Detailed information for compound 1111925

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 466.592 | Formula: C26H30N2O4S
  • H donors: 2 H acceptors: 3 LogP: 2.48 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1C)C)CN(Cc1cccs1)Cc1ccc(cc1)OC(C(=O)O)(C)C
  • InChi: 1S/C26H30N2O4S/c1-18-7-12-23(19(2)14-18)27-24(29)17-28(16-22-6-5-13-33-22)15-20-8-10-21(11-9-20)32-26(3,4)25(30)31/h5-14H,15-17H2,1-4H3,(H,27,29)(H,30,31)
  • InChiKey: ZIDZJLMNJDVTDJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens peroxisome proliferator-activated receptor alpha Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni nuclear hormone receptor superfamily protein-related Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma japonicum ko:K08701 nuclear receptor, subfamily 1, invertebrate, putative Get druggable targets OG5_137778 All targets in OG5_137778
Schistosoma japonicum IPR008946,Nuclear receptor, ligand-binding,domain-containing Get druggable targets OG5_137778 All targets in OG5_137778
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor alpha 468 aa 397 aa 25.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica hypothetical protein 0.0075 0.1017 1
Leishmania major C-8 sterol isomerase-like protein 0.0366 0.538 1
Brugia malayi hypothetical protein 0.0136 0.1932 0.311
Loa Loa (eye worm) hypothetical protein 0.0013 0.0095 0.0126
Schistosoma mansoni hypothetical protein 0.0075 0.1017 0.1017
Echinococcus multilocularis cpg binding protein 0.0035 0.0425 0.0375
Echinococcus granulosus intermediate filament protein 0.0029 0.0326 0.0275
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0478 0.0585
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0536 0.075
Schistosoma mansoni ferritin 0.0017 0.0149 0.0149
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0805 0.0926
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0078 0.0097
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.1017 0.1017
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0097
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0805 0.0756
Plasmodium vivax SET domain protein, putative 0.0061 0.0805 0.0926
Entamoeba histolytica hypothetical protein 0.0075 0.1017 1
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0478 0.0747
Loa Loa (eye worm) hypothetical protein 0.0014 0.0103 0.0138
Echinococcus multilocularis pyruvate kinase 0.0031 0.0355 0.0304
Schistosoma mansoni hypothetical protein 0.0081 0.1111 0.1111
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0097
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0078 0.0078
Schistosoma mansoni ap endonuclease 0.0019 0.0173 0.0173
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0126 0.0176
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.0397 0.0616
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0173 0.0121
Schistosoma mansoni cpg binding protein 0.0035 0.0425 0.0425
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0078 0.0078
Schistosoma mansoni pyruvate kinase 0.0039 0.0478 0.0478
Schistosoma mansoni hypothetical protein 0.0081 0.1111 0.1111
Trypanosoma brucei Peptide deformylase 2 0.0181 0.2605 0.4669
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0805 0.0805
Echinococcus multilocularis ferritin 0.0017 0.0149 0.0096
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0478 0.0747
Mycobacterium ulcerans peptide deformylase 0.0474 0.6996 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0078 0.0078
Schistosoma mansoni cpg binding protein 0.0034 0.0397 0.0397
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0078 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1316 0.127
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.1111 0.1064
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0078 0.0097
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0478 0.0446
Echinococcus multilocularis pyruvate kinase 0.0039 0.0478 0.0427
Loa Loa (eye worm) hypothetical protein 0.0187 0.2699 0.4354
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0078 0.0025
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0173 0.0253
Onchocerca volvulus Huntingtin homolog 0.0136 0.1932 0.2663
Brugia malayi nuclear receptor NHR-88 0.0012 0.0078 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0078 0.0025
Loa Loa (eye worm) histone methyltransferase 0.0013 0.0083 0.0106
Onchocerca volvulus 0.0477 0.7041 1
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0422 0.6223 0.6223
Schistosoma mansoni apoferritin-2 0.0017 0.0149 0.0149
Onchocerca volvulus 0.0061 0.0805 0.1045
Schistosoma mansoni lamin 0.0029 0.0326 0.0326
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0536 0.0532
Entamoeba histolytica hypothetical protein 0.0075 0.1017 1
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0181 0.2605 0.4669
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0078 0.0097
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0013 0.0083 0.0031
Schistosoma mansoni cpg binding protein 0.0035 0.0425 0.0425
Schistosoma mansoni hypothetical protein 0.0399 0.5869 0.5869
Schistosoma mansoni hypothetical protein 0.0175 0.2523 0.2523
Trypanosoma brucei Polypeptide deformylase 1 0.0181 0.2605 0.4669
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.1111 0.1064
Brugia malayi steroid hormone receptor 0.0012 0.0078 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1316 0.127
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0078 0.0097
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.2076 0.3343
Echinococcus multilocularis pyruvate kinase 0.002 0.0194 0.0142
Brugia malayi Pre-SET motif family protein 0.0419 0.6175 1
Brugia malayi intermediate filament protein 0.0029 0.0326 0.0501
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0078 0.0097
Schistosoma mansoni hypothetical protein 0.0081 0.1111 0.1111
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.1316 0.127
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1316 0.1316
Echinococcus multilocularis GPCR, family 2 0.0081 0.1111 0.1064
Echinococcus multilocularis pyruvate kinase 0.0039 0.0478 0.0427
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0478 0.0446
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0078 0.0078
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0078 0.0025
Trichomonas vaginalis set domain proteins, putative 0.0477 0.7041 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0078 0.0097
Leishmania major polypeptide deformylase-like protein, putative 0.0181 0.2605 0.4669
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0078 0.0078
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0536 0.0532
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0071 0.0087
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0078 0.0025
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0173 0.0234
Brugia malayi Pre-SET motif family protein 0.0061 0.0805 0.1279
Brugia malayi Calcitonin receptor-like protein seb-1 0.0257 0.3739 0.6044
Echinococcus multilocularis pyruvate kinase 0.002 0.0194 0.0142
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0078 0.0078
Loa Loa (eye worm) acetyltransferase 0.0146 0.2076 0.3343
Echinococcus multilocularis dnaJ subfamily B 0.0477 0.7043 0.7027
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0366 0.538 0.871
Trypanosoma cruzi Peptide deformylase 2, putative 0.0181 0.2605 0.4669
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0257 0.3739 0.6044
Onchocerca volvulus 0.0029 0.0326 0.0357
Brugia malayi ecdysteroid receptor 0.0012 0.0078 0.0097
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.0932 0.1112
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.2076 0.2076
Schistosoma mansoni hypothetical protein 0.0477 0.7043 0.7043
Trypanosoma cruzi Peptide deformylase 2, putative 0.0181 0.2605 0.4669
Plasmodium vivax peptide deformylase, putative 0.0474 0.6996 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0318 0.0488
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0078 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0078 0.0097
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0474 0.6996 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0536 0.0486
Leishmania major pyruvate kinase 0.0039 0.0478 0.0585
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0078 0.0025
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0103 0.0051
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0078 0.0025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1316 0.1316
Echinococcus granulosus dnaJ subfamily B 0.0477 0.7043 0.7027
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0097
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0474 0.6996 1
Schistosoma mansoni microtubule-associated protein tau 0.0675 1 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0078 0.0097
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0478 0.0667
Plasmodium falciparum pyruvate kinase 2 0.002 0.0194 0.0031
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0478 0.0575
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0078 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0078 0.0097
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0078 0.0097
Schistosoma mansoni ferritin 0.0017 0.0149 0.0149
Echinococcus granulosus expressed protein 0.0017 0.0149 0.0096
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0078 0.0078
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0078 0.0078
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0302 0.0461
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0078 0.0025
Trypanosoma brucei C-8 sterol isomerase, putative 0.0366 0.538 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0078 0.0097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.1017 0.0969
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0805 0.0805
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0326 0.0501
Onchocerca volvulus 0.0034 0.0397 0.0458
Echinococcus granulosus lamin 0.0029 0.0326 0.0275
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0478 0.0481
Echinococcus granulosus pyruvate kinase 0.0039 0.0478 0.0427
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0181 0.2605 0.4669
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0078 0.0025
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0326 0.0501
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0478 0.0747
Chlamydia trachomatis peptide deformylase 0.0474 0.6996 1
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0078 0.0097
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0173 0.0121
Giardia lamblia Pyruvate kinase 0.0039 0.0478 0.9838
Brugia malayi latrophilin 2 splice variant baaae 0.0175 0.2523 0.4068
Loa Loa (eye worm) hypothetical protein 0.0027 0.0302 0.0461
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0478 0.0585
Plasmodium falciparum peptide deformylase 0.0474 0.6996 1
Echinococcus granulosus pyruvate kinase 0.002 0.0194 0.0142
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0173 0.0234
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0097
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0478 0.0481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0078 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.1316 0.1316
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0474 0.6996 1
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0194 0.0031
Schistosoma mansoni apoferritin-2 0.0017 0.0149 0.0149
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0061 0.0805 0.0805
Toxoplasma gondii hypothetical protein 0.0474 0.6996 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0805 0.0756
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0366 0.538 1
Echinococcus granulosus pyruvate kinase 0.0039 0.0478 0.0427
Loa Loa (eye worm) hypothetical protein 0.0257 0.3739 0.6044
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.1316 0.2108
Echinococcus granulosus pyruvate kinase 0.002 0.0194 0.0142
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0173 0.0036
Trichomonas vaginalis ferritin, putative 0.0017 0.0149 0.0199
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0097
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0173 0.0253
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0478 0.0575
Schistosoma mansoni hypothetical protein 0.0081 0.1111 0.1111
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0078 0.0097
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0536 0.0532
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0078 0.0078
Plasmodium falciparum pyruvate kinase 0.0039 0.0478 0.0446
Onchocerca volvulus 0.0029 0.0326 0.0357
Schistosoma mansoni coup transcription factor 0.0012 0.0078 0.0078
Echinococcus granulosus pyruvate kinase 0.002 0.0194 0.0142
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0257 0.3739 0.6044
Schistosoma mansoni ferritin light chain 0.0017 0.0149 0.0149
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0194 0.0031
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0478 0.0747
Loa Loa (eye worm) hypothetical protein 0.0136 0.1932 0.311
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0478 0.0747
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.1111 0.1776
Giardia lamblia Pyruvate kinase 0.002 0.0194 0.0674
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0078 0.0025
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.1316 0.127
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0126 0.0176
Schistosoma mansoni ferritin 0.0017 0.0149 0.0149
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.2015 0.1973
Echinococcus granulosus lamin dm0 0.0029 0.0326 0.0275
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.1017 0.0969
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0078 0.0078
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0078 0.0097
Brugia malayi CXXC zinc finger family protein 0.0034 0.0397 0.0616
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0761 0.0712
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0078 0.0097
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0078 0.0025
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0805 0.0756
Echinococcus multilocularis musashi 0.0029 0.0326 0.0275
Echinococcus granulosus cpg binding protein 0.0035 0.0425 0.0375
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.1111 0.1776
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0173 0.0036
Echinococcus multilocularis geminin 0.0399 0.5869 0.5847
Brugia malayi nuclear hormone receptor 0.0012 0.0078 0.0097
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0078 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0326 0.0501
Echinococcus multilocularis microtubule associated protein 2 0.0675 1 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0078 0.0097
Schistosoma mansoni hypothetical protein 0.0399 0.5869 0.5869
Loa Loa (eye worm) hypothetical protein 0.0081 0.1111 0.1776
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.2076 0.2034
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0078 0.0078
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0078 0.0025
Loa Loa (eye worm) hypothetical protein 0.0013 0.0095 0.0126
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.1111 0.1064
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0078 0.0097
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0011 0.0053 0.0053
Schistosoma mansoni pyruvate kinase 0.002 0.0194 0.0194
Schistosoma mansoni intermediate filament proteins 0.0029 0.0326 0.0326
Leishmania major pyruvate kinase 0.0039 0.0478 0.0585
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0478 0.0575
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0483 0.367
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0078 0.0097
Schistosoma mansoni ferritin 0.0017 0.0149 0.0149
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0478 0.0585
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0478 0.0481
Echinococcus multilocularis lamin dm0 0.0029 0.0326 0.0275
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0078 0.0025
Echinococcus granulosus GPCR family 2 0.0081 0.1111 0.1064
Entamoeba histolytica hypothetical protein 0.0075 0.1017 1
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0078 0.0025
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.1111 0.1064
Echinococcus multilocularis expressed protein 0.0017 0.0149 0.0096
Loa Loa (eye worm) hypothetical protein 0.0175 0.2523 0.4068
Brugia malayi hypothetical protein 0.0075 0.1017 0.1623
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0483 0.0454
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0078 0.0025
Loa Loa (eye worm) hypothetical protein 0.0039 0.0478 0.0747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0078 0.0097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0805 0.0805
Echinococcus multilocularis pyruvate kinase 0.002 0.0194 0.0142
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0073 0.0993 0.0993
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.1316 0.2108
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0536 0.075
Brugia malayi Latrophilin receptor protein 2 0.0081 0.1111 0.1776
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0173 0.0036
Brugia malayi F/Y-rich N-terminus family protein 0.0012 0.0081 0.0103
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0078 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0078 0.0097
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0478 0.0667
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0483 1
Schistosoma mansoni lamin 0.0029 0.0326 0.0326
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0302 0.152
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0103 0.0051
Schistosoma mansoni ap endonuclease 0.0019 0.0173 0.0173
Schistosoma mansoni ferritin light chain 0.0017 0.0149 0.0149
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0013 0.0083 0.0031
Loa Loa (eye worm) hypothetical protein 0.0061 0.0805 0.1279
Loa Loa (eye worm) hypothetical protein 0.0012 0.0078 0.0097
Loa Loa (eye worm) hypothetical protein 0.0366 0.538 0.871
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0173 0.0036
Loa Loa (eye worm) hypothetical protein 0.0136 0.1932 0.311
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0078 0.0097
Echinococcus multilocularis lamin 0.0029 0.0326 0.0275
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0326 0.0501
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.6175 1
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0078 0.0078
Treponema pallidum polypeptide deformylase (def) 0.0474 0.6996 1
Schistosoma mansoni pyruvate kinase 0.0039 0.0478 0.0478
Echinococcus granulosus ferritin 0.0017 0.0149 0.0096
Onchocerca volvulus Huntingtin homolog 0.0136 0.1932 0.2663
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0478 0.0585
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0078 0.0025
Echinococcus granulosus geminin 0.0399 0.5869 0.5847

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 700 nM Agonist activity at Gal4-fused human PPARalpha ChEMBL. 20452212

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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