Detailed information for compound 1128346

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 226.167 | Formula: C6H15N2O5P
  • H donors: 4 H acceptors: 5 LogP: -5.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: NCCC(=O)N(CCCP(=O)(O)O)O
  • InChi: 1S/C6H15N2O5P/c7-3-2-6(9)8(10)4-1-5-14(11,12)13/h10H,1-5,7H2,(H2,11,12,13)
  • InChiKey: NPRVVDXQQZESLR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli 1-deoxy-D-xylulose 5-phosphate reductoisomerase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Neospora caninum 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium yoelii 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras Get druggable targets OG5_130462 All targets in OG5_130462
Babesia bovis 1-deoxy-D-xylulose 5-phosphate reductoisomerase family protein Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase Get druggable targets OG5_130462 All targets in OG5_130462
Theileria parva 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium knowlesi 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
Plasmodium berghei 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative Get druggable targets OG5_130462 All targets in OG5_130462
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major cathepsin L-like protease 0.0146 0.0772 1
Echinococcus granulosus cathepsin L cysteine protease 0.002 0.0029 0.0022
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0039 0.03
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0322 0.1028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0029 0.0022
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0029 0.0131
Echinococcus granulosus histone acetyltransferase KAT2B 0.0156 0.0827 0.1781
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0322 0.0668
Echinococcus granulosus cathepsin l cysteine peptidase 0.0038 0.0138 0.0263
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.022 0.2053
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0125 0.0234
Echinococcus granulosus dna polymerase eta 0.0022 0.0039 0.0044
Brugia malayi Muscleblind-like protein 0.0171 0.0917 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.007 0.0322 0.0668
Trypanosoma cruzi cysteine peptidase, putative 0.0038 0.0138 0.1583
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0125 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Brugia malayi Cathepsin L-like precursor 0.0026 0.0064 0.0497
Leishmania major trypanothione reductase 0.0052 0.022 0.2663
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0125 0.0981
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0039 0.0267
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0134 0.0697 0.901
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0612 0.8837
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0612 0.8837
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0772 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1771
Trypanosoma cruzi major cysteine proteinase, putative 0.0115 0.0588 0.7558
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0029 0.0022
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0038 0.0138 0.1128
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0038 0.0138 0.1128
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0064 0.0497
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0064 0.0098
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.2966 1
Giardia lamblia DINP protein human, muc B family 0.0022 0.0039 0.1368
Onchocerca volvulus Cathepsin F homolog 0.0038 0.0138 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.0584 0.6295
Echinococcus granulosus dna polymerase kappa 0.0022 0.0039 0.0044
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0019 0.0248
Loa Loa (eye worm) hypothetical protein 0.0171 0.0917 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0152 0.7832
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0125 0.0106
Brugia malayi acetyltransferase, GNAT family protein 0.016 0.0853 0.9283
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1771
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0029 0.0375
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0152 0.0452
Schistosoma mansoni aldehyde dehydrogenase 0.007 0.0322 0.0668
Loa Loa (eye worm) acetyltransferase 0.016 0.0853 0.9266
Plasmodium falciparum cysteine proteinase falcipain 3 0.0038 0.0138 0.0404
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0138 0.7963
Echinococcus granulosus GPCR family 2 0.0036 0.0125 0.0234
Loa Loa (eye worm) hypothetical protein 0.0036 0.0125 0.0981
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0039 0.0224
Echinococcus multilocularis geminin 0.0194 0.1054 0.1037
Echinococcus granulosus cathepsin L cysteine proteinase 0.0038 0.0138 0.0263
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0039 0.002
Echinococcus multilocularis cysteine protease 0.0038 0.0138 0.0119
Plasmodium vivax vivapain-2 0.0038 0.0138 0.0404
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0148 0.0285
Leishmania major DNA polymerase eta, putative 0.0022 0.0039 0.0267
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Loa Loa (eye worm) glutathione reductase 0.0052 0.022 0.2053
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0166 1
Echinococcus multilocularis cysteine protease 0.0038 0.0138 0.0119
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Onchocerca volvulus 0.0038 0.0138 1
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus granulosus cathepsin L 0.002 0.0029 0.0022
Trypanosoma cruzi cruzipain precursor, putative 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0612 0.1709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0166 0.0499
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.0584 0.621
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0138 0.0119
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0019 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0029 0.011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Brugia malayi glutathione reductase 0.0052 0.022 0.2231
Plasmodium vivax glutathione reductase, putative 0.0052 0.022 0.068
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0038 0.0138 0.0404
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.022 0.2985
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0039 0.0044
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0612 0.8837
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0039 0.0068
Brugia malayi hypothetical protein 0.004 0.0148 0.144
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0322 0.1028
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.022 0.2663
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0148 0.0285
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0612 0.8837
Schistosoma mansoni hypothetical protein 0.0194 0.1054 0.2283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.002 0.0029 0.0375
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.016 0.0853 0.1839
Plasmodium falciparum thioredoxin reductase 0.0052 0.022 0.068
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0064 0.2534
Schistosoma mansoni hypothetical protein 0.004 0.0148 0.0285
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.007 0.0322 0.4513
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0152 0.7832
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0508
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0152 0.0452
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0138 0.0263
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0039 0.1183
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0039 0.0224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni cathepsin F (C01 family) 0.0038 0.0138 0.0263
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0152 0.0452
Onchocerca volvulus 0.0038 0.0138 1
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.022 0.068
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0039 0.03
Onchocerca volvulus 0.0038 0.0138 1
Leishmania major cysteine peptidase A (CPA) 0.0038 0.0138 0.1583
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0138 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0019 0.0248
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.007 0.0322 0.4025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Mycobacterium ulcerans aldehyde dehydrogenase 0.007 0.0322 0.1028
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0039 0.0044
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0189 1
Schistosoma mansoni DNA polymerase eta 0.0022 0.0039 0.0044
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0125 0.1183
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0039 0.002
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Loa Loa (eye worm) hypothetical protein 0.0171 0.0917 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0038 0.0138 0.0404
Loa Loa (eye worm) hypothetical protein 0.0078 0.0372 0.3789
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0508
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1771
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0039 0.0068
Onchocerca volvulus 0.0038 0.0138 1
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Toxoplasma gondii cathepsin CPL 0.0038 0.0138 0.0404
Echinococcus granulosus cysteine protease 0.002 0.0029 0.0022
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Trypanosoma cruzi cysteine proteinase, putative 0.002 0.0029 0.0131
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0039 0.0508
Leishmania major cathepsin L-like protease 0.0038 0.0138 0.1583
Leishmania major cathepsin L-like protease 0.0146 0.0772 1
Loa Loa (eye worm) inositol-1 0.0041 0.0152 0.1289
Echinococcus multilocularis muscleblind protein 0.0171 0.0917 0.09
Onchocerca volvulus 0.0038 0.0138 1
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0166 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0038 0.0138 0.0119
Brugia malayi Thioredoxin reductase 0.0052 0.022 0.2231
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Echinococcus granulosus muscleblind protein 0.0171 0.0917 0.1981
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0189 0.0578
Plasmodium falciparum glutathione reductase 0.0052 0.022 0.068
Onchocerca volvulus 0.0038 0.0138 1
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0039 0.0508
Brugia malayi Inositol-1 0.0041 0.0152 0.1484
Plasmodium vivax vivapain-3 0.002 0.0029 0.0033
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.016 0.0853 0.0835
Leishmania major DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Loa Loa (eye worm) cysteine protease 0.0038 0.0138 0.1128
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0152 0.0134
Trypanosoma brucei unspecified product 0.0022 0.0039 0.0508
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0064 0.2623
Entamoeba histolytica cysteine protease, putative 0.0038 0.0138 0.7963
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0127 0.1611
Echinococcus granulosus microtubule associated protein 2 0.079 0.4553 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0279
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0038 0.0138 0.7003
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.069 1
Loa Loa (eye worm) ctsf protein 0.0038 0.0138 0.1128
Plasmodium vivax vivapain-2 0.0038 0.0138 0.0404
Onchocerca volvulus 0.0038 0.0138 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0148 0.013
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.022 0.0201
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.069 0.1984
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0125 0.0106
Trypanosoma brucei trypanothione reductase 0.0052 0.022 0.2844
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0279
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.052 0.2966 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0039 0.0044
Entamoeba histolytica cysteine proteinase, putative 0.0038 0.0138 0.7963
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0039 0.0508
Echinococcus granulosus cathepsin l1 0.0038 0.0138 0.0263
Trypanosoma cruzi cysteine peptidase, putative 0.002 0.0029 0.0131
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0152 0.0294
Plasmodium falciparum cysteine proteinase falcipain 1 0.002 0.0029 0.0033
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0138 0.0119
Echinococcus granulosus cathepsin l1 0.0026 0.0064 0.0098
Trypanosoma cruzi cysteine peptidase, putative 0.0146 0.0772 1
Plasmodium vivax vivapain-1 0.002 0.0029 0.0033
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.069 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0039 0.0748
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.0584 0.6295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0029 0.0579
Brugia malayi Papain family cysteine protease containing protein 0.002 0.0029 0.011
Echinococcus multilocularis microtubule associated protein 2 0.079 0.4553 0.4543
Schistosoma mansoni hypothetical protein 0.0036 0.0125 0.0234
Leishmania major cathepsin L-like protease 0.0146 0.0772 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0029 0.0579
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0189 1
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.002 0.0029 0.0131
Toxoplasma gondii thioredoxin reductase 0.0052 0.022 0.068
Brugia malayi cathepsin L-like precursor 0.0026 0.0064 0.0497
Echinococcus multilocularis GPCR, family 2 0.0036 0.0125 0.0106
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.0064 0.0497
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0189 0.0375
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0125 0.1183
Schistosoma mansoni hypothetical protein 0.0078 0.0372 0.0778
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0189 0.0578
Schistosoma mansoni inositol monophosphatase 0.0041 0.0152 0.0294
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.022 0.0442
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.052 0.2966 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0146 0.0772 1
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0372 0.3929
Loa Loa (eye worm) hypothetical protein 0.0026 0.0064 0.0279
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0189 0.0578
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.052 0.2966 1
Echinococcus multilocularis dna polymerase eta 0.0022 0.0039 0.002
Schistosoma mansoni hypothetical protein 0.0194 0.1054 0.2283
Brugia malayi Papain family cysteine protease containing protein 0.0038 0.0138 0.1327
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0064 0.2623
Echinococcus multilocularis cathepsin L 0.002 0.0029 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0038 0.0138 0.7003
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0019 0.0248
Trypanosoma cruzi cysteine protease, putative 0.002 0.0029 0.0131
Toxoplasma gondii aldehyde dehydrogenase 0.007 0.0322 0.1028
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0039 0.0267
Plasmodium vivax unspecified product 0.002 0.0029 0.0033
Schistosoma mansoni microtubule-associated protein tau 0.079 0.4553 1
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0125 0.0647 0.9353
Brugia malayi Cathepsin L-like precursor 0.0038 0.0138 0.1327
Echinococcus multilocularis cathepsin L cysteine protease 0.0038 0.0138 0.0119
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.007 0.0322 0.0304
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0152 0.899
Entamoeba histolytica hypothetical protein 0.004 0.0148 0.8705
Loa Loa (eye worm) hypothetical protein 0.0038 0.0138 0.1128
Loa Loa (eye worm) hypothetical protein 0.0114 0.0584 0.621
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.002 0.0029 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0038 0.0138 0.7003
Mycobacterium tuberculosis Probable reductase 0.0119 0.0612 0.8837
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0612 0.8837
Onchocerca volvulus Cathepsin L homolog 0.0038 0.0138 1
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0039 0.1183
Echinococcus multilocularis muscleblind protein 1 0.0171 0.0917 0.09
Schistosoma mansoni inositol monophosphatase 0.0041 0.0152 0.0294
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0152 0.1974
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0039 0.0267
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.069 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0152 0.7832
Loa Loa (eye worm) fibroinase 0.0038 0.0138 0.1128
Echinococcus granulosus geminin 0.0194 0.1054 0.2283

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -4.8 Inhibitory concentration against DOXP reductoisomerase ChEMBL. 15887963

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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