Detailed information for compound 1139436

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 331.363 | Formula: C18H21NO5
  • H donors: 4 H acceptors: 3 LogP: 2.13 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Cc1ccc2c(c1)OCO2)NC[C@@H](c1ccc(c(c1)O)O)O
  • InChi: 1S/C18H21NO5/c1-11(6-12-2-5-17-18(7-12)24-10-23-17)19-9-16(22)13-3-4-14(20)15(21)8-13/h2-5,7-8,11,16,19-22H,6,9-10H2,1H3/t11?,16-/m0/s1
  • InChiKey: LUMAEVHDZXIGEP-NBFOKTCDSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable peptidase 0.0179 0.145 0.2396
Trypanosoma brucei metacaspase 5, putative 0.1027 0.9791 1
Onchocerca volvulus 0.0046 0.0141 0.0256
Loa Loa (eye worm) runx1 0.0064 0.032 0.066
Brugia malayi Transient-receptor-potential like protein 0.0041 0.0094 0.0156
Echinococcus multilocularis transient receptor potential ion channel A 0.0093 0.0602 0.0582
Trypanosoma brucei metacaspase MCA2 0.1027 0.9791 1
Onchocerca volvulus Cell death protein 3 homolog 0.0283 0.2478 0.5247
Echinococcus granulosus integrin alpha ps 0.0038 0.0061 0.004
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0037 0.0053 0.0083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0101 0.0683 0.1433
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0251 0.0256
Echinococcus granulosus acylamino acid releasing enzyme 0.0057 0.0251 0.0231
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0214 0.1796 0.1779
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0101 0.0683 0.0663
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0332 0.0799
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0131 0.0984 0.1005
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.011 0.0771 0.0752
Onchocerca volvulus Prolyl endopeptidase homolog 0.043 0.3918 0.8321
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.043 0.3918 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0732 0.0314
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0106 0.0732 0.0748
Onchocerca volvulus 0.0048 0.0161 0.0299
Schistosoma mansoni neuropeptide receptor 0.0166 0.1328 0.3354
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0211 0.1769 0.1752
Echinococcus multilocularis neuropeptide receptor 0.0166 0.1328 0.131
Schistosoma mansoni integrin alpha-ps 0.0038 0.0061 0.0103
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.01 0.0675 0.0689
Echinococcus multilocularis caspase 0.0283 0.2478 0.2463
Echinococcus granulosus transcription factor Dp 1 0.0044 0.0123 0.0103
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.2478 0.9426
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0283 0.2478 0.9426
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.2614 1
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0179 0.145 0.1481
Brugia malayi hypothetical protein 0.0043 0.0114 0.02
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0106 0.0732 0.0748
Echinococcus granulosus TRP transient receptor potential channel 0.0041 0.0094 0.0073
Loa Loa (eye worm) prolyl oligopeptidase 0.0057 0.0251 0.0514
Echinococcus multilocularis voltage dependent calcium channel 0.0214 0.1796 0.1779
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.2614 1
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.015 0.013
Trypanosoma brucei prolyl oligopeptidase, putative 0.0179 0.145 0.1481
Echinococcus granulosus caspase 2 0.0283 0.2478 0.2463
Loa Loa (eye worm) hypothetical protein 0.006 0.0283 0.0581
Echinococcus multilocularis transient receptor potential gamma protein 0.0101 0.0686 0.0666
Toxoplasma gondii aldehyde dehydrogenase 0.0326 0.2894 0.2941
Schistosoma mansoni caspase-3 (C14 family) 0.0283 0.2478 0.6306
Echinococcus granulosus caspase 0.0283 0.2478 0.2463
Echinococcus granulosus jumonji domain containing protein 0.0047 0.015 0.013
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0332 0.0799
Loa Loa (eye worm) mbt repeat family protein 0.0048 0.0161 0.0322
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0161 0.036
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0214 0.1796 0.1779
Loa Loa (eye worm) hypothetical protein 0.0041 0.0094 0.0179
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.01 0.0675 0.0689
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0224 0.1891 0.1931
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0283 0.2478 0.9426
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0326 0.2894 0.8154
Loa Loa (eye worm) hypothetical protein 0.0214 0.1796 0.3805
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0367 0.0347
Loa Loa (eye worm) hypothetical protein 0.0047 0.0156 0.0312
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0211 0.1769 0.3734
Loa Loa (eye worm) hypothetical protein 0.043 0.3918 0.8325
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.2478 0.9426
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0226 0.0206
Loa Loa (eye worm) MBCTL1 0.0054 0.0226 0.046
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0211 0.1769 0.4487
Trypanosoma cruzi metacaspase, putative 0.1027 0.9791 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0021 0.0023
Echinococcus multilocularis geminin 0.0362 0.3254 0.3241
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.2614 1
Schistosoma mansoni caspase-7 (C14 family) 0.0283 0.2478 0.6306
Loa Loa (eye worm) hypothetical protein 0.0283 0.2478 0.5258
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0283 0.2478 0.6306
Echinococcus multilocularis GPCR, family 2 0.0101 0.0683 0.0663
Loa Loa (eye worm) hypothetical protein 0.0058 0.0256 0.0525
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0057 0.0251 0.0256
Echinococcus multilocularis Protein lozenge 0.0064 0.032 0.03
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.009 0.0178
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0131 0.0984 0.1005
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.01 0.0675 0.0689
Loa Loa (eye worm) hypothetical protein 0.0218 0.1834 0.3885
Schistosoma mansoni hypothetical protein 0.0101 0.0683 0.1699
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0214 0.1796 0.1779
Plasmodium falciparum peptidase, putative 0.0057 0.0251 0.0236
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.009 0.0178
Loa Loa (eye worm) hypothetical protein 0.0046 0.0141 0.0278
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0211 0.1769 0.1752
Brugia malayi mbt repeat family protein 0.0048 0.0161 0.0299
Loa Loa (eye worm) RNA binding protein 0.0065 0.0332 0.0687
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0332 0.0687
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.1042 0.2199
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0101 0.0683 0.0663
Brugia malayi Serine carboxypeptidase S28 family protein 0.0101 0.0685 0.1419
Loa Loa (eye worm) voltage-dependent calcium channel 0.0047 0.0156 0.0312
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.1543 0.1526
Leishmania major oligopeptidase b 0.0179 0.145 0.1083
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0283 0.2478 0.2463
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0048 0.0161 0.036
Trypanosoma brucei prolyl endopeptidase 0.043 0.3918 0.4001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.02 0.0461
Plasmodium vivax hypothetical protein, conserved 0.0283 0.2478 0.2515
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.043 0.3918 0.372
Loa Loa (eye worm) hypothetical protein 0.0063 0.0315 0.065
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0226 0.0438
Trypanosoma cruzi metacaspase, putative 0.1027 0.9791 1
Echinococcus granulosus neuropeptide receptor 0.0166 0.1328 0.131
Echinococcus granulosus transient receptor potential ion channel A 0.0093 0.0602 0.0582
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0251 0.0256
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0283 0.2478 0.9426
Brugia malayi MH2 domain containing protein 0.0137 0.1042 0.2181
Schistosoma mansoni jumonji domain containing protein 0.0087 0.0549 0.1357
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0179 0.145 0.1481
Echinococcus multilocularis caspase 8 0.0283 0.2478 0.2463
Echinococcus multilocularis short transient receptor potential channel 6 0.0069 0.0367 0.0347
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0179 0.145 0.1481
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0057 0.0251 0.0591
Toxoplasma gondii hypothetical protein 0.0039 0.0072 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.2478 0.9426
Echinococcus granulosus Dipeptidyl peptidase 9 0.01 0.0675 0.0655
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0438 0.0447
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0226 0.0527
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.2614 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0226 0.0206
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0179 0.145 0.1083
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.2614 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0326 0.2894 0.2626
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0251 0.0492
Schistosoma mansoni hypothetical protein 0.0046 0.0141 0.0308
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0179 0.145 0.2938
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.043 0.3918 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.02 0.018
Trypanosoma cruzi oligopeptidase b 0.0179 0.145 0.1481
Trichomonas vaginalis glucosylceramidase, putative 0.0297 0.2614 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0072 0.0133
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0214 0.1796 0.1779
Echinococcus granulosus geminin 0.0362 0.3254 0.3241
Loa Loa (eye worm) jmjC domain-containing protein 0.0069 0.0372 0.0772
Plasmodium falciparum metacaspase 1 0.1027 0.9791 1
Plasmodium vivax metacaspase 1, putative 0.1027 0.9791 1
Toxoplasma gondii transporter, cation channel family protein 0.0047 0.0156 0.0139
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0367 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1712 0.6183
Schistosoma mansoni integrin alpha 0.0038 0.0061 0.0103
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1609 0.5746
Trypanosoma cruzi metacaspase 5, putative 0.1027 0.9791 1
Brugia malayi Muscle positioning protein 4 0.0046 0.0141 0.0256
Mycobacterium ulcerans aldehyde dehydrogenase 0.0326 0.2894 1
Onchocerca volvulus 0.0046 0.0141 0.0256
Loa Loa (eye worm) hypothetical protein 0.0046 0.0141 0.0278
Loa Loa (eye worm) hypothetical protein 0.0101 0.0683 0.1433
Echinococcus multilocularis G protein coupled receptor 139 0.0166 0.1328 0.131
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0057 0.0251 0.0236
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0093 0.0602 0.0582
Echinococcus multilocularis prolyl endopeptidase 0.043 0.3918 0.3905
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.1543 0.1526
Loa Loa (eye worm) hypothetical protein 0.0101 0.0685 0.1439
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.2478 0.9426
Echinococcus multilocularis sodium channel protein 0.0093 0.0602 0.0582
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.02 0.0384
Schistosoma mansoni voltage-gated cation channel 0.0214 0.1796 0.4555
Toxoplasma gondii prolyl endopeptidase 0.043 0.3918 0.3989
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0214 0.1796 0.1779
Onchocerca volvulus 0.051 0.4704 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0048 0.0161 0.014
Leishmania major mitochondrial DNA polymerase beta 0.0224 0.1891 0.1553
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0251 0.0236
Schistosoma mansoni hypothetical protein 0.0291 0.2549 0.6487
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.02 0.0461
Echinococcus multilocularis neuropeptide s receptor 0.1048 1 1
Brugia malayi prolyl oligopeptidase family protein 0.01 0.0675 0.1396
Toxoplasma gondii hypothetical protein 0.0036 0.0045 0.0025
Schistosoma mansoni hypothetical protein 0.0362 0.3254 0.8298
Toxoplasma gondii PAN domain-containing protein 0.0288 0.2524 0.2563
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.02 0.0406
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.02 0.0461
Loa Loa (eye worm) hypothetical protein 0.0054 0.0226 0.046
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.02 0.018
Schistosoma mansoni hypothetical protein 0.0362 0.3254 0.8298
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0319 0.2826 0.5989
Schistosoma mansoni transient receptor potential channel 0.0069 0.0367 0.0888
Onchocerca volvulus 0.0046 0.0141 0.0256
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0076 0.0438 0.0418
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0041 0.0094 0.0073
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.01 0.0675 0.0253
Schistosoma mansoni transient receptor potential channel 0.0069 0.0367 0.0888
Brugia malayi mbt repeat family protein 0.0048 0.0161 0.0299
Echinococcus granulosus caspase 8 0.0283 0.2478 0.2463
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0283 0.2478 0.9426
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0283 0.2478 0.2515
Echinococcus multilocularis integrin alpha ps 0.0038 0.0061 0.004
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0283 0.2478 0.5247
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.01 0.0675 0.1678
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0283 0.2478 0.2515
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0076 0.0438 0.0418
Trypanosoma cruzi metacaspase, putative 0.1027 0.9791 1
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0373 0.3357 1
Schistosoma mansoni aldehyde dehydrogenase 0.0326 0.2894 0.7374
Loa Loa (eye worm) hypothetical protein 0.0039 0.0072 0.0133
Brugia malayi jmjC domain containing protein 0.0041 0.009 0.0148
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0283 0.2478 0.9426
Trypanosoma brucei oligopeptidase b 0.0179 0.145 0.1481
Plasmodium falciparum metacaspase-like protein 0.0283 0.2478 0.2515
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0214 0.1796 0.4555
Brugia malayi prolyl oligopeptidase family protein 0.0211 0.1769 0.3734
Schistosoma mansoni sex comb on midleg homolog 0.0048 0.0161 0.036
Loa Loa (eye worm) hypothetical protein 0.0101 0.0685 0.1439
Echinococcus granulosus short transient receptor potential channel 6 0.0069 0.0367 0.0347
Echinococcus granulosus polycomb protein SCMH1 0.0048 0.0161 0.014
Loa Loa (eye worm) hypothetical protein 0.0101 0.0685 0.1439
Brugia malayi TAR-binding protein 0.0065 0.0332 0.0665
Trypanosoma cruzi metacaspase 5, putative 0.1027 0.9791 1
Trypanosoma brucei metacaspase MCA3 0.1027 0.9791 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.009 0.007
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0283 0.2478 0.9426
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0332 0.0687
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0283 0.2478 0.9426
Schistosoma mansoni hypothetical protein 0.0101 0.0683 0.1699
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.01 0.0675 0.0669
Brugia malayi Calcitonin receptor-like protein seb-1 0.0319 0.2826 0.5989
Echinococcus granulosus neuropeptide receptor A26 0.1048 1 1
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0251 0.0492
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0048 0.0161 0.0299
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.02 0.018
Echinococcus multilocularis caspase 2 0.0283 0.2478 0.2463
Loa Loa (eye worm) hypothetical protein 0.0048 0.0161 0.0322
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.009 0.0171
Brugia malayi jmjC domain containing protein 0.011 0.0771 0.1603
Toxoplasma gondii PAN domain-containing protein 0.0288 0.2524 0.2563
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0021 0.0023
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1609 0.5746
Echinococcus multilocularis voltage dependent calcium channel 0.0214 0.1796 0.1779
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0224 0.1891 0.1931
Loa Loa (eye worm) DOMON domain-containing protein 0.0046 0.0141 0.0278
Leishmania major metacaspase, putative 0.1027 0.9791 1
Onchocerca volvulus Glucosylceramidase homolog 0.0195 0.1609 0.3391
Echinococcus multilocularis acylamino acid releasing enzyme 0.0057 0.0251 0.0231
Schistosoma mansoni aldehyde dehydrogenase 0.0326 0.2894 0.7374
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0224 0.1891 0.1931
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0214 0.1796 0.379
Loa Loa (eye worm) hypothetical protein 0.051 0.4704 1
Loa Loa (eye worm) calcium channel 0.0214 0.1796 0.3805
Loa Loa (eye worm) hypothetical protein 0.0057 0.0251 0.0514
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0297 0.2614 0.5547
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0297 0.2614 0.5537
Echinococcus multilocularis Lysosomal Pro X carboxypeptidase 0.0101 0.0685 0.0666
Trypanosoma cruzi prolyl endopeptidase 0.043 0.3918 0.4001
Trypanosoma brucei metacaspase 0.0283 0.2478 0.2531
Echinococcus granulosus GPCR family 2 0.0101 0.0683 0.0663
Loa Loa (eye worm) integrin alpha pat-2 0.0083 0.0508 0.1061
Schistosoma mansoni transient receptor potential channel 4 0.0101 0.0686 0.1707
Giardia lamblia Alanyl dipeptidyl peptidase 0.0057 0.0251 1
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0063 0.0315 0.0629
Echinococcus granulosus tar DNA binding protein 0.0065 0.0332 0.0312
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0438 0.0447
Echinococcus multilocularis integrin alpha ps 0.0038 0.0061 0.004
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0179 0.145 0.2396
Brugia malayi SEA domain containing protein 0.0046 0.0141 0.0256
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0283 0.2478 0.2463
Loa Loa (eye worm) hypothetical protein 0.0283 0.2478 0.5258
Schistosoma mansoni lozenge 0.0064 0.032 0.0767
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0326 0.2894 0.288
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.2478 0.9426
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.0179 0.145 0.5
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0332 0.0312
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0214 0.1796 0.1779
Loa Loa (eye worm) hypothetical protein 0.0101 0.0686 0.144
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0101 0.0683 0.0663
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.011 0.0771 0.0752
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0332 0.0799
Brugia malayi Integrin alpha pat-2 precursor 0.0038 0.0061 0.0086
Mycobacterium ulcerans aldehyde dehydrogenase 0.0326 0.2894 1
Echinococcus granulosus voltage dependent calcium channel 0.0214 0.1796 0.1779
Brugia malayi hypothetical protein 0.051 0.4704 1
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1609 0.5746
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0076 0.0438 0.0891
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0326 0.2894 0.288
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0332 0.0665
Echinococcus multilocularis polycomb protein SCMH1 0.0048 0.0161 0.014
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.009 0.007
Schistosoma mansoni lysosomal Pro-Xaa carboxypeptidase (S28 family) 0.0101 0.0685 0.1706
Echinococcus multilocularis SAM and MBT domain containing protein 0.0048 0.0161 0.014
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0214 0.1796 0.1779
Schistosoma mansoni hypothetical protein 0.0101 0.0683 0.1699
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0101 0.0683 0.1413
Echinococcus granulosus Lysosomal Pro X carboxypeptidase 0.0101 0.0685 0.0666
Schistosoma mansoni caspase-7 (C14 family) 0.0283 0.2478 0.6306
Brugia malayi Cell death protein 3 precursor 0.0283 0.2478 0.5247
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0283 0.2478 0.9426
Loa Loa (eye worm) hypothetical protein 0.051 0.4704 1
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.1027 0.9791 1
Trichomonas vaginalis conserved hypothetical protein 0.0283 0.2478 0.9426
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0101 0.0683 0.0663
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.01 0.0675 0.0689
Onchocerca volvulus 0.0046 0.0141 0.0256
Echinococcus multilocularis Dipeptidyl peptidase 9 0.01 0.0675 0.0655
Trypanosoma cruzi oligopeptidase b 0.0179 0.145 0.1481
Brugia malayi RNA binding protein 0.0065 0.0332 0.0665
Giardia lamblia Alanyl dipeptidyl peptidase 0.0057 0.0251 1
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0332 0.0799
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1609 0.5746
Brugia malayi latrophilin 2 splice variant baaae 0.0218 0.1834 0.3871
Brugia malayi prolyl oligopeptidase family protein 0.043 0.3918 0.8321
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1609 0.5746
Toxoplasma gondii hypothetical protein 0.0057 0.0251 0.0236
Loa Loa (eye worm) hypothetical protein 0.0057 0.0251 0.0514
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.02 0.018
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0214 0.1796 0.4555
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0076 0.0438 1
Loa Loa (eye worm) hypothetical protein 0.0319 0.2826 0.5999
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0283 0.2478 0.9426
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1609 0.5746
Loa Loa (eye worm) prolyl oligopeptidase 0.0211 0.1769 0.3748
Brugia malayi Latrophilin receptor protein 2 0.0101 0.0683 0.1413
Schistosoma mansoni hypothetical protein 0.0101 0.0683 0.1699
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0319 0.2826 0.5999
Echinococcus multilocularis neuropeptide receptor A26 0.1048 1 1
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.1042 0.2199
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0076 0.0438 0.0447
Echinococcus granulosus prolyl endopeptidase 0.043 0.3918 0.3905
Echinococcus granulosus voltage dependent calcium channel 0.0047 0.0156 0.0136
Trichomonas vaginalis glucosylceramidase, putative 0.0195 0.1609 0.5746
Echinococcus multilocularis transcription factor Dp 1 0.0044 0.0123 0.0103
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0057 0.0251 0.0591
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0226 0.0206
Trypanosoma cruzi metacaspase, putative 0.1027 0.9791 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0326 0.2894 1
Trypanosoma brucei Metacaspase-4 0.0283 0.2478 0.2531
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0076 0.0438 0.0912
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0038 0.0068 0.0069
Onchocerca volvulus 0.0049 0.0177 0.0335
Schistosoma mansoni hypothetical protein 0.0218 0.1834 0.4653
Echinococcus granulosus transient receptor potential gamma protein 0.0101 0.0686 0.0666
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0226 0.0206
Loa Loa (eye worm) hypothetical protein 0.0043 0.0114 0.0223
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0332 0.0799
Schistosoma mansoni transient receptor potential channel 0.0101 0.0686 0.1707
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0076 0.0438 0.1071
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.1712 0.6183

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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