Detailed information for compound 1100939

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 370.215 | Formula: C14H10BrF2N3S
  • H donors: 2 H acceptors: 0 LogP: 3.97 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: NC(=S)N/N=C(/c1cccc(c1)Br)\c1cc(F)cc(c1)F
  • InChi: 1S/C14H10BrF2N3S/c15-10-3-1-2-8(4-10)13(19-20-14(18)21)9-5-11(16)7-12(17)6-9/h1-7H,(H3,18,20,21)/b19-13-
  • InChiKey: DJDZAHCEPMBTNJ-UYRXBGFRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cathepsin L Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin L 333 aa 359 aa 30.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0032 0.0482 1
Toxoplasma gondii cathepsin B 0.006 0.1467 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.5409 0.5409
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Brugia malayi Cathepsin L-like cysteine proteinase 0.0023 0.0166 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Schistosoma mansoni importin beta-1 0.0028 0.0347 0.0347
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0482 0.0482
Trypanosoma brucei cysteine peptidase C (CPC) 0.006 0.1467 1
Brugia malayi cathepsin L-like precursor 0.0023 0.0166 0.0307
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.006 0.1467 1
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0 0.5
Entamoeba histolytica hypothetical protein 0.0023 0.0158 0.3283
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0482 0.3286
Echinococcus granulosus cathepsin l1 0.0032 0.0482 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0166 0.1131
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0158 0.0293
Echinococcus multilocularis cathepsin b 0.0171 0.5409 0.5409
Trichomonas vaginalis ran, putative 0.0021 0.0084 0.057
Echinococcus multilocularis cysteine protease 0.0032 0.0482 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Loa Loa (eye worm) fibroinase 0.0032 0.0482 0.0482
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0482 0.3286
Brugia malayi Cathepsin L-like precursor 0.0032 0.0482 0.0891
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0018 0.0034
Onchocerca volvulus 0.0032 0.0482 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0019 0.0018 0.0382
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0482 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.0019 0.0018 0.0382
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0166
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0084 0.1733
Plasmodium falciparum cysteine proteinase falcipain 3 0.0032 0.0482 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.5409 0.5409
Brugia malayi Cathepsin L-like precursor 0.0032 0.0482 0.0891
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0084 0.0154
Entamoeba histolytica cysteine proteinase 2 0.0019 0.0018 0.0382
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Giardia lamblia Cathepsin B precursor 0.006 0.1467 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0482 0.3286
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0018 0.0382
Echinococcus multilocularis cathepsin L 0.0019 0.0018 0.0018
Leishmania major cathepsin L-like protease 0.0032 0.0482 0.3286
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0482 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0018 0.0126
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0171 0.5409 0.5409
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0347 0.0347
Brugia malayi Cathepsin L-like precursor 0.0032 0.0482 0.0891
Leishmania major importin beta-1 subunit, putative 0.0023 0.0158 0.1079
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0482 0.3286
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Loa Loa (eye worm) hypothetical protein 0.0028 0.0347 0.0347
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0482 0.3286
Leishmania major cathepsin L-like protease 0.0032 0.0482 0.3286
Onchocerca volvulus 0.0032 0.0482 1
Leishmania major cathepsin L-like protease 0.0032 0.0482 0.3286
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0032 0.0482 0.0482
Brugia malayi Cathepsin L-like precursor 0.0032 0.0482 0.0891
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0166
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0126
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0347 0.2365
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0482 0.0482
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Loa Loa (eye worm) cathepsin B 0.006 0.1467 0.1467
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Entamoeba histolytica cysteine proteinase, putative 0.0032 0.0482 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0482 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0032 0.0482 0.3286
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0018 0.0382
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0084 0.057
Entamoeba histolytica cysteine protease, putative 0.0032 0.0482 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0018 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.0023 0.0166 0.3442
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0932 0.0932
Trypanosoma cruzi cruzipain precursor, putative 0.0032 0.0482 0.0891
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0018 0.0034
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0018 0.0034
Onchocerca volvulus Cathepsin F homolog 0.0032 0.0482 1
Brugia malayi Cathepsin L-like precursor 0.0032 0.0482 0.0891
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0482 0.3286
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0171 0.5409 1
Plasmodium vivax vivapain-2 0.0032 0.0482 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0932 0.0932
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.006 0.1467 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0158 0.1079
Onchocerca volvulus 0.0032 0.0482 1
Echinococcus granulosus cathepsin l1 0.0023 0.0166 0.0166
Echinococcus multilocularis cysteine protease 0.0032 0.0482 0.0482
Echinococcus granulosus importin subunit beta 1 0.0028 0.0347 0.0347
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.0018 0.0018
Echinococcus multilocularis cathepsin b 0.0171 0.5409 0.5409
Plasmodium vivax importin-beta 2, putative 0.0028 0.0347 0.7196
Echinococcus granulosus cathepsin b 0.0171 0.5409 0.5409
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0482 0.0891
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0171 0.5409 0.5409
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0084 0.1733
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0482 0.0482
Schistosoma mansoni cathepsin F (C01 family) 0.0023 0.0166 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Schistosoma mansoni ran 0.0021 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0019 0.0018 0.0126
Echinococcus granulosus cathepsin b 0.0171 0.5409 0.5409
Giardia lamblia Cathepsin B precursor 0.006 0.1467 1
Echinococcus granulosus cysteine protease 0.0019 0.0018 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Leishmania major cathepsin L-like protease 0.0032 0.0482 0.3286
Leishmania major GTP-binding protein, putative 0.0021 0.0084 0.057
Schistosoma mansoni ran 0.0021 0.0084 0.0084
Plasmodium vivax vivapain-1 0.0019 0.0018 0.0382
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0084 0.057
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Loa Loa (eye worm) hypothetical protein 0.0171 0.5409 0.5409
Onchocerca volvulus 0.0032 0.0482 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0932 0.0932
Loa Loa (eye worm) hypothetical protein 0.0032 0.0482 0.0482
Loa Loa (eye worm) cysteine protease 0.0032 0.0482 0.0482
Brugia malayi Papain family cysteine protease containing protein 0.0032 0.0482 0.0891
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0932 0.0932
Onchocerca volvulus Cathepsin L homolog 0.0032 0.0482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Leishmania major cysteine peptidase A (CPA) 0.0032 0.0482 0.3286
Echinococcus multilocularis cathepsin L cysteine protease 0.0032 0.0482 0.0482
Trypanosoma cruzi cysteine proteinase, putative 0.0019 0.0018 0.0034
Echinococcus granulosus cathepsin L 0.0019 0.0018 0.0018
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Brugia malayi Importin beta-1 subunit 0.0028 0.0347 0.0641
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0 0.5
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0932 0.0932
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0018 0.0034
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0932 0.0932
Onchocerca volvulus 0.0032 0.0482 1
Leishmania major cathepsin L-like protease 0.0032 0.0482 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0932 0.0932
Plasmodium vivax vivapain-2 0.0032 0.0482 1
Toxoplasma gondii cathepsin CPL 0.0032 0.0482 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0347 0.2365
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0019 0.0018 0.0034
Onchocerca volvulus 0.0032 0.0482 1
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0482 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0482 0.3286
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0032 0.0482 0.0482
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0482 0.3286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0018 0.0126
Leishmania major cathepsin L-like protease 0.0032 0.0482 0.3286
Echinococcus granulosus cathepsin l cysteine peptidase 0.0032 0.0482 0.0482
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0482 0.0891
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0032 0.0482 1
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0018 0.0382
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0032 0.0482 0.0482
Loa Loa (eye worm) hypothetical protein 0.0023 0.0166 0.0166
Plasmodium vivax unspecified product 0.0019 0.0018 0.0382
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0158 0.1079
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0158 0.1079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Giardia lamblia Cathepsin B precursor 0.006 0.1467 1
Leishmania major cathepsin L-like protease 0.0032 0.0482 0.3286
Loa Loa (eye worm) ctsf protein 0.0032 0.0482 0.0482
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Onchocerca volvulus 0.0032 0.0482 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0084 0.0084
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0932 0.0932
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0084 0.0154
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0084 0.0154
Trypanosoma cruzi cysteine protease, putative 0.0019 0.0018 0.0034
Schistosoma mansoni cathepsin F (C01 family) 0.0032 0.0482 0.0482
Brugia malayi RNA, U transporter 1 0.008 0.2186 0.4042
Entamoeba histolytica cysteine protease, putative 0.0019 0.0018 0.0382
Entamoeba histolytica Ran family GTPase 0.0021 0.0084 0.1733
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0 0.5
Leishmania major cathepsin L-like protease 0.0032 0.0482 0.3286
Echinococcus multilocularis snurportin 1 0.03 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0032 0.0482 0.3286
Plasmodium vivax vivapain-3 0.0019 0.0018 0.0382
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0023 0.0166 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.03 1 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.006 0.1467 0.2713
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0347 0.2365
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.03 1 1
Brugia malayi cathepsin B-like cysteine proteinase 0.0171 0.5409 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0023 0.0166 0.1131
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0018 0.0382
Brugia malayi Cathepsin L-like precursor 0.0032 0.0482 0.0891
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0032 0.0482 0.3286
Plasmodium falciparum importin beta, putative 0.0028 0.0347 0.7196
Echinococcus granulosus cathepsin L cysteine proteinase 0.0032 0.0482 0.0482
Brugia malayi Cathepsin L-like precursor 0.0023 0.0166 0.0307
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0932 0.1723
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0032 0.0482 0.3286
Brugia malayi Cathepsin L-like precursor 0.0023 0.0166 0.0307
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0084 0.057
Trypanosoma cruzi cysteine peptidase, putative 0.0032 0.0482 0.0891
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.006 0.1467 0.1467

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 59.4 nM Inhibition of human liver cathepsin L ChEMBL. 20089402
IC50 (binding) > 10000 nM Inhibition of human liver cathepsin B ChEMBL. 20089402

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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