Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MDM2 proto-oncogene, E3 ubiquitin protein ligase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.006 | 0.2026 | 0.2435 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.3916 | 0.4813 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0862 | 0.1454 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.1732 | 0.389 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.1732 | 0.389 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0862 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0862 | 0.2201 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0862 | 0.0971 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0036 | 0.0862 | 0.2201 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.014 | 0.0063 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1984 | 0.2383 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.01 | 0.3916 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.0974 | 0.1768 |
Onchocerca volvulus | 0.0036 | 0.0862 | 0.5 | |
Echinococcus multilocularis | geminin | 0.0186 | 0.804 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.3916 | 0.4813 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.1984 | 0.2383 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.023 | 0.0176 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.1732 | 0.4423 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.092 | 0.1044 |
Plasmodium vivax | hypothetical protein, conserved | 0.0036 | 0.0862 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.01 | 0.3916 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.006 | 0.2026 | 0.2435 |
Loa Loa (eye worm) | beta-lactamase | 0.0036 | 0.0862 | 0.2201 |
Echinococcus granulosus | geminin | 0.0186 | 0.804 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.092 | 0.235 |
Brugia malayi | beta-lactamase family protein | 0.0036 | 0.0862 | 0.1454 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.006 | 0.2026 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0036 | 0.0862 | 0.0971 |
Brugia malayi | beta-lactamase | 0.0036 | 0.0862 | 0.1454 |
Brugia malayi | Bromodomain containing protein | 0.0074 | 0.2707 | 0.6616 |
Trichomonas vaginalis | esterase, putative | 0.0036 | 0.0862 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0862 | 0.5 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0862 | 0.0971 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0862 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.3916 | 0.4813 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0862 | 0.2201 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0036 | 0.0862 | 0.0971 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.804 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2026 | 0.2435 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.014 | 0.0358 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0037 | 0.092 | 0.1618 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0036 | 0.0862 | 0.1454 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0036 | 0.0862 | 0.0971 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0862 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0977 | 0.2496 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1089 | 0.2781 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.01 | 0.3916 | 0.4813 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.1732 | 0.4423 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0862 | 0.2201 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0036 | 0.0862 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0862 | 0.2201 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.3916 | 0.4813 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0036 | 0.0862 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0063 | 0.2153 | 0.2595 |
Onchocerca volvulus | 0.0036 | 0.0862 | 0.5 | |
Onchocerca volvulus | 0.0036 | 0.0862 | 0.5 | |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.023 | 0.0176 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.01 | 0.3916 | 0.4813 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2026 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.006 | 0.2026 | 0.1274 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2026 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0186 | 0.804 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0036 | 0.0862 | 0.0971 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0036 | 0.0862 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0862 | 0.2201 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0862 | 0.2201 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0036 | 0.0862 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.01 | 0.3916 | 0.4813 |
Mycobacterium leprae | conserved hypothetical protein | 0.0036 | 0.0862 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2505 | 0.6396 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.006 | 0.2026 | 0.2435 |
Mycobacterium leprae | Probable lipase LipE | 0.0036 | 0.0862 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.006 | 0.2026 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1179 | 0.3012 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.006 | 0.2026 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.023 | 0.0176 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.38 uM | Inhibition of p53-MDM2 expressed in Escherichia coli BL-21 (DE3) after 1 hr by fluorescence polarization competitive binding assay | ChEMBL. | 21855354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.