TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 300.306 | Formula: C17H16O5
H donors: 2 H acceptors: 3 LogP: 3.18 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: COc1ccc(cc1)C[C@@H]1COc2c(C1=O)c(O)cc(c2)O
InChi: 1S/C17H16O5/c1-21-13-4-2-10(3-5-13)6-11-9-22-15-8-12(18)7-14(19)16(15)17(11)20/h2-5,7-8,11,18-19H,6,9H2,1H3/t11-/m1/s1
InChiKey: IERGURVELWCYAW-LLVKDONJSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0183	0.0177
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0067	0.0183	0.0169
Echinococcus multilocularis	nuclear receptor nhr 48	0.0031	0.0016	0.001
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus multilocularis	protein KINase family member (kin 25)	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Schistosoma mansoni	serine/threonine protein kinase	0.0857	0.3935	0.3931
Giardia lamblia	Kinase, NEK	0.0857	0.3935	1
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2136	1	1
Entamoeba histolytica	acetyltransferase, GNAT family	0.008	0.0246	0.0194
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0857	0.3935	0.3931
Brugia malayi	Tyrosine-protein kinase PR2	0.0857	0.3935	0.3931
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1278	0.5932	0.5929
Trichomonas vaginalis	conserved hypothetical protein	0.0857	0.3935	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0288	0.1233	0.1227
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0681	0.1731
Trypanosoma cruzi	protein kinase, putative	0.0857	0.3935	1
Echinococcus granulosus	SH2 domain containing protein 7	0.1278	0.5932	0.5929
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Schistosoma mansoni	tensin-related	0.1278	0.5932	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Schistosoma mansoni	hypothetical protein	0.004	0.0058	0.0052
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0053	0.0046
Echinococcus multilocularis		0.1278	0.5932	0.5929
Onchocerca volvulus		0.0857	0.3935	0.3927
Echinococcus granulosus	SH2 motif	0.1278	0.5932	0.5929
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0857	0.3935	0.3931
Brugia malayi	Protein kinase domain containing protein	0.2136	1	1
Schistosoma mansoni	nuclear receptor nhr-48	0.0031	0.0016	0.001
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Brugia malayi	ecdysone receptor	0.0031	0.0016	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Onchocerca volvulus		0.1278	0.5932	0.5926
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.004	0.0055	0.0041
Onchocerca volvulus	Protein ultraspiracle homolog	0.0067	0.0183	0.0169
Echinococcus multilocularis	tensin	0.1278	0.5932	0.5929
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	FL cytokine receptor	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.1278	0.5932	0.5929
Leishmania major	hypothetical protein, conserved	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.0857	0.3935	1
Loa Loa (eye worm)	TK protein kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Brugia malayi	SH2 domain containing protein	0.1278	0.5932	0.5929
Echinococcus granulosus	protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2136	1	1
Plasmodium falciparum	histone acetyltransferase GCN5	0.008	0.0246	0.061
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0031	0.0016	0.001
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1108	0.2815
Echinococcus multilocularis	Niemann Pick C1 protein	0.0139	0.0527	0.0521
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Trichomonas vaginalis	TK family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0145	0.0554	0.1249
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	ecdysteroid receptor	0.0067	0.0183	0.0177
Toxoplasma gondii	STE kinase	0.0857	0.3935	1
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	SRC-1	0.2136	1	1
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1278	0.5932	0.5929
Echinococcus granulosus	Niemann Pick C1 protein	0.0097	0.0329	0.0323
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1278	0.5932	0.5929
Onchocerca volvulus		0.1278	0.5932	0.5926
Echinococcus multilocularis	activin receptor type	0.0857	0.3935	0.3931
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.0857	0.3935	0.3903
Brugia malayi	SH2 domain containing protein	0.1278	0.5932	0.5929
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0031	0.0016	0.001
Loa Loa (eye worm)	protein kinase domain-containing protein	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/ROR protein kinase	0.0857	0.3935	0.3931
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0087	0.028	0.0698
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0031	0.0016	0.001
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0857	0.3935	1
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Schistosoma mansoni	tyrosine kinase	0.2136	1	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0067	0.0183	0.0177
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2136	1	1
Echinococcus granulosus	signal transduction protein lnk realted	0.1278	0.5932	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0183	0.0177
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Brugia malayi	protein-tyrosine kinase	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0183	0.0177
Echinococcus granulosus	kinase suppressor of Ras 1	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Entamoeba histolytica	ankyrin repeat protein	0.0857	0.3935	0.3903
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.0857	0.3935	0.3903
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0069	0.0175
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1278	0.5932	0.5929
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Schistosoma mansoni	hypothetical protein	0.0313	0.1353	0.1348
Loa Loa (eye worm)	TK/ACK protein kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Echinococcus granulosus	hypothetical protein	0.1278	0.5932	0.5929
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1278	0.5932	0.5929
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.0725	0.1842
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.0857	0.3935	0.3931
Schistosoma mansoni	hypothetical protein	0.0175	0.0696	0.069
Schistosoma mansoni	tensin-related	0.1278	0.5932	0.5929
Loa Loa (eye worm)	TK protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	serine/threonine protein kinase	0.0857	0.3935	0.3931
Brugia malayi	Nuclear hormone receptor E75	0.0031	0.0016	0.001
Echinococcus multilocularis	sterol regulatory element binding protein	0.0042	0.0065	0.0059
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Echinococcus granulosus	tyrosine kinase	0.2136	1	1
Loa Loa (eye worm)	TK protein kinase	0.2136	1	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1278	0.5932	0.5929
Brugia malayi	Tensin	0.1278	0.5932	0.5929
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0031	0.0016	0.001
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Echinococcus granulosus	activin receptor type	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	X box binding protein 1	0.0313	0.1353	0.1348
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0067	0.0183	0.0177
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0681	0.1731
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0034	0.0028
Giardia lamblia	Kinase	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Echinococcus granulosus	tyrosine protein kinase Blk	0.2136	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0311	0.0304
Schistosoma mansoni	signal transduction protein lnk-related	0.1278	0.5932	0.5929
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2136	1	1
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0296	0.1272	0.1267
Echinococcus granulosus	tyrosine protein kinase csk	0.0857	0.3935	0.3931
Echinococcus granulosus	c src tyrosine kinase	0.2136	1	1
Brugia malayi	Protein kinase domain containing protein	0.2136	1	1
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1278	0.5932	0.5929
Schistosoma mansoni	retinoic acid receptor RXR	0.0067	0.0183	0.0177
Schistosoma mansoni	coup transcription factor	0.0067	0.0183	0.0177
Schistosoma mansoni	tensin	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	tyrosine protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.0857	0.3935	0.3927
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2136	1	1
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0067	0.0183	0.0177
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Onchocerca volvulus		0.0857	0.3935	0.3927
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	fibroblast growth factor receptor 4	0.0857	0.3935	0.3931
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0065	0.0059
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	Steroid receptor seven-up type 2	0.0067	0.0183	0.0177
Onchocerca volvulus	Bile acid receptor homolog	0.0067	0.0183	0.0169
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2136	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.0857	0.3935	0.3931
Brugia malayi	acetyltransferase, GNAT family protein	0.0296	0.1272	0.1267
Onchocerca volvulus		0.1278	0.5932	0.5926
Echinococcus granulosus	activated cdc42 kinase 1	0.0857	0.3935	0.3931
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0345	0.1504	0.1499
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Entamoeba histolytica	tyrosin kinase, putative	0.0857	0.3935	0.3903
Loa Loa (eye worm)	O-glycosyl hydrolase family 30 protein	0.0261	0.1108	0.1102
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0052	0.0116	0.0115
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0031	0.0016	0.001
Echinococcus multilocularis	SH2 domain containing protein 7	0.1278	0.5932	0.5929
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Leishmania major	protein kinase, putative	0.0857	0.3935	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0311	0.0304
Echinococcus granulosus	growth factor receptor bound protein 2	0.1278	0.5932	0.5929
Entamoeba histolytica	receptor protein kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	activated cdc42 kinase 1	0.0857	0.3935	0.3931
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0035	0.0034	0.0028
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Loa Loa (eye worm)	serine/threonine protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.2136	1	1
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Brugia malayi	nuclear receptor NHR-67	0.0031	0.0016	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	tailless protein	0.0031	0.0016	0.001
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2136	1	1
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0031	0.0016	0.001
Brugia malayi	SH2 domain containing protein	0.1278	0.5932	0.5929
Loa Loa (eye worm)	TK protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	snurportin 1	0.0313	0.1353	0.1347
Brugia malayi	O-Glycosyl hydrolase family 30 protein	0.0261	0.1108	0.1102
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0031	0.0016	0.0002
Plasmodium falciparum	protein kinase, putative	0.0857	0.3935	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0857	0.3935	1
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0278	0.1188	0.1183
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0067	0.0183	0.0177
Plasmodium falciparum	protein kinase, putative	0.0857	0.3935	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2136	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0857	0.3935	1
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.0857	0.3935	0.3931
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	tyrosine protein kinase pr2	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0034	0.0028
Loa Loa (eye worm)	STAT protein	0.1278	0.5932	0.5929
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Trichomonas vaginalis	protein kinase atn1, putative	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0329	0.0323
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.0857	0.3935	0.3927
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0067	0.0183	0.0177
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0067	0.0183	0.0177
Schistosoma mansoni	tyrosine kinase	0.2136	1	1
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.0857	0.3935	0.3931
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.2136	1	1
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0087	0.028	0.0713
Echinococcus granulosus	activated cdc42 kinase 1	0.0857	0.3935	0.3931
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0055	0.0139
Schistosoma mansoni	shc transforming protein	0.1278	0.5932	0.5929
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0016	0.001
Loa Loa (eye worm)	TK/FAK protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2136	1	1
Entamoeba histolytica	SH2 domain containing protein	0.1278	0.5932	0.591
Giardia lamblia	Protein 21.1	0.0857	0.3935	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1278	0.5932	0.5929
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0087	0.028	0.0698
Mycobacterium ulcerans	hypothetical protein	0.0161	0.0631	0.5
Schistosoma mansoni	hypothetical protein	0.1278	0.5932	0.5929
Trichomonas vaginalis	conserved hypothetical protein	0.0042	0.0065	0.0166
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.0857	0.3935	0.3931
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0099	0.0336	0.033
Schistosoma mansoni	hypothetical protein	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK protein kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Schistosoma mansoni	chromobox protein	0.0071	0.0202	0.0196
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Onchocerca volvulus		0.0031	0.0016	0.0002
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1278	0.5932	0.5929
Brugia malayi	Variant SH3 domain containing protein	0.1278	0.5932	0.5929
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0035	0.0034	0.0028
Schistosoma mansoni	serine/threonine protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	NCK adaptor protein	0.1278	0.5932	0.5929
Brugia malayi	Variant SH3 domain containing protein	0.1278	0.5932	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.0857	0.3935	0.3931
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0857	0.3935	0.3931
Trichomonas vaginalis	STE family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0067	0.0183	0.0177
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0093	0.0311	0.0304
Schistosoma mansoni	hypothetical protein	0.0313	0.1353	0.1347
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	protein kinase	0.0857	0.3935	0.3931
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0306	0.1318	0.3338
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0202	0.0513
Entamoeba histolytica	hypothetical protein, conserved	0.0857	0.3935	0.3903
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Entamoeba histolytica	receptor protein kinase, putative	0.0857	0.3935	0.3903
Plasmodium falciparum	tyrosine kinase-like protein	0.0857	0.3935	1
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2136	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0067	0.0183	0.0177
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0067	0.0183	0.0177
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	Niemann Pick C1 protein	0.0097	0.0329	0.0323
Echinococcus multilocularis	FTZ F1 alpha	0.0067	0.0183	0.0177
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1278	0.5932	0.5929
Brugia malayi	nuclear receptor RXR	0.0035	0.0034	0.0028
Echinococcus granulosus	epidermal growth factor receptor	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0034	0.0028
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0681	0.1731
Echinococcus granulosus	nuclear receptor nhr 48	0.0031	0.0016	0.001
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0031	0.0016	0.001
Echinococcus multilocularis	insulin receptor	0.0857	0.3935	0.3931
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0857	0.3935	0.3931
Brugia malayi	hypothetical protein	0.0031	0.0016	0.001
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0183	0.0177
Brugia malayi	SH2 domain containing protein	0.1278	0.5932	0.5929
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0857	0.3935	1
Loa Loa (eye worm)	TK protein kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	TK/Met protein kinase	0.0857	0.3935	0.3931
Onchocerca volvulus		0.0857	0.3935	0.3927
Loa Loa (eye worm)	DR-78	0.0031	0.0016	0.001
Brugia malayi	C-terminal src kinase protein 1	0.0857	0.3935	0.3931
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0681	0.1731
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0311	0.0304
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0031	0.0016	0.001
Echinococcus granulosus	receptor type guanylyl cyclase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Loa Loa (eye worm)	steroid hormone receptor	0.0067	0.0183	0.0177
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Schistosoma mansoni	hypothetical protein	0.004	0.0058	0.0052
Brugia malayi	Receptor family ligand binding region containing protein	0.0857	0.3935	0.3931
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0031	0.0016	0.001
Loa Loa (eye worm)	acetyltransferase	0.0296	0.1272	0.1267
Onchocerca volvulus		0.0857	0.3935	0.3927
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0681	0.1731
Entamoeba histolytica	protein kinase, putative	0.1278	0.5932	0.591
Trichomonas vaginalis	glucosylceramidase, putative	0.0181	0.0725	0.1842
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	geminin	0.0175	0.0696	0.069
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0202	0.0196
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0067	0.0183	0.0177
Echinococcus granulosus	tyrosine kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1278	0.5932	0.5929
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0067	0.0183	0.0177
Echinococcus multilocularis	SH2 motif	0.1278	0.5932	0.5929
Echinococcus granulosus	tyrosine protein kinase csk	0.0857	0.3935	0.3931
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Brugia malayi	RhoGAP domain containing protein	0.1278	0.5932	0.5929
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	heat shock protein 70	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Schistosoma mansoni	ephrin receptor	0.0857	0.3935	0.3931
Echinococcus multilocularis	microtubule associated protein 2	0.0699	0.3182	0.3177
Entamoeba histolytica	ankyrin repeat protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	tyrosine protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	protein tyrosine kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0067	0.0183	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Onchocerca volvulus		0.0031	0.0016	0.0002
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	protein tyrosine kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Echinococcus granulosus	expressed conserved protein	0.1278	0.5932	0.5929
Echinococcus multilocularis	kinase suppressor of Ras 1	0.0857	0.3935	0.3931
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0857	0.3935	0.3931
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0067	0.0183	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Plasmodium falciparum	protein kinase, putative	0.0857	0.3935	1
Onchocerca volvulus	Tyrosine kinase homolog	0.0857	0.3935	0.3927
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	TK/FER protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0067	0.0183	0.0177
Echinococcus granulosus	tyrosine protein kinase csk	0.0857	0.3935	0.3931
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Brugia malayi	hypothetical protein	0.0857	0.3935	0.3931
Echinococcus granulosus	insulin receptor	0.0857	0.3935	0.3931
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0031	0.0016	0.001
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0278	0.1188	0.1183
Echinococcus multilocularis	protein kinase	0.0857	0.3935	0.3931
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.0857	0.3935	0.3931
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	natriuretic peptide receptor 1	0.0857	0.3935	0.3931
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0067	0.0183	0.0177
Onchocerca volvulus		0.0857	0.3935	0.3927
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1278	0.5932	0.5926
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0093	0.0311	0.0304
Entamoeba histolytica	serine/threonine kinase, putative	0.0857	0.3935	0.3903
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	TK/ALK protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0857	0.3935	1
Echinococcus granulosus	geminin	0.0175	0.0696	0.069
Echinococcus granulosus	SHC transforming protein 3	0.1278	0.5932	0.5929
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0306	0.1318	0.3226
Schistosoma mansoni	tensin	0.1278	0.5932	0.5929
Echinococcus granulosus	microtubule associated protein 2	0.0699	0.3182	0.3177
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1278	0.5932	0.5929
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1278	0.5932	0.5929
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0067	0.0183	0.0177
Trypanosoma cruzi	protein kinase, putative	0.0857	0.3935	1
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0067	0.0183	0.0177
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1278	0.5932	0.5929
Giardia lamblia	Kinase, NEK	0.0857	0.3935	1
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	ephrin receptor	0.0857	0.3935	0.3931
Leishmania major	protein kinase, putative	0.0857	0.3935	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2136	1	1
Schistosoma mansoni	hypothetical protein	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0067	0.0183	0.0177
Echinococcus granulosus	integrin linked protein kinase	0.0857	0.3935	0.3931
Brugia malayi	steroid hormone receptor	0.0067	0.0183	0.0177
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2136	1	1
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1278	0.5932	0.5929
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2136	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.0857	0.3935	1
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	expressed conserved protein	0.0091	0.0301	0.0295
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Schistosoma mansoni	patched 1	0.0042	0.0065	0.0059
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0067	0.0183	0.0177
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0067	0.0183	0.0177
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0043	0.0071	0.0165
Brugia malayi	CHE-14 protein	0.0042	0.0065	0.0059
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2136	1	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.0857	0.3935	0.3931
Plasmodium vivax	protein kinase, putative	0.0857	0.3935	1
Trichomonas vaginalis	conserved hypothetical protein	0.0857	0.3935	1
Brugia malayi	ephrin receptor 1 precursor	0.0857	0.3935	0.3931
Brugia malayi	SH2 domain containing protein	0.1278	0.5932	0.5929
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Schistosoma mansoni	tensin	0.1278	0.5932	0.5929
Trypanosoma brucei	protein kinase, putative	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Onchocerca volvulus		0.0857	0.3935	0.3927
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0067	0.0183	0.0177
Schistosoma mansoni	thyroid hormone receptor	0.0345	0.1504	0.1499
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0067	0.0183	0.0177
Schistosoma mansoni	nuclear hormone receptor	0.0031	0.0016	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	growth factor receptor-bound protein	0.1278	0.5932	0.5929
Loa Loa (eye worm)	SH2 domain-containing protein	0.1278	0.5932	0.5929
Echinococcus granulosus	tyrosine protein kinase Srms	0.2136	1	1
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1278	0.5932	0.5926
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	tyrosine protein kinase shark	0.2136	1	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	integrin-linked kinase	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	tyrosine kinase	0.2136	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Brugia malayi	nuclear hormone receptor	0.0031	0.0016	0.001
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0067	0.0183	0.0177
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	SRC-1	0.2136	1	1
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0183	0.0177
Brugia malayi	bone morphogenetic protein type 1 receptor	0.0857	0.3935	0.3931
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1278	0.5932	0.5929
Schistosoma mansoni	hypothetical protein	0.004	0.0058	0.0052
Schistosoma mansoni	nuclear receptor	0.0031	0.0016	0.001
Schistosoma mansoni	zinc finger protein	0.0031	0.0016	0.001
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	ecdysone induced protein 78C	0.0067	0.0183	0.0177
Onchocerca volvulus		0.2136	1	1
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0042	0.0065	0.0059
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0681	0.1731
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	hypothetical protein	0.0278	0.1188	0.1183
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1278	0.5932	0.5929
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0097	0.0329	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0034	0.0028
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Echinococcus granulosus	FTZ F1 alpha	0.0067	0.0183	0.0177
Leishmania major	mitochondrial DNA polymerase beta	0.0306	0.1318	0.226
Entamoeba histolytica	serine/threonine kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	tyrosine protein kinase shark	0.2136	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	TK protein kinase	0.0857	0.3935	0.3931
Toxoplasma gondii	protein kinase domain-containing protein	0.0857	0.3935	1
Echinococcus granulosus	tensin	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0857	0.3935	0.3931
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2136	1	1
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0067	0.0183	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/ABL protein kinase	0.2136	1	1
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0067	0.0183	0.0177
Brugia malayi	nuclear hormone receptor family member odr-7	0.0031	0.0016	0.001
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0031	0.0016	0.001
Schistosoma mansoni	vav2	0.1278	0.5932	0.5929
Loa Loa (eye worm)	TK/CSK protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/FER protein kinase	0.0857	0.3935	0.3931
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/EPH protein kinase	0.0857	0.3935	0.3931
Onchocerca volvulus		0.2136	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1278	0.5932	0.5929
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0857	0.3935	0.3931
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0093	0.0311	0.0304
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1278	0.5932	0.591
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0857	0.3935	0.3931
Brugia malayi	Raf kinase	0.0857	0.3935	0.3931
Trypanosoma brucei	Pseudokinase, putative	0.0857	0.3935	1
Schistosoma mansoni	SH2A	0.1278	0.5932	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0183	0.0177
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2136	1	1
Schistosoma mansoni	tyrosine kinase	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0067	0.0183	0.0177
Echinococcus multilocularis	SH2 motif	0.1278	0.5932	0.5929
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0087	0.028	0.0713
Loa Loa (eye worm)	TK/FER protein kinase	0.0857	0.3935	0.3931
Echinococcus granulosus	raf serine:threonine protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0857	0.3935	0.3931
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Echinococcus multilocularis	epidermal growth factor receptor	0.0857	0.3935	0.3931
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0053	0.0046
Brugia malayi	SH2 domain containing protein	0.2136	1	1
Brugia malayi	hypothetical protein	0.0035	0.0034	0.0028
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0035	0.0034	0.0028
Echinococcus multilocularis	tyrosine protein kinase csk	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1278	0.5932	0.5929
Echinococcus granulosus	natriuretic peptide receptor 1	0.0857	0.3935	0.3931
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0857	0.3935	0.3931
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1278	0.5932	0.5929
Entamoeba histolytica	serine/threonine kinase, putative	0.0857	0.3935	0.3903
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0087	0.028	0.0698
Brugia malayi	Protein kinase domain containing protein	0.2136	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0067	0.0183	0.0177
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Schistosoma mansoni	serine/threonine RGC	0.0857	0.3935	0.3931
Brugia malayi	Protein kinase domain containing protein	0.2136	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0857	0.3935	1
Brugia malayi	RNA, U transporter 1	0.0083	0.0263	0.0257
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1278	0.5932	0.5929
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0031	0.0016	0.001
Brugia malayi	hypothetical protein	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Trichomonas vaginalis	conserved hypothetical protein	0.0857	0.3935	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	GTPase activating protein	0.1278	0.5932	0.5929
Brugia malayi	SH2 domain containing protein	0.2136	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0093	0.0311	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2136	1	1
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.0857	0.3935	0.3931
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1108	0.2815
Onchocerca volvulus		0.2136	1	1
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Brugia malayi	Nuclear hormone receptor E75	0.0031	0.0016	0.001
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0067	0.0183	0.0177
Loa Loa (eye worm)	TK/FER protein kinase	0.0857	0.3935	0.3931
Plasmodium vivax	tyrosine kinase-like protein, putative	0.0857	0.3935	1
Onchocerca volvulus		0.1278	0.5932	0.5926
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0161	0.0631	0.5
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0857	0.3935	0.3931
Schistosoma mansoni	nuclear hormone receptor	0.0067	0.0183	0.0177
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	heterochromatin protein 1	0.0071	0.0202	0.0196
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.2136	1	1
Entamoeba histolytica	cysteine surface protein, putative	0.0857	0.3935	0.3903
Onchocerca volvulus		0.2136	1	1
Schistosoma mansoni	hypothetical protein	0.0175	0.0696	0.069
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0311	0.0304
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2136	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1108	0.2815
Loa Loa (eye worm)	TK/FER protein kinase	0.0857	0.3935	0.3931
Toxoplasma gondii	hypothetical protein	0.0049	0.0101	0.0241
Entamoeba histolytica	serine/threonine kinase, putative	0.0857	0.3935	0.3903
Schistosoma mansoni	nck2/grb4	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	nuclear receptor NHR-88	0.0067	0.0183	0.0177
Echinococcus multilocularis	ephrin type A receptor 4 A	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	tyrosine kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	suppressor of cytokine signaling	0.1278	0.5932	0.5929
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	microtubule-associated protein tau	0.0699	0.3182	0.3177
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Brugia malayi	SH2 domain containing protein	0.1278	0.5932	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0034	0.0028
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2136	1	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0857	0.3935	0.3931
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	tyrosine protein kinase csk	0.0857	0.3935	0.3931
Brugia malayi	conserved hypotetical protein	0.0031	0.0016	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0857	0.3935	1
Brugia malayi	hypothetical protein	0.0031	0.0016	0.001
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2136	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Echinococcus multilocularis	N chimaerin	0.1278	0.5932	0.5929
Brugia malayi	hypothetical protein	0.1278	0.5932	0.5929
Loa Loa (eye worm)	TK/FER protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0067	0.0183	0.0177
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.0857	0.3935	0.3931
Onchocerca volvulus		0.1278	0.5932	0.5926
Echinococcus multilocularis	chromobox protein 1	0.0071	0.0202	0.0196
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1278	0.5932	0.5929
Echinococcus multilocularis	tensin	0.1278	0.5932	0.5929
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	TK/INSR protein kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0067	0.0183	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Brugia malayi	nuclear receptor NHR-88	0.0031	0.0016	0.001
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0067	0.0183	0.0177
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.0857	0.3935	0.3931
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0035	0.0034	0.0028
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0031	0.0016	0.0002
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0067	0.0183	0.0177
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.1623	0.7566	0.7564
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.0857	0.3935	0.3931
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0043	0.0069	0.0055
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0067	0.0183	0.0177
Echinococcus granulosus	thyroid hormone receptor alpha	0.0031	0.0016	0.001
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0313	0.1353	0.1347
Echinococcus multilocularis	SHC transforming protein 3	0.1278	0.5932	0.5929
Brugia malayi	hypothetical protein	0.0039	0.0053	0.0046
Echinococcus granulosus	expressed conserved protein	0.0091	0.0301	0.0295
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Entamoeba histolytica	serine/threonine kinase, putative	0.0857	0.3935	0.3903
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0053	0.0046
Loa Loa (eye worm)	SH2 domain-containing protein	0.1278	0.5932	0.5929
Entamoeba histolytica	tyrosin kinase, putative	0.0857	0.3935	0.3903
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	Niemann-Pick C1 protein precursor	0.0097	0.0329	0.0323
Schistosoma mansoni	thyroid hormone receptor	0.0345	0.1504	0.1499
Brugia malayi	Sex muscle abnormal protein 5	0.1278	0.5932	0.5929
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0031	0.0016	0.001
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0067	0.0183	0.0177
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1278	0.5932	0.5929
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0306	0.1318	0.3226
Onchocerca volvulus		0.0857	0.3935	0.3927
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	hypothetical protein	0.0039	0.0053	0.0046
Loa Loa (eye worm)	TK/DDR protein kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	epidermal growth factor receptor	0.0857	0.3935	0.3931
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0857	0.3935	1
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.0857	0.3935	0.3931
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.0857	0.3935	0.3931
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2136	1	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0139	0.0527	0.0521
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0183	0.0177
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0067	0.0183	0.0177
Echinococcus granulosus	chromobox protein 1	0.0071	0.0202	0.0196
Brugia malayi	Variant SH3 domain containing protein	0.1278	0.5932	0.5929
Echinococcus granulosus	SH2 motif	0.1278	0.5932	0.5929
Echinococcus multilocularis	c src tyrosine kinase	0.2136	1	1
Onchocerca volvulus		0.0857	0.3935	0.3927
Brugia malayi	SH2 domain containing protein	0.1278	0.5932	0.5929
Brugia malayi	Heterochromatin protein 1	0.0071	0.0202	0.0196
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.0857	0.3935	0.3931
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0857	0.3935	1
Loa Loa (eye worm)	TK protein kinase	0.0857	0.3935	0.3931
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1278	0.5932	0.5929
Echinococcus granulosus	ephrin type A receptor 4 A	0.0857	0.3935	0.3931
Schistosoma mansoni	RAR-like nuclear receptor	0.0067	0.0183	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0067	0.0183	0.0177
Schistosoma mansoni	adapter molecule crk	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	chromobox protein	0.0071	0.0202	0.0196
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.0857	0.3935	0.3931
Echinococcus granulosus	sterol regulatory element binding protein	0.0042	0.0065	0.0059
Toxoplasma gondii	protein kinase	0.0857	0.3935	1
Brugia malayi	orphan nuclear receptor NR2E1	0.0031	0.0016	0.001
Schistosoma mansoni	serine/threonine protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0031	0.0016	0.001
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Echinococcus granulosus	Protein patched homolog 1	0.0042	0.0065	0.0059
Entamoeba histolytica	serine/threonine kinase, putative	0.0857	0.3935	0.3903
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Echinococcus granulosus	protein tyrosine kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	suppressor of cytokine signaling	0.1278	0.5932	0.5929
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2136	1	1
Echinococcus granulosus	X box binding protein 1	0.0313	0.1353	0.1348
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0183	0.0177
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1278	0.5932	0.5929
Echinococcus granulosus	N chimaerin	0.1278	0.5932	0.5929
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0857	0.3935	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0067	0.0183	0.0177
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.0857	0.3935	0.3931
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0857	0.3935	1
Echinococcus granulosus	epidermal growth factor receptor	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0071	0.0202	0.0513
Echinococcus multilocularis	raf serine:threonine protein kinase	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0035	0.0034	0.0028
Entamoeba histolytica	tyrosin kinase, putative	0.0857	0.3935	0.3903
Brugia malayi	Guanylyl cyclase protein 23	0.0857	0.3935	0.3931
Echinococcus granulosus	chromobox protein 1	0.0071	0.0202	0.0196
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine protein kinase	0.0857	0.3935	0.3931
Echinococcus granulosus	tyrosine protein kinase HCK	0.0857	0.3935	0.3931
Echinococcus multilocularis	protein dispatched 1	0.0048	0.0093	0.0087
Trichomonas vaginalis	conserved hypothetical protein	0.0857	0.3935	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Schistosoma mansoni	nuclear receptor	0.0031	0.0016	0.001
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0035	0.0034	0.0028
Brugia malayi	Nuclear hormone receptor-like 1	0.0067	0.0183	0.0177
Onchocerca volvulus		0.2136	1	1
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1108	0.2815
Brugia malayi	Tyrosine-protein kinase abl-1	0.2136	1	1
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0067	0.0183	0.0177
Brugia malayi	Nuclear hormone receptor-like 1	0.0035	0.0034	0.0028
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2136	1	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0093	0.0311	0.0304
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1278	0.5932	0.5929
Echinococcus multilocularis	integrin linked protein kinase	0.0857	0.3935	0.3931
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0857	0.3935	0.3931
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Onchocerca volvulus		0.0857	0.3935	0.3927
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0857	0.3935	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0857	0.3935	0.3931
Echinococcus multilocularis	protein patched	0.0042	0.0065	0.0059
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1278	0.5932	0.5929
Brugia malayi	Variant SH3 domain containing protein	0.1278	0.5932	0.5929
Onchocerca volvulus		0.2136	1	1
Entamoeba histolytica	protein kinase, putative	0.0857	0.3935	0.3903
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1108	0.2815
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0087	0.028	0.0274
Trichomonas vaginalis	AGC family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0031	0.0016	0.001
Trichomonas vaginalis	glucosylceramidase, putative	0.0172	0.0681	0.1731
Loa Loa (eye worm)	hypothetical protein	0.0051	0.011	0.0104
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1278	0.5932	0.5929
Trichomonas vaginalis	chromobox protein, putative	0.0043	0.0069	0.0175
Entamoeba histolytica	tyrosin kinase, putative	0.0857	0.3935	0.3903
Brugia malayi	hypothetical protein	0.0035	0.0034	0.0028
Loa Loa (eye worm)	hypothetical protein	0.004	0.0055	0.0048
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0067	0.0183	0.0177
Schistosoma mansoni	growth factor receptor-bound protein	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0145	0.0554	0.1393
Brugia malayi	nuclear receptor RXR	0.0031	0.0016	0.001
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2136	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1278	0.5932	0.5929
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0857	0.3935	0.3931
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Trichomonas vaginalis	conserved hypothetical protein	0.0857	0.3935	1
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2136	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.0857	0.3935	0.3903
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.0857	0.3935	0.3931
Brugia malayi	photoreceptor-specific nuclear receptor	0.0067	0.0183	0.0177
Brugia malayi	Protein kinase domain containing protein	0.0857	0.3935	0.3931
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0067	0.0183	0.0177
Trichomonas vaginalis	CAMK family protein kinase	0.0857	0.3935	1
Echinococcus multilocularis	signal transduction protein lnk realted	0.1278	0.5932	0.5929
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Onchocerca volvulus		0.1278	0.5932	0.5926
Brugia malayi	nuclear hormone receptor	0.0067	0.0183	0.0177
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0857	0.3935	0.3931
Echinococcus granulosus	NCK adaptor protein	0.1278	0.5932	0.5929
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0014	0.0008
Onchocerca volvulus		0.0067	0.0183	0.0169
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0016	0.001
Echinococcus granulosus	tyrosine protein kinase pr2	0.0857	0.3935	0.3931
Schistosoma mansoni	hypothetical protein	0.004	0.0058	0.0052
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Echinococcus granulosus	retinal guanylyl cyclase 2	0.0857	0.3935	0.3931
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.0857	0.3935	0.3931
Echinococcus granulosus	snurportin 1	0.0313	0.1353	0.1347
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Echinococcus multilocularis	SH2 motif	0.1278	0.5932	0.5929
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2136	1	1
Schistosoma mansoni	protein kinase	0.0857	0.3935	0.3931
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Echinococcus multilocularis	transfer RNA-Thr	0.0857	0.3935	0.3931
Schistosoma mansoni	tyrosine kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	protein kinase domain containing protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	TK/FER protein kinase	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1278	0.5932	0.5929
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1278	0.5932	0.5929
Brugia malayi	chromobox protein homolog 3	0.004	0.0055	0.0048
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0857	0.3935	0.3931
Onchocerca volvulus	Glucosylceramidase homolog	0.0172	0.0681	0.0668
Trichomonas vaginalis	glucosylceramidase, putative	0.0261	0.1108	0.2815
Trichomonas vaginalis	conserved hypothetical protein	0.004	0.0055	0.0139
Brugia malayi	hypothetical protein	0.2136	1	1
Brugia malayi	Furin-like cysteine rich region family protein	0.0857	0.3935	0.3931
Entamoeba histolytica	hypothetical protein	0.0857	0.3935	0.3903
Loa Loa (eye worm)	TK/FER protein kinase	0.0857	0.3935	0.3931
Entamoeba histolytica	tyrosine kinase, putative	0.0857	0.3935	0.3903
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Echinococcus multilocularis	tyrosine kinase	0.2136	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Loa Loa (eye worm)	hypothetical protein	0.0857	0.3935	0.3931
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0296	0.1272	0.1267
Loa Loa (eye worm)	hypothetical protein	0.1278	0.5932	0.5929
Trichomonas vaginalis	TKL family protein kinase	0.0857	0.3935	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0067	0.0183	0.0177
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0031	0.0016	0.001
Schistosoma mansoni	tyrosine kinase	0.2136	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	> 100 uM	Cytotoxicity against human PANC1 cells in nutrient-deprived condition after 24 hrs by WST8 assay	ChEMBL.	19689125
IC50 (functional)	> 100 uM	Cytotoxicity against human HT1080 cells after 72 hrs by MTT assay	ChEMBL.	19689125
IC50 (functional)	> 100 uM	Cytotoxicity against human A549 cells after 72 hrs by MTT assay	ChEMBL.	19689125
IC50 (functional)	> 100 uM	Cytotoxicity against human HeLa cells after 72 hrs by MTT assay	ChEMBL.	19689125

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1079709

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1105144