Detailed information for compound 1097902

Basic information

Technical information
  • TDR Targets ID: 1097902
  • Name: N-[2,6-bis(phenylsulfanyl)pyridin-3-yl]-3-(2- chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4 -carboxamide
  • MW: 548.051 | Formula: C28H19ClFN3O2S2
  • H donors: 1 H acceptors: 3 LogP: 7.73 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(c1c(C)onc1c1c(F)cccc1Cl)Nc1ccc(nc1Sc1ccccc1)Sc1ccccc1
  • InChi: 1S/C28H19ClFN3O2S2/c1-17-24(26(33-35-17)25-20(29)13-8-14-21(25)30)27(34)31-22-15-16-23(36-18-9-4-2-5-10-18)32-28(22)37-19-11-6-3-7-12-19/h2-16H,1H3,(H,31,34)
  • InChiKey: MBKANQFMVCOITN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[2,6-bis(phenylsulfanyl)-3-pyridyl]-3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carboxamide
  • N-[2,6-bis(phenylthio)-3-pyridyl]-3-(2-chloro-6-fluorophenyl)-5-methyl-4-isoxazolecarboxamide
  • N-[2,6-bis(phenylthio)-3-pyridyl]-3-(2-chloro-6-fluoro-phenyl)-5-methyl-isoxazole-4-carboxamide
  • N-[2,6-bis(phenylsulfanyl)pyridin-3-yl]-3-(2-chloro-6-fluoro-phenyl)-5-methyl-1,2-oxazole-4-carboxamide
  • Oprea1_448158

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus nuclear receptor nhr 48 0.0014 0.0149 0.0133
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0496 0.073
Schistosoma mansoni cpg binding protein 0.0034 0.0593 0.0578
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.2732 0.2721
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0496 0.073
Schistosoma mansoni coup transcription factor 0.0029 0.0496 0.0481
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0014 0.0149 0.0133
Brugia malayi hypothetical protein 0.0016 0.0186 0.0215
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0496 0.0481
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0975 0.152
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0599 0.0896
Brugia malayi conserved hypotetical protein 0.0014 0.0149 0.0153
Mycobacterium leprae Probable lipase LipE 0.004 0.0733 0.2115
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0014 0.0149 0.0133
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0552 0.0818
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0496 0.0726
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0186 0.0171
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0496 0.0481
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0733 0.1118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0496 0.073
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0014 0.0149 0.0133
Echinococcus granulosus phd:f box containing protein 0.0034 0.0599 0.0585
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0733 1
Schistosoma mansoni jumonji domain containing protein 0.0127 0.2692 0.268
Leishmania major hypothetical protein, conserved 0.0034 0.0599 0.7958
Echinococcus multilocularis expressed protein 0.0035 0.0629 0.0614
Brugia malayi CXXC zinc finger family protein 0.0032 0.0552 0.0822
Schistosoma mansoni nuclear receptor 0.0014 0.0149 0.0133
Loa Loa (eye worm) jmjC domain-containing protein 0.0129 0.2732 0.4437
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0733 1
Schistosoma mansoni nuclear receptor 0.0014 0.0149 0.0133
Loa Loa (eye worm) TK/FAK protein kinase 0.027 0.5892 0.968
Loa Loa (eye worm) hypothetical protein 0.004 0.0733 0.1118
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0599 0.1015
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0975 0.0961
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0127 0.2692 0.268
Loa Loa (eye worm) hypothetical protein 0.0029 0.0496 0.0726
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.169 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0496 0.0481
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.061 0.8128
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0014 0.0149 0.0133
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0054 0.1052 0.4744
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0975 0.0961
Brugia malayi jmjC domain containing protein 0.0129 0.2732 0.4439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0975 0.0961
Echinococcus granulosus thyroid hormone receptor alpha 0.0014 0.0149 0.0133
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0496 0.073
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0149 0.0133
Loa Loa (eye worm) hypothetical protein 0.004 0.0733 0.1118
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0149 0.0133
Mycobacterium leprae conserved hypothetical protein 0.004 0.0733 0.2115
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0496 0.0481
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0496 0.0481
Schistosoma mansoni rotamase 0.0035 0.0629 0.0614
Loa Loa (eye worm) hypothetical protein 0.004 0.0733 0.1118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0496 0.0481
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0599 0.7958
Loa Loa (eye worm) hypothetical protein 0.0029 0.0496 0.0726
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.169 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0599 0.0896
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0733 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0496 0.0726
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0034 0.0599 0.0896
Loa Loa (eye worm) hypothetical protein 0.004 0.0733 0.1118
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0496 0.0481
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0496 0.073
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0496 0.0481
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0496 0.0481
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0496 0.0481
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0054 0.1052 0.0662
Echinococcus granulosus nuclear receptor co repressor related ncor 0.0291 0.6361 0.6355
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0496 0.0481
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0083 0.169 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0733 0.0718
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0496 0.0481
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0036 0.064 0.0625
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0599 0.7958
Toxoplasma gondii hypothetical protein 0.0028 0.0476 0.2467
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0496 0.073
Echinococcus granulosus Nuclear hormone receptor HR96 0.0014 0.0149 0.0133
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Brugia malayi nuclear hormone receptor family member nhr-6 0.0014 0.0149 0.0153
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0733 1
Loa Loa (eye worm) beta-lactamase 0.004 0.0733 0.1118
Schistosoma mansoni cpg binding protein 0.0034 0.0593 0.0578
Brugia malayi jmjC domain containing protein 0.0034 0.0599 0.0901
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0733 0.0718
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0733 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0129 0.2732 0.2721
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0496 0.073
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.169 0.5
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0496 0.595
Brugia malayi jmjC domain containing protein 0.0127 0.2692 0.4372
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0599 0.7958
Echinococcus granulosus cpg binding protein 0.0034 0.0593 0.0578
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0496 0.073
Loa Loa (eye worm) hypothetical protein 0.004 0.0733 0.1118
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0733 0.0718
Trichomonas vaginalis rotamase, putative 0.0035 0.0629 0.8584
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0629 0.0946
Loa Loa (eye worm) hypothetical protein 0.0016 0.0186 0.021
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0059 0.0044
Echinococcus multilocularis nuclear receptor nhr 48 0.0014 0.0149 0.0133
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0496 0.0481
Brugia malayi steroid hormone receptor 0.0029 0.0496 0.073
Onchocerca volvulus 0.0029 0.0496 0.595
Echinococcus multilocularis peptidase Clp (S14 family) 0.0054 0.1052 0.1038
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0016 0.0186 0.021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0014 0.0149 0.0133
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0083 0.169 1
Brugia malayi Protein kinase domain containing protein 0.027 0.5892 0.9681
Echinococcus granulosus expressed protein 0.0035 0.0629 0.0614
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0496 0.073
Brugia malayi nuclear hormone receptor 0.0014 0.0149 0.0153
Brugia malayi hypothetical protein 0.0016 0.0186 0.0215
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0496 0.0481
Brugia malayi nuclear receptor NHR-67 0.0014 0.0149 0.0153
Loa Loa (eye worm) hypothetical protein 0.0016 0.0186 0.021
Brugia malayi nuclear receptor NHR-88 0.0029 0.0496 0.073
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0496 0.0481
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0014 0.0149 0.0133
Brugia malayi Probable ClpP-like protease 0.0083 0.169 0.2709
Loa Loa (eye worm) hypothetical protein 0.004 0.0733 0.1118
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0599 0.0585
Brugia malayi jmjC domain containing protein 0.0034 0.0599 0.0901
Schistosoma mansoni zinc finger protein 0.0014 0.0149 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0496 0.0726
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.1352 0.1338
Echinococcus multilocularis dnaJ subfamily B 0.0454 1 1
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0733 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0186 0.021
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0083 0.169 0.5
Loa Loa (eye worm) hypothetical protein 0.0034 0.0599 0.0896
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0496 0.0726
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0599 0.0585
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Loa Loa (eye worm) DR-78 0.0014 0.0149 0.0149
Schistosoma mansoni peptidase Clp (S14 family) 0.0083 0.169 0.1677
Brugia malayi ecdysone receptor 0.0014 0.0149 0.0153
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0014 0.0149 0.0133
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0599 0.0585
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0127 0.2692 0.268
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0083 0.169 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0975 0.0961
Loa Loa (eye worm) hypothetical protein 0.0279 0.6084 1
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0599 0.0585
Schistosoma mansoni hypothetical protein 0.0454 1 1
Brugia malayi jmjC domain containing protein 0.0034 0.0599 0.0901
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0496 0.073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0496 0.0726
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0496 0.595
Onchocerca volvulus 0.004 0.0733 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0496 0.0726
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0975 0.0961
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.061 0.8128
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0733 0.1122
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0496 0.0481
Brugia malayi beta-lactamase family protein 0.004 0.0733 0.1122
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0083 0.169 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0496 0.0726
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0496 0.0481
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0149 0.0153
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0496 0.0481
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0186 0.0215
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0496 0.073
Brugia malayi beta-lactamase 0.004 0.0733 0.1122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0496 0.0726
Brugia malayi hypothetical protein 0.0014 0.0149 0.0153
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0599 0.3231
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0599 0.0585
Echinococcus granulosus protein tyrosine kinase 0.0267 0.5821 0.5814
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.0291 0.6361 0.6355
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0496 0.0481
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0083 0.169 1
Brugia malayi jmjC domain containing protein 0.0034 0.0599 0.0901
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0599 0.0585
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0629 0.8584
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Echinococcus granulosus peptidase Clp S14 family 0.0054 0.1052 0.1038
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0496 0.0481
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0014 0.0149 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0496 0.073
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.061 0.8128
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0496 0.0726
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0496 0.0481
Brugia malayi Nuclear hormone receptor E75 0.0014 0.0149 0.0153
Echinococcus multilocularis protein tyrosine kinase 0.0267 0.5821 0.5814
Echinococcus multilocularis lysine specific demethylase 5A 0.0127 0.2692 0.268
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0599 0.0585
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0975 0.0961
Echinococcus granulosus lysine specific demethylase 5A 0.0129 0.2732 0.2721
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0083 0.169 0.1677
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Loa Loa (eye worm) nuclear hormone receptor 0.0014 0.0149 0.0149
Brugia malayi Nuclear hormone receptor-like 1 0.0016 0.0186 0.0215
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0083 0.169 1
Plasmodium vivax hypothetical protein, conserved 0.004 0.0733 0.2115
Brugia malayi photoreceptor-specific nuclear receptor 0.0279 0.6084 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0014 0.0149 0.0149
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0496 0.0481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0496 0.0726
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0016 0.0186 0.021
Schistosoma mansoni thyroid hormone receptor 0.0029 0.0496 0.0481
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0599 0.0585
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0975 0.0961
Schistosoma mansoni nuclear receptor nhr-48 0.0014 0.0149 0.0133
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0496 0.0481
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0599 0.0585
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0496 0.0481
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0054 0.1052 0.0662
Echinococcus multilocularis thyroid hormone receptor alpha 0.0029 0.0496 0.0481
Brugia malayi beta-lactamase family protein 0.004 0.0733 0.1122
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0083 0.169 0.1677
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0599 0.3231
Brugia malayi tailless protein 0.0014 0.0149 0.0153
Loa Loa (eye worm) hypothetical protein 0.0083 0.169 0.2706
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0496 0.0481
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0599 0.0896
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0496 0.0481
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0186 0.0171
Trichomonas vaginalis rotamase, putative 0.0034 0.061 0.8329
Onchocerca volvulus 0.004 0.0733 1
Toxoplasma gondii ABC1 family protein 0.004 0.0733 0.4061
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0599 0.0585
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.061 0.3301
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0149 0.0133
Onchocerca volvulus 0.004 0.0733 1
Brugia malayi nuclear hormone receptor 0.0029 0.0496 0.073
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0733 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0599 0.0896
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0496 0.073
Onchocerca volvulus 0.0032 0.0552 0.6902
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0599 0.0585
Loa Loa (eye worm) hypothetical protein 0.0016 0.0186 0.021
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.119 0.6899
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.061 0.8128
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0496 0.0726
Brugia malayi hypothetical protein 0.0014 0.0149 0.0153
Trichomonas vaginalis esterase, putative 0.004 0.0733 1
Brugia malayi nuclear receptor RXR 0.0014 0.0149 0.0153
Schistosoma mansoni tyrosine kinase 0.0267 0.5821 0.5814
Loa Loa (eye worm) hypothetical protein 0.0029 0.0496 0.0726
Brugia malayi nuclear receptor RXR 0.0016 0.0186 0.0215
Leishmania major hypothetical protein, conserved 0.004 0.0733 1
Brugia malayi nuclear receptor NHR-88 0.0014 0.0149 0.0153
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0496 0.0481
Brugia malayi ecdysteroid receptor 0.0029 0.0496 0.073
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0496 0.073
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0496 0.0481
Schistosoma mansoni nuclear hormone receptor 0.0014 0.0149 0.0133
Echinococcus multilocularis cpg binding protein 0.0034 0.0593 0.0578
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0496 0.595
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0059 0.0044
Schistosoma mansoni cpg binding protein 0.0032 0.0552 0.0537
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0733 1
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0014 0.0149 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0496 0.073
Brugia malayi nuclear hormone receptor family member odr-7 0.0014 0.0149 0.0153
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0975 0.1524
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0016 0.0186 0.0171
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0014 0.0149 0.0133
Plasmodium vivax JmjC domain containing protein 0.0034 0.0599 0.1015
Loa Loa (eye worm) hypothetical protein 0.0029 0.0496 0.0726
Loa Loa (eye worm) hypothetical protein 0.0014 0.0149 0.0149
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0016 0.0186 0.0171
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0255 0.5553 1
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0083 0.169 1
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0036 0.064 0.0625
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.061 0.5
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0599 0.0585
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0629 0.095
Brugia malayi orphan nuclear receptor NR2E1 0.0014 0.0149 0.0153
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0733 0.0718

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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