Detailed information for compound 1065343

Basic information

Technical information
  • TDR Targets ID: 1065343
  • Name: N-butyl-6-(dimethylsulfamoyl)-N,1-dimethyl-4- oxoquinoline-3-carboxamide
  • MW: 379.474 | Formula: C18H25N3O4S
  • H donors: 0 H acceptors: 4 LogP: 1.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(C(=O)c1cn(C)c2c(c1=O)cc(cc2)S(=O)(=O)N(C)C)C
  • InChi: 1S/C18H25N3O4S/c1-6-7-10-20(4)18(23)15-12-21(5)16-9-8-13(11-14(16)17(15)22)26(24,25)19(2)3/h8-9,11-12H,6-7,10H2,1-5H3
  • InChiKey: OBFPILYTFDZMRR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-butyl-6-(dimethylsulfamoyl)-N,1-dimethyl-4-oxo-quinoline-3-carboxamide
  • N-butyl-6-(dimethylsulfamoyl)-N,1-dimethyl-4-oxo-3-quinolinecarboxamide
  • N-butyl-6-(dimethylsulfamoyl)-4-keto-N,1-dimethyl-quinoline-3-carboxamide
  • MLS000117448
  • SMR000094396

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glutamate receptor NMDA 0.1054 0.7462 0.746
Echinococcus granulosus nmda type glutamate receptor 0.1104 0.7827 0.7825
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0074 0.0065
Brugia malayi metabotropic glutamate receptor type 2 0.0051 0.0265 0.1456
Echinococcus multilocularis cpg binding protein 0.0065 0.0367 0.0358
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0254 0.1725 1
Echinococcus granulosus glutamate receptor 2 0.015 0.0977 0.0968
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0737 1
Loa Loa (eye worm) RNA binding protein 0.0069 0.0399 0.1556
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0024 0.0014
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1067 0.1058
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0292 0.1616
Toxoplasma gondii ABC1 family protein 0.0036 0.0157 0.1251
Loa Loa (eye worm) hypothetical protein 0.0036 0.0157 0.0554
Loa Loa (eye worm) glutamate receptor 0.0051 0.0265 0.1001
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0254 0.1725 0.5
Echinococcus granulosus lysosomal alpha glucosidase 0.0163 0.1067 0.1058
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0159 0.2207
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0137 0.097
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0157 0.1285
Schistosoma mansoni tyrosine kinase 0.0051 0.0265 0.0299
Schistosoma mansoni glutamate receptor kainate 0.0099 0.0612 0.0706
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0074 0.0339
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0342 0.132
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0017
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.015 0.0977 0.0968
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0231 0.086
Brugia malayi Receptor family ligand binding region containing protein 0.0051 0.0265 0.1456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0231 0.0259
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0159 0.0835
Echinococcus multilocularis mitogen activated protein kinase 0.0114 0.072 0.0711
Loa Loa (eye worm) hypothetical protein 0.0036 0.0157 0.0554
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0399 0.0456
Echinococcus multilocularis GPCR, family 2 0.0017 0.0024 0.0014
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0114 0.072 0.2892
Echinococcus granulosus tyrosine kinase 0.0051 0.0265 0.0256
Brugia malayi Glutamate receptor 1 precursor 0.0099 0.0612 0.349
Brugia malayi Guanylyl cyclase protein 23 0.0051 0.0265 0.1456
Brugia malayi Metabotropic glutamate receptor precursor. 0.0051 0.0265 0.1456
Brugia malayi RNA binding protein 0.0069 0.0399 0.2239
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0157 0.2185
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0051 0.0265 0.2578
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0163 0.1067 0.4334
Echinococcus granulosus receptor type guanylyl cyclase 0.0051 0.0265 0.0256
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0159 0.0149
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0092 0.0275
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.015 0.0977 0.0968
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.008 0.0095
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.015 0.0977 0.0968
Schistosoma mansoni glutamate receptor kainate 0.0099 0.0612 0.0706
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0037 0.0027
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0099 0.0612 0.0603
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0168 0.0889
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0137 0.097
Trypanosoma brucei protein kinase, putative 0.0114 0.072 1
Echinococcus granulosus glutamate receptor 2 0.0051 0.0265 0.0256
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0157 0.0173
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0157 0.0554
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0254 0.1725 0.5
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0114 0.072 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0159 0.131
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0157 0.1285
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.008 0.0095
Onchocerca volvulus 0.0051 0.0265 0.2578
Echinococcus multilocularis nmda type glutamate receptor 0.1104 0.7827 0.7825
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0399 0.0456
Echinococcus granulosus metabotropic glutamate receptor 5 0.0051 0.0265 0.0256
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.008 0.0978
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.015 0.0977 0.0968
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0017
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0074 0.0065
Loa Loa (eye worm) hypothetical protein 0.0036 0.0157 0.0554
Brugia malayi hypothetical protein 0.0025 0.008 0.0375
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0159 0.2207
Schistosoma mansoni alpha-glucosidase 0.014 0.0905 0.1049
Loa Loa (eye worm) RGC/RGC protein kinase 0.0051 0.0265 0.1001
Schistosoma mansoni glutamate receptor AMPA 0.0099 0.0612 0.0706
Onchocerca volvulus 0.0062 0.0342 0.4416
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0157 0.2185
Schistosoma mansoni cpg binding protein 0.0065 0.0367 0.0419
Loa Loa (eye worm) hypothetical protein 0.0036 0.0157 0.0554
Schistosoma mansoni ran 0.0024 0.0074 0.0076
Echinococcus multilocularis mitogen activated protein kinase 3 0.0114 0.072 0.0711
Mycobacterium leprae Probable lipase LipE 0.0036 0.0157 0.5
Echinococcus multilocularis NMDA receptor 0.0099 0.0612 0.0603
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0292 0.1115
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0137 0.0127
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1001
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0051 0.0265 0.0256
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0353 0.2431 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1001
Leishmania major extracellular receptor, putative 0.0051 0.0265 0.2953
Brugia malayi Receptor family ligand binding region containing protein 0.0051 0.0265 0.1456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0231 0.0259
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0159 0.131
Trypanosoma brucei glucosidase, putative 0.0036 0.0159 0.131
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0157 0.0825
Loa Loa (eye worm) RGC/RGC protein kinase 0.0051 0.0265 0.1001
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0051 0.0265 0.1456
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0159 0.4435
Echinococcus granulosus mitogen activated protein kinase 3 0.0114 0.072 0.0711
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0099 0.0612 0.0603
Schistosoma mansoni alpha-glucosidase 0.014 0.0905 0.1049
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.072 1
Schistosoma mansoni cpg binding protein 0.0062 0.0342 0.0389
Echinococcus multilocularis snurportin 1 0.0353 0.2431 0.2423
Brugia malayi Glutamate receptor 2 precursor 0.0099 0.0612 0.349
Brugia malayi Glycosyl hydrolases family 31 protein 0.0163 0.1067 0.6156
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.008 0.0092
Echinococcus granulosus GPCR family 2 0.0017 0.0024 0.0014
Onchocerca volvulus 0.0051 0.0265 0.2578
Echinococcus granulosus atrial natriuretic peptide receptor 0.0051 0.0265 0.0256
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0037 0.0052
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0157 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.1544 0.8845
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0051 0.0265 0.0256
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0074 0.0209
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.008 0.0095
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0231 0.0222
Trypanosoma cruzi extracellular receptor, putative 0.0051 0.0265 0.2953
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0168 0.0599
Brugia malayi beta-lactamase 0.0036 0.0157 0.0825
Leishmania major importin beta-1 subunit, putative 0.0027 0.0092 0.0275
Schistosoma mansoni glutamate receptor NMDA 0.1204 0.854 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0157 0.0173
Loa Loa (eye worm) glutamate receptor 2 0.0099 0.0612 0.2443
Echinococcus multilocularis nmda type glutamate receptor 0.1407 1 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0099 0.0612 0.0603
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0157 0.0148
Schistosoma mansoni glutamate receptor NMDA 0.0099 0.0612 0.0706
Giardia lamblia Kinase, CMGC MAPK 0.0114 0.072 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0159 0.4435
Echinococcus multilocularis lysosomal alpha glucosidase 0.0163 0.1067 0.1058
Entamoeba histolytica hypothetical protein 0.0051 0.0265 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0254 0.1725 1
Echinococcus multilocularis receptor type guanylyl cyclase 0.0051 0.0265 0.0256
Schistosoma mansoni tyrosine kinase 0.0051 0.0265 0.0299
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0157 0.0148
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0399 0.0456
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0131 0.0837 0.097
Schistosoma mansoni glutamate receptor kainate 0.0099 0.0612 0.0706
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0157 0.2185
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0024 0.0044
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.072 1
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0099 0.0612 0.0603
Brugia malayi RNA recognition motif domain containing protein 0.0069 0.0399 0.2239
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0159 0.2207
Brugia malayi RNA, U transporter 1 0.0094 0.0574 0.3267
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0935 0.3784
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0159 0.131
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0035 0.0108
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0935 0.3784
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0114 0.072 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.008 0.0978
Loa Loa (eye worm) glutamate receptor 1 0.0099 0.0612 0.2443
Schistosoma mansoni hypothetical protein 0.0017 0.0024 0.0017
Schistosoma mansoni alpha glucosidase 0.0036 0.0159 0.0175
Echinococcus multilocularis glutamate receptor 2 0.015 0.0977 0.0968
Brugia malayi beta-lactamase family protein 0.0036 0.0157 0.0825
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0024 0.0044
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0051 0.0265 0.0256
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1001
Loa Loa (eye worm) beta-lactamase 0.0036 0.0157 0.0554
Echinococcus granulosus tar DNA binding protein 0.0069 0.0399 0.0389
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0092 0.1279
Echinococcus granulosus importin subunit beta 1 0.0033 0.0137 0.0127
Echinococcus granulosus glutamate NMDA receptor subunit 0.0099 0.0612 0.0603
Echinococcus granulosus cpg binding protein 0.0065 0.0367 0.0358
Schistosoma mansoni hypothetical protein 0.0099 0.0612 0.0706
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0114 0.072 1
Schistosoma mansoni hypothetical protein 0.0353 0.2431 0.2838
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.015 0.0977 0.0968
Brugia malayi beta-lactamase family protein 0.0036 0.0157 0.0825
Loa Loa (eye worm) hypothetical protein 0.0036 0.0157 0.0554
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0051 0.0265 0.1001
Echinococcus granulosus metabotropic glutamate receptor 2 0.0051 0.0265 0.0256
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0024 0.0014
Loa Loa (eye worm) hypothetical protein 0.0036 0.0157 0.0554
Brugia malayi MH2 domain containing protein 0.0144 0.0935 0.538
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0292 0.1616
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0024 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0157 0.2185
Trichomonas vaginalis esterase, putative 0.0036 0.0157 0.2185
Loa Loa (eye worm) TAR-binding protein 0.0069 0.0399 0.1556
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1001
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0231 0.0222
Brugia malayi hypothetical protein 0.0051 0.0265 0.1456
Echinococcus multilocularis glutamate receptor 2 0.0051 0.0265 0.0256
Echinococcus granulosus dnaJ subfamily B 0.0877 0.6193 0.6189
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0399 0.0456
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0354 0.2437 0.243
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0157 0.5
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0159 0.2207
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0231 0.0222
Leishmania major hypothetical protein, conserved 0.0036 0.0157 0.1285
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0092 0.1279
Entamoeba histolytica hypothetical protein 0.0027 0.0092 0.0931
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0114 0.072 1
Leishmania major hypothetical protein, conserved 0.0025 0.008 0.0095
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0051 0.0265 0.1001
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0114 0.072 1
Brugia malayi follicle stimulating hormone receptor 0.0254 0.1723 1
Schistosoma mansoni importin beta-1 0.0033 0.0137 0.0149
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1001
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0137 0.0944
Echinococcus multilocularis dnaJ subfamily B 0.0877 0.6193 0.6189
Schistosoma mansoni hypothetical protein 0.0037 0.0168 0.0186
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0114 0.072 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1001
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0051 0.0265 0.1001
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0159 0.2207
Brugia malayi TAR-binding protein 0.0069 0.0399 0.2239
Schistosoma mansoni protein kinase 0.0051 0.0265 0.0299
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.015 0.0977 0.0968
Echinococcus multilocularis glutamate receptor NMDA 0.1054 0.7462 0.746
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0069 0.0399 0.1556
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0099 0.0612 0.0603
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0114 0.072 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0254 0.1725 0.5
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0157 0.2185
Brugia malayi Importin beta-1 subunit 0.0033 0.0137 0.0706
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0157 0.1285
Trichomonas vaginalis ran, putative 0.0024 0.0074 0.1033
Plasmodium vivax importin-beta 2, putative 0.0033 0.0137 0.7548
Loa Loa (eye worm) RGC/RGC protein kinase 0.0051 0.0265 0.1001
Brugia malayi MAP kinase sur-1 0.0114 0.072 0.4122
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0231 0.0222
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.072 0.0833
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0099 0.0612 0.0603
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.008 0.0738
Echinococcus multilocularis glutamate receptor 2 0.0099 0.0612 0.0603
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0092 0.1279
Plasmodium falciparum importin beta, putative 0.0033 0.0137 1
Schistosoma mansoni glutamate receptor AMPA 0.0099 0.0612 0.0706
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0159 0.2207
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0159 0.056
Brugia malayi CXXC zinc finger family protein 0.0062 0.0342 0.1906
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0159 0.2207
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0099 0.0612 0.0603
Schistosoma mansoni cpg binding protein 0.0065 0.0367 0.0419
Loa Loa (eye worm) hypothetical protein 0.0051 0.0265 0.1001
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0159 0.1276
Schistosoma mansoni ran 0.0024 0.0074 0.0076
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0114 0.072 0.9742
Chlamydia trachomatis glutamine binding protein 0.0254 0.1725 0.5
Schistosoma mansoni ATP-binding cassette transporter 0.0099 0.0612 0.0706
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0159 0.0149
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0231 0.1257
Echinococcus granulosus snurportin 1 0.0353 0.2431 0.2423
Onchocerca volvulus 0.0094 0.0575 1
Schistosoma mansoni hypothetical protein 0.0877 0.6193 0.7249
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0024 0.0014
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.015 0.0977 0.0968
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.015 0.0977 0.0968
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0159 0.2207
Schistosoma mansoni tar DNA-binding protein 0.0069 0.0399 0.0456
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0099 0.0612 0.0603
Echinococcus multilocularis tar DNA binding protein 0.0069 0.0399 0.0389
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0037 0.0027
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0231 0.0259
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.072 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0137 0.0469
Echinococcus granulosus mitogen activated protein kinase 0.0114 0.072 0.0711
Loa Loa (eye worm) hypothetical protein 0.0025 0.008 0.0234
Schistosoma mansoni metabotropic glutamate receptor 0.0051 0.0265 0.0299
Loa Loa (eye worm) hypothetical protein 0.0055 0.0292 0.1115
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0159 0.2207
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0254 0.1723 0.706
Echinococcus multilocularis tyrosine kinase 0.0051 0.0265 0.0256
Trichomonas vaginalis CMGC family protein kinase 0.0114 0.072 1
Schistosoma mansoni metabotropic glutamate receptor 0.0051 0.0265 0.0299

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3696 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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