Detailed information for compound 1127156

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 437.34 | Formula: C20H18Cl2N2O3S
  • H donors: 3 H acceptors: 3 LogP: 5.08 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCC[C@H]1[C@H](NC(=O)c2cc3c([nH]2)c(c(s3)Cl)Cl)Cc2c1cccc2
  • InChi: 1S/C20H18Cl2N2O3S/c21-17-18-15(28-19(17)22)9-14(23-18)20(27)24-13-8-10-4-1-2-5-11(10)12(13)6-3-7-16(25)26/h1-2,4-5,9,12-13,23H,3,6-8H2,(H,24,27)(H,25,26)/t12-,13-/m1/s1
  • InChiKey: XHHPEJRMENXQSF-CHWSQXEVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens phosphorylase, glycogen, liver Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Glycogen phosphorylase, brain form, putative Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus Glycosyl transferase family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Loa Loa (eye worm) glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Brugia malayi carbohydrate phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Neospora caninum hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
Onchocerca volvulus Glycogen phosphorylase homolog Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma mansoni glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Trichomonas vaginalis glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Giardia lamblia Glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus multilocularis Glycosyl transferase, family 35 Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium parvum glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Schistosoma japonicum ko:K00688 starch phosphorylase [EC2.4.1.1], putative Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Cryptosporidium hominis glycogen phosphorylase 1 Get druggable targets OG5_126999 All targets in OG5_126999
Chlamydia trachomatis glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Entamoeba histolytica glycogen phosphorylase, putative Get druggable targets OG5_126999 All targets in OG5_126999
Echinococcus granulosus glycogen phosphorylase Get druggable targets OG5_126999 All targets in OG5_126999
Candida albicans hypothetical protein Get druggable targets OG5_126999 All targets in OG5_126999
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0008 0.004 0.0087
Echinococcus multilocularis Glycosyl transferase, family 35 0.013 0.273 0.273
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0008 0.0044 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0029 0.0105
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0266 0.2613
Trichomonas vaginalis ran, putative 0.0023 0.0383 0.1404
Giardia lamblia Glycogen phosphorylase 0.013 0.273 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0383 0.3515
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0266 0.2613
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0455 0.3895
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0284 0.0284
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0284 0.2796
Brugia malayi AMP-binding enzyme family protein 0.0008 0.004 0.0146
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0266 0.2186
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0266 0.2312
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.1079 0.1468
Plasmodium falciparum glutathione reductase 0.0018 0.0266 0.2613
Echinococcus granulosus glycogen phosphorylase 0.013 0.273 0.273
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0251 0.0251
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0436 0.4052
Brugia malayi Thioredoxin reductase 0.0052 0.1017 0.3724
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0008 0.004 0.0087
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0266 0.2312
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0455 0.3895
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.004 0.0054
Schistosoma mansoni hypothetical protein 0.0038 0.0696 0.0696
Echinococcus multilocularis glycogen phosphorylase 0.013 0.273 0.273
Loa Loa (eye worm) hypothetical protein 0.002 0.0306 0.0417
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0266 0.2312
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0029 0.0105
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0008 0.004 0.0087
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0251 0.0341
Echinococcus granulosus glycogen phosphorylase 0.013 0.273 0.273
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0133 0.2781 1
Schistosoma mansoni hypothetical protein 0.0017 0.0251 0.0251
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0023 0.0383 0.0521
Entamoeba histolytica hypothetical protein 0.0026 0.0436 0.1596
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0266 0.2613
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0455 0.1513
Schistosoma mansoni glycogen phosphorylase 0.0056 0.1105 0.1105
Schistosoma mansoni glycogen phosphorylase 0.013 0.273 0.273
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0029 0.0105
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.2489 0.8933
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.273 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0455 0.4474
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0008 0.004 0.0328
Echinococcus granulosus snurportin 1 0.0341 0.7348 0.7348
Loa Loa (eye worm) hypothetical protein 0.002 0.0306 0.0417
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0341 0.7348 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0284 0.0387
Plasmodium falciparum importin beta, putative 0.0032 0.0568 0.5589
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0023 0.0383 0.0477
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.1105 0.4048
Mycobacterium ulcerans hypothetical protein 0.0027 0.0455 0.3895
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0029 0.0105
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0266 0.2613
Leishmania major trypanothione reductase 0.0052 0.1017 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0266 0.2613
Schistosoma mansoni ap endonuclease 0.0019 0.0284 0.0284
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0284 0.0075
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0284 0.0284
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.2489 0.8942
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.004 0.0393
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0455 0.1666
Echinococcus granulosus mixed lineage leukemia protein mll 0.0008 0.0044 0.0044
Brugia malayi Importin beta-1 subunit 0.0032 0.0568 0.2082
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0266 0.2613
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0054
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0266 0.0973
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0266 0.2312
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0266 0.2613
Toxoplasma gondii exonuclease III APE 0.0019 0.0284 0.2338
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0029 0.0105
Leishmania major importin beta-1 subunit, putative 0.0026 0.0436 0.4286
Schistosoma mansoni ap endonuclease 0.0019 0.0284 0.0284
Mycobacterium tuberculosis Probable oxidoreductase 0.0133 0.2781 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0306 0.0417
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0023 0.0383 0.3153
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0008 0.004 0.0087
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0436 0.1596
Loa Loa (eye worm) hypothetical protein 0.0032 0.0568 0.0773
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0266 0.0973
Loa Loa (eye worm) glycogen phosphorylase 0.013 0.273 0.3715
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0251 0.0251
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.004 0.0146
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0284 0.1041
Echinococcus granulosus GTP binding nuclear protein Ran 0.0023 0.0383 0.0383
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0029 0.0105
Schistosoma mansoni glycogen phosphorylase 0.013 0.273 0.273
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0008 0.004 0.004
Onchocerca volvulus 0.0032 0.0579 0.1939
Echinococcus granulosus g protein coupled receptor 0.0134 0.282 0.282
Loa Loa (eye worm) hypothetical protein 0.0055 0.1079 0.1468
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0455 0.3895
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.1215 1
Brugia malayi CXXC zinc finger family protein 0.0032 0.0579 0.2121
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.1017 0.1383
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0266 0.0266
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0284 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0306 0.0417
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.2489 0.8942
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.004 0.0146
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0284 0.1041
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0455 0.4474
Echinococcus multilocularis snurportin 1 0.0341 0.7348 0.7348
Entamoeba histolytica glycogen phosphorylase, putative 0.0056 0.1105 0.4048
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0029 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0008 0.004 0.0146
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0266 0.0266
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0029 0.0105
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0455 0.3895
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0266 0.2186
Echinococcus granulosus cpg binding protein 0.0034 0.0619 0.0619
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0455 0.3895
Entamoeba histolytica glycogenphosphorylase, putative 0.0056 0.1105 0.4048
Loa Loa (eye worm) hypothetical protein 0.002 0.0306 0.0417
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0266 0.212
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0008 0.004 0.0146
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0266 0.0973
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0044 0.0044
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0008 0.004 0.0393
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0008 0.0044 0.0044
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0568 0.4675
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.004 0.0087
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0455 0.1666
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0251 0.0251
Schistosoma mansoni ran 0.0023 0.0383 0.0383
Entamoeba histolytica Ran family GTPase 0.0023 0.0383 0.1404
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0029 0.0105
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.273 1
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0266 0.2312
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0251 0.0251
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0008 0.004 0.0054
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0008 0.004 0.0146
Loa Loa (eye worm) hypothetical protein 0.0038 0.0696 0.0947
Brugia malayi glutathione reductase 0.0052 0.1017 0.3724
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0266 0.2613
Mycobacterium tuberculosis Probable reductase 0.0119 0.2489 0.8942
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0008 0.004 0.0393
Brugia malayi RNA, U transporter 1 0.0091 0.186 0.6814
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0455 0.1513
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0266 0.2613
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0579 0.0788
Loa Loa (eye worm) hypothetical protein 0.0027 0.0455 0.0619
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0029 0.0105
Plasmodium falciparum thioredoxin reductase 0.0052 0.1017 1
Schistosoma mansoni hypothetical protein 0.0017 0.0251 0.0251
Schistosoma mansoni cpg binding protein 0.0034 0.0619 0.0619
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0455 0.1666
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0056 0.1105 0.3938
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0282 0.0963
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0284 0.2294
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0455 0.1587
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.016 0.0586
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0085 0.0311
Leishmania major acetyl-CoA synthetase, putative 0.0008 0.004 0.0393
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0455 0.3895
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0069 0.1377 0.1377
Loa Loa (eye worm) oxidoreductase 0.0008 0.004 0.0054
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0266 0.2613
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0029 0.0105
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0023 0.0383 0.377
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0023 0.0383 0.0383
Schistosoma mansoni hypothetical protein 0.0017 0.0251 0.0251
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0266 0.2312
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.2489 0.8942
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0133 0.2781 1
Plasmodium vivax glutathione reductase, putative 0.0052 0.1017 1
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.1017 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0455 0.1666
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0568 0.0568
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0568 0.5589
Echinococcus multilocularis dnaJ subfamily B 0.0462 1 1
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.016 0.0586
Schistosoma mansoni hypothetical protein 0.0462 1 1
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0008 0.004 0.0087
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0266 0.212
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.0266 0.0903
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0029 0.0105
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0306 0.105
Leishmania major GTP-binding protein, putative 0.0023 0.0383 0.377
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0284 0.097
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0284 0.1041
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0029 0.0105
Trichomonas vaginalis antibiotic synthetase, putative 0.0008 0.004 0.0146
Plasmodium vivax acetyl-CoA synthetase, putative 0.0008 0.004 0.0393
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0306 0.3013
Plasmodium falciparum thioredoxin reductase 0.0018 0.0266 0.2613
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0306 0.0165
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0284 1
Onchocerca volvulus Glycogen phosphorylase homolog 0.013 0.273 0.9676
Schistosoma mansoni ran 0.0023 0.0383 0.0383
Chlamydia trachomatis glycogen phosphorylase 0.013 0.273 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0266 0.2312
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.1017 0.1017
Plasmodium vivax importin-beta 2, putative 0.0032 0.0568 0.5589
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0088 0.0088
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0455 0.3895
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0133 0.2781 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0284 0.2796
Trichomonas vaginalis helicase, putative 0.0007 0.0029 0.0105
Echinococcus multilocularis GPCR, family 2 0.0017 0.0251 0.0251
Schistosoma mansoni importin beta-1 0.0032 0.0568 0.0568
Brugia malayi carbohydrate phosphorylase 0.013 0.273 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.1079 0.3953
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0008 0.0044 0.0044
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0266 0.212
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0029 0.0105
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0023 0.0383 0.377
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0455 0.4474
Schistosoma mansoni hypothetical protein 0.0017 0.0251 0.0251
Echinococcus multilocularis cpg binding protein 0.0034 0.0619 0.0619
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0455 0.1666
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0266 0.2312
Loa Loa (eye worm) histone methyltransferase 0.001 0.0088 0.0119
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.0696 0.2548
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0008 0.004 0.004
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0008 0.004 0.0393
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.1017 0.3619
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0023 0.0383 0.1404
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0282 0.0963
Echinococcus granulosus Glycosyl transferase family 35 0.013 0.273 0.273
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0251 0.0919
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0436 0.1596
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0284 0.2501
Brugia malayi AMP-binding enzyme family protein 0.0008 0.004 0.0146
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0056 0.1105 1
Loa Loa (eye worm) glutathione reductase 0.0052 0.1017 0.1383
Loa Loa (eye worm) hypothetical protein 0.0008 0.004 0.0054
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0455 0.1587
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0284 0.2796
Toxoplasma gondii propionate-CoA ligase 0.0008 0.004 0.0328
Schistosoma mansoni cpg binding protein 0.0032 0.0579 0.0579
Loa Loa (eye worm) hypothetical protein 0.0027 0.0455 0.0619
Echinococcus granulosus GPCR family 2 0.0017 0.0251 0.0251
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.2489 0.8942
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0029 0.0105
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.2489 0.8942
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0029 0.0105
Echinococcus multilocularis g protein coupled receptor 0.0134 0.282 0.282
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0284 0.1041
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0023 0.0383 0.3515
Toxoplasma gondii thioredoxin reductase 0.0052 0.1017 0.8364
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0266 0.2613
Echinococcus granulosus 7tm_1 domain containing protein 0.0137 0.2872 0.2872
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.004 0.0087
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0436 0.1596
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0008 0.004 0.0087
Entamoeba histolytica glycogen phosphorylase, putative 0.013 0.273 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.1017 0.1017
Brugia malayi AMP-binding enzyme family protein 0.0008 0.004 0.0146
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0306 0.3013
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.1017 1
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.004 0.0087
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0282 0.0963
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0008 0.004 0.0087
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0266 0.2613
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0088 0.0088
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0266 0.0266
Onchocerca volvulus 0.0134 0.282 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0455 0.0619
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0023 0.0383 0.377
Loa Loa (eye worm) hypothetical protein 0.0134 0.282 0.3838
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0282 0.0963
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0029 0.0105
Schistosoma mansoni cpg binding protein 0.0034 0.0619 0.0619
Schistosoma mansoni acetyl-CoA synthetase 0.0008 0.004 0.004
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0568 0.5589
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.1079 0.3953
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0284 0.2796
Plasmodium falciparum glutathione reductase 0.0052 0.1017 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0008 0.004 0.0087
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0306 0.2501
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0008 0.004 0.0328
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0266 0.2312
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0008 0.004 0.0393
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0251 0.0919
Echinococcus multilocularis glycogen phosphorylase 0.013 0.273 0.273
Trypanosoma brucei trypanothione reductase 0.0052 0.1017 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0455 0.1666
Echinococcus granulosus importin subunit beta 1 0.0032 0.0568 0.0568
Schistosoma mansoni hypothetical protein 0.0341 0.7348 0.7348
Trichomonas vaginalis glycogen phosphorylase, putative 0.013 0.273 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0284 0.2501
Onchocerca volvulus 0.0027 0.0455 0.1492
Loa Loa (eye worm) hypothetical protein 0.0017 0.0251 0.0341

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 54 nM Inhibition of human recombinant liver glycogen phosphorylase by multienzyme-coupled reaction ChEMBL. 20493691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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