TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 452.543 | Formula: C26H32N2O5
H donors: 2 H acceptors: 3 LogP: 3.17 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: OC[C@@H](NC(=O)[C@@H]1O[C@@H]2O[C@H]1C(=O)N([C@H]2Cc1ccccc1)Cc1ccccc1)CC(C)C
InChi: 1S/C26H32N2O5/c1-17(2)13-20(16-29)27-24(30)22-23-25(31)28(15-19-11-7-4-8-12-19)21(26(32-22)33-23)14-18-9-5-3-6-10-18/h3-12,17,20-23,26,29H,13-16H2,1-2H3,(H,27,30)/t20-,21-,22+,23+,26+/m0/s1
InChiKey: YZRBDOPVWVBWRR-NDRZJSJOSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0415	0.3664	0.3664
Echinococcus multilocularis	myotubularin protein 13	0.0209	0.1701	0.1701
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.0114	0.0114
Loa Loa (eye worm)	AGC/PKC/IOTA protein kinase	0.0415	0.3664	0.3643
Schistosoma mansoni	vav2	0.0214	0.1742	0.171
Echinococcus granulosus	[G-protein-coupledreceptor] kinase	0.0537	0.4825	0.4825
Echinococcus multilocularis	expressed conserved protein	0.0056	0.024	0.024
Trichomonas vaginalis	AGC family protein kinase	0.0415	0.3664	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0056	0.024	0.024
Echinococcus multilocularis	serine:threonine protein kinase MRCK beta	0.0214	0.1746	0.1746
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0883	0.0853
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0043	0.0114	0.0114
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0152	0.1159	0.1129
Echinococcus multilocularis	axis inhibition protein axin	0.0124	0.0883	0.0883
Plasmodium vivax	cAMP-dependent protein kinase catalytic subunit, putative	0.0415	0.3664	0.5
Echinococcus granulosus	regulator of G protein signaling 3	0.0124	0.0883	0.0883
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0204	0.1653	0.162
Echinococcus multilocularis	beta adrenergic receptor kinase	0.0326	0.2812	0.2812
Schistosoma mansoni	serine/threonine protein kinase	0.0214	0.1746	0.1713
Schistosoma mansoni	protein kinase C mu	0.0353	0.3065	0.3038
Loa Loa (eye worm)	hypothetical protein	0.0743	0.679	0.678
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0204	0.1653	0.162
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0124	0.0883	0.0848
Echinococcus granulosus	A kinase anchor protein 10 mitochondrial	0.0124	0.0883	0.0883
Schistosoma mansoni	tyrosine kinase	0.0043	0.0114	0.0075
Entamoeba histolytica	protein kinase, putative	0.0041	0.0093	0.0109
Entamoeba histolytica	PH domain containing protein kinase, putative	0.061	0.5517	1
Brugia malayi	hypothetical protein	0.0124	0.0883	0.0848
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0043	0.0114	0.0114
Echinococcus granulosus	serine:threonine protein kinase N2	0.06	0.5428	0.5428
Toxoplasma gondii	AGC kinase	0.0415	0.3664	1
Loa Loa (eye worm)	hypothetical protein	0.0209	0.1701	0.1673
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0227	0.1867	0.1867
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 1	0.0415	0.3664	1
Loa Loa (eye worm)	TK protein kinase	0.0039	0.0074	0.0041
Brugia malayi	Protein kinase domain containing protein	0.0276	0.234	0.231
Loa Loa (eye worm)	hypothetical protein	0.0703	0.6403	0.6391
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 2	0.0415	0.3664	1
Brugia malayi	hypothetical protein	0.0124	0.0883	0.0848
Schistosoma mansoni	hypothetical protein	0.02	0.1612	0.158
Echinococcus granulosus	unc 13 munc13	0.0227	0.1867	0.1867
Echinococcus granulosus	protein kinase c iota type	0.0655	0.5944	0.5944
Brugia malayi	PXA domain containing protein	0.0124	0.0883	0.0848
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0267	0.2251	0.2251
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0267	0.2251	0.2251
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0661	0.6003	0.5987
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.0114	0.0114
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0883	0.0853
Plasmodium falciparum	cAMP-dependent protein kinase catalytic subunit	0.0415	0.3664	1
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0056	0.024	0.024
Echinococcus multilocularis	N chimaerin	0.0204	0.1653	0.1653
Schistosoma mansoni	protein kinase C mu	0.02	0.1612	0.158
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0425	0.3753	0.6784
Loa Loa (eye worm)	hypothetical protein	0.0944	0.8697	0.8692
Echinococcus multilocularis	unc 13 (munc13)	0.0227	0.1867	0.1867
Brugia malayi	Hr1 repeat family protein	0.0267	0.2251	0.222
Echinococcus multilocularis	protein kinase c epsilon type	0.108	1	1
Entamoeba histolytica	hypothetical protein	0.0124	0.0883	0.155
Loa Loa (eye worm)	PXA domain-containing protein	0.0124	0.0883	0.0853
Entamoeba histolytica	hypothetical protein	0.0035	0.0039	0.001
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0996	0.9202	0.9202
Echinococcus multilocularis	RNA directed DNA polymerase	0.0503	0.4496	0.4496
Brugia malayi	Variant SH3 domain containing protein	0.0204	0.1653	0.162
Schistosoma mansoni	tyrosine kinase	0.0043	0.0114	0.0075
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0267	0.2251	0.2225
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0415	0.3664	0.3664
Echinococcus granulosus	raf serine:threonine protein kinase	0.0201	0.1624	0.1624
Trichomonas vaginalis	AGC family protein kinase	0.0276	0.234	0.5237
Leishmania major	protein kinase A catalytic subunit isoform 1	0.0415	0.3664	1
Schistosoma mansoni	serine/threonine protein kinase	0.0214	0.1746	0.1713
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0415	0.3664	0.3643
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0204	0.1653	0.1653
Trichomonas vaginalis	AGC family protein kinase	0.0267	0.2251	0.4917
Echinococcus granulosus	Rac GTPase activating protein 1	0.02	0.1612	0.1612
Entamoeba histolytica	protein kinase, putative	0.0276	0.234	0.4206
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0537	0.4825	0.4808
Echinococcus granulosus	N chimaerin	0.0204	0.1653	0.1653
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0039	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.02	0.1612	0.1584
Loa Loa (eye worm)	Ras association domain family 1 isoform A	0.02	0.1612	0.1584
Echinococcus multilocularis	G protein coupled receptor kinase 1	0.0202	0.1634	0.1634
Echinococcus granulosus	G protein coupled receptor kinase 1	0.0202	0.1634	0.1634
Echinococcus granulosus	regulator of G protein signaling 3	0.0124	0.0883	0.0883
Echinococcus multilocularis	G protein coupled receptor kinase 6	0.0537	0.4825	0.4825
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0043	0.0114	0.0114
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0267	0.2251	0.2225
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.024	0.0201
Loa Loa (eye worm)	hypothetical protein	0.02	0.1612	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0348	0.3021	0.2998
Loa Loa (eye worm)	hypothetical protein	0.1011	0.9335	0.9333
Echinococcus granulosus	protein kinase c eta type	0.02	0.1612	0.1612
Echinococcus multilocularis	axis inhibition protein axin	0.0124	0.0883	0.0883
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0124	0.0883	0.0848
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0034	0.0034	0.0034
Echinococcus multilocularis	serine threonine protein kinase	0.0796	0.7295	0.7295
Schistosoma mansoni	unc-13 (munc13)	0.0227	0.1867	0.1835
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0039	0.0039
Schistosoma mansoni	diacylglycerol kinase theta	0.02	0.1612	0.158
Schistosoma mansoni	rac gtpase activating protein	0.02	0.1612	0.158
Brugia malayi	RhoGAP domain containing protein	0.0204	0.1653	0.162
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0037	0.0063	0.0063
Echinococcus granulosus	axis inhibition protein axin	0.0124	0.0883	0.0883
Echinococcus granulosus	regulator of G protein signaling 7	0.0124	0.0883	0.0883
Brugia malayi	Protein kinase domain containing protein	0.0267	0.2251	0.222
Loa Loa (eye worm)	AGC/PKG protein kinase	0.0056	0.024	0.0207
Brugia malayi	p70 ribosomal S6 kinase beta	0.0267	0.2251	0.222
Loa Loa (eye worm)	RGS-3 protein	0.0124	0.0883	0.0853
Onchocerca volvulus		0.0348	0.3021	0.3461
Echinococcus multilocularis	Diacylglycerol kinase theta	0.02	0.1612	0.1612
Entamoeba histolytica	diacylglycerol kinase, putative	0.02	0.1612	0.288
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0267	0.2251	0.2225
Echinococcus granulosus	cGMP dependent protein kinase	0.0056	0.024	0.024
Echinococcus multilocularis	regulator of G protein signaling 7	0.0124	0.0883	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1026	0.0995
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0204	0.1653	0.1625
Echinococcus granulosus	protein kinase C gamma type	0.0796	0.7295	0.7295
Echinococcus granulosus	RNA directed DNA polymerase	0.0503	0.4496	0.4496
Leishmania major	protein kinase A catalytic subunit	0.0415	0.3664	1
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0267	0.2251	0.2251
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0043	0.0114	0.0114
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0043	0.0114	0.0114
Echinococcus multilocularis	enhancer of mRNA decapping protein 4	0.0401	0.3531	0.3531
Brugia malayi	C1-like domain containing protein	0.0353	0.3065	0.3038
Entamoeba histolytica	hypothetical protein	0.0035	0.0039	0.001
Schistosoma mansoni	z-protein (S1r protein)	0.0124	0.0883	0.0848
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0267	0.2251	0.2225
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0503	0.4496	0.4496
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0276	0.234	0.2314
Echinococcus granulosus	enhancer of mRNA decapping protein 4	0.0401	0.3531	0.3531
Loa Loa (eye worm)	hypothetical protein	0.0339	0.2932	0.2908
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0267	0.2251	0.2251
Loa Loa (eye worm)	AGC/GRK/GRK protein kinase	0.0661	0.6003	0.5989
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0883	0.0853
Echinococcus granulosus	tyrosine kinase	0.0039	0.0074	0.0074
Brugia malayi	protein-tyrosine kinase	0.0039	0.0074	0.0035
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0039	0.0039
Schistosoma mansoni	serine/threonine protein kinase	0.0326	0.2812	0.2783
Giardia lamblia	Kinase, AGC PKA	0.0415	0.3664	0.5
Onchocerca volvulus		0.0339	0.2932	0.3307
Brugia malayi	RhoGEF domain containing protein	0.02	0.1612	0.158
Toxoplasma gondii	AGC kinase	0.0267	0.2251	0.5873
Entamoeba histolytica	hypothetical protein	0.0035	0.0039	0.001
Brugia malayi	cAMP-dependent protein kinase catalytic subunit, putative	0.0415	0.3664	0.3639
Schistosoma mansoni	serine/threonine protein kinase	0.0267	0.2251	0.222
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0057	0.0247	0.0247
Brugia malayi	diacylglycerol kinase	0.02	0.1612	0.158
Echinococcus multilocularis	regulator of G protein signaling	0.0124	0.0883	0.0883
Loa Loa (eye worm)	AGC/GRK/BARK protein kinase	0.0326	0.2812	0.2787
Brugia malayi	Protein kinase domain containing protein	0.0214	0.1746	0.1713
Loa Loa (eye worm)	hypothetical protein	0.0743	0.679	0.678
Schistosoma mansoni	serine/threonine protein kinase	0.0996	0.9202	0.9198
Schistosoma mansoni	serine/threonine protein kinase	0.0326	0.2812	0.2783
Trichomonas vaginalis	AGC family protein kinase	0.0276	0.234	0.5237
Loa Loa (eye worm)	hypothetical protein	0.0138	0.1026	0.0995
Loa Loa (eye worm)	raf kinase	0.02	0.1612	0.1584
Entamoeba histolytica	protein kinase, putative	0.0276	0.234	0.4206
Loa Loa (eye worm)	hypothetical protein	0.02	0.1612	0.1584
Loa Loa (eye worm)	CAMK/PKD protein kinase	0.0353	0.3065	0.3042
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.004	0.009	0.0057
Loa Loa (eye worm)	RasGEF domain-containing protein	0.02	0.1612	0.1584
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0425	0.3753	0.6784
Brugia malayi	A-kinase anchor protein 10, precursor	0.0124	0.0883	0.0848
Echinococcus granulosus	Regulator of G protein signaling 20	0.0124	0.0883	0.0883
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0039	0.0074	0.0074
Brugia malayi	RhoGAP domain containing protein	0.02	0.1612	0.158
Loa Loa (eye worm)	hypothetical protein	0.02	0.1612	0.1584
Schistosoma mansoni	serine/threonine protein kinase	0.0267	0.2251	0.222
Loa Loa (eye worm)	hypothetical protein	0.0227	0.1867	0.1839
Schistosoma mansoni	atypical protein kinase C	0.0668	0.6076	0.606
Echinococcus granulosus	serine:threonine protein kinase N2	0.0267	0.2251	0.2251
Entamoeba histolytica	hypothetical protein	0.043	0.3803	0.6874
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.02	0.1612	0.1584
Schistosoma mansoni	regulator of G protein signaling	0.0124	0.0883	0.0848
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0201	0.1624	0.1624
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0883	0.0853
Loa Loa (eye worm)	hypothetical protein	0.02	0.1612	0.1584
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0267	0.2251	0.2251
Schistosoma mansoni	axis inhibition protein axin	0.0124	0.0883	0.0848
Toxoplasma gondii	AGC kinase	0.0415	0.3664	1
Schistosoma mansoni	unc-13 (munc13)	0.0227	0.1867	0.1835
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0415	0.3664	0.3664
Leishmania major	protein kinase A catalytic subunit isoform 2	0.0415	0.3664	1
Brugia malayi	Regulator of G protein signaling domain containing protein	0.0124	0.0883	0.0848
Brugia malayi	Ras association domain family 1 isoform A	0.02	0.1612	0.158
Echinococcus granulosus	axis inhibition protein axin	0.0124	0.0883	0.0883
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0415	0.3664	0.3664
Loa Loa (eye worm)	hypothetical protein	0.02	0.1612	0.1584
Schistosoma mansoni	serine/threonine protein kinase	0.0661	0.6003	0.5987
Echinococcus granulosus	tyrosine protein kinase HCK	0.0034	0.0034	0.0034
Trichomonas vaginalis	AGC family protein kinase	0.0276	0.234	0.5237
Brugia malayi	Pleckstrin Homology Domain	0.0209	0.1701	0.1669
Echinococcus granulosus	regulator of G protein signaling 7	0.0124	0.0883	0.0883
Echinococcus multilocularis	expressed protein	0.0124	0.0883	0.0883
Brugia malayi	regulator of G-protein signaling egl-10	0.0124	0.0883	0.0848
Schistosoma mansoni	axis inhibition protein axin	0.0124	0.0883	0.0848
Schistosoma mansoni	serine/threonine protein kinase	0.0267	0.2251	0.222
Entamoeba histolytica	diacylglycerol kinase, putative	0.02	0.1612	0.288
Entamoeba histolytica	protein kinase, putative	0.0267	0.2251	0.4044
Mycobacterium ulcerans	hypothetical protein	0.0042	0.0106	0.5
Brugia malayi	diacylglycerol kinase	0.02	0.1612	0.158
Schistosoma mansoni	regulator of G protein signaling 3 rgs3	0.0124	0.0883	0.0848
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0043	0.0114	0.0114
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0043	0.0114	0.0114
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0043	0.0114	0.0114
Brugia malayi	PXA domain containing protein	0.0124	0.0883	0.0848
Echinococcus granulosus	beta-adrenergic receptor kinase	0.0326	0.2812	0.2812
Echinococcus granulosus	Protein kinase C brain isozyme	0.0996	0.9202	0.9202
Loa Loa (eye worm)	AGC/PKA protein kinase	0.0415	0.3664	0.3643
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0543	0.4884	0.4866
Onchocerca volvulus		0.0227	0.1867	0.1459
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0037	0.0063	0.0063
Echinococcus multilocularis	protein kinase c eta type	0.02	0.1612	0.1612
Echinococcus multilocularis	Rac GTPase activating protein 1	0.02	0.1612	0.1612
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0267	0.2251	0.2251
Schistosoma mansoni	serine/threonine protein kinase	0.0267	0.2251	0.222
Brugia malayi	Phorbol esters/diacylglycerol binding domain	0.0353	0.3065	0.3038
Brugia malayi	regulator of G-protein signaling rgs-7	0.0124	0.0883	0.0848
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0204	0.1653	0.1653
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.108	1	1
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0415	0.3664	0.3664
Echinococcus multilocularis	regulator of G protein signaling 3	0.0124	0.0883	0.0883
Echinococcus granulosus	cAMP dependent protein kinase catalytic subunit	0.0415	0.3664	0.3664
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0267	0.2251	0.2251
Schistosoma mansoni	serine/threonine protein kinase	0.0056	0.024	0.0201
Echinococcus multilocularis	protein kinase c iota type	0.0655	0.5944	0.5944
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0267	0.2251	0.2251
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0043	0.0114	0.0114
Trichomonas vaginalis	AGC family protein kinase	0.0267	0.2251	0.4917
Echinococcus granulosus	expressed protein	0.0124	0.0883	0.0883
Schistosoma mansoni	regulator of G protein signaling 17 19 20 (rgs17 19 20)	0.0124	0.0883	0.0848
Schistosoma mansoni	protein kinase C	0.0227	0.1867	0.1835
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0056	0.024	0.024
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0883	0.0853
Echinococcus multilocularis	regulator of G protein signaling 3	0.0124	0.0883	0.0883
Echinococcus granulosus	Serine/threonine-protein kinase Genghis Khan	0.0214	0.1746	0.1746
Trichomonas vaginalis	AGC family protein kinase	0.0267	0.2251	0.4917
Trichomonas vaginalis	AGC family protein kinase	0.0276	0.234	0.5237
Echinococcus granulosus	myotubularin protein 13	0.0209	0.1701	0.1701
Trichomonas vaginalis	AGC family protein kinase	0.0276	0.234	0.5237
Brugia malayi	Protein kinase domain containing protein	0.0267	0.2251	0.222
Echinococcus multilocularis	regulator of G protein signaling 7	0.0124	0.0883	0.0883
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 2	0.0415	0.3664	1
Schistosoma mansoni	serine/threonine protein kinase	0.0415	0.3664	0.3639
Brugia malayi	Probable G protein-coupled receptor kinase F19C6.1, putative	0.0537	0.4825	0.4805
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0854	0.7839	0.7839
Schistosoma mansoni	regulator of G protein signaling	0.0124	0.0883	0.0848
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0276	0.234	0.6372
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0415	0.3664	1
Trichomonas vaginalis	AGC family protein kinase	0.0276	0.234	0.5237
Echinococcus multilocularis	Regulator of G protein signaling 20	0.0124	0.0883	0.0883
Schistosoma mansoni	regulator of G protein signaling	0.0124	0.0883	0.0848
Entamoeba histolytica	protein kinase, putative	0.0041	0.0093	0.0109
Trichomonas vaginalis	AGC family protein kinase	0.0276	0.234	0.5237
Echinococcus multilocularis	A kinase anchor protein 10, mitochondrial	0.0124	0.0883	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0415	0.3664	0.3643
Loa Loa (eye worm)	hypothetical protein	0.0503	0.4496	0.4478
Brugia malayi	SRC-1	0.0043	0.0114	0.0075
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0043	0.0114	0.0114
Entamoeba histolytica	hypothetical protein	0.0035	0.0039	0.001
Loa Loa (eye worm)	G protein signaling regulator EGL-10	0.0124	0.0883	0.0853
Loa Loa (eye worm)	G protein-coupled receptor kinase 1	0.0537	0.4825	0.4808
Entamoeba histolytica	hypothetical protein	0.0124	0.0883	0.155
Schistosoma mansoni	serine/threonine protein kinase	0.108	1	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0043	0.0114	0.0114
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0043	0.0114	0.0114
Loa Loa (eye worm)	SRC-1	0.0043	0.0114	0.0081
Trypanosoma cruzi	cAMP-dependent protein kinase catalytic subunit 3	0.0415	0.3664	1
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0267	0.2251	0.2225
Onchocerca volvulus		0.0743	0.679	1
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0267	0.2251	0.2225
Echinococcus granulosus	Diacylglycerol kinase theta	0.02	0.1612	0.1612
Toxoplasma gondii	protein kinase, cAMP-dependent, catalytic chain	0.0415	0.3664	1
Trypanosoma brucei	cAMP-dependent protein kinase catalytic subunit 1	0.0415	0.3664	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0043	0.0114	0.0114
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0227	0.1867	0.1867
Loa Loa (eye worm)	hypothetical protein	0.0743	0.679	0.678
Entamoeba histolytica	protein kinase, putative	0.0267	0.2251	0.4044
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0056	0.024	0.024
Schistosoma mansoni	serine/threonine protein kinase	0.0415	0.3664	0.3639
Schistosoma mansoni	serine/threonine kinase	0.0267	0.2251	0.222
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0253	0.2118	0.4438
Echinococcus granulosus	NDR protein kinase	0.0267	0.2251	0.2251
Trypanosoma brucei	protein kinase A catalytic subunit, putative	0.0415	0.3664	1
Schistosoma mansoni	serine/threonine protein kinase	0.0201	0.1624	0.1591
Echinococcus granulosus	tyrosine protein kinase Blk	0.0039	0.0074	0.0074
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0039	0.0074	0.0074
Brugia malayi	Egg laying defective protein 4	0.0056	0.024	0.0201
Echinococcus multilocularis	cAMP dependent protein kinase catalytic subunit	0.0415	0.3664	0.3664
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0043	0.0114	0.0114
Entamoeba histolytica	hypothetical protein	0.0124	0.0883	0.155
Entamoeba histolytica	hypothetical protein	0.02	0.1612	0.288
Brugia malayi	protein kinase C3,putative	0.0402	0.3533	0.3507
Echinococcus granulosus	protein kinase c epsilon type	0.108	1	1
Schistosoma mansoni	serine/threonine protein kinase	0.0415	0.3664	0.3639
Schistosoma mansoni	serine/threonine protein kinase	0.0996	0.9202	0.9198
Trichomonas vaginalis	AGC family protein kinase	0.0276	0.234	0.5237
Loa Loa (eye worm)	hypothetical protein	0.0124	0.0883	0.0853
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0039	0.0074	0.0074
Brugia malayi	Protein kinase c protein 2	0.0743	0.679	0.6778
Schistosoma mansoni	regulator of G protein signaling	0.0124	0.0883	0.0848
Toxoplasma gondii	diacylglycerol kinase, putative	0.02	0.1612	0.4009
Brugia malayi	Variant SH3 domain containing protein	0.004	0.009	0.0051
Schistosoma mansoni	regulator of G protein signaling	0.0124	0.0883	0.0848
Schistosoma mansoni	diacylglycerol kinase theta	0.02	0.1612	0.158

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (binding)	= 17 %	Inhibition of Candida albicans SAP2 at 10 uM by spectrophotometry	ChEMBL.	20184325
Inhibition (binding)	= 87 %	Inhibition of Candida albicans SAP2 at 10 uM by spectrophotometry relative to pepstatin A	ChEMBL.	20184325

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL600033

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1102587