Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | mbt repeat family protein | 0.0058 | 0.0277 | 0.227 |
Mycobacterium leprae | PROBABLE NICOTINATE-NUCLEOTIDE ADENYLYLTRANSFERASE NADD (DEAMIDO-NAD(+) PYROPHOSPHORYLASE) (DEAMIDO-NAD(+) DIPHOSPHORYLASE) (NIC | 0.0667 | 0.7162 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0667 | 0.7162 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0062 | 0.0323 | 0.1272 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0231 | 0.224 | 0.2206 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0037 | 0.0044 | 0.0357 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0231 | 0.224 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1222 | 1 |
Onchocerca volvulus | 0.0062 | 0.0323 | 0.0485 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0083 | 0.0569 | 0.1464 |
Brugia malayi | hypothetical protein | 0.0141 | 0.1222 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0062 | 0.0323 | 0.2645 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0066 | 0.0367 | 0.0325 |
Mycobacterium ulcerans | bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein | 0.0667 | 0.7162 | 0.5 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0066 | 0.0367 | 0.0325 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0058 | 0.0277 | 0.0235 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0083 | 0.0569 | 0.0528 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.031 | 0.254 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0058 | 0.0277 | 0.0235 |
Loa Loa (eye worm) | hypothetical protein | 0.0062 | 0.0323 | 0.2645 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.0569 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0367 | 0.3006 |
Plasmodium vivax | nicotinate-nucleotide adenylyltransferase, putative | 0.0667 | 0.7162 | 0.5 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0066 | 0.0367 | 0.0902 |
Loa Loa (eye worm) | hypothetical protein | 0.0117 | 0.0944 | 0.7721 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0044 | 0.0357 |
Brugia malayi | intermediate filament protein | 0.0062 | 0.0323 | 0.2645 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1937 | 0.5278 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.0569 | 0.1464 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.1222 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0355 | 0.3631 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.0569 | 0.5 |
Onchocerca volvulus | Huntingtin homolog | 0.0141 | 0.1222 | 1 |
Onchocerca volvulus | 0.0062 | 0.0323 | 0.0485 | |
Schistosoma mansoni | lamin | 0.0062 | 0.0323 | 0.0779 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.008 | 0.0527 | 0.4313 |
Echinococcus multilocularis | musashi | 0.0062 | 0.0323 | 0.0281 |
Echinococcus granulosus | intermediate filament protein | 0.0062 | 0.0323 | 0.1272 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0037 | 0.0044 | 0.0357 |
Mycobacterium tuberculosis | Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic | 0.0667 | 0.7162 | 0.5 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0277 | 0.0652 |
Echinococcus granulosus | geminin | 0.0205 | 0.1937 | 0.8619 |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0066 | 0.0367 | 0.1474 |
Loa Loa (eye worm) | intermediate filament protein | 0.0062 | 0.0323 | 0.2645 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0058 | 0.0277 | 0.0652 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0277 | 0.227 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0058 | 0.0277 | 0.1064 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0117 | 0.0944 | 0.7721 |
Echinococcus multilocularis | lamin dm0 | 0.0062 | 0.0323 | 0.0281 |
Echinococcus multilocularis | lamin | 0.0062 | 0.0323 | 0.0281 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0083 | 0.0569 | 0.2391 |
Brugia malayi | mbt repeat family protein | 0.0058 | 0.0277 | 0.227 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.1937 | 0.5278 |
Loa Loa (eye worm) | MBCTL1 | 0.0066 | 0.0367 | 0.3006 |
Plasmodium falciparum | nicotinamide/nicotinic acid mononucleotide adenylyltransferase | 0.0667 | 0.7162 | 0.5 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0062 | 0.0323 | 0.2645 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0117 | 0.0944 | 0.7721 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0066 | 0.0367 | 0.3006 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0117 | 0.0944 | 0.7721 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.0569 | 0.5 |
Schistosoma mansoni | lamin | 0.0062 | 0.0323 | 0.0779 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.0277 | 0.227 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0066 | 0.0367 | 0.1474 |
Brugia malayi | hypothetical protein | 0.0083 | 0.0569 | 0.4656 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0037 | 0.0044 | 0.0357 |
Schistosoma mansoni | intermediate filament proteins | 0.0062 | 0.0323 | 0.0779 |
Echinococcus granulosus | lamin | 0.0062 | 0.0323 | 0.1272 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0058 | 0.0277 | 0.1064 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.0527 | 0.1347 |
Entamoeba histolytica | hypothetical protein | 0.0083 | 0.0569 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0.1222 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.1937 | 0.1902 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0527 | 0.4313 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0058 | 0.0277 | 0.0652 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.