	0.0008	0.0008
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.034	0.4754
Trypanosoma cruzi	histone deacetylase, putative	0.0333	0.0707	0.07
Brugia malayi	Histone deacetylase family protein	0.0333	0.0707	0.0707
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0009	0.0002	0.0014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Schistosoma mansoni	cpg binding protein	0.0063	0.0119	0.16
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus granulosus	allatostatin A receptor	0.0009	0.0002	0.0014
Schistosoma mansoni	DNA (cytosine-5)-methyltransferase	0.002	0.0025	0.0313
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Trichomonas vaginalis	glucosylceramidase, putative	0.0173	0.0359	0.5031
Giardia lamblia	Histone deacetylase	0.0333	0.0706	1
Trypanosoma brucei	histone deacetylase 4	0.0333	0.0707	0.07
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus multilocularis	BRCA1 associated protein	0.0012	0.0008	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Brugia malayi	Dopamine receptor	0.0009	0.0002	0.0002
Brugia malayi	putative neuropeptide receptor	0.0009	0.0002	0.0002
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0002	0.0014
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0052	0.0094	0.124
Echinococcus multilocularis	fmrfamide receptor	0.0009	0.0002	0.0014
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0008	0.0006
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0044	0.0078	0.0078
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0002	0.0014
Trypanosoma cruzi	UDP-galactose 4-epimerase	0.0052	0.0094	0.0087
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Leishmania major	aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1	0.0034	0.0056	0.0049
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0009	0.0002	0.0002
Trypanosoma brucei	UDP-galactose 4-epimerase	0.005	0.009	0.0083
Echinococcus multilocularis	histone deacetylase 6	0.0333	0.0707	0.726
Plasmodium falciparum	histone deacetylase, putative	0.0333	0.0707	1
Echinococcus granulosus	neuropeptide receptor	0.0009	0.0002	0.0014
Trypanosoma brucei	Aminopeptidase M1, putative	0.0034	0.0056	0.0049
Loa Loa (eye worm)	histone deacetylase 3	0.0333	0.0706	0.0705
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.0056	0.0575
Brugia malayi	follicle stimulating hormone receptor	0.0009	0.0002	0.0002
Brugia malayi	hypothetical protein	0.0034	0.0056	0.0056
Echinococcus granulosus	u4:u6.u5 tri snrnp associated protein 2	0.0012	0.0008	0.0082
Onchocerca volvulus		0.0034	0.0056	0.1617
Schistosoma mansoni	histone deacetylase	0.0333	0.0706	0.9615
Echinococcus multilocularis	histone deacetylase	0.0333	0.0707	0.726
Onchocerca volvulus		0.0117	0.0236	0.6923
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0002	0.0014
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0527	0.7444
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0009	0.0002	0.0014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Loa Loa (eye worm)	neuropeptide F receptor	0.0009	0.0002	0.0001
Schistosoma mansoni	ubiquitin-specific peptidase 44 (C19 family)	0.0012	0.0008	0.0089
Trypanosoma brucei	cytosine-specific DNA methylase, putative	0.002	0.0025	0.0017
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0002	0.0014
Toxoplasma gondii	histone deacetylase HDAC4	0.0151	0.031	0.4322
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Trichomonas vaginalis	brca1-associated protein, putative	0.0012	0.0008	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0195	0.0405	0.0405
Toxoplasma gondii	Zn-finger in ubiquitin-hydrolases domain-containing protein	0.0012	0.0008	0.0006
Leishmania major	hypothetical protein, conserved	0.0017	0.0019	0.0011
Trypanosoma cruzi	histone deacetylase 1, putative	0.0333	0.0706	0.0698
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0022	0.003	0.0305
Schistosoma mansoni	family C19 non-peptidase homologue (C19 family)	0.0012	0.0008	0.0089
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0059	0.011	0.1483
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0008	0.0006
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0122	0.1647
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0122	0.1647
Echinococcus granulosus	serotonin receptor	0.0009	0.0002	0.0014
Leishmania major	histone deacetylase, putative	0.0333	0.0706	0.0698
Echinococcus multilocularis	neuropeptide Y receptor	0.0009	0.0002	0.0014
Schistosoma mansoni	Tata binding protein associated factor (M01 family)	0.0012	0.0008	0.0084
Echinococcus granulosus	cpg binding protein	0.0063	0.0119	0.1217
Brugia malayi	Protein kinase domain containing protein	0.0017	0.0019	0.0019
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0065	0.0122	0.0122
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0251	0.0527	0.0527
Plasmodium vivax	histone deacetylase 1, putative	0.0333	0.0706	0.9979
Brugia malayi	Melatonin receptor type 1A	0.0009	0.0002	0.0002
Brugia malayi	G-protein coupled receptor	0.0009	0.0002	0.0002
Trypanosoma brucei	metallo-peptidase, Clan MA(E) Family M1	0.0034	0.0056	0.0049
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0002	0.0014
Brugia malayi	TAR-binding protein	0.0065	0.0122	0.0122
Schistosoma mansoni	tar DNA-binding protein	0.0065	0.0122	0.1647
Echinococcus multilocularis	orexin receptor type 2	0.0009	0.0002	0.0014
Echinococcus multilocularis	aminopeptidase N	0.0117	0.0236	0.2417
Toxoplasma gondii	histone deacetylase HDAC2	0.0333	0.0706	0.9979
Toxoplasma gondii	kringle domain-containing protein	0.0017	0.0019	0.0154
Trypanosoma brucei	histone deacetylase 1	0.0333	0.0706	0.0698
Echinococcus granulosus	tm gpcr rhodopsin	0.0009	0.0002	0.0014
Trichomonas vaginalis	histone deacetylase 1, 2 ,3, putative	0.0333	0.0706	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0009	0.0002	0.0014
Mycobacterium ulcerans	aminopeptidase N PepN	0.0034	0.0056	0.0055
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0009	0.0002	0.0014
Trypanosoma cruzi	hypothetical protein, conserved	0.0017	0.0019	0.0011
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	0.0034	0.0056	0.0049
Echinococcus multilocularis	histone deacetylase 3	0.0333	0.0706	0.7245
Mycobacterium ulcerans	N-acetyl-1-D-myo-inosityl-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase MshB	0.0046	0.0082	0.0083
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0044	0.0078	0.1045
Echinococcus granulosus	biogenic amine 5HT receptor	0.0009	0.0002	0.0014
Entamoeba histolytica	histone deacetylase, putative	0.0333	0.0706	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0012	0.0008	0.0077
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0012	0.0008	0.0077
Schistosoma mansoni	aminopeptidase PILS (M01 family)	0.0037	0.0061	0.0817
Echinococcus multilocularis	histone deacetylase 6	0.0346	0.0734	0.7535
Schistosoma mansoni	family M1 non-peptidase homologue (M01 family)	0.0022	0.003	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Trypanosoma brucei	histone deacetylase 3	0.0333	0.0707	0.07
Giardia lamblia	UDP-glucose 4-epimerase	0.005	0.009	0.1178
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus granulosus	g protein coupled receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0002	0.0014
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0044	0.0078	0.08
Echinococcus multilocularis	neuropeptide receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0012	0.0008	0.0008
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0034	0.0056	0.0695
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0009	0.0002	0.0014
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0009	0.0002	0.0001
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0527	0.7444
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0161	0.0161
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Plasmodium vivax	DNA (cytosine-5)-methyltransferase, putative	0.002	0.0025	0.024
Schistosoma mansoni	histone deacetylase 1 2 3	0.0151	0.031	0.4212
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0008	0.0006
Brugia malayi	ORL1-like opioid receptor	0.0009	0.0002	0.0002
Loa Loa (eye worm)	histone deacetylase 1	0.0333	0.0706	0.0705
Echinococcus granulosus	hypothetical protein	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Plasmodium falciparum	ubiquitin carboxyl-terminal hydrolase, putative	0.0012	0.0008	0.0006
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0053	0.0096	0.1268
Echinococcus multilocularis	G protein coupled receptor 139	0.0009	0.0002	0.0014
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0009	0.0002	0.0014
Schistosoma mansoni	brca1-associated protein (brap2)	0.0012	0.0008	0.0089
Onchocerca volvulus		0.0061	0.0115	0.3364
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0022	0.003	0.003
Plasmodium vivax	U4/U6.U5 tri-snRNP-associated protein 2, putative	0.0012	0.0008	0.0006
Schistosoma mansoni	cpg binding protein	0.0061	0.0115	0.1552
Trypanosoma cruzi	metallo-peptidase, Clan MA(E) Family M1	0.0022	0.003	0.0022
Echinococcus granulosus	neuropeptide Y receptor	0.0009	0.0002	0.0014
Echinococcus multilocularis	allatostatin A receptor	0.0009	0.0002	0.0014
Trichomonas vaginalis	histone deacetylase, putative	0.0333	0.0706	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Echinococcus granulosus	fmrfamide receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0008	0.0008
Echinococcus multilocularis	g-protein coupled receptor	0.0009	0.0002	0.0014
Brugia malayi	putative neuropeptide receptor NPR1	0.0009	0.0002	0.0002
Trichomonas vaginalis	Clan MA, family M1, aminopeptidase N-like metallopeptidase	0.0034	0.0056	0.0695
Echinococcus multilocularis	serotonin receptor	0.0009	0.0002	0.0014
Onchocerca volvulus	Uncharacterized RING finger protein homolog	0.0012	0.0008	0.0194
Echinococcus granulosus	orexin receptor type 2	0.0009	0.0002	0.0014
Echinococcus granulosus	rhodopsin orphan GPCR	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0008	0.0008
Brugia malayi	Peptidase family M1 containing protein	0.0034	0.0056	0.0056
Echinococcus multilocularis	g protein coupled receptor	0.0009	0.0002	0.0014
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0002	0.0014
Echinococcus multilocularis	sex peptide receptor	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0009	0.0002	0.0014
Echinococcus granulosus	aminopeptidase N	0.0117	0.0236	0.2417
Trichomonas vaginalis	UDP-glucose 4-epimerase, putative	0.0052	0.0094	0.124
Schistosoma mansoni	histone deacetylase	0.0333	0.0706	0.9615
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Toxoplasma gondii	ubiquitin specific protease 39 isoform 2, putative	0.0012	0.0008	0.0006
Leishmania major	C-8 sterol isomerase-like protein	0.4603	1	1
Echinococcus granulosus	puromycin sensitive aminopeptidase	0.0034	0.0056	0.0575
Echinococcus granulosus	7TM GPCR rhodopsin	0.0009	0.0002	0.0014
Brugia malayi	histone deacetylase 1 (HD1)	0.0333	0.0706	0.0706
Trichomonas vaginalis	histone deacetylase, putative	0.0333	0.0706	1
Brugia malayi	Dopamine receptor protein 1	0.0009	0.0002	0.0002
Trichomonas vaginalis	NAD dependent epimerase/dehydratase, putative	0.0052	0.0094	0.124
Brugia malayi	RE15519p	0.0009	0.0002	0.0002
Brugia malayi	Disco-interacting protein 2 homolog	0.0039	0.0066	0.0066
Toxoplasma gondii	histone deacetylase HDAC3	0.0333	0.0706	0.9979
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Echinococcus granulosus	neuropeptides capa receptor	0.0009	0.0002	0.0014
Trypanosoma cruzi	aminopeptidase, putative	0.0034	0.0056	0.0049
Echinococcus multilocularis	UDP glucose 4 epimerase	0.0052	0.0094	0.0966
Onchocerca volvulus		0.0039	0.0066	0.1891
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Brugia malayi	Dopamine receptor protein 2	0.0009	0.0002	0.0002
Trypanosoma brucei	histone deacetylase 2	0.0151	0.031	0.0302
Echinococcus multilocularis	tissue type plasminogen activator	0.0017	0.0019	0.0188
Plasmodium vivax	histone deacetylase 2, putative	0.0333	0.0707	1
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Trypanosoma brucei	histone deacetylase, putative	0.0333	0.0707	0.07
Loa Loa (eye worm)	ubiquitin specific peptidase 39	0.0012	0.0008	0.0008
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0012	0.0008	0.0006
Loa Loa (eye worm)	peptidase family M1 containing protein	0.0094	0.0187	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0527	0.7444
Schistosoma mansoni	ubiquitin-specific peptidase 5 (C19 family)	0.0012	0.0008	0.0089
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0056	0.0575
Echinococcus multilocularis	puromycin sensitive aminopeptidase	0.0034	0.0056	0.0575
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0012	0.0008	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0209	0.0209
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0009	0.0002	0.0014
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.034	0.4754
Entamoeba histolytica	UDP-glucose 4-epimerase, putative	0.0052	0.0094	0.1235
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0009	0.0002	0.0014
Loa Loa (eye worm)	hypothetical protein	0.0009	0.0002	0.0001
Brugia malayi	RNA recognition motif domain containing protein	0.0065	0.0122	0.0122
Loa Loa (eye worm)	TYRA-2 protein	0.0009	0.0002	0.0001
Trypanosoma cruzi	metallo-peptidase, clan MA(E), family M1, putative	0.0034	0.0056	0.0049
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0009	0.0002	0.0014
Echinococcus granulosus	somatostatin receptor	0.0009	0.0002	0.0014
Plasmodium falciparum	histone deacetylase 1	0.0333	0.0706	0.9979
Brugia malayi	hypothetical protein	0.0009	0.0002	0.0002
Loa Loa (eye worm)	RNA binding protein	0.0065	0.0122	0.0122
Trichomonas vaginalis	glucosylceramidase, putative	0.0165	0.034	0.4754
Trichomonas vaginalis	glucosylceramidase, putative	0.0251	0.0527	0.7444

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 3 ug ml-1	In vitro inhibitory concentration for cytotoxic activity was tested against HeLa cells	ChEMBL.	No reference
IC50 (functional)	= 10 ug ml-1	In vitro inhibitory concentration for cytotoxic activity was tested against HeLa cells	ChEMBL.	No reference
IC50 (functional)	> 50 ug ml-1	In vitro inhibitory concentration for antiviral activity was tested against vero cells	ChEMBL.	No reference
IC50 (functional)	> 50 ug ml-1	In vitro inhibitory concentration for antiviral activity was tested against HEL cells	ChEMBL.	No reference
MIC (functional)	= 12.5 ug ml-1	In vitro minimum inhibitory concentration for antiviral activity was tested against Varicella-zoster virus(VZV)	ChEMBL.	No reference
MIC (functional)	= 50 ug ml-1	In vitro minimum inhibitory concentration for antiviral activity was tested against Herpes simplex virus type 1(HSV-1)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 201328

Bibliographic References

No literature references available for this target.

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Detailed information for compound 105968