TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 296.359 | Formula: C16H24O5
H donors: 3 H acceptors: 5 LogP: 1.54 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CC1C(=C)C(O)CC2[C@]1(C)CCC[C@]2(C)C(=O)O
InChi: 1S/C16H24O5/c1-9-10(7-13(18)19)15(2)5-4-6-16(3,14(20)21)12(15)8-11(9)17/h10-12,17H,1,4-8H2,2-3H3,(H,18,19)(H,20,21)/t10?,11?,12?,15-,16+/m1/s1
InChiKey: ZVBBGMJUCZRFPO-RFVWGAHZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Entamoeba histolytica	hypothetical protein	0.0139	0.1643	0.1643
Entamoeba histolytica	hypothetical protein	0.0048	0.0359	0.0359
Trypanosoma brucei	Phosphatidylinositol 3-kinase tor1	0.0737	1	1
Toxoplasma gondii	FATC domain-containing protein	0.0139	0.1643	0.1835
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0048	0.0359	0.0074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0247	0.315	0.315
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0048	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0055	0.0055
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0117	0.1335	0.8749
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0048	0.0359	0.0359
Plasmodium falciparum	phosphatidylinositol 3- and 4-kinase, putative	0.0048	0.0359	0.5696
Entamoeba histolytica	protein kinase, putative	0.0064	0.0587	0.0587
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0225	0.0225
Giardia lamblia	Hypothetical protein	0.0048	0.0359	0.0074
Trypanosoma cruzi	Protein kinase B	0.0047	0.0346	0.006
Loa Loa (eye worm)	hypothetical protein	0.0155	0.1866	0.1866
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0225	0.0225
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0247	0.315	0.315
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0247	0.315	0.315
Entamoeba histolytica	hypothetical protein	0.0048	0.0359	0.0359
Echinococcus granulosus	serine:threonine protein kinase SMG1	0.0139	0.1643	0.1643
Echinococcus granulosus	serine/threonine protein kinase	0.0047	0.0346	0.0346
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0436	0.5791	0.5791
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.0048	0.0359	0.0359
Trypanosoma brucei	trypanothione reductase	0.0051	0.0413	0.0056
Entamoeba histolytica	phosphatidylinositol 3-kinase 3, putative	0.0048	0.0359	0.0359
Echinococcus multilocularis	PIK kinase, FAT and Armadillo domain containing protein	0.0108	0.1201	0.1201
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0645	0.0645
Plasmodium falciparum	phosphatidylinositol 3-kinase	0.0048	0.0359	0.5696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.5251	0.5251
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0117	0.1335	0.8749
Onchocerca volvulus		0.0048	0.0359	1
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.013	0.1518	1
Trichomonas vaginalis	PIKK family atypical protein kinase	0.044	0.5852	0.5852
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0092	0.0978	0.0712
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0055	0.0055
Plasmodium vivax	hypothetical protein	0.0048	0.0359	0.5696
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0048	0.0359	0.0359
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0048	0.0359	0.0359
Echinococcus granulosus	Glutaredoxin protein 5	0.0042	0.0281	0.0281
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0092	0.0978	0.0978
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0047	0.0346	0.0346
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0064	0.0587	0.0587
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0398	0.5259	0.5259
Brugia malayi	FAT domain containing protein	0.0108	0.1201	0.1201
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0139	0.1643	0.1643
Schistosoma mansoni	ataxia telangiectasia mutated (atm)-related	0.0737	1	1
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.0048	0.0359	0.0306
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0048	0.0359	0.0074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0548	0.7359	0.7359
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0139	0.1643	0.1643
Toxoplasma gondii	target of rapamycin (TOR), putative	0.0548	0.7359	1
Loa Loa (eye worm)	hypothetical protein	0.0108	0.1201	0.1201
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0398	0.5259	0.5259
Leishmania major	hypothetical protein, unknown function	0.0048	0.0359	0.0306
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0586	0.7891	0.7891
Mycobacterium tuberculosis	Probable oxidoreductase	0.013	0.1518	1
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0048	0.0359	0.208
Echinococcus granulosus	thioredoxin glutathione reductase	0.0051	0.0413	0.0413
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0247	0.315	0.3113
Leishmania major	target of rapamycin (TOR) kinase 1, putative	0.0737	1	1
Brugia malayi	glutathione reductase	0.0051	0.0413	0.0413
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0048	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0359	0.0359
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.0048	0.0359	0.0359
Plasmodium vivax	phosphatidylinositol 3- and 4-kinase, putative	0.0048	0.0359	0.5696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0629	0.8493	0.8493
Loa Loa (eye worm)	phosphatidylinositol 3	0.0048	0.0359	0.0359
Echinococcus multilocularis	Zinc finger, PHD finger	0.0048	0.0359	0.0359
Entamoeba histolytica	protein kinase, putative	0.0068	0.0645	0.0645
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0026	0.0055	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0139	0.1643	0.1643
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0055	0.0055
Plasmodium falciparum	glutathione reductase	0.0051	0.0413	1
Trichomonas vaginalis	AGC family protein kinase	0.0026	0.0059	0.0059
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0436	0.5791	0.5791
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0055	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0198	0.2459	0.2459
Echinococcus granulosus	DNA dependent protein kinase catalytic subunit	0.0048	0.0359	0.0359
Brugia malayi	latrophilin 2 splice variant baaae	0.0037	0.0213	0.0213
Mycobacterium tuberculosis	Probable dehydrogenase	0.0117	0.1335	0.8749
Echinococcus granulosus	PIK kinase FAT and Armadillo domain containing protein	0.0108	0.1201	0.1201
Loa Loa (eye worm)	hypothetical protein	0.015	0.1794	0.1794
Entamoeba histolytica	PH domain containing protein kinase, putative	0.0047	0.0346	0.0346
Entamoeba histolytica	protein kinase, putative	0.0068	0.0645	0.0645
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0055	0.5
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0048	0.0359	0.0074
Mycobacterium tuberculosis	Probable reductase	0.0117	0.1335	0.8749
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0051	0.0413	0.2451
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0737	1	1
Giardia lamblia	Phosphatidylinositol 4-kinase	0.0048	0.0359	0.0074
Entamoeba histolytica	acyl-coA synthetase, putative	0.0026	0.0055	0.0055
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0247	0.315	0.315
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.0048	0.0359	0.0359
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0048	0.0359	0.0359
Echinococcus multilocularis		0.0048	0.0359	0.0359
Trypanosoma brucei	FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative	0.0306	0.3975	0.375
Echinococcus granulosus	serine threonine protein kinase nrc	0.0042	0.0287	0.0287
Loa Loa (eye worm)	phosphatidylinositol 3	0.0048	0.0359	0.0359
Leishmania major	phosphatidylinositol 3-related kinase, putative	0.0247	0.315	0.3113
Plasmodium falciparum	thioredoxin reductase	0.0051	0.0413	1
Entamoeba histolytica	hypothetical protein	0.0038	0.0225	0.0225
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0048	0.0359	0.0359
Trypanosoma brucei	phosphatidylinositol 4-kinase, putative	0.0737	1	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0055	0.0055
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0247	0.315	0.2895
Plasmodium vivax	phosphatidylinositol 3-kinase, putative	0.0048	0.0359	0.5696
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0048	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0139	0.1643	0.1643
Schistosoma mansoni	phosphatidylinositol 3-kinase class	0.0048	0.0359	0.0359
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0359	0.0359
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0055	0.0055
Entamoeba histolytica	FKBP-rapamycin associated protein (FRAP), putative	0.0737	1	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0026	0.0055	0.0055
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0117	0.1335	0.8749
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0026	0.0055	0.5
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0048	0.0359	0.0074
Trichomonas vaginalis	conserved hypothetical protein	0.0108	0.1201	0.1201
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0048	0.0359	0.0359
Plasmodium falciparum	phosphatidylinositol 4-kinase	0.0048	0.0359	0.5696
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0048	0.0359	0.0074
Loa Loa (eye worm)	phosphatidylinositol kinase	0.0048	0.0359	0.0359
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0026	0.0055	0.5
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0548	0.7359	0.7359
Leishmania major	phosphatidylinositol 3-kinase, putative	0.0048	0.0359	0.0306
Schistosoma mansoni	phosphatidylinositol 4-kinase type-II	0.0048	0.0359	0.0359
Leishmania major	target of rapamycin kinase (TOR) kinase 3	0.0587	0.79	0.7888
Entamoeba histolytica	hypothetical protein	0.0048	0.0359	0.0359
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0139	0.1643	0.1396
Echinococcus granulosus	sodium:potassium dependent atpase beta subunit	0.0042	0.0281	0.0281
Echinococcus multilocularis	serine threonine protein kinase nrc serine threonine protein kinase gad	0.0042	0.0287	0.0287
Echinococcus multilocularis	FKBP12 rapamycin complex associated protein	0.0737	1	1
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.0048	0.0359	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0645	0.0645
Loa Loa (eye worm)	phosphatidylinositol 3	0.0048	0.0359	0.0359
Brugia malayi	p70 ribosomal S6 kinase beta	0.0064	0.0587	0.0587
Echinococcus multilocularis	nervana 2	0.0042	0.0281	0.0281
Loa Loa (eye worm)	phosphatidylinositol 3	0.0048	0.0359	0.0359
Giardia lamblia	GTOR	0.0737	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0026	0.0055	0.5
Entamoeba histolytica	Phosphatidylinositol 3- and 4-kinase family	0.0139	0.1643	0.1643
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0048	0.0359	0.0359
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0117	0.1335	0.8749
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0048	0.0359	0.0359
Echinococcus granulosus	phosphatidylinositol 4 kinase beta	0.0048	0.0359	0.0359
Trypanosoma cruzi	target of rapamycin kinase 3	0.0587	0.79	0.7838
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.5251	0.5251
Echinococcus multilocularis	DNA dependent protein kinase catalytic subunit	0.0048	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.044	0.5852	0.5852
Leishmania major	trypanothione reductase	0.0051	0.0413	0.0361
Loa Loa (eye worm)	phosphatidylinositol 3	0.0247	0.315	0.315
Loa Loa (eye worm)	hypothetical protein	0.0139	0.1643	0.1643
Loa Loa (eye worm)	thioredoxin reductase	0.0051	0.0413	0.0413
Loa Loa (eye worm)	phosphatidylinositol 3	0.0737	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0048	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0586	0.7891	0.7891
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.0048	0.0359	0.0359
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0247	0.315	0.2948
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0048	0.0359	0.0359
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0645	0.0645
Schistosoma mansoni	phosphatidylinositol 3-and 4-kinase	0.0247	0.315	0.315
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0051	0.0413	0.0413
Echinococcus granulosus	nervana 2	0.0042	0.0281	0.0281
Echinococcus granulosus	phosphatidylinositol 3 and 4 kinase	0.0247	0.315	0.315
Entamoeba histolytica	hypothetical protein	0.0038	0.0225	0.0225
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0645	0.0645
Leishmania major	phosphatidylinositol kinase, putative	0.0048	0.0359	0.0306
Leishmania major	target of rapamycin (TOR) kinase 2, putative	0.0737	1	1
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0048	0.0359	0.0359
Entamoeba histolytica	hypothetical protein	0.0038	0.0225	0.0225
Trypanosoma brucei	phosphatidylinositol 3-related kinase, putative	0.0247	0.315	0.2895
Trichomonas vaginalis	PIKK family atypical protein kinase	0.044	0.5852	0.5852
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0048	0.0359	0.0359
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0054	0.0452	0.0452
Echinococcus granulosus	FKBP12 rapamycin complex associated protein	0.0737	1	1
Loa Loa (eye worm)	hypothetical protein	0.0054	0.0452	0.0452
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0048	0.0359	0.0359
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0048	0.0359	0.0074
Schistosoma mansoni	hypothetical protein	0.0037	0.0213	0.0213
Echinococcus multilocularis	sodium:potassium dependent atpase beta subunit	0.0042	0.0281	0.0281
Trypanosoma cruzi	trypanothione reductase, putative	0.0051	0.0413	0.013
Trypanosoma brucei	target of rapamycin kinase 3, putative	0.0587	0.79	0.7822
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0048	0.0359	0.0359
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0139	0.1643	0.1643
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0048	0.0359	0.5696
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0586	0.7891	0.7891
Echinococcus multilocularis	serine:threonine protein kinase SMG1	0.0139	0.1643	0.1643
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0048	0.0359	0.0359
Echinococcus granulosus	nervana 2	0.0042	0.0281	0.0281
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0048	0.0359	0.0359
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0068	0.0645	0.0297
Toxoplasma gondii	thioredoxin reductase	0.0051	0.0413	0.0077
Schistosoma mansoni	fkbp-rapamycin associated protein	0.0139	0.1643	0.1643
Onchocerca volvulus		0.0048	0.0359	1
Mycobacterium leprae	conserved hypothetical protein	0.0048	0.0359	0.208
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0054	0.0452	0.0452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0737	1	1
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.0048	0.0359	0.0359
Loa Loa (eye worm)	glutathione reductase	0.0051	0.0413	0.0413
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0055	0.0055
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0048	0.0359	0.0359
Echinococcus granulosus	serine protein kinase ATM	0.0139	0.1643	0.1643
Entamoeba histolytica	hypothetical protein	0.0038	0.0225	0.0225
Trypanosoma cruzi	phosphatidylinositol 3-related kinase, putative	0.0247	0.315	0.2948
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0054	0.0452	0.0452
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0398	0.5259	0.5259
Schistosoma mansoni	hypothetical protein	0.0038	0.0225	0.0225
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0586	0.7891	0.7891
Plasmodium vivax	thioredoxin reductase, putative	0.0051	0.0413	1
Trypanosoma brucei	phosphatidylinositol 3-kinase tor, putative	0.0349	0.4568	0.4366
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0645	0.0645
Echinococcus multilocularis	nervana 2	0.0042	0.0281	0.0281
Echinococcus multilocularis	rac serine:threonine kinase	0.0047	0.0346	0.0346
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0048	0.0359	0.0359
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0247	0.315	0.315
Toxoplasma gondii	AGC kinase	0.0064	0.0587	0.0325
Brugia malayi	hypothetical protein	0.0038	0.0225	0.0225
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor1	0.0737	1	1
Entamoeba histolytica	protein kinase 2, putative	0.0042	0.0287	0.0287
Entamoeba histolytica	phosphatidylinositol3-kinaseTor2, putative	0.0737	1	1
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.0048	0.0359	0.0359
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0048	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0478	0.6384	0.6384
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0048	0.0359	0.0359
Trypanosoma cruzi	phosphatidylinositol kinase, putative	0.0048	0.0359	0.0074
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0048	0.0359	0.0359
Giardia lamblia	Phosphoinositide-3-kinase, class 3	0.0048	0.0359	0.0074
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0225	0.0225
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0247	0.315	0.315
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0048	0.0359	0.0359
Trypanosoma cruzi	rac serine-threonine kinase, putative	0.0047	0.0346	0.006
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0048	0.0359	0.0359
Mycobacterium ulcerans	hypothetical protein	0.0026	0.0055	0.5
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0213	0.0213
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0645	0.0645
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.0048	0.0359	0.0359
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0117	0.1335	0.8749
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0139	0.1643	0.1396
Loa Loa (eye worm)	phosphatidylinositol 3	0.0048	0.0359	0.0359
Schistosoma mansoni	serine/threonine-protein kinase	0.0047	0.0346	0.0346
Echinococcus multilocularis	phosphatidylinositol 3 and 4 kinase	0.0247	0.315	0.315
Echinococcus multilocularis	serine protein kinase ATM	0.0139	0.1643	0.1643
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0397	0.5251	0.5251
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0048	0.0359	0.0359
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0048	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0586	0.7891	0.7891
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0398	0.5259	0.5259
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0048	0.0359	0.0074
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0048	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0139	0.1643	0.1643
Echinococcus granulosus	Phosphatidylinositol 4 kinase type 2 beta	0.0048	0.0359	0.0359
Brugia malayi	Protein kinase domain containing protein	0.0068	0.0645	0.0645
Trypanosoma cruzi	phosphatidylinositol 4-kinase, putative	0.0048	0.0359	0.0074
Trichomonas vaginalis	AGC family protein kinase	0.0068	0.0645	0.0645
Trypanosoma brucei	phosphatidylinositol kinase related protein, putative	0.0139	0.1643	0.1332
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0548	0.7359	0.7359
Brugia malayi	Thioredoxin reductase	0.0051	0.0413	0.0413
Schistosoma mansoni	hypothetical protein	0.0108	0.1201	0.1201
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.0048	0.0359	0.0359
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.013	0.1518	1
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.0048	0.0359	0.0074
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0494	0.6607	0.6607
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0548	0.7359	0.7359
Leishmania major	hypothetical protein, conserved	0.0048	0.0359	0.0306
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.013	0.1518	1
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.0048	0.0359	0.0359
Trichomonas vaginalis	conserved hypothetical protein	0.0155	0.1866	0.1866
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0026	0.0055	0.5
Entamoeba histolytica	protein kinase rad3, putative	0.0139	0.1643	0.1643
Plasmodium vivax	hypothetical protein, conserved	0.0048	0.0359	0.5696
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0978	0.0978
Echinococcus multilocularis	Phosphatidylinositol 4 kinase type 2 beta	0.0048	0.0359	0.0359
Entamoeba histolytica	hypothetical protein	0.0048	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0737	1	1
Schistosoma mansoni	serine/threonine-protein kinase	0.0047	0.0346	0.0346
Echinococcus multilocularis	Glutaredoxin protein 5	0.0042	0.0281	0.0281
Trichomonas vaginalis	conserved hypothetical protein	0.0092	0.0978	0.0978
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0048	0.0359	0.0359
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0048	0.0359	0.0359
Leishmania major	phosphatidylinositol 4-kinase, putative	0.0048	0.0359	0.0306
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0068	0.0645	0.0645
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0048	0.0359	0.0359
Toxoplasma gondii	non-specific serine/threonine protein kinase	0.0155	0.1866	0.2153
Trypanosoma cruzi	Phosphatidylinositol 3-kinase tor2	0.0737	1	1
Leishmania major	phosphatidylinositol kinase related protein, putative	0.0048	0.0359	0.0306
Echinococcus granulosus	calcium:calmodulin dependent protein kinase	0.0042	0.0287	0.0287
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0548	0.7359	0.7359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0548	0.7359	0.7359
Plasmodium vivax	phosphatidylinositol 4-kinase, putative	0.0048	0.0359	0.5696
Schistosoma mansoni	hypothetical protein	0.0048	0.0359	0.0359
Brugia malayi	AMP-binding enzyme family protein	0.0026	0.0055	0.0055
Plasmodium vivax	glutathione reductase, putative	0.0051	0.0413	1
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.0048	0.0359	0.0359
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.0048	0.0359	0.0359
Trichomonas vaginalis	PIKK family atypical protein kinase	0.0548	0.7359	0.7359

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)		Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as LDH activity at 4760 ng/ml after 72 hrs by malstat reagent method	ChEMBL.	19928902
Inhibition (functional)		Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as LDH activity at 4760 ng/ml after 72 hrs by malstat reagent method	ChEMBL.	19928902

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1077022

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1113862