TDR Targets

Basic information

Technical information

TDR Targets ID: 1085061
Name: 5-(1H-indazol-6-ylamino)-2H-1,2,4-triazin-3-o ne
MW: 228.21 | Formula: C10H8N6O
H donors: 3 H acceptors: 5 LogP: 0.68 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1nncc(n1)Nc1ccc2c(c1)[nH]nc2
InChi: 1S/C10H8N6O/c17-10-14-9(5-12-16-10)13-7-2-1-6-4-11-15-8(6)3-7/h1-5H,(H,11,15)(H2,13,14,16,17)
InChiKey: BWTONTRMGUMYCX-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

ZINC07996484

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	eukaryotic translation initiation factor 2-alpha kinase 2	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania infantum	protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative	Get druggable targets OG5_133400	All targets in OG5_133400
Trypanosoma cruzi	Eukaryotic translation initiation factor 2-alpha kinase 2	Get druggable targets OG5_133400	All targets in OG5_133400
Trypanosoma brucei gambiense	protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative	Get druggable targets OG5_133400	All targets in OG5_133400
Trypanosoma cruzi	Eukaryotic translation initiation factor 2-alpha kinase 2	Get druggable targets OG5_133400	All targets in OG5_133400
Trypanosoma brucei	eukaryotic translation initiation factor 2-alpha kinase 2	Get druggable targets OG5_133400	All targets in OG5_133400
Leishmania braziliensis	protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative	Get druggable targets OG5_133400	All targets in OG5_133400
Trypanosoma cruzi	Eukaryotic translation initiation factor 2-alpha kinase 2	Get druggable targets OG5_133400	All targets in OG5_133400
Trypanosoma congolense	Eukaryotic translation initiation factor 2-alpha kinase 2	Get druggable targets OG5_133400	All targets in OG5_133400
Trichomonas vaginalis	STE family protein kinase	Get druggable targets OG5_133400	All targets in OG5_133400
Leishmania donovani	Eukaryotic translation initiation factor 2-alpha kinase 2	Get druggable targets OG5_133400	All targets in OG5_133400
Leishmania mexicana	protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative	Get druggable targets OG5_133400	All targets in OG5_133400
Trichomonas vaginalis	AGC family protein kinase	Get druggable targets OG5_133400	All targets in OG5_133400
Plasmodium vivax	serine/threonine protein kinase, putative	Get druggable targets OG5_133400	All targets in OG5_133400
Leishmania major	protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative	Get druggable targets OG5_133400	All targets in OG5_133400

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.201	1
Echinococcus multilocularis	lamin dm0	0.0026	0.0602	0.0624
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0031	0.0804	0.3415
Schistosoma mansoni	serine/threonine protein kinase	0.005	0.1618	0.7863
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0179	0.017
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0804	0.0841
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1385	0.1465
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0052	0.1692	0.1812
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0804	0.3415
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0804	0.0861
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.201	0.5
Trichomonas vaginalis	STE family protein kinase	0.0084	0.3052	0.1711
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0179	0.017
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0179	0.0106
Echinococcus multilocularis	lamin	0.0026	0.0602	0.0624
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0179	0.017
Loa Loa (eye worm)	intermediate filament protein	0.0026	0.0602	0.0645
Onchocerca volvulus	Huntingtin homolog	0.012	0.4586	0.4239
Brugia malayi	Intermediate filament tail domain containing protein	0.0026	0.0602	0.0564
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0978	0.4366
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0052	0.1692	0.1741
Schistosoma mansoni	intermediate filament proteins	0.0026	0.0602	0.2314
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0216	0.8723	0.9341
Plasmodium vivax	serine/threonine protein kinase, putative	0.0084	0.3052	1
Entamoeba histolytica	hypothetical protein	0.0035	0.0978	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0978	0.1028
Entamoeba histolytica	hypothetical protein	0.0035	0.0978	0.5
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0179	0.0106
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.005	0.1618	0.6755
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.0992	0.0984
Entamoeba histolytica	hypothetical protein	0.0035	0.0978	0.5
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0014	0.008	0.0086
Onchocerca volvulus	Huntingtin homolog	0.012	0.4586	0.4239
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.201	0.2135
Schistosoma mansoni	hypothetical protein	0.0035	0.0992	0.444
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.1489	0.1522
Trypanosoma cruzi	Eukaryotic translation initiation factor 2-alpha kinase 2	0.0084	0.3052	1
Schistosoma mansoni	survival motor neuron protein	0.0047	0.1489	0.7156
Schistosoma mansoni	hypothetical protein	0.0035	0.0978	0.4366
Trichomonas vaginalis	set domain proteins, putative	0.0246	1	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.005	0.1618	0.1733
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0978	0.1028
Echinococcus multilocularis	musashi	0.0026	0.0602	0.0624
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1385	0.6589
Echinococcus granulosus	mitogen activated protein kinase	0.005	0.1618	0.1715
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.201	0.2135
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0804	0.3415
Giardia lamblia	Kinase, CMGC MAPK	0.005	0.1618	0.5
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.201	1
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.201	1
Trypanosoma cruzi	Eukaryotic translation initiation factor 2-alpha kinase 2	0.0083	0.3017	0.9755
Brugia malayi	Pre-SET motif family protein	0.0031	0.0804	0.0782
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0602	0.0645
Echinococcus multilocularis	mitogen activated protein kinase	0.005	0.1618	0.1715
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1385	0.1465
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0755	0.0788
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.201	0.2729
Loa Loa (eye worm)	hypothetical protein	0.012	0.4586	0.4911
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0582	0.0623
Trypanosoma cruzi	Eukaryotic translation initiation factor 2-alpha kinase 2	0.0084	0.3052	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0179	0.017
Brugia malayi	intermediate filament protein	0.0026	0.0602	0.0564
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0179	0.0191
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.1385	0.141
Leishmania major	protein kinase, putative,eukaryotic translation initiation factor 2-alpha kinase precursor, putative	0.0084	0.3052	1
Brugia malayi	Pre-SET motif family protein	0.0216	0.8723	0.9335
Echinococcus granulosus	GPCR family 2	0.0016	0.0179	0.017
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.201	0.5
Echinococcus granulosus	lamin dm0	0.0026	0.0602	0.0624
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.1385	0.1465
Echinococcus granulosus	lamin	0.0026	0.0602	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0052	0.1692	0.1812
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1385	0.6589
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0804	0.0841
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.1385	0.1483
Loa Loa (eye worm)	hypothetical protein	0.0231	0.9338	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.1385	0.1465
Brugia malayi	hypothetical protein	0.012	0.4586	0.4867
Brugia malayi	hypothetical protein	0.0231	0.9338	1
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0992	0.1062
Onchocerca volvulus		0.0031	0.0804	0.0214
Trichomonas vaginalis	AGC family protein kinase	0.0084	0.3052	0.1711
Loa Loa (eye worm)	hypothetical protein	0.012	0.4586	0.4911
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0179	0.0191
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.1385	0.6589
Trypanosoma brucei	eukaryotic translation initiation factor 2-alpha kinase 2	0.0084	0.3052	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.201	0.5
Echinococcus granulosus	mitogen activated protein kinase 3	0.005	0.1618	0.1715
Schistosoma mansoni	lamin	0.0026	0.0602	0.2314
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.9338	1
Onchocerca volvulus		0.0047	0.1489	0.0944
Echinococcus granulosus	intermediate filament protein	0.0026	0.0602	0.0624
Entamoeba histolytica	hypothetical protein	0.0035	0.0978	0.5
Echinococcus multilocularis	mitogen activated protein kinase 3	0.005	0.1618	0.1715
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0179	0.017
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0804	0.0841
Brugia malayi	hypothetical protein	0.0035	0.0978	0.097
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0026	0.0602	0.0645
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0052	0.1692	0.1741
Schistosoma mansoni	lamin	0.0026	0.0602	0.2314
Brugia malayi	MAP kinase sur-1	0.005	0.1618	0.1661
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.201	0.5
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.9338	1
Loa Loa (eye worm)	hypothetical protein	0.0013	0.0021	0.0022
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0804	0.3415
Schistosoma mansoni	hypothetical protein	0.0047	0.1489	0.7156

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 13 uM	Inhibition of human recombinant PKR autophosphorylation using poly[I:C] after 10 mins by luminescent assay	ChEMBL.	21632247

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1802611

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1085061