TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 309.254 | Formula: C14H16NO5P
H donors: 3 H acceptors: 5 LogP: 0.67 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: ON(C(=O)c1cccc2c1cccc2)CCCP(=O)(O)O
InChi: 1S/C14H16NO5P/c16-14(15(17)9-4-10-21(18,19)20)13-8-3-6-11-5-1-2-7-12(11)13/h1-3,5-8,17H,4,9-10H2,(H2,18,19,20)
InChiKey: GQEOAWGCRFYWAA-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Neospora caninum	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium yoelii	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	Get druggable targets OG5_130462	All targets in OG5_130462
Babesia bovis	1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium knowlesi	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Theileria parva	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium berghei	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium ulcerans	hypothetical protein	0.0038	0.027	0.0411
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0098	0.0997	0.0978
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.0997	0.0978
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0366	0.087
Schistosoma mansoni	hypothetical protein	0.0048	0.0402	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0483	0.5644	1
Schistosoma mansoni	biogenic amine receptor	0.0098	0.0997	0.2457
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0366	0.087
Brugia malayi	beta-lactamase family protein	0.0038	0.027	0.0477
Echinococcus granulosus	sex peptide receptor	0.0098	0.0997	0.1736
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6082	1
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.015	0.3372
Schistosoma mansoni	hypothetical protein	0.0098	0.0997	0.2457
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.052	0.6082	1
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0158	0.028
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0123	0.1305	0.4781
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.015	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.027	0.0927
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.0997	0.0978
Echinococcus multilocularis	GPCR, family 2	0.0048	0.0402	0.0382
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0158	0.0346
Onchocerca volvulus		0.0098	0.0997	0.5693
Schistosoma mansoni	adenoreceptor	0.0098	0.0997	0.2457
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0098	0.0997	0.1766
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.027	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Mycobacterium tuberculosis	Conserved protein	0.0038	0.027	0.0927
Echinococcus granulosus	serotonin receptor	0.0098	0.0997	0.1736
Loa Loa (eye worm)	fli-1 protein	0.0219	0.2456	0.4351
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0098	0.0997	0.2457
Echinococcus granulosus	G protein coupled receptor 139	0.0098	0.0997	0.1736
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0098	0.0997	0.2457
Loa Loa (eye worm)	hypothetical protein	0.0153	0.1664	0.2948
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.0997	0.2457
Onchocerca volvulus		0.015	0.1631	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Onchocerca volvulus		0.0098	0.0997	0.5693
Echinococcus multilocularis	neuropeptides capa receptor	0.0098	0.0997	0.0978
Onchocerca volvulus		0.0098	0.0997	0.5693
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0366	0.0615
Brugia malayi	hypothetical protein	0.0038	0.0272	0.0482
Brugia malayi	GnHR receptor homolog	0.0098	0.0997	0.1766
Brugia malayi	Ets-domain containing protein	0.0072	0.0686	0.1216
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.027	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.0366	0.087
Mycobacterium tuberculosis	Probable dehydrogenase	0.0111	0.1155	0.4225
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.0366	0.0649
Echinococcus multilocularis	GA binding protein alpha chain	0.0072	0.0686	0.0667
Echinococcus granulosus	GA binding protein alpha chain	0.0072	0.0686	0.1184
Echinococcus granulosus	g protein coupled receptor	0.0098	0.0997	0.1736
Brugia malayi	sulfakinin receptor protein	0.0098	0.0997	0.1766
Brugia malayi	G-protein coupled receptor	0.0098	0.0997	0.1766
Schistosoma mansoni	hypothetical protein	0.0346	0.3993	1
Onchocerca volvulus		0.0098	0.0997	0.5693
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Brugia malayi	hypothetical protein	0.015	0.1631	0.2889
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0098	0.0997	0.1766
Echinococcus granulosus	g-protein coupled receptor	0.0098	0.0997	0.1736
Loa Loa (eye worm)	hypothetical protein	0.015	0.1631	0.2889
Schistosoma mansoni	opsin-like receptor	0.0098	0.0997	0.2457
Echinococcus granulosus	neuropeptide receptor	0.0098	0.0997	0.1736
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Onchocerca volvulus		0.0098	0.0997	0.5693
Onchocerca volvulus		0.0098	0.0997	0.5693
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0272	0.0447
Loa Loa (eye worm)	hypothetical protein	0.0105	0.108	0.1913
Plasmodium vivax	glutathione reductase, putative	0.0049	0.0404	0.0632
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0098	0.0997	0.1766
Onchocerca volvulus		0.0098	0.0997	0.5693
Loa Loa (eye worm)	transcription factor SMAD2	0.0131	0.1392	0.2466
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	opsin-like receptor	0.0098	0.0997	0.2457
Onchocerca volvulus		0.0098	0.0997	0.5693
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.027	0.6494
Brugia malayi	beta-lactamase family protein	0.0038	0.027	0.0477
Brugia malayi	hypothetical protein	0.0018	0.0032	0.0057
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0048	0.0402	0.0678
Leishmania major	hypothetical protein, conserved	0.0038	0.027	0.6494
Schistosoma mansoni	hypothetical protein	0.0098	0.0997	0.2457
Echinococcus multilocularis	G protein coupled receptor 139	0.0098	0.0997	0.0978
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0098	0.0997	0.1736
Schistosoma mansoni	neuropeptide F-like receptor	0.0098	0.0997	0.2457
Onchocerca volvulus		0.0098	0.0997	0.5693
Brugia malayi	neuropeptide F receptor	0.0098	0.0997	0.1766
Brugia malayi	intermediate filament protein	0.0028	0.0158	0.028
Onchocerca volvulus		0.0098	0.0997	0.5693
Echinococcus granulosus	allatostatin A receptor	0.0098	0.0997	0.1736
Mycobacterium tuberculosis	Conserved protein	0.0038	0.027	0.0927
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.0997	0.2457
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0366	0.0346
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0098	0.0997	0.1736
Echinococcus granulosus	neuropeptides capa receptor	0.0098	0.0997	0.1736
Echinococcus multilocularis	neuropeptide Y receptor	0.0098	0.0997	0.0978
Toxoplasma gondii	ABC1 family protein	0.0038	0.027	0.0411
Brugia malayi	hypothetical protein	0.0483	0.5644	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0123	0.1305	0.1781
Schistosoma mansoni	hypothetical protein	0.0048	0.0402	0.0959
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	neuropeptide s receptor	0.0098	0.0997	0.0978
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0153	0.1664	0.2948
Echinococcus granulosus	tm gpcr rhodopsin	0.0098	0.0997	0.1736
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0111	0.1155	0.1524
Echinococcus multilocularis	g-protein coupled receptor	0.0098	0.0997	0.0978
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0098	0.0997	0.2457
Echinococcus granulosus	fmrfamide receptor	0.0098	0.0997	0.1736
Echinococcus multilocularis	sex peptide receptor	0.0098	0.0997	0.0978
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.027	0.0411
Loa Loa (eye worm)	hypothetical protein	0.0038	0.027	0.0477
Loa Loa (eye worm)	thioredoxin reductase	0.0049	0.0404	0.0716
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0098	0.0997	0.0978
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.027	0.0927
Echinococcus granulosus	neuropeptides capa receptor	0.0098	0.0997	0.1736
Schistosoma mansoni	hypothetical protein	0.0105	0.108	0.2666
Schistosoma mansoni	hypothetical protein	0.0098	0.0997	0.2457
Echinococcus granulosus	neuropeptide receptor	0.0098	0.0997	0.1736
Schistosoma mansoni	amine GPCR	0.0098	0.0997	0.2457
Echinococcus granulosus	g protein coupled receptor	0.0098	0.0997	0.1736
Brugia malayi	follicle stimulating hormone receptor	0.0098	0.0997	0.1766
Echinococcus granulosus	neuropeptide FF receptor 2	0.0098	0.0997	0.1736
Echinococcus multilocularis	neuropeptide receptor	0.0098	0.0997	0.0978
Brugia malayi	ORL1-like opioid receptor	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Giardia lamblia	NADH oxidase lateral transfer candidate	0.0017	0.0021	0.5
Brugia malayi	glutathione reductase	0.0049	0.0404	0.0716
Brugia malayi	AKH receptor	0.0098	0.0997	0.1766
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.0997	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	hypothetical protein	0.0098	0.0997	0.2457
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.0997	0.0978
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0098	0.0997	0.0978
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.0997	0.2457
Brugia malayi	putative neuropeptide receptor NPR1	0.0098	0.0997	0.1766
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.027	0.0927
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0098	0.0997	0.2457
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0098	0.0997	0.1736
Brugia malayi	Thioredoxin reductase	0.0049	0.0404	0.0716
Brugia malayi	Dopamine receptor protein 2	0.0098	0.0997	0.1766
Schistosoma mansoni	gabp alpha	0.0072	0.0686	0.1676
Echinococcus granulosus	lamin	0.0028	0.0158	0.0245
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0098	0.0997	0.0978
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0098	0.0997	0.2457
Trypanosoma cruzi	trypanothione reductase, putative	0.0049	0.0404	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0098	0.0997	0.5693
Brugia malayi	larval opioid receptor	0.0098	0.0997	0.1766
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.015	0.3372
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	neuropeptide Y receptor	0.0098	0.0997	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.0997	0.1736
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.015	0.0213
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.0366	0.0615
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0098	0.0997	0.1766
Mycobacterium ulcerans	lipase LipD	0.0038	0.027	0.0411
Onchocerca volvulus		0.0038	0.027	0.0755
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0158	0.028
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.0125	0.1324	0.4854
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.027	0.0411
Schistosoma mansoni	neuropeptide f receptor 76f	0.0098	0.0997	0.2457
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	fmrfamide receptor	0.0098	0.0997	0.0978
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6082	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0048	0.0402	0.0678
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0017	0.0021	0.0037
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0098	0.0997	0.1736
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0098	0.0997	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0402	0.0712
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.0997	0.0978
Brugia malayi	Dopamine receptor	0.0098	0.0997	0.1766
Mycobacterium ulcerans	beta-lactamase	0.0038	0.027	0.0411
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0049	0.0404	0.1427
Loa Loa (eye worm)	hypothetical protein	0.0028	0.015	0.0266
Schistosoma mansoni	growth hormone secretagogue receptor	0.0098	0.0997	0.2457
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Onchocerca volvulus		0.0098	0.0997	0.5693
Schistosoma mansoni	hypothetical protein	0.0346	0.3993	1
Schistosoma mansoni	opsin-like receptor	0.0098	0.0997	0.2457
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0038	0.027	0.0477
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.027	0.0627
Schistosoma mansoni	hypothetical protein	0.0038	0.0272	0.0633
Plasmodium falciparum	glutathione reductase	0.0049	0.0404	0.0632
Onchocerca volvulus		0.0038	0.027	0.0755
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.015	0.0213
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Onchocerca volvulus		0.0098	0.0997	0.5693
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0098	0.0997	0.1766
Echinococcus granulosus	neuropeptide Y receptor	0.0098	0.0997	0.1736
Echinococcus multilocularis	somatostatin receptor	0.0098	0.0997	0.0978
Echinococcus granulosus	hypothetical protein	0.0098	0.0997	0.1736
Toxoplasma gondii	thioredoxin reductase	0.0049	0.0404	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0152	0.0269
Echinococcus multilocularis	neuropeptides capa receptor	0.0098	0.0997	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Brugia malayi	hypothetical protein	0.0028	0.015	0.0266
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0048	0.0402	0.0382
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Entamoeba histolytica	hypothetical protein	0.0038	0.0272	0.5
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0098	0.0997	0.1736
Onchocerca volvulus		0.0098	0.0997	0.5693
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0272	0.0252
Echinococcus multilocularis	musashi	0.0028	0.0158	0.0138
Loa Loa (eye worm)	MH2 domain-containing protein	0.0131	0.1392	0.2466
Schistosoma mansoni	hypothetical protein	0.0099	0.1006	0.248
Loa Loa (eye worm)	hypothetical protein	0.0038	0.027	0.0477
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6082	1
Schistosoma mansoni	biogenic amine receptor	0.0098	0.0997	0.2457
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	g protein coupled receptor	0.0098	0.0997	0.0978
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0158	0.028
Loa Loa (eye worm)	hypothetical protein	0.0038	0.027	0.0477
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0098	0.0997	0.0978
Echinococcus multilocularis	orexin receptor type 2	0.0098	0.0997	0.0978
Echinococcus multilocularis	g protein coupled receptor	0.0098	0.0997	0.0978
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.027	0.0927
Schistosoma mansoni	survival motor neuron protein	0.0099	0.1006	0.248
Loa Loa (eye worm)	hypothetical protein	0.0038	0.027	0.0477
Brugia malayi	Serotonin receptor	0.0098	0.0997	0.1766
Brugia malayi	Melatonin receptor type 1A	0.0098	0.0997	0.1766
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.0997	0.1736
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0098	0.0997	0.2457
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0153	0.1664	0.2948
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0098	0.0997	0.0978
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0098	0.0997	0.5693
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.027	1
Brugia malayi	putative neuropeptide receptor	0.0098	0.0997	0.1766
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	biogenic amine receptor	0.0098	0.0997	0.2457
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0272	0.0633
Echinococcus multilocularis	neuropeptide receptor A26	0.0098	0.0997	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0062	0.056	0.0993
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0098	0.0997	0.2457
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0098	0.0997	0.0978
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0098	0.0997	0.2457
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.0366	0.0346
Schistosoma mansoni	amine GPCR	0.0098	0.0997	0.2457
Loa Loa (eye worm)	glutathione reductase	0.0049	0.0404	0.0716
Brugia malayi	neuropeptide F receptor	0.0098	0.0997	0.1766
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0098	0.0997	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus granulosus	7TM GPCR rhodopsin	0.0098	0.0997	0.1736
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0098	0.0997	0.0978
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0111	0.1155	0.4225
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6082	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.0997	0.1736
Schistosoma mansoni	hypothetical protein	0.0048	0.0402	0.0959
Schistosoma mansoni	neuropeptide receptor	0.0098	0.0997	0.2457
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0098	0.0997	0.1766
Echinococcus granulosus	tm gpcr rhodopsin	0.0098	0.0997	0.1736
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0098	0.0997	0.0978
Echinococcus granulosus	7tm_1 domain containing protein	0.0098	0.0997	0.1736
Brugia malayi	MH2 domain containing protein	0.0131	0.1392	0.2466
Plasmodium vivax	thioredoxin reductase, putative	0.0049	0.0404	0.0632
Echinococcus multilocularis	fmrfamide receptor	0.0098	0.0997	0.0978
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.027	0.0927
Loa Loa (eye worm)	G-protein coupled receptor	0.0098	0.0997	0.1766
Echinococcus granulosus	neuropeptide receptor A26	0.0098	0.0997	0.1736
Echinococcus multilocularis	allatostatin A receptor	0.0098	0.0997	0.0978
Echinococcus granulosus	intermediate filament protein	0.0028	0.0158	0.0245
Brugia malayi	G protein-coupled receptor F59B2.13	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0111	0.1155	0.4225
Onchocerca volvulus		0.0098	0.0997	0.5693
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	amine GPCR	0.0098	0.0997	0.2457
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0048	0.0402	0.0382
Brugia malayi	RE15519p	0.0098	0.0997	0.1766
Brugia malayi	G-protein coupled receptor	0.0098	0.0997	0.1766
Onchocerca volvulus		0.0098	0.0997	0.5693
Echinococcus granulosus	tm gpcr rhodopsin	0.0098	0.0997	0.1736
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0072	0.0686	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0153	0.1664	0.2948
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.027	0.0443
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.0997	0.2457
Echinococcus multilocularis	dro:myosuppressin receptor	0.0098	0.0997	0.0978
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.0997	0.0978
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	amine GPCR	0.0098	0.0997	0.2457
Echinococcus granulosus	orexin receptor type 2	0.0098	0.0997	0.1736
Echinococcus granulosus	somatostatin receptor	0.0098	0.0997	0.1736
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.2706	1
Echinococcus multilocularis	survival motor neuron protein 1	0.0483	0.5644	0.5635
Trichomonas vaginalis	esterase, putative	0.0038	0.027	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0098	0.0997	0.1766
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.027	0.0627
Loa Loa (eye worm)	TYRA-2 protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0098	0.0997	0.0978
Echinococcus multilocularis	g protein coupled receptor	0.0098	0.0997	0.0978
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.0997	0.0978
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0111	0.1155	0.4225
Brugia malayi	Serotonin receptor	0.0098	0.0997	0.1766
Echinococcus granulosus	g protein coupled receptor	0.0098	0.0997	0.1736
Trypanosoma brucei	trypanothione reductase	0.0049	0.0404	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0098	0.0997	0.2457
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0098	0.0997	0.0978
Mycobacterium tuberculosis	Probable reductase	0.0111	0.1155	0.4225
Schistosoma mansoni	ets-related	0.0219	0.2456	0.6131
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0098	0.0997	0.1766
Brugia malayi	beta-lactamase	0.0038	0.027	0.0477
Entamoeba histolytica	hypothetical protein	0.0038	0.0272	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.027	0.6494
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0098	0.0997	0.0978
Echinococcus multilocularis	lamin	0.0028	0.0158	0.0138
Brugia malayi	Latrophilin receptor protein 2	0.0048	0.0402	0.0712
Schistosoma mansoni	amine GPCR	0.0098	0.0997	0.2457
Loa Loa (eye worm)	neuropeptide F receptor	0.0098	0.0997	0.1766
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.0997	0.1736
Brugia malayi	G protein-coupled receptor	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Mycobacterium tuberculosis	Conserved protein	0.0038	0.027	0.0927
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.6082	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0098	0.0997	0.0978
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0098	0.0997	0.2457
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.015	0.0213
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.0997	0.2457
Echinococcus granulosus	biogenic amine 5HT receptor	0.0098	0.0997	0.1736
Echinococcus multilocularis	lamin dm0	0.0028	0.0158	0.0138
Echinococcus granulosus	lamin dm0	0.0028	0.0158	0.0245
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.0366	0.0649
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.6082	1
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0049	0.0404	0.0384
Echinococcus multilocularis	neuropeptide receptor	0.0098	0.0997	0.0978
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0098	0.0997	0.2457
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.027	0.0927
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus granulosus	neuropeptide s receptor	0.0098	0.0997	0.1736
Schistosoma mansoni	myosin xvIII	0.0098	0.0997	0.2457
Echinococcus multilocularis	geminin	0.0346	0.3993	0.398
Schistosoma mansoni	lamin	0.0028	0.0158	0.0346
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.0997	0.2457
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.027	0.6494
Brugia malayi	hypothetical protein	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Echinococcus multilocularis	serotonin receptor	0.0098	0.0997	0.0978
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0098	0.0997	0.1736
Brugia malayi	Fli-1 protein	0.0219	0.2456	0.4351
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.0997	0.1736
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0099	0.1006	0.1782
Brugia malayi	Dopamine receptor protein 1	0.0098	0.0997	0.1766
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Brugia malayi	Ets-domain containing protein	0.0072	0.0686	0.1216
Echinococcus granulosus	geminin	0.0346	0.3993	0.7063
Onchocerca volvulus		0.0098	0.0997	0.5693
Leishmania major	hypothetical protein, conserved	0.0028	0.015	0.3372
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0098	0.0997	0.1766
Echinococcus multilocularis	serotonin receptor	0.0098	0.0997	0.0978
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0098	0.0997	0.0978
Schistosoma mansoni	hypothetical protein	0.0048	0.0402	0.0959
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.027	0.0927
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.0997	0.2457
Loa Loa (eye worm)	neuropeptide F receptor	0.0098	0.0997	0.1766
Plasmodium falciparum	thioredoxin reductase	0.0049	0.0404	0.0632
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	lamin	0.0028	0.0158	0.0346
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0098	0.0997	0.1736
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0098	0.0997	0.2457
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.027	0.0477
Echinococcus granulosus	neuropeptide Y receptor	0.0098	0.0997	0.1736
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.0997	0.2457
Schistosoma mansoni	neuropeptide receptor	0.0098	0.0997	0.2457
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.027	0.0477
Echinococcus granulosus	thioredoxin glutathione reductase	0.0049	0.0404	0.0681
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0098	0.0997	0.2457
Schistosoma mansoni	neuropeptide F-like receptor	0.0098	0.0997	0.2457
Schistosoma mansoni	neuropeptide receptor	0.0098	0.0997	0.2457
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.027	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0098	0.0997	0.2457
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0111	0.1155	0.4225
Schistosoma mansoni	histamine h1 receptor	0.0098	0.0997	0.2457
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.027	1
Onchocerca volvulus		0.0099	0.1006	0.5756
Loa Loa (eye worm)	G-protein coupled receptor	0.0098	0.0997	0.1766
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0098	0.0997	0.2457
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.0997	0.1736
Entamoeba histolytica	hypothetical protein	0.0038	0.0272	0.5
Onchocerca volvulus		0.0038	0.027	0.0755
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0098	0.0997	0.1736
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.6082	1
Schistosoma mansoni	neuropeptide receptor	0.0098	0.0997	0.2457
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0048	0.0402	0.0712
Mycobacterium tuberculosis	Probable oxidoreductase	0.0123	0.1305	0.4781
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0098	0.0997	0.0978
Echinococcus granulosus	biogenic amine 5HT receptor	0.0098	0.0997	0.1736
Onchocerca volvulus		0.0098	0.0997	0.5693
Echinococcus granulosus	dro:myosuppressin receptor	0.0098	0.0997	0.1736
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0098	0.0997	0.1736
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.015	0.3372
Echinococcus granulosus	survival motor neuron protein 1	0.0483	0.5644	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0123	0.1305	0.4781
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0158	0.028
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0048	0.0402	0.0712
Brugia malayi	latrophilin 2 splice variant baaae	0.0105	0.108	0.1913
Leishmania major	trypanothione reductase	0.0049	0.0404	1
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0098	0.0997	0.2457
Echinococcus granulosus	rhodopsin orphan GPCR	0.0098	0.0997	0.1736
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.027	0.0249
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0098	0.0997	0.2457
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.027	0.0411
Entamoeba histolytica	hypothetical protein	0.0038	0.0272	0.5
Loa Loa (eye worm)	hypothetical protein	0.0098	0.0997	0.1766
Loa Loa (eye worm)	beta-lactamase	0.0038	0.027	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0038	0.027	0.0477
Echinococcus granulosus	GPCR family 2	0.0048	0.0402	0.0678

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= -6.64	Inhibitory concentration against DOXP reductoisomerase	ChEMBL.	15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL607412

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1100308