TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 455.378 | Formula: C19H16Cl2N2O3S2
H donors: 3 H acceptors: 3 LogP: 5.11 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CSC[C@H]1[C@H](NC(=O)c2cc3c([nH]2)c(c(s3)Cl)Cl)Cc2c1cccc2
InChi: 1S/C19H16Cl2N2O3S2/c20-16-17-14(28-18(16)21)6-13(22-17)19(26)23-12-5-9-3-1-2-4-10(9)11(12)7-27-8-15(24)25/h1-4,6,11-12,22H,5,7-8H2,(H,23,26)(H,24,25)/t11-,12-/m1/s1
InChiKey: PBMXOEGUCUSDDO-VXGBXAGGSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	phosphorylase, glycogen, liver	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Candida albicans	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	Glycogen phosphorylase, brain form, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Brugia malayi	carbohydrate phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	Glycosyl transferase, family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Loa Loa (eye worm)	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma mansoni	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Onchocerca volvulus	Glycogen phosphorylase homolog	Get druggable targets OG5_126999	All targets in OG5_126999
Neospora caninum	hypothetical protein	Get druggable targets OG5_126999	All targets in OG5_126999
Trichomonas vaginalis	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Giardia lamblia	Glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Schistosoma japonicum	ko:K00688 starch phosphorylase [EC2.4.1.1], putative	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium parvum	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus multilocularis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Cryptosporidium hominis	glycogen phosphorylase 1	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	Glycosyl transferase family 35	Get druggable targets OG5_126999	All targets in OG5_126999
Candida albicans	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Echinococcus granulosus	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999
Entamoeba histolytica	glycogen phosphorylase, putative	Get druggable targets OG5_126999	All targets in OG5_126999
Chlamydia trachomatis	glycogen phosphorylase	Get druggable targets OG5_126999	All targets in OG5_126999

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0696	0.0937
Brugia malayi	ecdysteroid receptor	0.003	0.0696	0.1256
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.5545	1
Entamoeba histolytica	glycogenphosphorylase, putative	0.0056	0.1955	0.3283
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1955	0.3283
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0907	0.1636
Leishmania major	DNA polymerase eta, putative	0.0033	0.0817	0.4775
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1437	0.1933
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0696	0.0937
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0907	0.1324
Trichomonas vaginalis	esterase, putative	0.0035	0.0907	0.1324
Onchocerca volvulus		0.0035	0.0907	0.0435
Mycobacterium tuberculosis	Probable lipase LipD	0.0035	0.0907	0.0722
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0696	0.1256
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1437	0.1933
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0785	0.1057
Brugia malayi	ImpB/MucB/SamB family protein	0.0047	0.1493	0.2693
Loa Loa (eye worm)	hypothetical protein	0.003	0.0696	0.1256
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.4167	0.7515
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0785	0.1416
Trypanosoma brucei	hypothetical protein, conserved	0.0035	0.0907	0.5471
Echinococcus granulosus	Glycosyl transferase family 35	0.013	0.5545	0.7461
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0696	0.0937
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0907	0.1324
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0696	0.1256
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0696	0.1256
Loa Loa (eye worm)	transcription factor SMAD2	0.0119	0.5006	0.9028
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.5545	0.7461
Loa Loa (eye worm)	hypothetical protein	0.003	0.0696	0.1256
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0785	0.1416
Loa Loa (eye worm)	hypothetical protein	0.003	0.0696	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0907	0.1636
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0696	0.0937
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0035	0.0907	0.1221
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0785	0.1057
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0907	0.5471
Echinococcus multilocularis	thyroid hormone receptor alpha	0.003	0.0696	0.0937
Onchocerca volvulus	Glycogen phosphorylase homolog	0.013	0.5545	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0696	0.0937
Schistosoma mansoni	hypothetical protein	0.0032	0.0785	0.1057
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0785	0.1057
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0696	0.1256
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0046	0.1437	0.2591
Loa Loa (eye worm)	hypothetical protein	0.003	0.0696	0.1256
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0696	0.0937
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0696	0.1256
Echinococcus granulosus	dna polymerase kappa	0.002	0.02	0.0269
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0401	0.1558
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0907	0.0722
Echinococcus granulosus	glycogen phosphorylase	0.013	0.5545	0.7461
Schistosoma mansoni	thyroid hormone receptor	0.003	0.0696	0.0937
Brugia malayi	beta-lactamase	0.0035	0.0907	0.1636
Schistosoma mansoni	glycogen phosphorylase	0.013	0.5545	0.7461
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0696	0.0937
Toxoplasma gondii	ABC1 family protein	0.0035	0.0907	1
Brugia malayi	ImpB/MucB/SamB family protein	0.002	0.02	0.036
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.2602	0.4692
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0696	0.0937
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0033	0.0817	0.8223
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0907	0.0722
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.5545	1
Echinococcus multilocularis	terminal deoxycytidyl transferase rev1	0.002	0.02	0.0269
Loa Loa (eye worm)	beta-lactamase	0.0035	0.0907	0.1636
Echinococcus granulosus	dna polymerase eta	0.0047	0.1493	0.2009
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0696	0.0937
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0696	0.0937
Brugia malayi	carbohydrate phosphorylase	0.013	0.5545	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0785	0.1057
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0907	0.1636
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.002	0.02	0.0269
Schistosoma mansoni	hypothetical protein	0.0032	0.0785	0.1057
Echinococcus granulosus	beta LACTamase domain containing family member	0.0035	0.0907	0.1221
Brugia malayi	steroid hormone receptor	0.003	0.0696	0.1256
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1437	0.1933
Schistosoma mansoni	terminal deoxycytidyl transferase	0.002	0.02	0.0269
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0696	0.0937
Mycobacterium ulcerans	beta-lactamase	0.0035	0.0907	0.4032
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1437	0.1933
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0035	0.0907	0.0722
Brugia malayi	nuclear hormone receptor	0.003	0.0696	0.1256
Onchocerca volvulus		0.0035	0.0907	0.0435
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0696	0.0937
Entamoeba histolytica	glycogen phosphorylase, putative	0.013	0.5545	1
Echinococcus multilocularis	geminin	0.0169	0.7432	1
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0696	0.0937
Trypanosoma cruzi	PAB1-binding protein , putative	0.0024	0.0401	0.1558
Mycobacterium leprae	conserved hypothetical protein	0.0035	0.0907	0.5
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0696	0.0937
Echinococcus granulosus	glycogen phosphorylase	0.013	0.5545	0.7461
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0907	0.1636
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0696	0.1256
Loa Loa (eye worm)	MH2 domain-containing protein	0.0119	0.5006	0.9028
Entamoeba histolytica	glycogen phosphorylase, putative	0.0056	0.1955	0.3283
Trichomonas vaginalis	penicillin-binding protein, putative	0.0035	0.0907	0.1324
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0696	0.1256
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0785	0.1057
Giardia lamblia	Glycogen phosphorylase	0.013	0.5545	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0696	0.1256
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0696	0.0937
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0696	0.0937
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0907	0.1636
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0035	0.0907	0.1636
Mycobacterium ulcerans	esterase/lipase LipP	0.0035	0.0907	0.4032
Schistosoma mansoni	hypothetical protein	0.007	0.2602	0.3501
Echinococcus granulosus	GPCR family 2	0.0032	0.0785	0.1057
Mycobacterium tuberculosis	Probable glycogen phosphorylase GlgP	0.0056	0.1955	0.1791
Brugia malayi	beta-lactamase family protein	0.0035	0.0907	0.1636
Chlamydia trachomatis	glycogen phosphorylase	0.013	0.5545	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0046	0.1437	0.1933
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0696	0.1256
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0696	0.0937
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0696	0.0937
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0907	0.1324
Schistosoma mansoni	hypothetical protein	0.0032	0.0785	0.1057
Echinococcus multilocularis	dna polymerase eta	0.0047	0.1493	0.2009
Loa Loa (eye worm)	hypothetical protein	0.003	0.0696	0.1256
Echinococcus granulosus	terminal deoxycytidyl transferase rev1	0.002	0.02	0.0269
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0046	0.1437	0.1933
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0401	0.0724
Echinococcus multilocularis	glycogen phosphorylase	0.013	0.5545	0.7461
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0785	0.1416
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0401	0.5
Brugia malayi	hypothetical protein	0.0024	0.0401	0.0724
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0696	0.1256
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0696	0.0937
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0907	0.1221
Brugia malayi	nuclear receptor NHR-88	0.003	0.0696	0.1256
Schistosoma mansoni	DNA polymerase eta	0.0047	0.1493	0.2009
Mycobacterium ulcerans	lipase LipD	0.0035	0.0907	0.4032
Onchocerca volvulus		0.0035	0.0907	0.0435
Mycobacterium ulcerans	hypothetical protein	0.0035	0.0907	0.4032
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0696	0.1256
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0696	0.1256
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0035	0.0907	0.1636
Leishmania major	hypothetical protein, conserved	0.0035	0.0907	0.5471
Trichomonas vaginalis	D-aminoacylase, putative	0.0035	0.0907	0.1324
Echinococcus multilocularis	dna polymerase kappa	0.002	0.02	0.0269
Mycobacterium tuberculosis	Probable esterase LipL	0.0035	0.0907	0.0722
Loa Loa (eye worm)	ImpB/MucB/SamB family protein	0.002	0.02	0.036
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0046	0.1437	0.1933
Leishmania major	hypothetical protein, conserved	0.0024	0.0401	0.1558
Trypanosoma cruzi	DNA polymerase eta, putative	0.0047	0.1493	1
Loa Loa (eye worm)	hypothetical protein	0.0047	0.1493	0.2693
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0696	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0907	0.1636
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.4167	0.7515
Loa Loa (eye worm)	hypothetical protein	0.007	0.2602	0.4692
Schistosoma mansoni	coup transcription factor	0.003	0.0696	0.0937
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0696	0.0937
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0696	0.1256
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0035	0.0907	0.0722
Mycobacterium ulcerans	glycogen phosphorylase GlgP	0.0056	0.1955	1
Mycobacterium leprae	Probable lipase LipE	0.0035	0.0907	0.5
Brugia malayi	beta-lactamase family protein	0.0035	0.0907	0.1636
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0785	0.1057
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0035	0.0907	0.4032
Mycobacterium tuberculosis	Probable hydrolase	0.0035	0.0907	0.0722
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0696	0.1256
Schistosoma mansoni	glycogen phosphorylase	0.0056	0.1955	0.263
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0696	0.0937
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0696	0.1256
Loa Loa (eye worm)	hypothetical protein	0.0102	0.4167	0.7515
Loa Loa (eye worm)	hypothetical protein	0.003	0.0696	0.1256
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0696	0.0937
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0035	0.0907	0.1221
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0696	0.0937
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0046	0.1437	0.2591
Trypanosoma cruzi	hypothetical protein, conserved	0.0035	0.0907	0.5471
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0696	0.1256
Loa Loa (eye worm)	glycogen phosphorylase	0.013	0.5545	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0024	0.0401	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0696	0.1256
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0696	0.1256
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0035	0.0907	0.0722
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0696	0.0937
Trichomonas vaginalis	glycogen phosphorylase, putative	0.013	0.5545	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0696	0.1256
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0696	0.0937
Schistosoma mansoni	hypothetical protein	0.0169	0.7432	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0696	0.0937
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0696	0.1256
Echinococcus multilocularis	Glycosyl transferase, family 35	0.013	0.5545	0.7461
Trypanosoma cruzi	DNA polymerase eta, putative	0.0033	0.0817	0.4775
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0696	0.0937
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0785	0.1416
Plasmodium vivax	hypothetical protein, conserved	0.0035	0.0907	1
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0696	0.1256
Trypanosoma brucei	DNA polymerase eta, putative	0.0047	0.1493	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.4167	0.7515
Loa Loa (eye worm)	hypothetical protein	0.003	0.0696	0.1256
Leishmania major	DNA polymerase eta, putative	0.0047	0.1493	1
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0696	0.0937
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0696	0.1256
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0696	0.1256
Schistosoma mansoni	glycogen phosphorylase	0.013	0.5545	0.7461
Schistosoma mansoni	hypothetical protein	0.0169	0.7432	1
Brugia malayi	MH2 domain containing protein	0.0119	0.5006	0.9028
Mycobacterium tuberculosis	Probable lipase LipE	0.0035	0.0907	0.0722
Echinococcus granulosus	geminin	0.0169	0.7432	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0696	0.1256
Trypanosoma brucei	PAB1-binding protein , putative	0.0024	0.0401	0.1558
Mycobacterium tuberculosis	Conserved protein	0.0035	0.0907	0.0722

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 40 nM	Inhibition of human recombinant liver glycogen phosphorylase by multienzyme-coupled reaction	ChEMBL.	20493691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1082392

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1109223