Detailed information for compound 1097795

Basic information

Technical information
  • TDR Targets ID: 1097795
  • Name: 2-[(5-amino-2-phenyl-1,2,4-triazol-3-yl)sulfa nyl]-N-methyl-N-phenylacetamide
  • MW: 339.415 | Formula: C17H17N5OS
  • H donors: 1 H acceptors: 3 LogP: 3.25 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Nc1nc(n(n1)c1ccccc1)SCC(=O)N(c1ccccc1)C
  • InChi: 1S/C17H17N5OS/c1-21(13-8-4-2-5-9-13)15(23)12-24-17-19-16(18)20-22(17)14-10-6-3-7-11-14/h2-11H,12H2,1H3,(H2,18,20)
  • InChiKey: PLAZEIXTUPQVGE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[(5-amino-2-phenyl-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-N-phenyl-acetamide
  • 2-[(5-amino-2-phenyl-1,2,4-triazol-3-yl)thio]-N-methyl-N-phenylacetamide
  • 2-[(5-amino-2-phenyl-1,2,4-triazol-3-yl)thio]-N-methyl-N-phenyl-acetamide
  • 2-[(5-amino-2-phenyl-1,2,4-triazol-3-yl)sulfanyl]-N-methyl-N-phenyl-ethanamide
  • MLS000119187
  • A3316/0140990
  • SMR000096116
  • IDI1_004057
  • ZINC00111440
  • ChemDiv2_005342
  • Acetamide, 2-(5-amino-2-phenyl-2H-[1,2,4]triazol-3-ylsulfanyl)-N-methyl-N-phenyl-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0166 0.115 0.1353
Plasmodium vivax methionine aminopeptidase 1a, putative 0.1114 0.8416 0.8414
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0252 0.0252
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Toxoplasma gondii histone deacetylase HDAC2 0.0062 0.0352 0.0339
Giardia lamblia Methionine aminopeptidase 0.0141 0.0956 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0308 0.0296
Loa Loa (eye worm) initiation factor 2-associated protein 0.0141 0.0956 0.0945
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.1114 0.8416 1
Trypanosoma brucei methionine aminopeptidase, putative 0.1321 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.1461 0.145
Toxoplasma gondii transcriptional elongation factor FACT140 0.0141 0.0956 0.0945
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0067 0.0054
Toxoplasma gondii peptidase D, putative 0.0141 0.0956 0.0945
Trichomonas vaginalis set domain proteins, putative 0.0232 0.1656 1
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.1321 1 1
Echinococcus granulosus methionine aminopeptidase type I 0.0141 0.0956 0.0945
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0102 0.0089
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0067 0.0054
Echinococcus granulosus geminin 0.0166 0.115 0.1138
Trypanosoma brucei histone deacetylase 1 0.0062 0.0352 0.0339
Schistosoma mansoni hypothetical protein 0.0166 0.115 0.1353
Mycobacterium ulcerans dipeptidase PepE 0.0141 0.0956 0.0799
Loa Loa (eye worm) hypothetical protein 0.0033 0.0134 0.0121
Plasmodium falciparum methionine aminopeptidase 1c, putative 0.0141 0.0956 0.0945
Leishmania major histone deacetylase, putative 0.0062 0.0352 0.0339
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0025 0.0067 0.0054
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0094 0.0081
Schistosoma mansoni aminopeptidase P homologue (M24 family) 0.0141 0.0956 0.1123
Echinococcus granulosus xaa pro aminopeptidase 0.0141 0.0956 0.0945
Brugia malayi hypothetical protein 0.0025 0.0067 0.0067
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Onchocerca volvulus FACT complex subunit SPT16 homolog 0.0141 0.0956 0.5742
Brugia malayi Histone deacetylase family protein 0.0018 0.0013 0.0013
Echinococcus multilocularis methionine aminopeptidase, type I 0.0141 0.0956 0.0945
Leishmania major methionine aminopeptidase 2, putative 0.0141 0.0956 0.0945
Echinococcus granulosus histone deacetylase 1 0.0062 0.0352 0.0339
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.2021 0.2011
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0352 0.0339
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0279 0.0267
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.1114 0.8416 1
Schistosoma mansoni hypothetical protein 0.0033 0.0134 0.0144
Brugia malayi Histone deacetylase 1 0.0062 0.0352 0.0352
Plasmodium falciparum histone deacetylase 1 0.0062 0.0352 0.0339
Plasmodium vivax methionine aminopeptidase 1b, putative 0.1321 1 1
Plasmodium falciparum proliferation-associated protein 2g4, putative 0.0141 0.0956 0.0945
Echinococcus granulosus xaa Pro dipeptidase 0.0141 0.0956 0.0945
Leishmania major aminopeptidase P, putative,metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Treponema pallidum methionine aminopeptidase (map) 0.1114 0.8416 1
Onchocerca volvulus 0.0141 0.0956 0.5742
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.1114 0.8416 1
Plasmodium vivax methionine aminopeptidase 1c, putative 0.0141 0.0956 0.0945
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Onchocerca volvulus Dipeptidase C homolog 0.0141 0.0956 0.5742
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0102 0.0106
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0141 0.0956 0.0945
Echinococcus multilocularis xaa pro aminopeptidase 0.0141 0.0956 0.0945
Giardia lamblia Xaa-Pro dipeptidase 0.0141 0.0956 1
Echinococcus multilocularis histone deacetylase 1 0.0062 0.0352 0.0339
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1321 1 1
Mycobacterium ulcerans dipeptidase 0.0141 0.0956 0.0799
Plasmodium vivax histone deacetylase 1, putative 0.0062 0.0352 0.0339
Schistosoma mansoni histone deacetylase 0.0062 0.0352 0.0403
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0067 0.0054
Chlamydia trachomatis methionine aminopeptidase 0.1114 0.8416 1
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0067 0.0054
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.1321 1 1
Toxoplasma gondii methionine aminopeptidase 0.1114 0.8416 0.8414
Leishmania major hypothetical protein, conserved 0.0141 0.0956 0.0945
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.1321 1 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.1114 0.8416 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0102 0.0106
Schistosoma mansoni histone deacetylase 0.0062 0.0352 0.0403
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.1114 0.8416 0.8414
Plasmodium falciparum FACT complex subunit SPT16, putative 0.0141 0.0956 0.0945
Entamoeba histolytica hypothetical protein, conserved 0.0141 0.0956 1
Schistosoma mansoni aminopeptidase P1 (M24 family) 0.0141 0.0956 0.1123
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Giardia lamblia Xaa-Pro dipeptidase 0.0141 0.0956 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Brugia malayi Pre-SET motif family protein 0.0204 0.144 0.144
Entamoeba histolytica methionine aminopeptidase, putative 0.0141 0.0956 1
Mycobacterium ulcerans methionine aminopeptidase MapB 0.1114 0.8416 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0141 0.0956 0.0945
Brugia malayi histone deacetylase 1 (HD1) 0.0062 0.0352 0.0352
Brugia malayi DNA-binding protein, 42 kDa containing protein 0.0141 0.0956 0.0956
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Trypanosoma cruzi Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative 0.0141 0.0956 0.0945
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0102 0.0106
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.1114 0.8416 0.8414
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.0308 0.0352
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0102 0.0089
Entamoeba histolytica Xaa-Pro dipeptidase, putative 0.0141 0.0956 1
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24, putative 0.0141 0.0956 0.0945
Schistosoma mansoni methionyl aminopeptidase 2 (M24 family) 0.0141 0.0956 0.1123
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Toxoplasma gondii histone deacetylase HDAC3 0.0062 0.0352 0.0339
Toxoplasma gondii hypothetical protein 0.0207 0.1461 0.145
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.1321 1 1
Entamoeba histolytica peptidase, putative 0.0141 0.0956 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0134 0.0134
Brugia malayi metallopeptidase family M24 containing protein 0.0141 0.0956 0.0956
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0141 0.0956 0.1123
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0308 0.0308
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.1321 1 1
Plasmodium vivax proliferation-associated protein 2g4, putative 0.0141 0.0956 0.0945
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.1114 0.8416 1
Loa Loa (eye worm) histone deacetylase 3 0.0062 0.0352 0.0339
Plasmodium vivax hypothetical protein, conserved 0.0207 0.1461 0.145
Toxoplasma gondii creatinase domain-containing protein 0.0141 0.0956 0.0945
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Entamoeba histolytica aminopeptidase, putative 0.0141 0.0956 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.0308 0.0296
Echinococcus granulosus histone deacetylase 3 0.0062 0.0352 0.0339
Echinococcus granulosus xaa Pro dipeptidase 0.0141 0.0956 0.0945
Mycobacterium tuberculosis Probable cytoplasmic peptidase PepQ 0.0141 0.0956 0.0799
Mycobacterium tuberculosis Dipeptidase PepE 0.0141 0.0956 0.0799
Onchocerca volvulus 0.0029 0.0102 0.0541
Schistosoma mansoni proliferation-associated protein 2G4 38kDa (M24 family) 0.0141 0.0956 0.1123
Loa Loa (eye worm) histone deacetylase 1 0.0062 0.0352 0.0339
Leishmania major histone deacetylase, putative 0.0062 0.0352 0.0339
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Toxoplasma gondii methionine aminopeptidase 0.1321 1 1
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.1321 1 1
Echinococcus multilocularis xaa Pro dipeptidase 0.0141 0.0956 0.0945
Mycobacterium ulcerans methionine aminopeptidase 0.1114 0.8416 1
Trypanosoma cruzi hypothetical protein, conserved 0.0207 0.1461 0.145
Loa Loa (eye worm) hypothetical protein 0.0141 0.0956 0.0945
Leishmania major transcription factor-like protein 0.0141 0.0956 0.0945
Plasmodium falciparum HP12 protein homolog, putative 0.0207 0.1461 0.145
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Trypanosoma cruzi aminopeptidase P, putative 0.0141 0.0956 0.0945
Plasmodium falciparum aminopeptidase P 0.0141 0.0956 0.0945
Trypanosoma cruzi aminopeptidase P1, putative 0.0141 0.0956 0.0945
Toxoplasma gondii methionine aminopeptidase 2, putative 0.0141 0.0956 0.0945
Brugia malayi Pre-SET motif family protein 0.0029 0.0102 0.0102
Echinococcus multilocularis Proliferation associated protein 2G4 0.0141 0.0956 0.0945
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.1114 0.8416 1
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.1321 1 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Leishmania major hypothetical protein, conserved 0.0025 0.0067 0.0054
Loa Loa (eye worm) hypothetical protein 0.0049 0.0252 0.0239
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0252 0.0252
Plasmodium vivax SET domain protein, putative 0.0029 0.0102 0.0089
Plasmodium vivax FACT complex subunit SPT16, putative 0.0141 0.0956 0.0945
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0252 0.0239
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.0308 0.0296
Brugia malayi metallopeptidase family M24 containing protein 0.0141 0.0956 0.0956
Echinococcus multilocularis methionyl aminopeptidase 2 0.0141 0.0956 0.0945
Plasmodium vivax methionine aminopeptidase 2, putative 0.0141 0.0956 0.0945
Plasmodium falciparum methionine aminopeptidase 2 0.0141 0.0956 0.0945
Loa Loa (eye worm) metallopeptidase family M24 containing protein 0.0141 0.0956 0.0945
Brugia malayi follicle stimulating hormone receptor 0.028 0.2021 0.2021
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0067 0.0054
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0352 0.0339
Plasmodium vivax peptidase, putative 0.0141 0.0956 0.0945
Schistosoma mansoni chromatin-specific transcription elongation factor 140 kDa subunit (M24 family) 0.0141 0.0956 0.1123
Loa Loa (eye worm) hypothetical protein 0.0141 0.0956 0.0945
Onchocerca volvulus 0.0232 0.1656 1
Trypanosoma brucei Metallopeptidase family M24, putative 0.0141 0.0956 0.0945
Loa Loa (eye worm) DNA-binding protein 0.0141 0.0956 0.0945
Brugia malayi metallopeptidase family M24 containing protein 0.0141 0.0956 0.0956
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.1114 0.8416 1
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Brugia malayi Histone deacetylase family protein 0.0018 0.0013 0.0013
Leishmania major hypothetical protein, conserved 0.0207 0.1461 0.145
Leishmania major aminopeptidase P1, putative,metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Echinococcus granulosus methionyl aminopeptidase 2 0.0141 0.0956 0.0945
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Loa Loa (eye worm) hypothetical protein 0.0062 0.0352 0.0339
Loa Loa (eye worm) methionine aminopeptidase type I 0.1321 1 1
Toxoplasma gondii proliferation-associated protein 2G4, putative 0.0141 0.0956 0.0945
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0102 0.0089
Trypanosoma brucei Facilitates chromatin transcription complex subunit spt16 0.0141 0.0956 0.0945
Echinococcus multilocularis geminin 0.0166 0.115 0.1138
Mycobacterium ulcerans cytoplasmic peptidase PepQ 0.0141 0.0956 0.0799
Schistosoma mansoni peptidase 0.0141 0.0956 0.1123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0102 0.0106
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0794 0.5965 0.5959
Brugia malayi histone deacetylase 3 (HD3) 0.0062 0.0352 0.0352
Echinococcus multilocularis histone deacetylase 3 0.0062 0.0352 0.0339
Brugia malayi histone deacetylase 11 0.0018 0.0013 0.0013
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.144 0.1429
Mycobacterium ulcerans aminopeptidase 0.0141 0.0956 0.0799
Schistosoma mansoni Xaa-Pro dipeptidase (M24 family) 0.0141 0.0956 0.1123
Trypanosoma brucei Xaa-Pro aminopeptidase, putative 0.0141 0.0956 0.0945
Trypanosoma cruzi Metallopeptidase family M24, putative 0.0141 0.0956 0.0945
Trypanosoma brucei hypothetical protein, conserved 0.0207 0.1461 0.145
Loa Loa (eye worm) hypothetical protein 0.0029 0.0102 0.0089
Echinococcus granulosus FACT complex subunit SPT16 0.0141 0.0956 0.0945
Brugia malayi initiation factor 2-associated protein. 0.0141 0.0956 0.0956
Trypanosoma brucei metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Echinococcus granulosus Proliferation associated protein 2G4 0.0141 0.0956 0.0945
Onchocerca volvulus Methionine aminopeptidase 2 homolog 0.0141 0.0956 0.5742
Echinococcus multilocularis FACT complex subunit SPT16 0.0141 0.0956 0.0945
Trichomonas vaginalis Clan MG, familly M24, aminopeptidase P-like metallopeptidase 0.0141 0.0956 0.4637
Loa Loa (eye worm) hypothetical protein 0.0141 0.0956 0.0945
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.1114 0.8416 0.8414
Echinococcus multilocularis Xaa Pro aminopeptidase 3 0.0141 0.0956 0.0945
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0102 0.0089
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0067 0.0054
Trypanosoma cruzi metallo-peptidase, Clan MG, Family M24 0.0141 0.0956 0.0945
Echinococcus granulosus Xaa Pro aminopeptidase 3 0.0141 0.0956 0.0945
Trypanosoma brucei methionine aminopeptidase 2, putative 0.0141 0.0956 0.0945
Echinococcus multilocularis xaa Pro dipeptidase 0.0141 0.0956 0.0945

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 33 % Inhibition of human adenosine 2A receptor at 1 mM ChEMBL. 20095623
Ki (binding) > 100 uM Inhibition of human adenosine 2A receptor ChEMBL. 20095623
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.9433 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.