TDR Targets

Basic information

Technical information

TDR Targets ID: 1103376
Name: [(E)-3-(acetyl-hydroxyamino)prop-1-enyl]phosp honic acid
MW: 195.11 | Formula: C5H10NO5P
H donors: 3 H acceptors: 5 LogP: -2.44 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)N(C/C=C/P(=O)(O)O)O
InChi: 1S/C5H10NO5P/c1-5(7)6(8)3-2-4-12(9,10)11/h2,4,8H,3H2,1H3,(H2,9,10,11)/b4-2+
InChiKey: LJCWFOKLHHHANO-DUXPYHPUSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

[(E)-3-(acetyl-hydroxy-amino)prop-1-enyl]phosphonic acid
[(E)-3-(ethanoyl-hydroxy-amino)prop-1-enyl]phosphonic acid

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium knowlesi	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Theileria parva	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium berghei	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Babesia bovis	1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	Get druggable targets OG5_130462	All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462
Neospora caninum	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	Get druggable targets OG5_130462	All targets in OG5_130462
Plasmodium yoelii	1-deoxy-D-xylulose 5-phosphate reductoisomerase	Get druggable targets OG5_130462	All targets in OG5_130462

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	acetylcholinesterase	0.0087	0.0603	0.0641
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0064	0.0407	0.082
Brugia malayi	RNA binding protein	0.0071	0.0468	0.2381
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0468	0.3174
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.006	0.0371	0.1873
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0204	0.4856
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0057	0.0347	0.2056
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0204	0.1029
Echinococcus granulosus	carboxylesterase 5A	0.0087	0.0603	0.0641
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0186	0.1451	0.75
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0152	0.1155	0.124
Giardia lamblia	Kinase, CMGC MAPK	0.0057	0.0347	0.9697
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0347	0.2056
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0186	0.1451	0.156
Mycobacterium ulcerans	lipase LipD	0.0186	0.1451	0.3288
Echinococcus granulosus	neutral alpha glucosidase AB	0.004	0.0204	0.0209
Loa Loa (eye worm)	beta-lactamase	0.0186	0.1451	0.75
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.033	0.1659
Brugia malayi	Carboxylesterase family protein	0.0087	0.0603	0.3083
Trypanosoma brucei	protein kinase, putative	0.0057	0.0347	0.239
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0071	0.0468	0.2381
Loa Loa (eye worm)	hypothetical protein	0.0055	0.033	0.1659
Onchocerca volvulus		0.0186	0.1451	0.5935
Echinococcus multilocularis	carboxylesterase 5A	0.0087	0.0603	0.0641
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.0023	0.0061	0.0054
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Schistosoma mansoni	ap endonuclease	0.0058	0.0356	0.2391
Onchocerca volvulus	Huntingtin homolog	0.0243	0.193	1
Schistosoma mansoni	alpha glucosidase	0.004	0.0204	0.1338
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0061	0.0258
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0134	0.1002	0.2227
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0468	0.3174
Echinococcus multilocularis	dna polymerase eta	0.0023	0.0061	0.0054
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0152	0.1155	0.7947
Mycobacterium tuberculosis	Conserved protein	0.0186	0.1451	0.1398
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0152	0.1155	0.124
Treponema pallidum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4287	1
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.0023	0.0061	0.0054
Trypanosoma cruzi	PAB1-binding protein , putative	0.0056	0.034	0.2006
Onchocerca volvulus	Huntingtin homolog	0.0243	0.193	1
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0058	0.0356	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0152	0.1155	0.7947
Loa Loa (eye worm)	hypothetical protein	0.0056	0.034	0.1711
Echinococcus granulosus	dna polymerase kappa	0.0023	0.0061	0.0054
Brugia malayi	MAP kinase sur-1	0.0057	0.0347	0.1747
Onchocerca volvulus		0.0186	0.1451	0.5935
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0468	0.3174
Onchocerca volvulus		0.0161	0.1236	0.4116
Schistosoma mansoni	alpha-glucosidase	0.0155	0.1183	0.8139
Schistosoma mansoni	hypothetical protein	0.0172	0.1325	0.9124
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0468	0.3174
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0186	0.1451	0.1398
Brugia malayi	beta-lactamase	0.0186	0.1451	0.75
Loa Loa (eye worm)	hypothetical protein	0.0243	0.193	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1451	0.75
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0064	0.0407	0.2063
Echinococcus granulosus	tumor protein p63	0.1101	0.9237	1
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0152	0.1155	0.124
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0186	0.1451	0.1398
Echinococcus multilocularis	tar DNA binding protein	0.0071	0.0468	0.0495
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Trypanosoma brucei	glucosidase, putative	0.004	0.0204	0.1407
Brugia malayi	Glycosyl hydrolases family 31 protein	0.004	0.0204	0.1004
Schistosoma mansoni	cellular tumor antigen P53	0.0161	0.1236	0.8508
Echinococcus multilocularis	acetylcholinesterase	0.0087	0.0603	0.0641
Trichomonas vaginalis	D-aminoacylase, putative	0.0186	0.1451	1
Echinococcus granulosus	geminin	0.0172	0.1325	0.1423
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0204	0.1029
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0134	0.1002	0.0947
Schistosoma mansoni	aldehyde dehydrogenase	0.0134	0.1002	0.6885
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0204	0.1029
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0057	0.0347	0.2056
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0064	0.0407	0.0429
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0347	0.2056
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0347	0.2056
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0057	0.0347	0.1747
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1432	0.7403
Trichomonas vaginalis	D-aminoacylase, putative	0.0186	0.1451	1
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0064	0.0407	0.082
Echinococcus granulosus	mitogen activated protein kinase 3	0.0057	0.0347	0.0363
Brugia malayi	Carboxylesterase family protein	0.0087	0.0603	0.3083
Toxoplasma gondii	aldehyde dehydrogenase	0.0134	0.1002	0.1955
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0058	0.0356	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0134	0.1002	0.1074
Mycobacterium tuberculosis	Probable esterase LipL	0.0186	0.1451	0.1398
Mycobacterium ulcerans	hypothetical protein	0.0186	0.1451	0.3288
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0058	0.0356	0.2452
Loa Loa (eye worm)	hypothetical protein	0.0243	0.193	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0186	0.1451	1
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0184	0.1432	0.5778
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0603	0.3083
Echinococcus multilocularis	lysosomal alpha glucosidase	0.018	0.1396	0.1501
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0183	0.0891
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Trichomonas vaginalis	penicillin-binding protein, putative	0.0186	0.1451	1
Mycobacterium tuberculosis	Conserved protein	0.0186	0.1451	0.1398
Brugia malayi	hypothetical protein	0.0243	0.193	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0186	0.1451	0.3288
Trichomonas vaginalis	ap endonuclease, putative	0.0058	0.0356	0.212
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0204	0.1029
Mycobacterium ulcerans	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4287	1
Trichomonas vaginalis	D-aminoacylase, putative	0.0186	0.1451	1
Brugia malayi	beta-lactamase family protein	0.0186	0.1451	0.75
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0057	0.0347	0.239
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0057	0.0347	0.0363
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0061	0.0258
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0134	0.1002	0.6774
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0134	0.1002	0.2227
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Trichomonas vaginalis	neutral alpha-glucosidase ab precursor, putative	0.004	0.0204	0.1029
Toxoplasma gondii	LsmAD domain-containing protein	0.0056	0.034	0.0333
Loa Loa (eye worm)	TAR-binding protein	0.0071	0.0468	0.2381
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0204	0.1029
Chlamydia trachomatis	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4287	0.5
Schistosoma mansoni	DNA polymerase eta	0.0023	0.0061	0.0344
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0152	0.1155	0.124
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0152	0.1155	0.5961
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Trypanosoma cruzi	PAB1-binding protein , putative	0.0056	0.034	0.2006
Mycobacterium tuberculosis	Probable hydrolase	0.0186	0.1451	0.1398
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0057	0.0347	0.2056
Mycobacterium leprae	PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS	0.052	0.4287	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0058	0.0356	0.004
Echinococcus granulosus	beta LACTamase domain containing family member	0.0186	0.1451	0.156
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1451	0.75
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0064	0.0407	0.2493
Leishmania major	hypothetical protein, conserved	0.0186	0.1451	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1451	0.75
Loa Loa (eye worm)	hypothetical protein	0.0087	0.0603	0.3083
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0061	0.0421
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0183	0.0891
Echinococcus granulosus	acetylcholinesterase	0.0087	0.0603	0.0641
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Loa Loa (eye worm)	acetylcholinesterase 1	0.0087	0.0603	0.3083
Trichomonas vaginalis	sucrase-isomaltase, putative	0.004	0.0204	0.1029
Trypanosoma cruzi	hypothetical protein, conserved	0.0186	0.1451	1
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.018	0.1396	0.7216
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0087	0.0603	0.411
Brugia malayi	beta-lactamase family protein	0.0186	0.1451	0.75
Entamoeba histolytica	glycosyl hydrolase, family 31 protein	0.004	0.0204	0.4856
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0058	0.0356	0.1793
Schistosoma mansoni	serine/threonine protein kinase	0.0057	0.0347	0.2329
Schistosoma mansoni	hypothetical protein	0.0037	0.0183	0.1188
Brugia malayi	RNA recognition motif domain containing protein	0.0071	0.0468	0.2381
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0186	0.1451	1
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0064	0.0407	0.0429
Trypanosoma cruzi	hypothetical protein, conserved	0.0186	0.1451	1
Echinococcus granulosus	acetylcholinesterase	0.0087	0.0603	0.0641
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0058	0.0356	0.212
Loa Loa (eye worm)	RNA binding protein	0.0071	0.0468	0.2381
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0186	0.1451	0.3288
Schistosoma mansoni	ap endonuclease	0.0058	0.0356	0.2391
Brugia malayi	ImpB/MucB/SamB family protein	0.0023	0.0061	0.0258
Loa Loa (eye worm)	glycosyl hydrolase family 31 protein	0.004	0.0204	0.1004
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0057	0.0347	0.2056
Echinococcus multilocularis	tumor protein p63	0.1101	0.9237	1
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0057	0.0347	0.2056
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0061	0.0421
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0186	0.1451	0.1398
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0064	0.0407	0.2751
Trichomonas vaginalis	ap endonuclease, putative	0.0058	0.0356	0.212
Echinococcus multilocularis	neutral alpha glucosidase AB	0.004	0.0204	0.0209
Brugia malayi	TAR-binding protein	0.0071	0.0468	0.2381
Toxoplasma gondii	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.4287	1
Leishmania major	alpha glucosidase II subunit, putative	0.004	0.0204	0.1029
Loa Loa (eye worm)	hypothetical protein	0.0161	0.1236	0.6381
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0064	0.0407	0.0348
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.0023	0.0061	0.0258
Plasmodium falciparum	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4287	1
Mycobacterium tuberculosis	Conserved protein	0.0186	0.1451	0.1398
Echinococcus multilocularis	dna polymerase kappa	0.0023	0.0061	0.0054
Trypanosoma brucei	DNA polymerase IV, putative	0.0023	0.0061	0.0421
Wolbachia endosymbiont of Brugia malayi	1-deoxy-D-xylulose 5-phosphate reductoisomerase	0.052	0.4287	1
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0204	0.1029
Schistosoma mansoni	tar DNA-binding protein	0.0071	0.0468	0.3174
Echinococcus granulosus	lysosomal alpha glucosidase	0.018	0.1396	0.1501
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.033	0.1659
Schistosoma mansoni	terminal deoxycytidyl transferase	0.0023	0.0061	0.0344
Trichomonas vaginalis	alpha-glucosidase, putative	0.004	0.0204	0.1029
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.033	0.1659
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Mycobacterium tuberculosis	Probable lipase LipE	0.0186	0.1451	0.1398
Trypanosoma brucei	DNA polymerase kappa, putative	0.0023	0.0061	0.0421
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0058	0.0356	0.0373
Trypanosoma brucei	DNA polymerase eta, putative	0.0023	0.0061	0.0421
Schistosoma mansoni	aldehyde dehydrogenase	0.0134	0.1002	0.6885
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0058	0.0356	0.212
Trichomonas vaginalis	esterase, putative	0.0186	0.1451	1
Loa Loa (eye worm)	carboxylesterase	0.0087	0.0603	0.3083
Toxoplasma gondii	exonuclease III APE	0.0058	0.0356	0.0371
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1451	0.75
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0057	0.0347	0.2056
Schistosoma mansoni	hypothetical protein	0.0025	0.0078	0.0459
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0058	0.0356	0.0296
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0186	0.1451	1
Leishmania major	hypothetical protein, conserved	0.0056	0.034	0.2006
Mycobacterium tuberculosis	Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras	0.0125	0.0928	0.0872
Trypanosoma brucei	hypothetical protein, conserved	0.0186	0.1451	1
Trichomonas vaginalis	maltase-glucoamylase, putative	0.004	0.0204	0.1029
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0152	0.1155	0.7947
Mycobacterium ulcerans	beta-lactamase	0.0186	0.1451	0.3288
Plasmodium vivax	1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative	0.052	0.4287	1
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1451	0.75
Onchocerca volvulus		0.0186	0.1451	0.5935
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0134	0.1002	0.1074
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0058	0.0356	0.0373
Schistosoma mansoni	alpha-glucosidase	0.0155	0.1183	0.8139
Trichomonas vaginalis	CMGC family protein kinase	0.0057	0.0347	0.2056
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0186	0.1451	0.75
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0058	0.0356	0.212
Brugia malayi	Glycosyl hydrolases family 31 protein	0.018	0.1396	0.7216
Mycobacterium tuberculosis	Probable lipase LipD	0.0186	0.1451	0.1398
Schistosoma mansoni	hypothetical protein	0.0172	0.1325	0.9124
Echinococcus multilocularis	geminin	0.0172	0.1325	0.1423
Toxoplasma gondii	ABC1 family protein	0.0186	0.1451	0.3053
Brugia malayi	exodeoxyribonuclease III family protein	0.0058	0.0356	0.1793
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0134	0.1002	0.2227
Echinococcus multilocularis	lysosomal alpha glucosidase	0.018	0.1396	0.1501
Echinococcus granulosus	dna polymerase eta	0.0023	0.0061	0.0054
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0025	0.0078	0.0072
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0025	0.0078	0.0072
Trypanosoma cruzi	hypothetical protein, conserved	0.004	0.0204	0.1029
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0058	0.0356	0.004
Echinococcus granulosus	mitogen activated protein kinase	0.0057	0.0347	0.0363
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0058	0.0356	0.0697
Brugia malayi	N-terminal motif family protein	0.0184	0.1432	0.7403
Plasmodium vivax	hypothetical protein, conserved	0.0186	0.1451	0.2814
Trypanosoma brucei	unspecified product	0.0023	0.0061	0.0421
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0057	0.0347	0.0349
Brugia malayi	hypothetical protein	0.0056	0.034	0.1711
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0152	0.1155	0.5961
Trypanosoma brucei	PAB1-binding protein , putative	0.0056	0.034	0.2343
Echinococcus granulosus	tar DNA binding protein	0.0071	0.0468	0.0495
Brugia malayi	hypothetical protein	0.0036	0.0171	0.0833
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0023	0.0061	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0186	0.1451	0.75
Echinococcus multilocularis	mitogen activated protein kinase	0.0057	0.0347	0.0363

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= -7.19	Inhibitory concentration against DOXP reductoisomerase	ChEMBL.	15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL606521

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1103376