TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 319.251 | Formula: C11H18N3O6P
H donors: 4 H acceptors: 6 LogP: -4.81 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@H]1C[C@@H](CN1CP(=O)(O)O)n1cc(C)c(=O)[nH]c1=O
InChi: 1S/C11H18N3O6P/c1-7-3-14(11(17)12-10(7)16)8-2-9(5-15)13(4-8)6-21(18,19)20/h3,8-9,15H,2,4-6H2,1H3,(H,12,16,17)(H2,18,19,20)/t8-,9+/m0/s1
InChiKey: BCVVBNIZARFJMT-DTWKUNHWSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Rattus norvegicus	Thymidine phosphorylase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Echinococcus granulosus	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Mycobacterium ulcerans	thymidine phosphorylase	Get druggable targets OG5_131632	All targets in OG5_131632
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	Get druggable targets OG5_131632	All targets in OG5_131632

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	thymidine phosphorylase	0.0765	0.8893	0.8887
Loa Loa (eye worm)	hypothetical protein	0.011	0.1116	0.1958
Loa Loa (eye worm)	hypothetical protein	0.011	0.1116	0.1958
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.011	0.1116	0.1062
Loa Loa (eye worm)	hypothetical protein	0.011	0.1116	0.1958
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0021	0.006	0.0109
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.011	0.1116	0.2024
Brugia malayi	conserved hypotetical protein	0.0052	0.0427	0.0774
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0052	0.0427	0.0369
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.011	0.1116	0.1195
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.011	0.1116	0.2024
Mycobacterium tuberculosis	Probable anthranilate phosphoribosyltransferase TrpD	0.0216	0.2375	0.2644
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0501	0.0833
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.011	0.1116	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0124	0.2077
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0103	0.4632
Echinococcus granulosus	neuropeptide receptor A26	0.049	0.5622	0.6296
Onchocerca volvulus		0.011	0.1116	0.6138
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0058	0.0501	0.0498
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0124	0.0144
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.1416	0.7485
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0124	0.0144
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0051	0.0417	0.0681
Echinococcus multilocularis	neuropeptide receptor A26	0.049	0.5622	0.5595
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.1543	0.8188
Echinococcus granulosus	GPCR family 2	0.0051	0.0417	0.0404
Schistosoma mansoni	nuclear hormone receptor	0.0052	0.0427	0.2024
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0052	0.0427	0.0369
Loa Loa (eye worm)	hypothetical protein	0.011	0.112	0.1966
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0146	0.1543	0.274
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.011	0.1116	0.1958
Echinococcus granulosus	FTZ F1 alpha	0.011	0.1116	0.1195
Mycobacterium ulcerans	anthranilate phosphoribosyltransferase	0.0216	0.2375	0.2633
Onchocerca volvulus		0.0163	0.174	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0124	0.0225
Echinococcus multilocularis	FTZ F1 alpha	0.011	0.1116	0.1062
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.011	0.1116	0.1062
Schistosoma mansoni	nuclear receptor	0.0052	0.0427	0.2024
Loa Loa (eye worm)	steroid hormone receptor	0.011	0.1116	0.1958
Toxoplasma gondii	FATC domain-containing protein	0.0029	0.0153	0.26
Brugia malayi	hypothetical protein	0.0052	0.0427	0.0774
Loa Loa (eye worm)	hypothetical protein	0.011	0.1116	0.1958
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0161	0.1726	0.3073
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0021	0.0061	0.0076
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0124	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.1543	0.8188
Echinococcus multilocularis	survival motor neuron protein 1	0.0481	0.5513	0.5486
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0169	0.1814	0.1985
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0417	0.0681
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.011	0.1116	0.2024
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0052	0.0427	0.0774
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.011	0.1116	0.5828
Echinococcus multilocularis	thyroid hormone receptor alpha	0.011	0.1116	0.1062
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0052	0.0427	0.2024
Schistosoma mansoni	retinoic acid receptor RXR	0.011	0.1116	0.5828
Onchocerca volvulus	Bile acid receptor homolog	0.011	0.1116	0.6138
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0135	0.1416	0.2507
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0051	0.0417	0.0359
Brugia malayi	hypothetical protein	0.0052	0.0427	0.0774
Echinococcus granulosus	neuropeptide s receptor	0.049	0.5622	0.6296
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0103	0.0107
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0124	1
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0051	0.0417	1
Brugia malayi	hypothetical protein	0.0058	0.0501	0.0908
Brugia malayi	nuclear hormone receptor family member odr-7	0.0052	0.0427	0.0774
Brugia malayi	RNA recognition motif domain containing protein	0.0135	0.1416	0.2568
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.1543	0.1492
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0052	0.0427	0.0415
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.011	0.1116	0.1195
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0124	0.0089
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0103	0.1564
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0021	0.0061	0.0052
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0161	0.1726	0.313
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.011	0.1116	0.2024
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0029	0.0153	0.0513
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.011	0.1116	0.5828
Echinococcus granulosus	serine protein kinase ATM	0.0029	0.0153	0.0105
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0052	0.0427	0.1874
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Schistosoma mansoni	nuclear hormone receptor	0.0052	0.0427	0.2024
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0052	0.0427	0.0415
Schistosoma mansoni	thyroid hormone receptor	0.011	0.1116	0.5828
Brugia malayi	Nuclear hormone receptor E75	0.0052	0.0427	0.0774
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.1416	0.7485
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0029	0.0153	0.26
Entamoeba histolytica	hypothetical protein	0.0029	0.0153	0.3028
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0029	0.0153	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0124	0.2077
Schistosoma mansoni	hypothetical protein	0.0051	0.0417	0.1971
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0161	0.1726	0.313
Loa Loa (eye worm)	hypothetical protein	0.011	0.1116	0.1958
Brugia malayi	nuclear receptor NHR-88	0.0052	0.0427	0.0774
Schistosoma mansoni	hypothetical protein	0.0098	0.0975	0.5049
Loa Loa (eye worm)	hypothetical protein	0.0163	0.174	0.3099
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.011	0.1116	0.1062
Loa Loa (eye worm)	TAR-binding protein	0.0135	0.1416	0.2507
Schistosoma mansoni	steroid hormone receptor ad4bp	0.011	0.1116	0.5828
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.011	0.1116	0.5828
Echinococcus multilocularis	GPCR, family 2	0.0051	0.0417	0.0359
Echinococcus multilocularis	neuropeptide s receptor	0.049	0.5622	0.5595
Mycobacterium leprae	Probable anthranilate phosphoribosyltransferase TrpD	0.0216	0.2375	1
Schistosoma mansoni	coup transcription factor	0.011	0.1116	0.5828
Brugia malayi	hypothetical protein	0.0481	0.5513	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.011	0.1116	0.1062
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0501	0.0833
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.011	0.1116	0.1062
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0.0124	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0417	0.1971
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.011	0.1116	0.2024
Loa Loa (eye worm)	hypothetical protein	0.0481	0.5513	1
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Brugia malayi	nuclear receptor NHR-67	0.0052	0.0427	0.0774
Schistosoma mansoni	hypothetical protein	0.0051	0.0417	0.1971
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.011	0.1116	0.2024
Brugia malayi	ecdysone receptor	0.0052	0.0427	0.0774
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.011	0.1116	0.2024
Loa Loa (eye worm)	hypothetical protein	0.011	0.1116	0.1958
Brugia malayi	ecdysteroid receptor	0.011	0.1116	0.2024
Plasmodium falciparum	histone acetyltransferase GCN5	0.0047	0.0367	1
Brugia malayi	steroid hormone receptor	0.011	0.1116	0.2024
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0051	0.0417	0.0404
Echinococcus granulosus	nuclear receptor nhr 48	0.0052	0.0427	0.0415
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.011	0.1116	0.1195
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0124	0.2077
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0058	0.0501	0.2431
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0051	0.0417	0.0757
Brugia malayi	acetyltransferase, GNAT family protein	0.0174	0.1872	0.3394
Leishmania major	hypothetical protein, conserved	0.0025	0.0103	0.6751
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0058	0.0501	0.0443
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0051	0.0417	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.011	0.1116	0.6138
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.011	0.1116	0.2024
Brugia malayi	Latrophilin receptor protein 2	0.0051	0.0417	0.0757
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0174	0.1872	1
Schistosoma mansoni	hypothetical protein	0.0051	0.0417	0.1971
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0146	0.1543	0.2799
Loa Loa (eye worm)	phosphatidylinositol 3	0.0021	0.006	0.0028
Brugia malayi	hypothetical protein	0.0163	0.174	0.3156
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.011	0.1116	0.1958
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.011	0.1116	0.5828
Echinococcus multilocularis	serine protein kinase ATM	0.0029	0.0153	0.0093
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.011	0.1116	0.1062
Brugia malayi	orphan nuclear receptor NR2E1	0.0052	0.0427	0.0774
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0058	0.0501	0.0833
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.1416	0.7485
Loa Loa (eye worm)	RNA binding protein	0.0135	0.1416	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0052	0.0427	0.2024
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0052	0.0427	0.0774
Echinococcus granulosus	thyroid hormone receptor alpha	0.0052	0.0427	0.0415
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.011	0.1116	0.2024
Schistosoma mansoni	zinc finger protein	0.0052	0.0427	0.2024
Schistosoma mansoni	thyroid hormone receptor	0.011	0.1116	0.5828
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0029	0.0153	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0103	0.1204
Mycobacterium tuberculosis	Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase)	0.0765	0.8893	1
Echinococcus granulosus	thymidine phosphorylase	0.0765	0.8893	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0052	0.0427	0.0369
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.011	0.1116	0.5828
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0029	0.0153	0.0278
Brugia malayi	Steroid receptor seven-up type 2	0.011	0.1116	0.2024
Echinococcus multilocularis	nuclear receptor nhr 48	0.0052	0.0427	0.0369
Brugia malayi	TAR-binding protein	0.0135	0.1416	0.2568
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0105	0.011
Brugia malayi	nuclear hormone receptor	0.011	0.1116	0.2024
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0103	0.4632
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.1543	0.1679
Brugia malayi	hypothetical protein	0.0025	0.0103	0.0187
Brugia malayi	Nuclear hormone receptor-like 1	0.0058	0.0501	0.0908
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0052	0.0427	0.0369
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0051	0.0417	0.0404
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0052	0.0427	0.0369
Onchocerca volvulus		0.0052	0.0427	0.1874
Echinococcus granulosus	survival motor neuron protein 1	0.0481	0.5513	0.6173
Schistosoma mansoni	nuclear hormone receptor	0.011	0.1116	0.5828
Onchocerca volvulus		0.0052	0.0427	0.1874
Brugia malayi	latrophilin 2 splice variant baaae	0.011	0.112	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0501	0.0833
Schistosoma mansoni	survival motor neuron protein	0.0098	0.0975	0.5049
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Entamoeba histolytica	acetyltransferase, GNAT family	0.0047	0.0367	1
Brugia malayi	Nuclear hormone receptor E75	0.0052	0.0427	0.0774
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0124	0.0089
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0026	0.0124	0.0103
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0021	0.006	0.0109
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.011	0.1116	0.1958
Mycobacterium ulcerans	thymidine phosphorylase	0.0765	0.8893	1
Schistosoma mansoni	hypothetical protein	0.011	0.112	0.5851
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0124	0.0089
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0146	0.1543	0.8188
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0052	0.0427	0.0415
Brugia malayi	RNA binding protein	0.0135	0.1416	0.2568
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0051	0.0417	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0124	0.0089
Brugia malayi	nuclear receptor RXR	0.0052	0.0427	0.0774
Brugia malayi	Nuclear hormone receptor-like 1	0.011	0.1116	0.2024
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.011	0.1116	0.1958
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0103	0.1809
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.011	0.1116	0.2024
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.011	0.1116	0.1195
Brugia malayi	tailless protein	0.0052	0.0427	0.0774
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0124	0.0089
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0051	0.0417	1
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.011	0.1116	0.5828
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1726	0.3073
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.011	0.1116	0.2024
Brugia malayi	Nuclear hormone receptor-like 1	0.0058	0.0501	0.0908
Loa Loa (eye worm)	acetyltransferase	0.0174	0.1872	0.334
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.011	0.1116	0.6138
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0098	0.0975	0.1768
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Echinococcus granulosus	tar DNA binding protein	0.0135	0.1416	0.1535
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Brugia malayi	nuclear receptor RXR	0.0058	0.0501	0.0908
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0051	0.0417	1
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.1416	0.7485
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0124	0.0225
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0103	0.4632
Brugia malayi	nuclear hormone receptor	0.0052	0.0427	0.0774
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.011	0.1116	0.1958
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0052	0.0427	0.0698
Loa Loa (eye worm)	DR-78	0.0052	0.0427	0.0698
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.002	0.0045	0.0014
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0103	0.1809
Brugia malayi	hypothetical protein	0.0058	0.0501	0.0908
Schistosoma mansoni	nuclear receptor nhr-48	0.0052	0.0427	0.2024
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0052	0.0427	0.0415
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0051	0.0417	0.0404
Brugia malayi	nuclear receptor NHR-88	0.011	0.1116	0.2024
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0052	0.0427	0.1874
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0124	0.0089
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0124	0.0089
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.011	0.1116	0.1195
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0501	0.0833
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0124	0.0089
Chlamydia trachomatis	acylglycerophosphoethanolamine acyltransferase	0.002	0.0045	0.5
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0058	0.0501	0.2431
Schistosoma mansoni	nuclear receptor	0.0052	0.0427	0.2024
Brugia malayi	photoreceptor-specific nuclear receptor	0.011	0.1116	0.2024
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.011	0.1116	0.1195
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.011	0.1116	0.2024
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0146	0.1543	0.1679
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0427	0.0698
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.011	0.1116	0.1958
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0026	0.0124	0.0103
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.011	0.1116	0.1195
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0501	0.0833
Loa Loa (eye worm)	phosphatidylinositol 3	0.0021	0.006	0.0028
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.011	0.1116	0.1062
Echinococcus multilocularis	tar DNA binding protein	0.0135	0.1416	0.1364
Giardia lamblia	Histone acetyltransferase GCN5	0.0047	0.0367	1
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0124	0.0225
Schistosoma mansoni	tar DNA-binding protein	0.0135	0.1416	0.7485
Loa Loa (eye worm)	hypothetical protein	0.011	0.1116	0.1958
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0174	0.1872	0.1822
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0025	0.0105	0.4849
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0124	0.0144
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0146	0.1543	0.1492
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.011	0.1116	0.1958
Loa Loa (eye worm)	nuclear hormone receptor	0.0052	0.0427	0.0698
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0051	0.0417	0.0359
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0052	0.0427	0.0698
Loa Loa (eye worm)	hypothetical protein	0.011	0.1116	0.1958
Echinococcus granulosus	ecdysone induced protein 78C	0.011	0.1116	0.1195
Onchocerca volvulus		0.0098	0.0975	0.5264
Schistosoma mansoni	RAR-like nuclear receptor	0.011	0.1116	0.5828

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (binding)	= 0 %	Inhibition of thymidine phosphorylase in T cell lymphomas of Sprague-Dawley rat assessed as residual activity at 10 uM in presence of 100 uM thymidine and 200 uM phosphate	ChEMBL.	20053558
IC50 (binding)	= 250 nM	Inhibition of thymidine phosphorylase in T cell lymphomas of Sprague-Dawley rat in presence of 100 uM thymidine and 200 uM phosphate	ChEMBL.	20053558

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL599544

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1096311