Detailed information for compound 1063871

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.553 | Formula: C24H26N4O4S
  • H donors: 4 H acceptors: 3 LogP: 3.79 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 1
  • SMILES: O[C@H](COc1ccccc1)CNCCc1ccc(cc1)NC(=S)Nc1cccc(c1)[N+](=O)[O-]
  • InChi: 1S/C24H26N4O4S/c29-22(17-32-23-7-2-1-3-8-23)16-25-14-13-18-9-11-19(12-10-18)26-24(33)27-20-5-4-6-21(15-20)28(30)31/h1-12,15,22,25,29H,13-14,16-17H2,(H2,26,27,33)/t22-/m0/s1
  • InChiKey: PQTZELIXLXRZKD-QFIPXVFZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.0157 0.0215
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0051 0.0302
Mycobacterium ulcerans hypothetical protein 0.0155 0.361 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.1398 0.1398
Giardia lamblia Kinase, PLK 0.0095 0.2019 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0188 0.45 0.8884
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.1122 0.6616
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0209 0.5057 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0318 0.0318
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0042 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0318 0.0318
Echinococcus multilocularis GPCR, family 2 0.0031 0.0318 0.0318
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2019 0.5546
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0029 0.0265 0.0567
Brugia malayi intermediate filament protein 0.0057 0.1033 0.1885
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0265 0.0364
Loa Loa (eye worm) hypothetical protein 0.0057 0.1033 0.1885
Mycobacterium tuberculosis Probable dehydrogenase 0.0188 0.45 0.8884
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0244 0.0445
Brugia malayi jmjC domain containing protein 0.0071 0.1398 0.255
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0325 0.0592
Echinococcus granulosus Aminotransferase class III 0.0021 0.0064 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0461 0.0618
Loa Loa (eye worm) PHD-finger family protein 0.0058 0.1034 0.1887
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0265 0.0364
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0021 0.0064 0.0117
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.1122 0.1122
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.107 0.107
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0987 0.18
Schistosoma mansoni hypothetical protein 0.0058 0.1034 0.1034
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.1398 0.1398
Plasmodium vivax hypothetical protein, conserved 0.0058 0.1034 0.61
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0293 0.7297 1
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0325 0.0592
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0751 0.1534
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0029 0.0265 0.1565
Loa Loa (eye worm) hypothetical protein 0.0036 0.0461 0.0841
Echinococcus granulosus thioredoxin glutathione reductase 0.0083 0.1709 0.1709
Brugia malayi Cytochrome P450 family protein 0.0022 0.0098 0.0179
Loa Loa (eye worm) glutathione reductase 0.0082 0.1696 0.3094
Onchocerca volvulus 0.0057 0.1033 0.2498
Leishmania major mitochondrial DNA polymerase beta 0.0293 0.7297 1
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0029 0.0265 0.0364
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0098 0.0134
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0029 0.0265 0.1565
Echinococcus multilocularis geminin 0.0334 0.8384 0.8384
Mycobacterium tuberculosis Probable oxidoreductase 0.0209 0.5057 1
Trypanosoma brucei polo-like protein kinase 0.0095 0.2019 0.2767
Echinococcus granulosus PHD finger protein rhinoceros 0.0058 0.1034 0.1034
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.1034 0.61
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0188 0.4509 0.4509
Trypanosoma brucei cytochrome P450, putative 0.0022 0.0098 0.0134
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0461 0.0632
Loa Loa (eye worm) hypothetical protein 0.0058 0.1034 0.1887
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.2019 0.2767
Onchocerca volvulus 0.0147 0.3405 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0318 0.0581
Loa Loa (eye worm) CYP4Cod1 0.0022 0.0098 0.0179
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0188 0.45 0.8884
Brugia malayi Thioredoxin reductase 0.0082 0.1696 0.3094
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0029 0.0265 0.0484
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0265 0.0364
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0029 0.0265 0.0364
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0461 0.0461
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.2019 0.2019
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0461 0.0461
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0916 0.0916
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0265 0.0364
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0148 0.3428 0.9486
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0029 0.0265 0.1565
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0602 0.0825
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0029 0.0265 0.1565
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2019 0.5546
Loa Loa (eye worm) hypothetical protein 0.0048 0.0776 0.1415
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0188 0.45 0.8884
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0244 0.0244
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.0157 0.0927
Echinococcus multilocularis PHD finger protein rhinoceros 0.0058 0.1034 0.1034
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0461 0.0461
Plasmodium falciparum ornithine aminotransferase 0.0021 0.0064 0.038
Onchocerca volvulus Huntingtin homolog 0.0123 0.2765 0.7978
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.361 0.7102
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0029 0.0265 0.0265
Plasmodium vivax thioredoxin reductase, putative 0.0082 0.1696 1
Echinococcus granulosus tumor protein p63 0.0326 0.8175 0.8175
Echinococcus granulosus lamin dm0 0.0057 0.1033 0.1033
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0318 0.0318
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0189 0.0189
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0029 0.0265 0.0403
Schistosoma mansoni hypothetical protein 0.0031 0.0318 0.0318
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.2019 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.2072 0.378
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0058 0.1034 0.1034
Schistosoma mansoni hypothetical protein 0.0031 0.0318 0.0318
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.2019 0.2019
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0318 0.0318
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0916 0.0916
Loa Loa (eye worm) hypothetical protein 0.0123 0.2765 0.5045
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0188 0.4509 0.4509
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0751 0.1534
Schistosoma mansoni hypothetical protein 0.0031 0.0318 0.0318
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1122 0.2983
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0188 0.45 0.8884
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.7297 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0265 0.0364
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0082 0.1696 0.3268
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0461 0.1114
Toxoplasma gondii NADPH-glutathione reductase 0.0029 0.0265 0.1565
Plasmodium vivax ornithine aminotransferase, putative 0.0021 0.0064 0.038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0916 0.1672
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0157 0.0927
Loa Loa (eye worm) hypothetical protein 0.0066 0.126 0.2299
Mycobacterium tuberculosis Probable reductase 0.0188 0.45 0.8884
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.2072 0.378
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2019 0.5546
Plasmodium falciparum thioredoxin reductase 0.0082 0.1696 1
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0887 0.1618
Schistosoma mansoni jumonji domain containing protein 0.015 0.3481 0.3481
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.5481 1
Loa Loa (eye worm) thioredoxin reductase 0.0082 0.1696 0.3094
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2019 0.5546
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0029 0.0265 0.0364
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0188 0.45 0.8884
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0029 0.0265 0.0265
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0029 0.0265 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0022 0.0098 0.0095
Mycobacterium ulcerans hypothetical protein 0.0148 0.3428 0.9486
Schistosoma mansoni hypothetical protein 0.0031 0.0318 0.0318
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0987 0.0987
Echinococcus granulosus geminin 0.0334 0.8384 0.8384
Plasmodium vivax hypothetical protein, conserved 0.002 0.0051 0.0302
Brugia malayi hypothetical protein 0.0147 0.3405 0.6212
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0006 0.0009
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0265 0.0364
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.2019 0.2019
Echinococcus multilocularis tumor protein p63 0.0326 0.8175 0.8175
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0244 0.0244
Loa Loa (eye worm) intermediate filament protein 0.0057 0.1033 0.1885
Onchocerca volvulus Alhambra homolog 0.0058 0.1034 0.2501
Onchocerca volvulus 0.0057 0.1033 0.2498
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0461 0.0461
Brugia malayi follicle stimulating hormone receptor 0.0225 0.5481 1
Echinococcus multilocularis jumonji domain containing protein 0.008 0.1633 0.1633
Schistosoma mansoni cpg binding protein 0.0028 0.0244 0.0244
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1122 0.2983
Brugia malayi Cytochrome P450 family protein 0.0051 0.0856 0.1563
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.0157 0.0927
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0064 0.0064
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0987 0.2601
Schistosoma mansoni kinase 0.0048 0.0784 0.0784
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.1122 0.1122
Plasmodium falciparum glutathione reductase 0.0082 0.1696 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.1398 0.1398
Echinococcus multilocularis dnaJ subfamily B 0.0395 1 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0083 0.1709 0.1709
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.2019 0.2767
Echinococcus granulosus jumonji domain containing protein 0.008 0.1633 0.1633
Echinococcus granulosus peregrin 0.0058 0.1034 0.1034
Loa Loa (eye worm) hypothetical protein 0.0056 0.1006 0.1835
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.126 0.2299
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.1398 0.255
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0042 0.0042
Trypanosoma cruzi trypanothione reductase, putative 0.0082 0.1696 0.2324
Loa Loa (eye worm) hypothetical protein 0.0031 0.0318 0.0581
Toxoplasma gondii hypothetical protein 0.0047 0.0763 0.4502
Leishmania major trypanothione reductase 0.0082 0.1696 0.2324
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.3194 0.4377
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0265 0.0364
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0029 0.0265 0.0364
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0209 0.5057 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0157 0.0215
Treponema pallidum NADH oxidase 0.0029 0.0265 0.5
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0148 0.3428 1
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.0157 0.0927
Brugia malayi Cytochrome P450 family protein 0.0022 0.0098 0.0179
Echinococcus granulosus intermediate filament protein 0.0057 0.1033 0.1033
Brugia malayi PHD-finger family protein 0.002 0.0048 0.0088
Loa Loa (eye worm) hypothetical protein 0.0097 0.2072 0.378
Loa Loa (eye worm) jmjC domain-containing protein 0.0119 0.2661 0.4854
Plasmodium vivax glutathione reductase, putative 0.0082 0.1696 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0916 0.1672
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0148 0.3428 0.6737
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0021 0.0064 0.0064
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0029 0.0265 0.0364
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.2019 0.3684
Loa Loa (eye worm) hypothetical protein 0.0099 0.2126 0.3878
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0318 0.0581
Schistosoma mansoni intermediate filament proteins 0.0057 0.1033 0.1033
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1122 0.1122
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0461 0.0461
Toxoplasma gondii PHD-finger domain-containing protein 0.0058 0.1034 0.61
Loa Loa (eye worm) hypothetical protein 0.002 0.0048 0.0088
Brugia malayi hypothetical protein 0.0024 0.0157 0.0287
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0029 0.0265 0.0265
Echinococcus multilocularis lysine specific demethylase 5A 0.007 0.1356 0.1356
Plasmodium falciparum glutathione reductase 0.0029 0.0265 0.1565
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0006 0.0037
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0029 0.0265 0.1565
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0987 0.0987
Echinococcus granulosus lamin 0.0057 0.1033 0.1033
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0029 0.0265 0.0567
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0461 0.0618
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0461 0.0632
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.1122 0.1538
Echinococcus multilocularis lamin 0.0057 0.1033 0.1033
Trypanosoma cruzi cytochrome P450, putative 0.0022 0.0098 0.0134
Brugia malayi CXXC zinc finger family protein 0.0028 0.0244 0.0445
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.0987 0.1847
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0602 0.0825
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0916 0.0916
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0098 0.0179
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.0157 0.0215
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0029 0.0265 0.0364
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0461 0.0461
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.3194 0.4377
Brugia malayi glutathione reductase 0.0082 0.1696 0.3094
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0318 0.0581
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0602 0.0825
Echinococcus multilocularis lamin dm0 0.0057 0.1033 0.1033
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0916 0.0916
Onchocerca volvulus Huntingtin homolog 0.0123 0.2765 0.7978
Echinococcus multilocularis musashi 0.0057 0.1033 0.1033
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0021 0.0064 0.0118
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0021 0.0064 0.038
Brugia malayi jmjC domain containing protein 0.0188 0.4509 0.8227
Schistosoma mansoni lamin 0.0057 0.1033 0.1033
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0209 0.5057 1
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2019 0.5546
Brugia malayi PHD-finger family protein 0.0058 0.1034 0.1887
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0461 0.0841
Plasmodium falciparum phd finger protein, putative 0.0058 0.1034 0.61
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2019 0.5546
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.2019 0.2767
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0029 0.0265 0.0364
Schistosoma mansoni cpg binding protein 0.0029 0.0286 0.0286
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0916 0.0916
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0006 0.0009
Leishmania major hypothetical protein, conserved 0.0024 0.0157 0.0215
Toxoplasma gondii thioredoxin reductase 0.0082 0.1696 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.2765 0.5045
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0029 0.0265 0.0567
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0021 0.0064 0.0117
Schistosoma mansoni hypothetical protein 0.0066 0.126 0.126
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0916 0.0916
Schistosoma mansoni cpg binding protein 0.0029 0.0286 0.0286
Schistosoma mansoni hypothetical protein 0.0395 1 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.2019 0.3684
Loa Loa (eye worm) hypothetical protein 0.0024 0.0157 0.0287
Trypanosoma brucei trypanothione reductase 0.0082 0.1696 0.2324
Echinococcus granulosus ornithine aminotransferase 0.0021 0.0064 0.0064
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0461 0.0632
Echinococcus granulosus cpg binding protein 0.0029 0.0286 0.0286
Mycobacterium tuberculosis Probable aminotransferase 0.0148 0.3428 0.6737
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0265 0.0364
Schistosoma mansoni hypothetical protein 0.0019 0.0006 0.0006
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0903 0.5324
Trypanosoma cruzi trypanothione reductase, putative 0.0029 0.0265 0.0364
Echinococcus multilocularis Aminotransferase class III 0.0021 0.0064 0.0064
Plasmodium falciparum thioredoxin reductase 0.0029 0.0265 0.1565
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0916 0.0916
Giardia lamblia PHD finger protein 15 0.0058 0.1034 0.4384
Schistosoma mansoni lamin 0.0057 0.1033 0.1033
Brugia malayi Bromodomain containing protein 0.0058 0.1034 0.1887
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0987 0.1352
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0461 0.0618
Echinococcus multilocularis peregrin 0.0058 0.1034 0.1034
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0293 0.7297 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0022 0.0098 0.0179
Leishmania major cytochrome p450-like protein 0.0022 0.0098 0.0134
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0602 0.0825
Echinococcus multilocularis cpg binding protein 0.0029 0.0286 0.0286
Echinococcus granulosus GPCR family 2 0.0031 0.0318 0.0318
Brugia malayi AF-10 protein 0.0019 0.0006 0.0011
Echinococcus multilocularis ornithine aminotransferase 0.0021 0.0064 0.0064
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0057 0.1033 0.1885
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0776 0.0776
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.1122 0.2118
Brugia malayi hypothetical protein 0.0123 0.2765 0.5045
Loa Loa (eye worm) hypothetical protein 0.0028 0.0244 0.0445
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0148 0.3428 0.6737
Loa Loa (eye worm) hypothetical protein 0.0027 0.0216 0.0394
Loa Loa (eye worm) hypothetical protein 0.0027 0.0216 0.0394
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0842 0.1154
Schistosoma mansoni hypothetical protein 0.0334 0.8384 0.8384
Brugia malayi F/Y-rich N-terminus family protein 0.0027 0.0231 0.0422
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0029 0.0265 0.0364
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.2072 0.378
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.1122 0.2983
Schistosoma mansoni hypothetical protein 0.0334 0.8384 0.8384
Loa Loa (eye worm) cytochrome P450 family protein 0.0051 0.0856 0.1563
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0987 0.0987
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.2019 0.5617
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0265 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0461 0.0461
Onchocerca volvulus 0.0048 0.0776 0.1683
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.0987 0.2601
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0006 0.0037
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.1122 0.1122
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0461 0.0632
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2019 0.5546
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0029 0.0265 1
Brugia malayi Intermediate filament tail domain containing protein 0.0057 0.1033 0.1885
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0147 0.3405 0.6212
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.3194 0.4377

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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