Detailed information for compound 1090325

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 319.274 | Formula: C10H14N3O5PS
  • H donors: 3 H acceptors: 5 LogP: -1.65 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=c1[nH]c(=O)n(cc1C)C1CCN(C1)C(=S)P(=O)(O)O
  • InChi: 1S/C10H14N3O5PS/c1-6-4-13(9(15)11-8(6)14)7-2-3-12(5-7)10(20)19(16,17)18/h4,7H,2-3,5H2,1H3,(H,11,14,15)(H2,16,17,18)
  • InChiKey: LIDNWHXMCUSHHZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Thymidine phosphorylase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) Get druggable targets OG5_131632 All targets in OG5_131632
Mycobacterium ulcerans thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus granulosus thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
Echinococcus multilocularis thymidine phosphorylase Get druggable targets OG5_131632 All targets in OG5_131632
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni jumonji/arid domain-containing protein 0.0125 0.0434 0.1512
Onchocerca volvulus 0.045 0.1727 1
Brugia malayi hypothetical protein 0.0034 0.0072 0.0416
Loa Loa (eye worm) runx1 0.0056 0.016 0.0929
Onchocerca volvulus 0.0027 0.0042 0.0241
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0002 0.0065
Brugia malayi Importin beta-1 subunit 0.003 0.0054 0.0314
Echinococcus granulosus tyrosine protein kinase Fyn 0.0027 0.0042 0.0139
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0153 0.5039
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0153 0.0646
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0153 0.0646
Echinococcus multilocularis tyrosine protein kinase shark 0.0027 0.0042 0.0042
Echinococcus multilocularis geminin 0.0356 0.1353 0.1353
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.018
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0153 0.5039
Onchocerca volvulus 0.0029 0.0052 0.03
Schistosoma mansoni hypothetical protein 0.0086 0.0278 0.0966
Echinococcus granulosus caspase 0.0244 0.0907 0.3037
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.018 0.594
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0269 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0269 0.7807
Echinococcus multilocularis cpg binding protein 0.0031 0.0058 0.0058
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0153 0.5039
Onchocerca volvulus Cell death protein 3 homolog 0.0178 0.0645 0.3735
Onchocerca volvulus 0.0027 0.0042 0.0241
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0084 0.0269 1
Onchocerca volvulus 0.0027 0.0042 0.0241
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0153 0.0646
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0153 0.0646
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.2362 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0092 0.0303 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.0074 0.0246
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.0395 0.1307
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.0446 0.1479
Schistosoma mansoni caspase-7 (C14 family) 0.0244 0.0907 0.3155
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0017 0.0002 0.0065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.2362 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0153 0.5039
Echinococcus multilocularis microtubule associated protein 2 0.0738 0.2874 0.2874
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0129 0.0745
Echinococcus granulosus tyrosine protein kinase ABL1 0.0027 0.0042 0.0139
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0027 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0303 0.1283
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0092 0.0303 0.1283
Schistosoma mansoni hypothetical protein 0.0318 0.1201 0.4178
Loa Loa (eye worm) hypothetical protein 0.0178 0.0645 0.3735
Schistosoma mansoni tyrosine kinase 0.0027 0.0042 0.0145
Loa Loa (eye worm) hypothetical protein 0.0027 0.0042 0.0241
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0092 0.0303 0.1283
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0269 0.8868
Brugia malayi mbt repeat family protein 0.0048 0.0129 0.0745
Echinococcus granulosus neuropeptide s receptor 0.0469 0.1806 0.605
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0067 0.0067
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0185 0.0603
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0055 0.0154 0.0498
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0027 0.0042 0.0176
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0067 0.0233
Mycobacterium tuberculosis Probable reductase 0.0115 0.0395 0.1307
Schistosoma mansoni importin beta-1 0.003 0.0054 0.0189
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0032 0.0135
Onchocerca volvulus 0.0027 0.0042 0.0241
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.0005 0.0023
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0153 0.0153
Echinococcus multilocularis Polycystic kidney disease protein 0.0103 0.0344 0.0344
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.0395 0.1307
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0303 0.1283
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Trypanosoma cruzi metacaspase, putative 0.0092 0.0303 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0005 0.018
Echinococcus multilocularis lipoxygenase domain containing protein 0.0103 0.0344 0.0344
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.018
Echinococcus granulosus lipoxygenase domain containing protein 0.0103 0.0344 0.1153
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0067 0.0388
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0185 0.6114
Echinococcus granulosus tyrosine protein kinase Fyn 0.0027 0.0042 0.0139
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0155 0.054
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0269 0.0883
Echinococcus multilocularis c src tyrosine kinase 0.0027 0.0042 0.0042
Echinococcus multilocularis Protein lozenge 0.0056 0.016 0.016
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.2362 1
Schistosoma mansoni loxhd1 0.0103 0.0344 0.1197
Echinococcus multilocularis neuropeptide receptor A26 0.0469 0.1806 0.1806
Brugia malayi Protein kinase domain containing protein 0.0027 0.0042 0.0241
Echinococcus granulosus caspase 2 0.0178 0.0645 0.2161
Echinococcus granulosus lipoxygenase domain containing protein 0.0103 0.0344 0.1153
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0419 0.1604 0.1604
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0067 0.0233
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0054 0.1789
Brugia malayi mbt repeat family protein 0.0048 0.0129 0.0745
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0033 0.0067 0.0388
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.2362 1
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0155 0.0155
Schistosoma mansoni polycystin 1-related 0.0103 0.0344 0.1197
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0005 0.018
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0002 0.0065
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0023 0.0023
Echinococcus multilocularis tyrosine kinase 0.0027 0.0042 0.0042
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0216 0.0796 0.2655
Leishmania major GTP-binding protein, putative 0.0022 0.0023 0.0756
Schistosoma mansoni tyrosine kinase 0.0027 0.0042 0.0145
Loa Loa (eye worm) TK/ABL protein kinase 0.0027 0.0042 0.0241
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0017 0.0002 0.0065
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0055 0.0154 0.0498
Echinococcus multilocularis thioredoxin glutathione reductase 0.0051 0.0137 0.0137
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0067 0.0233
Giardia lamblia Fructose-bisphosphate aldolase 0.0609 0.2362 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0092 0.0303 0.1283
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0092 0.0303 0.1283
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0147 0.4261
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0156 0.5141
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0052 0.03
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0027 0.0042 0.0042
Echinococcus granulosus cpg binding protein 0.0031 0.0058 0.0196
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0092 0.0303 0.1754
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0666
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.018
Echinococcus granulosus thioredoxin glutathione reductase 0.0051 0.0137 0.0459
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0609 0.2362 1
Schistosoma mansoni ran 0.0022 0.0023 0.008
Leishmania major importin beta-1 subunit, putative 0.0024 0.0032 0.1049
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.0696 0.0696
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0084 0.0269 1
Loa Loa (eye worm) doublecortin family protein 0.0103 0.0344 0.1992
Plasmodium vivax glutathione reductase, putative 0.0051 0.0137 0.3982
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.0395 0.1307
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0005 0.0018
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0054 0.1789
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0092 0.0303 0.1283
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.2362 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0027 0.0042 0.0241
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0182 0.0634
Onchocerca volvulus 0.0103 0.0344 0.1992
Schistosoma mansoni rab6-interacting 0.0103 0.0344 0.1197
Trypanosoma cruzi metacaspase, putative 0.0092 0.0303 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0084 0.0269 0.1117
Brugia malayi jmjC domain containing protein 0.0033 0.0067 0.0388
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Leishmania major hypothetical protein, conserved 0.0033 0.0067 0.2209
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0129 0.0448
Echinococcus multilocularis caspase 3 0.0152 0.0539 0.0539
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.0446 0.3697
Echinococcus multilocularis tyrosine protein kinase Abl 0.0027 0.0042 0.0042
Mycobacterium ulcerans thymidine phosphorylase 0.0765 0.2985 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0756
Loa Loa (eye worm) SRC-1 0.0027 0.0042 0.0241
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.0395 0.1307
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0027 0.0042 0.0145
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0124 0.0428 0.0428
Echinococcus granulosus neuropeptide receptor A26 0.0469 0.1806 0.605
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0153 0.5039
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0244 0.0907 0.3037
Echinococcus granulosus dnaJ subfamily B 0.0415 0.159 0.5326
Schistosoma mansoni cpg binding protein 0.0031 0.0058 0.0203
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.2362 1
Brugia malayi jmjC domain containing protein 0.0125 0.0434 0.2515
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0017 0.0002 0.0002
Trichomonas vaginalis ran, putative 0.0022 0.0023 0.0097
Brugia malayi hypothetical protein 0.0086 0.0278 0.1608
Echinococcus multilocularis lysine specific demethylase 5A 0.0124 0.0428 0.0428
Plasmodium falciparum glutathione reductase 0.0018 0.0005 0.0159
Schistosoma mansoni microtubule-associated protein tau 0.0738 0.2874 1
Trypanosoma cruzi metacaspase 5, putative 0.0092 0.0303 1
Echinococcus granulosus peptidase Clp S14 family 0.0055 0.0154 0.0516
Brugia malayi Protein kinase domain containing protein 0.0027 0.0042 0.0241
Schistosoma mansoni hypothetical protein 0.0415 0.159 0.5533
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.0074 0.0074
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0027 0.0042 0.0042
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0155 0.052
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0147 0.4261
Schistosoma mansoni cpg binding protein 0.0029 0.0052 0.018
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0005 0.018
Schistosoma mansoni hypothetical protein 0.0356 0.1353 0.471
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0067 0.2209
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0023 0.0756
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.018
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.005 0.1465
Echinococcus granulosus tyrosine kinase 0.0027 0.0042 0.0139
Echinococcus multilocularis tyrosine protein kinase Blk 0.0027 0.0042 0.0042
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0027 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0054 0.0314
Onchocerca volvulus 0.0053 0.0146 0.0847
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0017 0.0002 0.0007
Leishmania major protein kinase, putative 0.0017 0.0002 0.0065
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0067 0.0388
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0005 0.018
Echinococcus granulosus Polycystic kidney disease protein 0.0103 0.0344 0.1153
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0005 0.018
Echinococcus multilocularis activin receptor type 0.0017 0.0002 0.0002
Echinococcus multilocularis peptidase Clp (S14 family) 0.0055 0.0154 0.0154
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0084 0.0269 0.7807
Schistosoma mansoni tyrosine kinase 0.0027 0.0042 0.0145
Echinococcus multilocularis neuropeptide s receptor 0.0469 0.1806 0.1806
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0153 0.0511
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0067 0.0224
Plasmodium falciparum protein kinase, putative 0.0017 0.0002 0.0057
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0609 0.2362 1
Schistosoma mansoni lipoxygenase 0.0419 0.1604 0.5582
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0005 0.0159
Loa Loa (eye worm) hypothetical protein 0.045 0.1727 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0344 0.1992
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0129 0.0448
Onchocerca volvulus 0.0086 0.0278 0.1608
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0067 0.0233
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0185 0.0603
Echinococcus granulosus lysine specific demethylase 5A 0.0125 0.0434 0.1455
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0153 0.0531
Brugia malayi Protein kinase domain containing protein 0.0027 0.0042 0.0241
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0027 0.0042 0.0042
Echinococcus granulosus c src tyrosine kinase 0.0027 0.0042 0.0139
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.005 0.1465
Schistosoma mansoni lipoxygenase 0.0234 0.0869 0.3024
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0298 0.1121 0.3744
Entamoeba histolytica protein kinase domain containing protein 0.0017 0.0002 0.0008
Plasmodium falciparum thioredoxin reductase 0.0018 0.0005 0.0159
Schistosoma mansoni ran 0.0022 0.0023 0.008
Schistosoma mansoni rab6-interacting 0.0103 0.0344 0.1197
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Plasmodium falciparum glutathione reductase 0.0051 0.0137 0.3982
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0129 0.0431
Toxoplasma gondii hypothetical protein 0.0029 0.005 0.1664
Loa Loa (eye worm) hypothetical protein 0.045 0.1727 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.018
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0005 0.0159
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0124 0.0428 0.1433
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0027 0.0042 0.0139
Echinococcus granulosus tyrosine protein kinase Blk 0.0027 0.0042 0.0139
Echinococcus granulosus activin receptor type 0.0017 0.0002 0.0007
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0147 0.4839
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0419 0.1604 0.5374
Loa Loa (eye worm) hypothetical protein 0.0311 0.1176 0.6808
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0067 0.2209
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.018 0.0603
Schistosoma mansoni lozenge 0.0056 0.016 0.0558
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0153 0.0153
Leishmania major trypanothione reductase 0.0051 0.0137 0.4523
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.018 0.0586
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0303 0.1283
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0756
Echinococcus granulosus microtubule associated protein 2 0.0738 0.2874 0.9627
Loa Loa (eye worm) hypothetical protein 0.0092 0.0303 0.1754
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0055 0.0154 0.0967
Brugia malayi CXXC zinc finger family protein 0.0029 0.0052 0.03
Echinococcus multilocularis muscleblind protein 0.0311 0.1176 0.1176
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.0796 0.2655
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.018 0.1042
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0298 0.1121 1
Echinococcus granulosus RUN 0.0103 0.0344 0.1153
Echinococcus granulosus caspase 3 0.0152 0.0539 0.1807
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0027 0.0042 0.0042
Echinococcus multilocularis tyrosine protein kinase Srms 0.0027 0.0042 0.0042
Loa Loa (eye worm) MBCTL1 0.0055 0.0155 0.0899
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0027 0.0042 0.0042
Entamoeba histolytica hypothetical protein 0.0024 0.0032 0.0135
Loa Loa (eye worm) hypothetical protein 0.0033 0.0067 0.0388
Schistosoma mansoni tyrosine kinase 0.0027 0.0042 0.0145
Brugia malayi protein-tyrosine kinase 0.0027 0.0042 0.0241
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0303 0.1283
Brugia malayi Muscleblind-like protein 0.0311 0.1176 0.6808
Echinococcus granulosus apoptotic protease activating factor 1 0.0086 0.0278 0.093
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0092 0.0303 0.1283
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0067 0.0224
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0084 0.0269 0.2039
Loa Loa (eye worm) TK protein kinase 0.0027 0.0042 0.0241
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.018 0.0586
Onchocerca volvulus 0.0027 0.0042 0.0241
Echinococcus granulosus caspase 8 0.0092 0.0303 0.1015
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0092 0.0303 0.1283
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.0696 0.2331
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.2362 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0027 0.0042 0.0042
Brugia malayi hypothetical protein 0.045 0.1727 1
Brugia malayi jmjC domain containing protein 0.0033 0.0067 0.0388
Plasmodium falciparum metacaspase 1 0.0092 0.0303 0.8804
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0147 0.4839
Echinococcus granulosus tyrosine protein kinase shark 0.0027 0.0042 0.0139
Schistosoma mansoni tyrosine kinase 0.0027 0.0042 0.0145
Schistosoma mansoni hypothetical protein 0.0024 0.003 0.0105
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0153 0.5039
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0216 0.0796 0.6968
Echinococcus multilocularis caspase 0.0244 0.0907 0.0907
Echinococcus granulosus tyrosine protein kinase Srms 0.0027 0.0042 0.0139
Schistosoma mansoni hypothetical protein 0.0103 0.0344 0.1197
Plasmodium vivax multidomain scavenger receptor, putative 0.0103 0.0344 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0185 0.0645
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0185 0.0603
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.018
Loa Loa (eye worm) hypothetical protein 0.0055 0.0155 0.0899
Trypanosoma cruzi metacaspase, putative 0.0092 0.0303 1
Trypanosoma brucei trypanothione reductase 0.0051 0.0137 0.4523
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0129 0.0448
Plasmodium vivax metacaspase 1, putative 0.0092 0.0303 0.8804
Echinococcus granulosus tyrosine protein kinase Lyn 0.0027 0.0044 0.0146
Plasmodium falciparum importin beta, putative 0.003 0.0054 0.1575
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0129 0.0431
Schistosoma mansoni protein kinase 0.0017 0.0002 0.0007
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0027 0.0042 0.0139
Trypanosoma brucei metacaspase MCA2 0.0092 0.0303 1
Schistosoma mansoni peptidase Clp (S14 family) 0.0084 0.0269 0.0935
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0005 0.018
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.0446 0.1479
Echinococcus granulosus snurportin 1 0.0318 0.1201 0.4022
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0185 0.0621
Loa Loa (eye worm) hypothetical protein 0.0053 0.0147 0.0849
Brugia malayi Thioredoxin reductase 0.0051 0.0137 0.0793
Schistosoma mansoni caspase-3 (C14 family) 0.0244 0.0907 0.3155
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0153 0.0884
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0067 0.2209
Echinococcus multilocularis dnaJ subfamily B 0.0415 0.159 0.159
Trypanosoma brucei Metacaspase-4 0.0092 0.0303 1
Brugia malayi jmjC domain containing protein 0.0124 0.0428 0.2477
Echinococcus multilocularis importin subunit beta 1 0.003 0.0054 0.0054
Brugia malayi SH2 domain containing protein 0.0027 0.0042 0.0241
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0092 0.0303 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0185 0.0645
Trypanosoma brucei metacaspase MCA3 0.0092 0.0303 1
Brugia malayi hypothetical protein 0.0103 0.0344 0.1992
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.018 0.0586
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0005 0.0159
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0298 0.1121 0.3744
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0146 0.0509
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0067 0.2209
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0129 0.0129
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.003 0.0101
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0023 0.0666
Echinococcus granulosus tyrosine protein kinase Src42A 0.0027 0.0042 0.0139
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0092 0.0303 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0023 0.0756
Trypanosoma cruzi metacaspase, putative 0.0092 0.0303 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.018
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0147 0.4839
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0067 0.1945
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0147 0.4839
Echinococcus multilocularis lipoxygenase domain containing protein 0.0103 0.0344 0.0344
Echinococcus granulosus importin subunit beta 1 0.003 0.0054 0.0182
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0097
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.0395 0.3218
Onchocerca volvulus 0.0103 0.0344 0.1992
Echinococcus multilocularis caspase 8 0.0092 0.0303 0.0303
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0092 0.0303 0.1054
Brugia malayi SH2 domain containing protein 0.0027 0.0042 0.0241
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.0395 0.1307
Loa Loa (eye worm) hypothetical protein 0.0084 0.0269 0.1556
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0164 0.0947
Schistosoma mansoni jumonji domain containing protein 0.0124 0.0428 0.1489
Loa Loa (eye worm) hypothetical protein 0.0033 0.0067 0.0388
Echinococcus multilocularis tumor protein p63 0.0361 0.1374 0.1374
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0147 0.4261
Plasmodium vivax thioredoxin reductase, putative 0.0051 0.0137 0.3982
Treponema pallidum fructose-bisphosphate aldolase 0.0609 0.2362 1
Schistosoma mansoni cpg binding protein 0.0031 0.0058 0.0203
Plasmodium vivax importin-beta 2, putative 0.003 0.0054 0.1575
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0153 0.5039
Brugia malayi MAP kinase sur-1 0.0054 0.0153 0.0884
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.0446 0.1479
Echinococcus multilocularis snurportin 1 0.0318 0.1201 0.1201
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0032 0.0135
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0027 0.0042 0.0042
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0054 0.1789
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Echinococcus granulosus muscleblind protein 0.0311 0.1176 0.3939
Plasmodium vivax JmjC domain containing protein 0.0033 0.0067 0.1945
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0244 0.0907 0.0907
Schistosoma mansoni protein kinase 0.0017 0.0002 0.0007
Plasmodium vivax hypothetical protein, conserved 0.0092 0.0303 0.8804
Onchocerca volvulus 0.0048 0.0129 0.0745
Brugia malayi glutathione reductase 0.0051 0.0137 0.0793
Onchocerca volvulus 0.0027 0.0042 0.0241
Brugia malayi RNA, U transporter 1 0.0085 0.0273 0.1579
Echinococcus multilocularis thymidine phosphorylase 0.0765 0.2985 0.2985
Plasmodium falciparum LCCL domain-containing protein 0.0103 0.0344 1
Trypanosoma brucei protein kinase, putative 0.0054 0.0153 0.5039
Schistosoma mansoni hypothetical protein 0.0294 0.1108 0.3857
Brugia malayi SRC-1 0.0027 0.0042 0.0241
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0005 0.0019
Trypanosoma cruzi trypanothione reductase, putative 0.0051 0.0137 0.4523
Brugia malayi Protein kinase domain containing protein 0.0027 0.0042 0.0241
Echinococcus granulosus thymidine phosphorylase 0.0765 0.2985 1
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0027 0.0042 0.0042
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0005 0.0005
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0153 0.0646
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0005 0.018
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0032 0.0135
Brugia malayi Cell death protein 3 precursor 0.0178 0.0645 0.3735
Trypanosoma cruzi metacaspase 5, putative 0.0092 0.0303 1
Echinococcus granulosus tyrosine kinase 0.0027 0.0042 0.0139
Brugia malayi Probable ClpP-like protease 0.0084 0.0269 0.1556
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0027 0.0042 0.0042
Schistosoma mansoni protein kinase 0.0017 0.0002 0.0007
Echinococcus multilocularis RUN 0.0103 0.0344 0.0344
Trypanosoma brucei metacaspase 5, putative 0.0092 0.0303 1
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0067 0.2209
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0084 0.0269 0.09
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.018 0.018
Loa Loa (eye worm) TK/FER protein kinase 0.0027 0.0042 0.0241
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0318 0.1201 0.6952
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0023 0.0077
Schistosoma mansoni hypothetical protein 0.0356 0.1353 0.471
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0185 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0303 0.1283
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0153 0.0511
Echinococcus multilocularis caspase 2 0.0178 0.0645 0.0645
Schistosoma mansoni tyrosine kinase 0.0027 0.0042 0.0145
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0027 0.0042 0.0042
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.018 0.0626
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0084 0.0269 0.8868
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0155 0.052
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0005 0.018
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0005 0.018
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0084 0.0269 0.0269
Leishmania major metacaspase, putative 0.0092 0.0303 1
Brugia malayi jmjC domain containing protein 0.0033 0.0067 0.0388
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0067 0.0224
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0005 0.018
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0051 0.0137 0.0442
Toxoplasma gondii thioredoxin reductase 0.0051 0.0137 0.4523
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0005 0.0023
Echinococcus granulosus geminin 0.0356 0.1353 0.4534
Loa Loa (eye worm) hypothetical protein 0.0311 0.1176 0.6808
Plasmodium falciparum thioredoxin reductase 0.0051 0.0137 0.3982
Brugia malayi hypothetical protein 0.0103 0.0344 0.1992
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0133
Brugia malayi hypothetical protein 0.0027 0.0042 0.0241
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0084 0.0269 0.0883
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0027 0.0042 0.0139
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0032 0.1049
Echinococcus granulosus phd:f box containing protein 0.0033 0.0067 0.0224
Loa Loa (eye worm) hypothetical protein 0.0053 0.0146 0.0847
Leishmania major hypothetical protein, conserved 0.0053 0.0147 0.4839
Brugia malayi jmjC domain containing protein 0.0033 0.0067 0.0388
Trypanosoma brucei protein kinase, putative 0.0017 0.0002 0.0065
Echinococcus multilocularis apoptotic protease activating factor 1 0.0086 0.0278 0.0278
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0153 0.5039
Plasmodium falciparum metacaspase-like protein 0.0092 0.0303 0.8804
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0092 0.0303 0.1283
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0092 0.0303 0.1283
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0067 0.0067
Trichomonas vaginalis conserved hypothetical protein 0.0092 0.0303 0.1283
Loa Loa (eye worm) hypothetical protein 0.0086 0.0278 0.1608
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0027 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0048 0.0129 0.0745
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0129 0.0129
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0609 0.2362 1
Brugia malayi Doublecortin family protein 0.0103 0.0344 0.1992
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0185 0.0603
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0027 0.0042 0.0139
Loa Loa (eye worm) glutathione reductase 0.0051 0.0137 0.0793
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0005 0.0159
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0067 0.0388
Echinococcus granulosus tyrosine protein kinase Fyn 0.0027 0.0042 0.0139
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0027 0.0042 0.0139
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0005 0.018
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0023 0.0133
Loa Loa (eye worm) jmjC domain-containing protein 0.0125 0.0434 0.2515
Brugia malayi hypothetical protein 0.0053 0.0147 0.0849
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0029 0.005 0.0191
Trypanosoma brucei metacaspase 0.0092 0.0303 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0344 0.1992
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0067 0.0233
Brugia malayi Protein kinase domain containing protein 0.0027 0.0042 0.0241
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0155 0.0899
Echinococcus multilocularis muscleblind protein 1 0.0311 0.1176 0.1176
Echinococcus granulosus tumor protein p63 0.0361 0.1374 0.4604
Loa Loa (eye worm) thioredoxin reductase 0.0051 0.0137 0.0793
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0005 0.018
Entamoeba histolytica Ran family GTPase 0.0022 0.0023 0.0097
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0005 0.0032
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0185 0.6114
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0067 0.0067
Schistosoma mansoni jumonji/arid domain-containing protein 0.0125 0.0434 0.1512
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0129 0.0745
Echinococcus granulosus tyrosine protein kinase Src64B 0.0027 0.0042 0.0139
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0005 0.0023
Schistosoma mansoni caspase-7 (C14 family) 0.0178 0.0645 0.2244
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0067 0.0067
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0765 0.2985 1

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 9 % Inhibition of thymidine phosphorylase in T cell lymphomas of Sprague-Dawley rat assessed as residual activity at 10 uM in presence of 100 uM thymidine and 200 uM phosphate ChEMBL. 20053558
IC50 (binding) = 190 nM Inhibition of thymidine phosphorylase in T cell lymphomas of Sprague-Dawley rat in presence of 100 uM thymidine and 200 uM phosphate ChEMBL. 20053558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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