Detailed information for compound 1078148

Basic information

Technical information
  • TDR Targets ID: 1078148
  • Name: 1-([1,3]oxazolo[4,5-b]pyridin-2-yl)ethanone
  • MW: 162.145 | Formula: C8H6N2O2
  • H donors: 0 H acceptors: 3 LogP: 1.04 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)c1nc2c(o1)cccn2
  • InChi: 1S/C8H6N2O2/c1-5(11)8-10-7-6(12-8)3-2-4-9-7/h2-4H,1H3
  • InChiKey: KVJFUHZFUWUQMV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-oxazolo[4,5-b]pyridin-2-ylethanone
  • 1-(2-oxazolo[4,5-b]pyridinyl)ethanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens diacylglycerol lipase, alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_129115 All targets in OG5_129115
Leishmania donovani Lipase (class 3), putative Get druggable targets OG5_129115 All targets in OG5_129115
Trypanosoma brucei gambiense lipase domain protein, putative Get druggable targets OG5_129115 All targets in OG5_129115
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_129115 All targets in OG5_129115
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_129115 All targets in OG5_129115
Trypanosoma congolense lipase domain protein, putative Get druggable targets OG5_129115 All targets in OG5_129115
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta Get druggable targets OG5_129115 All targets in OG5_129115
Echinococcus granulosus sn1 specific diacylglycerol lipase beta Get druggable targets OG5_129115 All targets in OG5_129115
Trypanosoma brucei lipase domain protein, putative Get druggable targets OG5_129115 All targets in OG5_129115
Trypanosoma congolense lipase domain protein, putative Get druggable targets OG5_129115 All targets in OG5_129115
Brugia malayi Lipase family protein Get druggable targets OG5_129115 All targets in OG5_129115
Leishmania major hypothetical protein, conserved Get druggable targets OG5_129115 All targets in OG5_129115
Trichomonas vaginalis lipase containing protein, putative Get druggable targets OG5_129115 All targets in OG5_129115
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_129115 All targets in OG5_129115
Loa Loa (eye worm) lipase Get druggable targets OG5_129115 All targets in OG5_129115
Trichomonas vaginalis lipase containing protein, putative Get druggable targets OG5_129115 All targets in OG5_129115
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_129115 All targets in OG5_129115
Onchocerca volvulus Get druggable targets OG5_129115 All targets in OG5_129115
Trypanosoma brucei lipase domain protein, putative Get druggable targets OG5_129115 All targets in OG5_129115
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0016 0.0135 0.0135
Brugia malayi MH2 domain containing protein 0.0118 0.3143 0.4805
Echinococcus multilocularis musashi 0.0029 0.0538 0.0538
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0014 0.0093 0.0142
Echinococcus granulosus intermediate filament protein 0.0029 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0034 0.0667 0.1019
Schistosoma mansoni hypothetical protein 0.0016 0.0135 0.0135
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0135 0.0135
Echinococcus multilocularis lamin dm0 0.0029 0.0538 0.0538
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0138 0.0212
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0544 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0077 0.0118
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0135 0.0207
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0544 0.0544
Schistosoma mansoni hypothetical protein 0.0016 0.0135 0.0135
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.3143 0.4805
Plasmodium vivax SET domain protein, putative 0.0029 0.0544 0.5
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.5718 0.8742
Schistosoma mansoni hypothetical protein 0.0048 0.1078 0.1078
Echinococcus multilocularis sn1 specific diacylglycerol lipase beta 0.0173 0.4762 0.4762
Echinococcus multilocularis GPCR, family 2 0.0016 0.0135 0.0135
Onchocerca volvulus 0.0029 0.0538 0.0821
Onchocerca volvulus 0.0234 0.6553 1
Onchocerca volvulus 0.0048 0.1078 0.1644
Leishmania major hypothetical protein, conserved 0.0173 0.4762 0.5
Trypanosoma brucei lipase domain protein, putative 0.0173 0.4762 0.5
Onchocerca volvulus 0.0029 0.0538 0.0821
Trichomonas vaginalis set domain proteins, putative 0.0234 0.6553 1
Brugia malayi Lipase family protein 0.0173 0.4762 0.728
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.1078 0.1647
Echinococcus granulosus lamin dm0 0.0029 0.0538 0.0538
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0544 0.0544
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0667 0.1019
Trypanosoma brucei lipase domain protein, putative 0.0173 0.4762 0.5
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0544 0.0544
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0544 0.0544
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0512 0.0512
Schistosoma mansoni lamin 0.0029 0.0538 0.0538
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0135 0.0207
Loa Loa (eye worm) lipase 0.0173 0.4762 0.728
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1125 0.1719
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0135 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0544 0.0544
Schistosoma mansoni hypothetical protein 0.0016 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0029 0.0538 0.0822
Loa Loa (eye worm) hypothetical protein 0.0016 0.0135 0.0207
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0538 0.0822
Trypanosoma cruzi hypothetical protein, conserved 0.0173 0.4762 0.5
Loa Loa (eye worm) hypothetical protein 0.0233 0.6541 1
Onchocerca volvulus 0.0029 0.0544 0.083
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0538 0.0822
Loa Loa (eye worm) hypothetical protein 0.0029 0.0544 0.0832
Schistosoma mansoni survival motor neuron protein 0.0048 0.1078 0.1078
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1125 0.1719
Brugia malayi intermediate filament protein 0.0029 0.0538 0.0822
Schistosoma mansoni intermediate filament proteins 0.0029 0.0538 0.0538
Echinococcus granulosus sn1 specific diacylglycerol lipase beta 0.0173 0.4762 0.4762
Loa Loa (eye worm) hypothetical protein 0.0014 0.0077 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0173 0.4762 0.5
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.3143 0.4805
Echinococcus granulosus GPCR family 2 0.0016 0.0135 0.0135
Echinococcus granulosus lamin 0.0029 0.0538 0.0538
Brugia malayi hypothetical protein 0.0233 0.6541 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0522 0.0798
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0538 0.0822
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.6541 0.6541
Echinococcus multilocularis lamin 0.0029 0.0538 0.0538
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1125 0.1719
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.6541 0.6541
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0093 0.0093
Schistosoma mansoni lamin 0.0029 0.0538 0.0538
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0034 0.0667 0.0667
Loa Loa (eye worm) hypothetical protein 0.0049 0.1125 0.1719
Onchocerca volvulus 0.0173 0.4762 0.7267
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0138 0.0212
Brugia malayi Pre-SET motif family protein 0.0205 0.5718 0.8742
Brugia malayi Pre-SET motif family protein 0.0029 0.0544 0.0832
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0135 0.0207
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0093 0.0093
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0544 0.0544
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0544 0.0544

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 5 Inhibition of full-length human DAGLalpha expressed in HEK293T cell membranes using para-nitrophenylbutyrate by colorimetric assay ChEMBL. 26584396
Ki (binding) > 100 uM Inhibition of FAAH ChEMBL. 21764305

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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