TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 392.891 | Formula: C22H26ClFO3
H donors: 2 H acceptors: 3 LogP: 6.58 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)CCCCCC(c1c(O)c(C)c(c(c1C)Cl)C)c1ccc(cc1)F
InChi: 1S/C22H26ClFO3/c1-13-14(2)22(27)20(15(3)21(13)23)18(7-5-4-6-8-19(25)26)16-9-11-17(24)12-10-16/h9-12,18,27H,4-8H2,1-3H3,(H,25,26)
InChiKey: KRCOYINJFOJHLY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	peroxisome assembly protein 26	0.0047	0.0199	0.0189
Brugia malayi	alpha-tubulin	0.0047	0.0199	0.0227
Loa Loa (eye worm)	hypothetical protein	0.1167	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.0199	0.0189
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0142	0.1028	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0142	0.1028	0.1019
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0142	0.1028	0.1019
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0142	0.1028	0.1019
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.0142	0.1028	0.1019
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.0142	0.1028	0.1174
Echinococcus granulosus	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Trypanosoma brucei	beta tubulin	0.0085	0.0525	0.5108
Trypanosoma brucei	alpha tubulin	0.0047	0.0199	0.1931
Loa Loa (eye worm)	BEN-1 protein	0.0085	0.0525	0.0525
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0142	0.1028	0.1174
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0142	0.1028	0.1019
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.0142	0.1028	0.1019
Entamoeba histolytica	tubulin alpha chain, putative	0.0047	0.0199	0.1834
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0142	0.1028	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Trypanosoma brucei	beta tubulin	0.0085	0.0525	0.5108
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Giardia lamblia	Beta tubulin	0.0085	0.0525	0.0405
Echinococcus granulosus	tubulin alpha 1C chain	0.0047	0.0199	0.0189
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0175	0.0165
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.0142	0.1028	0.1028
Echinococcus multilocularis	peroxisome assembly protein 26	0.0047	0.0199	0.0189
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0006	0.0006
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.1167	1	1
Echinococcus multilocularis	tubulin subunit TubB	0.0047	0.0199	0.0189
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.1025	0.8757	0.8755
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.1167	1	1
Trypanosoma brucei	alpha tubulin	0.0047	0.0199	0.1931
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.0142	0.1028	0.1019
Brugia malayi	Blistered cuticle protein 3	0.0026	0.001	0.0011
Toxoplasma gondii	beta tubulin	0.0085	0.0525	0.0525
Echinococcus granulosus	tubulin alpha 3 chain	0.0047	0.0199	0.0189
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0047	0.0199	0.0189
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Schistosoma mansoni	tubulin subunit alpha	0.0047	0.0199	0.0189
Schistosoma mansoni	alpha tubulin	0.0047	0.0199	0.0189
Echinococcus multilocularis	tubulin alpha 1C chain	0.0047	0.0199	0.0189
Echinococcus granulosus	tubulin gamma 1 chain	0.0039	0.0125	0.0115
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.1025	0.8757	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus multilocularis	tubulin alpha 1C chain	0.0047	0.0199	0.0189
Loa Loa (eye worm)	BEN-1 protein	0.0085	0.0525	0.0525
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.1167	1	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Plasmodium falciparum	tubulin epsilon chain, putative	0.0039	0.0125	0.1217
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.003	0.0051	0.0438
Echinococcus multilocularis	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.001	0.0011
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.1167	1	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0045	0.0175	0.0175
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1028	0.1028
Echinococcus multilocularis	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Plasmodium falciparum	alpha tubulin 2	0.0047	0.0199	0.1931
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Plasmodium vivax	tubulin gamma chain, putative	0.0039	0.0125	0.1217
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.0199	0.0189
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Giardia lamblia	NADPH oxidoreductase, putative	0.0081	0.0494	0.0373
Loa Loa (eye worm)	beta-tubulin	0.0085	0.0525	0.0525
Brugia malayi	tubulin alpha chain - mouse	0.0047	0.0199	0.0227
Brugia malayi	Tubulin alpha chain	0.0047	0.0199	0.0227
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.0199	0.1883
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0081	0.0494	0.4769
Schistosoma mansoni	tubulin subunit beta	0.0085	0.0525	0.0516
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Trypanosoma brucei	beta tubulin	0.0039	0.0125	0.1217
Echinococcus multilocularis	hypothetical protein	0.0047	0.0199	0.0189
Loa Loa (eye worm)	tubulin alpha-2 chain	0.0047	0.0199	0.0199
Giardia lamblia	Alpha-tubulin	0.0047	0.0199	0.0074
Loa Loa (eye worm)	tubulin alpha chain	0.0047	0.0199	0.0199
Trypanosoma cruzi	hypothetical protein, conserved	0.0142	0.1028	1
Echinococcus multilocularis	tubulin subunit beta	0.0085	0.0525	0.0516
Trypanosoma brucei	hypothetical protein, conserved	0.0142	0.1028	1
Schistosoma mansoni	alpha tubulin	0.0047	0.0199	0.0189
Plasmodium falciparum	tubulin beta chain	0.0085	0.0525	0.5108
Trypanosoma cruzi	alpha tubulin, putative	0.0047	0.0199	0.1931
Echinococcus granulosus	tubulin alpha chain	0.0047	0.0199	0.0189
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0142	0.1028	0.1019
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.001	0.0011
Leishmania major	hypothetical protein, conserved	0.0142	0.1028	1
Echinococcus granulosus	tubulin epsilon chain	0.0039	0.0125	0.0115
Trypanosoma cruzi	tubulin gamma chain	0.0039	0.0125	0.1217
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Trichomonas vaginalis	tubulin alpha chain, putative	0.0039	0.0125	0.1166
Plasmodium falciparum	phosphodiesterase delta, putative	0.0142	0.1028	1
Giardia lamblia	Alpha-tubulin	0.0047	0.0199	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Leishmania major	cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100	0.0142	0.1028	1
Plasmodium vivax	tubulin epsilon chain, putative	0.0039	0.0125	0.1217
Entamoeba histolytica	tubulin family protein	0.0085	0.0525	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0142	0.1028	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.0142	0.1028	0.1019
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Trypanosoma brucei	tubulin gamma chain	0.0039	0.0125	0.1217
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0142	0.1028	1
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Echinococcus multilocularis	beta tubulin	0.0085	0.0525	0.0516
Echinococcus multilocularis	tubulin alpha 3 chain	0.0047	0.0199	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Echinococcus granulosus	tubulin alpha 3 chain	0.0047	0.0199	0.0189
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.1028	1
Plasmodium vivax	tubulin alpha chain, putative	0.0047	0.0199	0.1931
Trypanosoma cruzi	hypothetical protein, conserved	0.0142	0.1028	1
Schistosoma mansoni	tubulin subunit epsilon	0.0039	0.0125	0.0115
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Plasmodium falciparum	tubulin gamma chain	0.0039	0.0125	0.1217
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0142	0.1028	0.1174
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus granulosus	tubulin alpha chain	0.0047	0.0199	0.0189
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.001	0.0011
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.0142	0.1028	0.1019
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.0199	0.1883
Brugia malayi	hypothetical protein	0.0026	0.001	0.0011
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0175	0.0165
Trypanosoma cruzi	hypothetical protein, conserved	0.0142	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Brugia malayi	tubulin alpha-2 chain	0.0047	0.0199	0.0227
Loa Loa (eye worm)	tubulin alpha chain	0.0047	0.0199	0.0199
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0142	0.1028	0.1174
Brugia malayi	hypothetical protein	0.0147	0.1074	0.1227
Trichomonas vaginalis	tubulin gamma chain, putative	0.0039	0.0125	0.1166
Trichomonas vaginalis	tubulin gamma chain, putative	0.0039	0.0125	0.1166
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1028	0.1028
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0175	0.0165
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.0142	0.1028	0.1174
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0047	0.0199	0.0189
Leishmania major	gamma-tubulin	0.0039	0.0125	0.1217
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.001	0.0011
Loa Loa (eye worm)	alpha-tubulin	0.0047	0.0199	0.0199
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Toxoplasma gondii	tubulin/FtsZ family, GTPase domain-containing protein	0.0039	0.0125	0.0125
Echinococcus granulosus	tubulin subunit TubB	0.0047	0.0199	0.0189
Brugia malayi	Peroxidasin	0.0026	0.001	0.0011
Plasmodium vivax	tubulin alpha chain, putative	0.0047	0.0199	0.1931
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.0142	0.1028	0.1019
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus granulosus	tubulin alpha	0.0039	0.0125	0.0115
Echinococcus granulosus	tubulin beta 1 chain	0.0085	0.0525	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0142	0.1028	0.1028
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.1167	1	1
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0081	0.0494	0.4769
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Giardia lamblia	NADPH oxidoreductase, putative	0.0081	0.0494	0.0373
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0142	0.1028	1
Trypanosoma brucei	alpha tubulin	0.0047	0.0199	0.1931
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Echinococcus granulosus	Tubulin alpha 1 chain	0.0047	0.0199	0.0189
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.0142	0.1028	0.1174
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Echinococcus granulosus	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Echinococcus granulosus	Tubulin alpha 1 chain	0.0047	0.0199	0.0189
Schistosoma mansoni	tubulin subunit alpha	0.0047	0.0199	0.0189
Echinococcus multilocularis	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.0142	0.1028	0.1019
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.0199	0.1883
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.0199	0.0189
Echinococcus multilocularis	tubulin alpha	0.0039	0.0125	0.0115
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.0142	0.1028	0.1019
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.1167	1	1
Echinococcus multilocularis	beta tubulin	0.0085	0.0525	0.0516
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0199	0.0199
Trypanosoma brucei	beta tubulin	0.0085	0.0525	0.5108
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.001	0.001
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.0142	0.1028	0.1019
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.0142	0.1028	0.1019
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0047	0.0199	0.1883
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus granulosus	tubulin alpha 1C chain	0.0047	0.0199	0.0189
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Plasmodium vivax	phosphodiesterase gamma, putative	0.0142	0.1028	1
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.0199	0.1883
Giardia lamblia	NADPH oxidoreductase, putative	0.0081	0.0494	0.0373
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0142	0.1028	0.1019
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0081	0.0494	0.4769
Echinococcus granulosus	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0142	0.1028	1
Trypanosoma cruzi	epsilon tubulin, putative	0.0039	0.0125	0.1217
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Trypanosoma cruzi	cAMP phosphodiesterase A, putative	0.0142	0.1028	1
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Trypanosoma brucei	alpha tubulin	0.0047	0.0199	0.1931
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0142	0.1028	1
Brugia malayi	Tubulin gamma chain	0.0039	0.0125	0.0143
Schistosoma mansoni	tubulin subunit alpha	0.0047	0.0199	0.0189
Toxoplasma gondii	beta-tubulin, putative	0.0085	0.0525	0.0525
Loa Loa (eye worm)	tubulin beta-1 chain	0.0085	0.0525	0.0525
Echinococcus granulosus	Tubulin alpha 1 chain	0.0047	0.0199	0.0189
Trypanosoma brucei	cAMP phosphodiesterase A, putative	0.0142	0.1028	1
Entamoeba histolytica	tubulin family protein	0.0085	0.0525	1
Leishmania major	cAMP-specific phosphodiesterase, putative	0.0142	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.003	0.0051	0.0051
Echinococcus multilocularis	Tubulin alpha 1 chain	0.0047	0.0199	0.0189
Trypanosoma brucei	epsilon tubulin	0.0039	0.0125	0.1217
Echinococcus granulosus	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0047	0.0199	0.1883
Leishmania major	epsilon tubulin, putative	0.0039	0.0125	0.1217
Loa Loa (eye worm)	alpha-tubulin isotype 2	0.003	0.0051	0.0051
Schistosoma mansoni	tubulin subunit beta	0.0085	0.0525	0.0516
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.0142	0.1028	0.1019
Loa Loa (eye worm)	animal heme peroxidase	0.0026	0.001	0.001
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0142	0.1028	1
Giardia lamblia	hypothetical protein	0.0142	0.1028	0.0915
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.0142	0.1028	0.1019
Trypanosoma cruzi	epsilon tubulin, putative	0.0039	0.0125	0.1217
Loa Loa (eye worm)	tubulin beta chain	0.0085	0.0525	0.0525
Loa Loa (eye worm)	PDE1B protein	0.0142	0.1028	0.1028
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Echinococcus multilocularis	tubulin epsilon chain	0.0039	0.0125	0.0115
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0045	0.0175	0.0165
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.0199	0.1883
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0142	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Brugia malayi	Tubulin beta-1 chain	0.0085	0.0525	0.06
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.1028	1
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.1025	0.8757	0.8757
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Echinococcus granulosus	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Giardia lamblia	Beta tubulin	0.0085	0.0525	0.0405
Echinococcus granulosus	tubulin beta 4A class IVa	0.0085	0.0525	0.0516
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0175	0.0165
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Plasmodium falciparum	alpha tubulin 1	0.0047	0.0199	0.1931
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus multilocularis	tubulin gamma 1 chain	0.0039	0.0125	0.0115
Schistosoma mansoni	tubulin subunit beta	0.0085	0.0525	0.0516
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Trypanosoma cruzi	beta tubulin, putative	0.0085	0.0525	0.5108
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0045	0.0175	0.0165
Loa Loa (eye worm)	tubulin alpha 2	0.003	0.0051	0.0051
Trypanosoma brucei	epsilon tubulin	0.0039	0.0125	0.1217
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Entamoeba histolytica	tubulin alpha-1 chain	0.0047	0.0199	0.1834
Echinococcus multilocularis	Tubulin beta 2C chain	0.0085	0.0525	0.0516
Onchocerca volvulus		0.0147	0.1074	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Loa Loa (eye worm)	tubulin beta-4 chain	0.0085	0.0525	0.0525
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Trypanosoma brucei	cAMP-specific phosphodiesterase, putative	0.0142	0.1028	1
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.0199	0.0189
Trypanosoma cruzi	hypothetical protein, conserved	0.0142	0.1028	1
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.1025	0.8757	0.8755
Echinococcus multilocularis	tubulin beta 1 chain	0.0085	0.0525	0.0516
Trichomonas vaginalis	conserved hypothetical protein	0.0061	0.0316	0.3037
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0142	0.1028	0.1019
Trypanosoma cruzi	cAMP specific phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus granulosus	tubulin alpha chain	0.0047	0.0199	0.0189
Trypanosoma cruzi	cAMP-specific phosphodiesterase, putative	0.0142	0.1028	1
Trichomonas vaginalis	tubulin alpha chain, putative	0.0085	0.0525	0.5079
Brugia malayi	Animal haem peroxidase family protein	0.0026	0.001	0.0011
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.0142	0.1028	0.1019
Schistosoma mansoni	tubulin subunit beta	0.0085	0.0525	0.0516
Loa Loa (eye worm)	blistered cuticle protein 3	0.0026	0.001	0.001
Trypanosoma brucei	epsilon tubulin	0.0039	0.0125	0.1217
Toxoplasma gondii	alpha tubulin TUBA1	0.0047	0.0199	0.0199
Echinococcus multilocularis	tubulin alpha 3 chain	0.0047	0.0199	0.0189
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0085	0.0525	0.5079
Trichomonas vaginalis	tubulin gamma chain, putative	0.0085	0.0525	0.5079
Leishmania major	beta tubulin	0.0085	0.0525	0.5108
Echinococcus granulosus	tubulin alpha chain	0.0047	0.0199	0.0189
Giardia lamblia	Hypothetical protein	0.0142	0.1028	0.0915
Trichomonas vaginalis	tubulin alpha-1 chain, putative	0.0047	0.0199	0.1883
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0142	0.1028	1
Plasmodium falciparum	phosphodiesterase gamma, putative	0.0142	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.0147	0.1074	0.1074
Schistosoma mansoni	alpha tubulin	0.0047	0.0199	0.0189
Toxoplasma gondii	alpha-tubulin I, putative	0.0047	0.0199	0.0199
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Schistosoma mansoni	tubulin subunit beta	0.0085	0.0525	0.0516
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0085	0.0525	0.5079
Treponema pallidum	ATP-binding protein (ylxH-1)	0.0449	0.3717	0.5
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.0142	0.1028	0.1019
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Echinococcus granulosus	alpha tubulin	0.0047	0.0199	0.0189
Brugia malayi	Tubulin alpha-2 chain	0.0047	0.0199	0.0227
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.0142	0.1028	1
Loa Loa (eye worm)	alpha-tubulin	0.0047	0.0199	0.0199
Trichomonas vaginalis	tubulin, putative	0.0085	0.0525	0.5079
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0045	0.0175	0.02
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0142	0.1028	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Trypanosoma brucei	cAMP-specific phosphodiesterase	0.0142	0.1028	1
Brugia malayi	beta-tubulin, identical	0.0085	0.0525	0.06
Loa Loa (eye worm)	tubulin alpha-3 chain	0.0025	0.0006	0.0006
Loa Loa (eye worm)	tubulin beta-2A chain	0.0085	0.0525	0.0525
Echinococcus granulosus	tubulin alpha chain	0.0047	0.0199	0.0189
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0142	0.1028	0.1028
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0085	0.0525	0.0516
Trichomonas vaginalis	tubulin beta chain, putative	0.0047	0.0199	0.1883
Trichomonas vaginalis	tubulin beta chain, putative	0.0085	0.0525	0.5079
Brugia malayi	Tubulin alpha-2 chain	0.0047	0.0199	0.0227
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.0142	0.1028	1
Trypanosoma brucei	beta tubulin	0.0085	0.0525	0.5108
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.0142	0.1028	0.1019
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.001	0.001
Leishmania major	alpha tubulin	0.0047	0.0199	0.1931
Loa Loa (eye worm)	tubulin alpha 2	0.003	0.0051	0.0051
Schistosoma mansoni	tubulin subunit beta	0.0085	0.0525	0.0516
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Loa Loa (eye worm)	tubulin gamma chain	0.0039	0.0125	0.0125
Giardia lamblia	Beta tubulin	0.0085	0.0525	0.0405
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Trichomonas vaginalis	conserved hypothetical protein	0.0081	0.0494	0.4769
Echinococcus multilocularis	tubulin alpha chain	0.0047	0.0199	0.0189
Leishmania major	hypothetical protein, conserved	0.0142	0.1028	1
Schistosoma mansoni	tubulin subunit gamma	0.0039	0.0125	0.0115
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0045	0.0175	0.0165
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.0142	0.1028	1
Echinococcus granulosus	tubulin subunit beta	0.0085	0.0525	0.0516
Echinococcus granulosus	beta tubulin	0.0085	0.0525	0.0516
Echinococcus granulosus	beta tubulin	0.0085	0.0525	0.0516
Plasmodium vivax	tubulin beta chain, putative	0.0085	0.0525	0.5108
Trichomonas vaginalis	conserved hypothetical protein	0.0142	0.1028	1
Toxoplasma gondii	beta-1 tubulin, putative	0.0085	0.0525	0.0525

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.00000084 M	Inhibition of specific binding of [3H]-U-46,619 to TXA2/PGH2 receptor in guinea pig platelet membrane	ChEMBL.	1535377

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 113271