Detailed information for compound 1093132

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 249.306 | Formula: C14H19NO3
  • H donors: 2 H acceptors: 3 LogP: 2.51 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC(=O)NCC(=O)c1ccc(cc1)O
  • InChi: 1S/C14H19NO3/c1-2-3-4-5-14(18)15-10-13(17)11-6-8-12(16)9-7-11/h6-9,16H,2-5,10H2,1H3,(H,15,18)
  • InChiKey: ZEVRIGOUYMJMLE-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0153 0.015
Schistosoma mansoni DNA polymerase eta 0.0019 0.0032 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.013 0.1191
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.013 0.2384
Loa Loa (eye worm) fli-1 protein 0.0248 0.1008 0.1006
Entamoeba histolytica hypothetical protein 0.0123 0.0476 1
Leishmania major trypanothione reductase 0.0047 0.0153 0.2883
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.013 0.2384
Plasmodium vivax sphingomyelin synthase 1, putative 0.0123 0.0476 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.048
Entamoeba histolytica hypothetical protein 0.0123 0.0476 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0119 0.0461 0.0459
Schistosoma mansoni gabp alpha 0.0082 0.03 0.1907
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.054 0.3436
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0107 0.0406 0.2584
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.048
Entamoeba histolytica hypothetical protein 0.0123 0.0476 1
Brugia malayi transcription factor E74 isoform 0.0012 0.0002 0.0001
Brugia malayi hypothetical protein 0.0016 0.0021 0.0019
Echinococcus multilocularis pyruvate kinase 0.0067 0.0238 0.1511
Brugia malayi Bromodomain containing protein 0.0036 0.0106 0.0104
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.013 0.2384
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0175 0.0699 0.7277
Leishmania major pyruvate kinase 0.0067 0.0238 0.475
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0076 0.048
Echinococcus granulosus ETS domain containing protein Elk 1 0.0012 0.0002 0.0016
Plasmodium falciparum phd finger protein, putative 0.0033 0.0091 0.1521
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0557 0.3543
Echinococcus multilocularis GA binding protein alpha chain 0.0082 0.03 0.1907
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.041 0.7712
Toxoplasma gondii pyruvate kinase PyKII 0.0034 0.0099 0.1694
Echinococcus multilocularis PHD finger protein rhinoceros 0.0033 0.0091 0.0577
Echinococcus multilocularis dna polymerase eta 0.0019 0.0032 0.0203
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0476 0.4997
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0002 0.0016
Echinococcus multilocularis peregrin 0.0036 0.0106 0.0671
Echinococcus granulosus GPCR family 2 0.0119 0.0461 0.2932
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0076 0.048
Plasmodium falciparum glutathione reductase 0.0047 0.0153 0.2883
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0309
Echinococcus granulosus pyruvate kinase 0.0034 0.0099 0.0627
Schistosoma mansoni hypothetical protein 0.038 0.1573 1
Brugia malayi jmjC domain containing protein 0.0039 0.012 0.0118
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0091 0.1521
Brugia malayi Fli-1 protein 0.0248 0.1008 0.1007
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0107 0.0406 0.2584
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0145 0.0922
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0032 0.0226
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0022 0.0309
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.0803 0.5107
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0115 0.1875
Echinococcus multilocularis pyruvate kinase 0.0034 0.0099 0.0627
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0813 0.0811
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.0803 0.5107
Echinococcus multilocularis ETS transcription factor Elf 1 0.0012 0.0002 0.0016
Schistosoma mansoni hypothetical protein 0.0258 0.1052 0.6689
Echinococcus multilocularis GPCR, family 2 0.0119 0.0461 0.2932
Loa Loa (eye worm) hypothetical protein 0.007 0.025 0.0247
Plasmodium falciparum thioredoxin reductase 0.0047 0.0153 0.2883
Loa Loa (eye worm) hypothetical protein 0.0123 0.0476 0.0474
Echinococcus granulosus pyruvate kinase 0.0034 0.0099 0.0627
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Mycobacterium ulcerans pyruvate kinase 0.0067 0.0238 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0022 0.5
Brugia malayi glutathione reductase 0.0047 0.0153 0.0151
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0153 0.0971
Brugia malayi Calcitonin receptor-like protein seb-1 0.0378 0.1561 0.156
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0461 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.012 0.0117
Loa Loa (eye worm) pyruvate kinase-PB 0.0047 0.0151 0.0149
Echinococcus multilocularis protein C ets 2 0.0012 0.0002 0.0016
Echinococcus granulosus pyruvate kinase 0.0034 0.0099 0.0627
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0059 0.1106
Giardia lamblia Pyruvate kinase 0.0034 0.0099 0.3566
Brugia malayi Thioredoxin reductase 0.0047 0.0153 0.0151
Brugia malayi pyruvate kinase 0.0014 0.0012 0.001
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.041 0.8837
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.012 0.0763
Echinococcus granulosus sphingomyelin synthase protein 1 0.0123 0.0476 0.3029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.0803 0.5107
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0238 0.1893
Trypanosoma brucei unspecified product 0.0019 0.0032 0.0528
Echinococcus granulosus dna polymerase eta 0.0019 0.0032 0.0203
Loa Loa (eye worm) jmjC domain-containing protein 0.0067 0.0238 0.0236
Brugia malayi PHD-finger family protein 0.0033 0.0091 0.0089
Loa Loa (eye worm) hypothetical protein 0.2358 1 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0461 1
Brugia malayi Ets-domain containing protein 0.0082 0.03 0.0298
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0238 0.1893
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0067 0.0238 0.4918
Trypanosoma brucei pyruvate kinase 1 0.0067 0.0238 0.4912
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.0203
Echinococcus granulosus pyruvate kinase 0.0067 0.0238 0.1511
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0238 0.0235
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0002 0.0016
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0032 0.003
Plasmodium falciparum sphingomyelin synthase 2, putative 0.0123 0.0476 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0099 0.0627
Trypanosoma brucei inositol phosphorylceramide synthase 0.0123 0.0476 1
Plasmodium vivax glutathione reductase, putative 0.0047 0.0153 0.2883
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.002 0.0038 0.0037
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0082 0.03 0.0298
Echinococcus multilocularis pyruvate kinase 0.0053 0.0177 0.1128
Loa Loa (eye worm) acetyltransferase 0.0142 0.0557 0.0555
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0528
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0476 1
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0153 0.2883
Loa Loa (eye worm) hypothetical protein 0.0123 0.0476 0.0474
Brugia malayi hypothetical protein 0.0151 0.0593 0.0592
Echinococcus multilocularis ETS domain containing protein Elk 1 0.0012 0.0002 0.0016
Schistosoma mansoni ets-related 0.0248 0.1008 0.6412
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0076 0.048
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0059 0.0823
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0115 0.2058
Loa Loa (eye worm) hypothetical protein 0.0258 0.1052 0.105
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0059 0.0823
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0032 0.0203
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0119 0.0461 0.2932
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0557 0.0556
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.013 0.1191
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0145 0.0922
Plasmodium vivax sphingomyelin synthase 2, putative 0.0123 0.0476 1
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0476 0.4997
Echinococcus granulosus PHD finger protein rhinoceros 0.0033 0.0091 0.0577
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.012 0.0763
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0071 0.0451
Schistosoma mansoni spingomyelin synthetase-related 0.0123 0.0476 0.3029
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0032 0.0203
Brugia malayi pyruvate kinase, muscle isozyme 0.0014 0.0012 0.001
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0378 0.1561 0.156
Echinococcus multilocularis geminin 0.038 0.1573 1
Onchocerca volvulus Alhambra homolog 0.0033 0.0091 0.0178
Echinococcus granulosus ETS transcription factor Elf 1 0.0012 0.0002 0.0016
Entamoeba histolytica hypothetical membrane-spanning protein 0.0123 0.0476 1
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0238 0.0235
Schistosoma mansoni pyruvate kinase 0.0067 0.0238 0.1511
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0137
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0032 0.0226
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0076 0.048
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0003 0.0001
Entamoeba histolytica hypothetical protein 0.0123 0.0476 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0238 0.0235
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.0803 0.5107
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0012 0.0002 0.0012
Plasmodium vivax pyruvate kinase 2, putative 0.0034 0.0099 0.1694
Echinococcus granulosus ETS transcription factor Elf 5 0.0012 0.0002 0.0016
Toxoplasma gondii thioredoxin reductase 0.0047 0.0153 0.2883
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0032 0.003
Brugia malayi DNA-binding protein D-ETS-3 0.0012 0.0002 0.0001
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.041 0.8837
Schistosoma mansoni ets 0.0012 0.0002 0.0016
Treponema pallidum NADH oxidase 0.0016 0.0022 0.5
Trypanosoma cruzi sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0476 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0032 0.0528
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0476 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0309
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.02 0.0803 0.5107
Echinococcus granulosus dna polymerase kappa 0.0019 0.0032 0.0203
Mycobacterium tuberculosis Probable reductase 0.0107 0.041 0.8837
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.02 0.0803 0.0801
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0153 0.2883
Schistosoma mansoni pyruvate kinase 0.0067 0.0238 0.1511
Echinococcus multilocularis ewsr:fli fusion protein type 0.0012 0.0002 0.0016
Brugia malayi Pyruvate kinase, M2 isozyme 0.0067 0.0238 0.0236
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.0823
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.02 0.0803 0.5107
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0238 0.475
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0032 0.0203
Giardia lamblia DINP protein human, muc B family 0.0019 0.0032 0.0476
Trypanosoma brucei ceramide phosphorylethanolamine synthase 0.0123 0.0476 1
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0123 0.0476 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0461 1
Echinococcus multilocularis pyruvate kinase 0.0067 0.0238 0.1511
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0003 0.0001
Echinococcus granulosus ETS transcription factor Elf 2 0.0012 0.0002 0.0016
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 1 0.0123 0.0476 0.0475
Onchocerca volvulus Pyruvate kinase homolog 0.0067 0.0238 0.1893
Onchocerca volvulus 0.0151 0.0593 0.6047
Trypanosoma cruzi pyruvate kinase 2, putative 0.0067 0.0238 0.475
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0076 0.1186
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0137
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0476 0.4997
Schistosoma mansoni hypothetical protein 0.0119 0.0461 0.2932
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0123 0.0476 0.3029
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0032 0.0113
Echinococcus multilocularis pyruvate kinase 0.0034 0.0099 0.0627
Brugia malayi Ets-domain containing protein 0.0012 0.0002 0.0001
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0119 0.0461 0.2932
Chlamydia trachomatis pyruvate kinase 0.0067 0.0238 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.041 0.8837
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0032 0.0476
Echinococcus granulosus GA binding protein alpha chain 0.0082 0.03 0.1907
Plasmodium vivax SET domain protein, putative 0.0029 0.0076 0.1186
Giardia lamblia PHD finger protein 15 0.0033 0.0091 0.3202
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0123 0.0476 0.0475
Loa Loa (eye worm) hypothetical protein 0.0123 0.0476 0.0474
Brugia malayi Pyruvate kinase, muscle isozyme 0.0067 0.0238 0.0236
Brugia malayi Latrophilin receptor protein 2 0.0119 0.0461 0.0459
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0115 0.4333
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 3 0.0123 0.0476 0.0475
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.041 0.8837
Loa Loa (eye worm) hypothetical protein 0.0175 0.0699 0.0696
Echinococcus granulosus pyruvate kinase 0.0067 0.0238 0.1511
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0226
Toxoplasma gondii PHD-finger domain-containing protein 0.0033 0.0091 0.1521
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0238 0.2374
Schistosoma mansoni jumonji domain containing protein 0.0085 0.0313 0.199
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0022 0.0137
Schistosoma mansoni hypothetical protein 0.0119 0.0461 0.2932
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0226
Loa Loa (eye worm) latrophilin receptor protein 2 0.0119 0.0461 0.0459
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0022 0.0309
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0032 0.0234
Loa Loa (eye worm) glutathione reductase 0.0047 0.0153 0.015
Plasmodium falciparum sphingomyelin synthase 1, putative 0.0123 0.0476 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Leishmania major DNA polymerase kappa, putative 0.0019 0.0032 0.0226
Brugia malayi Sphingomyelin synthase-related 1 0.0123 0.0476 0.0475
Trypanosoma brucei sphingomyelin/ceramide phosphorylethanolamine synthase, bifunctional 0.0123 0.0476 1
Brugia malayi latrophilin 2 splice variant baaae 0.0258 0.1052 0.105
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0153 0.2985
Loa Loa (eye worm) hypothetical protein 0.0378 0.1561 0.1559
Trichomonas vaginalis pyruvate kinase, putative 0.0067 0.0238 0.2374
Plasmodium vivax pyruvate kinase, putative 0.0067 0.0238 0.475
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0091 0.1521
Echinococcus multilocularis ETS transcription factor Elf 2 0.0012 0.0002 0.0016
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0022 0.5
Trypanosoma brucei trypanothione reductase 0.0047 0.0153 0.3103
Leishmania major DNA polymerase eta, putative 0.0019 0.0032 0.0226
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0022 0.002
Toxoplasma gondii pyruvate kinase PyK1 0.0067 0.0238 0.475
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Loa Loa (eye worm) pyruvate kinase 0.0014 0.0012 0.001
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0012 0.0002 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0076 0.048
Echinococcus granulosus geminin 0.038 0.1573 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Loa Loa (eye worm) hypothetical protein 0.0033 0.0091 0.0088
Loa Loa (eye worm) PHD-finger family protein 0.0033 0.0091 0.0088
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0119 0.0461 0.2932
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.012 0.0763
Brugia malayi jmjC domain containing protein 0.0107 0.0406 0.0405
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0032 0.0113
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0016
Brugia malayi Pre-SET motif family protein 0.0202 0.0813 0.0811
Giardia lamblia Pyruvate kinase 0.0067 0.0238 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0153 0.0971
Schistosoma mansoni hypothetical protein 0.0119 0.0461 0.2932
Schistosoma mansoni hypothetical protein 0.0119 0.0461 0.2932
Echinococcus granulosus protein C ets 2 0.0012 0.0002 0.0016
Loa Loa (eye worm) pyruvate kinase 0.0067 0.0238 0.0235
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0032 0.0029
Entamoeba histolytica pyruvate kinase, putative 0.0047 0.0151 0.2685
Loa Loa (eye worm) hypothetical protein 0.0151 0.0593 0.0591
Schistosoma mansoni pyruvate kinase 0.0034 0.0099 0.0627
Brugia malayi hypothetical protein 0.0025 0.0059 0.0057
Echinococcus multilocularis ets variant gene 4 0.0012 0.0002 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0226
Schistosoma mansoni hypothetical protein 0.0033 0.0091 0.0577
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.013 0.0827
Loa Loa (eye worm) hypothetical protein 0.0056 0.019 0.0187
Trypanosoma brucei pyruvate kinase 1, putative 0.0067 0.0238 0.4912
Loa Loa (eye worm) hypothetical protein 0.0047 0.0151 0.0149
Leishmania major hypothetical protein, conserved 0.0025 0.0059 0.0823
Loa Loa (eye worm) hypothetical protein 0.0119 0.0461 0.0459
Leishmania major phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0123 0.0476 1
Brugia malayi Pre-SET motif family protein 0.0029 0.0076 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Echinococcus granulosus peregrin 0.0036 0.0106 0.0671
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0557 0.3543
Schistosoma mansoni elf1 0.0012 0.0002 0.0016
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0059 0.0823
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.041 0.8837
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0461 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0033 0.0091 0.0577
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.02 0.0803 0.0801
Loa Loa (eye worm) hypothetical protein 0.0019 0.0032 0.0029
Toxoplasma gondii hypothetical protein 0.0123 0.0476 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0059 0.0057
Echinococcus granulosus ewsr:fli fusion protein type 0.0012 0.0002 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0123 0.0476 0.4997
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0823
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.02 0.0803 0.5107
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.012 0.0763
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0528
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0119 0.0461 0.2932
Brugia malayi Phosphatidylcholine:ceramide cholinephosphotransferase 2 0.0123 0.0476 0.0475
Trichomonas vaginalis set domain proteins, putative 0.023 0.0932 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0378 0.1561 0.1559
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0032 0.0226
Schistosoma mansoni ets-related 0.0012 0.0002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0123 0.0476 0.0474
Plasmodium falciparum pyruvate kinase 2 0.0034 0.0099 0.1694
Brugia malayi N-terminal motif family protein 0.0175 0.0699 0.0697
Brugia malayi Ets-domain containing protein 0.0082 0.03 0.0298
Echinococcus multilocularis ETS transcription factor Elf 5 0.0012 0.0002 0.0016
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0032 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Plasmodium falciparum pyruvate kinase 0.0067 0.0238 0.475
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0032 0.0528
Loa Loa (eye worm) hypothetical protein 0.0029 0.0076 0.0073
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0032 0.0476
Leishmania major pyruvate kinase 0.0067 0.0238 0.475
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0032 0.0528
Schistosoma mansoni hypothetical protein 0.0012 0.0002 0.0016
Entamoeba histolytica hypothetical protein 0.0123 0.0476 1
Schistosoma mansoni hypothetical protein 0.038 0.1573 1
Onchocerca volvulus 0.023 0.0932 1
Loa Loa (eye worm) hypothetical protein 0.0123 0.0476 0.0474
Trichomonas vaginalis hypothetical protein 0.0123 0.0476 0.4997
Trichomonas vaginalis sphingomyelin synthetase, putative 0.0123 0.0476 0.4997
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0032 0.0203
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0059 0.0823

Activities

Activity type Activity value Assay description Source Reference
GI (functional) Antimicrobial activity against Candida albicans at 100 ug/mL after 24 hrs by serial dilution method ChEMBL. 21591808
GI (functional) Antimicrobial activity against Escherichia coli at 100 ug/mL after 24 hrs by serial dilution method ChEMBL. 21591808

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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