Detailed information for compound 1073842

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1379.89 | Formula: C64H71ClN20O12S
  • H donors: 12 H acceptors: 14 LogP: -0.44 Rotable bonds: 39
    Rule of 5 violations (Lipinski): 4
  • SMILES: N[C@@H](C(=O)Nc1cc(n(c1)C)C(=O)Nc1nc(n(c1)C)C(=O)Nc1cc(n(c1)C)C(=O)Nc1cc(n(c1)C)C(=O)NCCCCCCCNC(=O)c1cccc(c1)C(=O)O)CCNC(=O)c1nc(cn1C)NC(=O)c1cc(cn1C)NC(=O)c1cc(cn1C)NC(=O)c1sccc1Cl
  • InChi: 1S/C64H71ClN20O12S/c1-79-29-38(23-44(79)56(88)68-19-12-10-8-9-11-18-67-54(86)35-14-13-15-36(22-35)64(96)97)71-58(90)46-27-41(32-81(46)3)74-63(95)53-76-50(34-85(53)7)78-59(91)47-24-37(28-82(47)4)70-55(87)43(66)16-20-69-62(94)52-75-49(33-84(52)6)77-60(92)48-25-39(30-83(48)5)72-57(89)45-26-40(31-80(45)2)73-61(93)51-42(65)17-21-98-51/h13-15,17,21-34,43H,8-12,16,18-20,66H2,1-7H3,(H,67,86)(H,68,88)(H,69,94)(H,70,87)(H,71,90)(H,72,89)(H,73,93)(H,74,95)(H,77,92)(H,78,91)(H,96,97)/t43-/m1/s1
  • InChiKey: KMKPYWZARWKWLI-VZUYHUTRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus intermediate filament protein 0.011 0.0634 0.0634
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0211 0.0332
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0211 0.1356
Echinococcus multilocularis beta LACTamase domain containing family member 0.0077 0.0403 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0142 0.0909
Plasmodium vivax SET domain protein, putative 0.0031 0.0084 0.2076
Loa Loa (eye worm) hypothetical protein 0.0077 0.0403 0.2527
Echinococcus granulosus geminin 0.0167 0.1029 0.1029
Loa Loa (eye worm) transcription factor SMAD2 0.0248 0.1596 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0493 0.3292 1
Brugia malayi amine oxidase, flavin-containing family protein 0.0054 0.0245 0.1532
Mycobacterium tuberculosis Probable esterase LipL 0.0077 0.0403 0.1071
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0211 0.0211
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0409 0.2708 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0403 0.0615
Onchocerca volvulus 0.011 0.0634 0.4072
Mycobacterium tuberculosis Probable hydrolase 0.0077 0.0403 0.1071
Schistosoma mansoni lamin 0.011 0.0634 0.0634
Entamoeba histolytica hypothetical protein 0.0077 0.0408 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0142 0.0909
Mycobacterium ulcerans beta-lactamase 0.0077 0.0403 0.1071
Brugia malayi beta-lactamase 0.0077 0.0403 0.2527
Schistosoma mansoni apoferritin-2 0.0027 0.0057 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0142 0.0909
Mycobacterium ulcerans dehydrogenase 0.0054 0.0245 0.058
Schistosoma mansoni hypothetical protein 0.0167 0.1029 0.1029
Leishmania major hypothetical protein, conserved 0.0077 0.0403 0.0634
Toxoplasma gondii hypothetical protein 0.0151 0.0919 1
Mycobacterium ulcerans lipase LipD 0.0077 0.0403 0.1071
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0133 0.0835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0084 0.0084
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0076 0.0076
Loa Loa (eye worm) hypothetical protein 0.0054 0.0245 0.1532
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Loa Loa (eye worm) hypothetical protein 0.011 0.0634 0.3972
Brugia malayi hypothetical protein 0.0054 0.0245 0.1532
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0211 0.0313
Mycobacterium leprae Probable lipase LipE 0.0077 0.0403 0.1307
Echinococcus granulosus protoporphyrinogen oxidase 0.0355 0.2335 0.2335
Loa Loa (eye worm) hypothetical protein 0.0038 0.0133 0.0835
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.0245 0.058
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0142 0.0223
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0211 0.0332
Giardia lamblia GTOR 0.0049 0.0211 0.5
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0254 0.1595
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0403 0.259
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0084 0.0084
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0077 0.0403 0.1071
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0319 0.0501
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0074 0.0478
Schistosoma mansoni ferritin 0.0027 0.0057 0.0057
Echinococcus granulosus tumor protein p63 0.0727 0.4914 0.4914
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Loa Loa (eye worm) hypothetical protein 0.0077 0.0403 0.2527
Loa Loa (eye worm) hypothetical protein 0.0077 0.0403 0.2527
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0211 0.0211
Schistosoma mansoni apoferritin-2 0.0027 0.0057 0.0057
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0054 0.0245 0.6063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0055 0.0352
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0054 0.0245 0.058
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0409 0.2708 0.2708
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0077 0.0403 0.2527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0211 0.1356
Echinococcus multilocularis lamin dm0 0.011 0.0634 0.0634
Mycobacterium leprae conserved hypothetical protein 0.0077 0.0403 0.1307
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.1352 0.8473
Brugia malayi Pre-SET motif family protein 0.0213 0.1352 0.8473
Onchocerca volvulus 0.0077 0.0403 0.259
Mycobacterium ulcerans esterase/lipase LipP 0.0077 0.0403 0.1071
Loa Loa (eye worm) MH2 domain-containing protein 0.0248 0.1596 1
Schistosoma mansoni ferritin 0.0027 0.0057 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0072 0.0465
Mycobacterium ulcerans monoamine oxidase 0.0054 0.0245 0.058
Leishmania major cathepsin L-like protease 0.0071 0.0362 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0797
Brugia malayi beta-lactamase family protein 0.0077 0.0403 0.2527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0054 0.0245 0.0245
Mycobacterium ulcerans hypothetical protein 0.0493 0.3292 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0077 0.0403 0.1071
Treponema pallidum bacterioferrin (TpF1) 0.0027 0.0057 0.5
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0053 0.0239 0.0239
Mycobacterium tuberculosis Conserved protein 0.0077 0.0403 0.1071
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0443 0.2945 0.4616
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0403 0.259
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0403 0.0403
Onchocerca volvulus 0.0077 0.0403 0.259
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0257 0.0403
Schistosoma mansoni ferritin light chain 0.0027 0.0057 0.0057
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0362 0.0568
Mycobacterium tuberculosis Possible penicillin-binding protein 0.049 0.327 0.9932
Loa Loa (eye worm) hypothetical protein 0.0053 0.0239 0.15
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0054 0.0245 0.6063
Loa Loa (eye worm) hypothetical protein 0.0077 0.0403 0.2527
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0077 0.0408 0.0408
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0077 0.0403 0.1071
Echinococcus granulosus lamin 0.011 0.0634 0.0634
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0077 0.0408 0.0408
Trypanosoma cruzi cruzipain precursor, putative 0.0071 0.0362 0.0568
Onchocerca volvulus 0.0243 0.1557 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0084 0.0084
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0409 0.2708 0.8194
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0142 0.0909
Leishmania major cathepsin L-like protease 0.0071 0.0362 0.0568
Schistosoma mansoni lamin 0.011 0.0634 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0797
Echinococcus multilocularis ferritin 0.0027 0.0057 0.0057
Trichomonas vaginalis ferritin, putative 0.0027 0.0057 0.0365
Entamoeba histolytica hypothetical protein 0.0077 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0084 0.0524
Mycobacterium tuberculosis Possible oxidoreductase 0.0054 0.0245 0.058
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0054 0.0245 0.058
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0077 0.0403 0.1071
Schistosoma mansoni ferritin 0.0027 0.0057 0.0057
Leishmania major UDP-galactopyranose mutase 0.0054 0.0245 0.0384
Entamoeba histolytica hypothetical protein 0.0077 0.0408 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0084 0.0911
Loa Loa (eye worm) hypothetical protein 0.0108 0.062 0.3885
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0132 0.0784 0.1232
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0054 0.0245 1
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0245 0.6063
Brugia malayi cytoplasmic intermediate filament protein 0.0059 0.028 0.1754
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Trypanosoma cruzi UDP-galactopyranose mutase 0.0054 0.0245 0.0384
Loa Loa (eye worm) hypothetical protein 0.0077 0.0403 0.2527
Brugia malayi beta-lactamase family protein 0.0077 0.0403 0.2527
Echinococcus multilocularis 0.0054 0.0245 0.0245
Loa Loa (eye worm) beta-lactamase 0.0077 0.0403 0.2527
Echinococcus multilocularis tumor protein p63 0.0727 0.4914 0.4914
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0797
Echinococcus multilocularis expressed protein 0.0027 0.0057 0.0057
Echinococcus granulosus beta LACTamase domain containing family member 0.0077 0.0403 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0797
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0211 0.0332
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0211 0.0332
Brugia malayi intermediate filament protein 0.011 0.0634 0.3972
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0054 0.0245 1
Brugia malayi SWIRM domain containing protein 0.0054 0.0245 0.1532
Onchocerca volvulus 0.0054 0.0245 0.1571
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0055 0.0352
Entamoeba histolytica hypothetical protein 0.0077 0.0408 1
Schistosoma mansoni hypothetical protein 0.0167 0.1029 0.1029
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0032 0.0031
Mycobacterium tuberculosis Conserved protein 0.0077 0.0403 0.1071
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0132 0.0784 0.1232
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0211 0.1323
Schistosoma mansoni hypothetical protein 0.0077 0.0408 0.0408
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0403 0.259
Echinococcus granulosus ferritin 0.0027 0.0057 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0797
Echinococcus multilocularis protoporphyrinogen oxidase 0.0409 0.2708 0.2708
Schistosoma mansoni ferritin 0.0027 0.0057 0.0057
Trichomonas vaginalis penicillin-binding protein, putative 0.0077 0.0403 0.259
Mycobacterium tuberculosis Probable lipase LipD 0.0077 0.0403 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0797
Loa Loa (eye worm) intermediate filament protein 0.011 0.0634 0.3972
Loa Loa (eye worm) hypothetical protein 0.0054 0.0245 0.1532
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0092 0.059
Loa Loa (eye worm) hypothetical protein 0.0055 0.0254 0.1595
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0132 0.0784 0.1232
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0936 0.6366 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0053 0.0239 0.0239
Loa Loa (eye worm) hypothetical protein 0.0054 0.0245 0.1532
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0403 0.0634
Echinococcus granulosus lysine specific histone demethylase 1A 0.0054 0.0245 0.0245
Echinococcus granulosus lamin dm0 0.011 0.0634 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0074 0.0478
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0443 0.2945 0.4626
Leishmania major mitochondrial DNA polymerase beta 0.0936 0.6366 1
Trypanosoma cruzi UDP-galactopyranose mutase 0.0054 0.0245 0.0384
Mycobacterium ulcerans oxidoreductase 0.0054 0.0245 0.058
Brugia malayi Intermediate filament tail domain containing protein 0.011 0.0634 0.3972
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.016 0.0984 0.1546
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0124 0.0797
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0074 0.0478
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0211 0.0211
Loa Loa (eye worm) hypothetical protein 0.0054 0.0245 0.1532
Trichomonas vaginalis D-aminoacylase, putative 0.0077 0.0403 0.259
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0211 0.0313
Mycobacterium tuberculosis Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) 0.0355 0.2335 0.704
Echinococcus multilocularis geminin 0.0167 0.1029 0.1029
Loa Loa (eye worm) hypothetical protein 0.0077 0.0403 0.2527
Schistosoma mansoni transcription factor LCR-F1 0.0077 0.0408 0.0408
Plasmodium vivax hypothetical protein, conserved 0.0077 0.0403 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0245 0.1532
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0362 0.0568
Toxoplasma gondii ABC1 family protein 0.0077 0.0403 0.439
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0254 0.1595
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0254 0.1595
Schistosoma mansoni amine oxidase 0.0054 0.0245 0.0245
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0055 0.035
Mycobacterium ulcerans hypothetical protein 0.0077 0.0403 0.1071
Plasmodium vivax hypothetical protein, conserved 0.0054 0.0245 0.6063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0084 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0403 0.0634
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0936 0.6366 1
Onchocerca volvulus 0.011 0.0634 0.4072
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.011 0.0634 0.3972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0142 0.0909
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0211 0.1323
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1557 1
Onchocerca volvulus 0.0077 0.0403 0.259
Schistosoma mansoni amine oxidase 0.0054 0.0245 0.0245
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0054 0.0245 0.0245
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0936 0.6366 1
Trichomonas vaginalis esterase, putative 0.0077 0.0403 0.259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0099 0.0637
Onchocerca volvulus 0.0031 0.0084 0.0538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0055 0.035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0077 0.0403 0.0403
Schistosoma mansoni intermediate filament proteins 0.011 0.0634 0.0634
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Loa Loa (eye worm) hypothetical protein 0.0106 0.0609 0.3818
Toxoplasma gondii target of rapamycin (TOR), putative 0.0036 0.0124 0.135
Brugia malayi Pre-SET motif family protein 0.0031 0.0084 0.0524
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0142 0.0223
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0211 0.5172
Echinococcus multilocularis musashi 0.011 0.0634 0.0634
Echinococcus granulosus expressed protein 0.0027 0.0057 0.0057
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0077 0.0403 0.2527
Schistosoma mansoni cellular tumor antigen P53 0.0106 0.0609 0.0609
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0071 0.0362 0.055
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0059 0.028 0.1754
Onchocerca volvulus 0.0106 0.0609 0.3914
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0084 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0211 0.1356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0055 0.035
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0132 0.0784 0.1215
Schistosoma mansoni hypothetical protein 0.0038 0.0133 0.0133
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0211 0.5172
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0443 0.2945 0.4626
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0084 0.0084
Mycobacterium tuberculosis Conserved protein 0.0077 0.0403 0.1071
Brugia malayi MH2 domain containing protein 0.0248 0.1596 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0225 0.1412
Loa Loa (eye worm) hypothetical protein 0.0051 0.0225 0.1412
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0142 0.0204
Loa Loa (eye worm) hypothetical protein 0.0054 0.0245 0.1532
Echinococcus multilocularis lamin 0.011 0.0634 0.0634
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0072 0.0465
Plasmodium falciparum protoporphyrinogen oxidase 0.0054 0.0245 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0055 0.0352
Trypanosoma cruzi cysteine peptidase, putative 0.0071 0.0362 0.0568
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0055 0.0352
Brugia malayi hypothetical protein 0.0077 0.0408 0.2558
Toxoplasma gondii histone lysine-specific demethylase 0.0054 0.0245 0.2661
Mycobacterium tuberculosis Probable lipase LipE 0.0077 0.0403 0.1071
Leishmania major cathepsin L-like protease 0.0071 0.0362 0.0568
Schistosoma mansoni ferritin light chain 0.0027 0.0057 0.0057
Echinococcus granulosus lysine specific histone demethylase 1A 0.0054 0.0245 0.0245
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0054 0.0245 0.2661
Chlamydia trachomatis protoporphyrinogen oxidase 0.0409 0.2708 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0161 0.1037
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0027 0.0057 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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