Detailed information for compound 1140931

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 331.267 | Formula: C13H8F3NO4S
  • H donors: 1 H acceptors: 4 LogP: 2.89 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(F)(F)F)CN1C(=O)S/C(=C\c2ccc(cc2)O)/C1=O
  • InChi: 1S/C13H8F3NO4S/c14-13(15,16)10(19)6-17-11(20)9(22-12(17)21)5-7-1-3-8(18)4-2-7/h1-5,18H,6H2/b9-5-
  • InChiKey: JGQMGJPMKHDJMH-UITAMQMPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bos taurus Aldose reductase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense prostaglandin f synthase. putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni pol-related Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae PROBABLE OXIDOREDUCTASE Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldehyde reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum ko:K00011 aldehyde reductase [EC1.1.1.21], putative Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma mansoni aldo-keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium leprae Conserved hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Neospora caninum Oxidoreductase, aldo/keto reductase family, related Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania mexicana prostaglandin f2-alpha synthase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium tuberculosis Probable oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Entamoeba histolytica aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei gambiense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania infantum prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans similar to mammalian aldo/keto reductases Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma congolense prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma brucei prostaglandin f synthase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Schistosoma japonicum IPR001395,Aldo/keto reductase,domain-containing Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldehyde reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Toxoplasma gondii aldose reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Trypanosoma cruzi aldo/keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis dihydrodiol dehydrogenase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Onchocerca volvulus Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Loa Loa (eye worm) oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Brugia malayi oxidoreductase, aldo/keto reductase family protein Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis aldehyde reductase, putative,oxidoreductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Giardia lamblia Aldose reductase Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania donovani aldo-keto reductase-like protein Get druggable targets OG5_126583 All targets in OG5_126583
Mycobacterium ulcerans oxidoreductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase family 1, member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Candida albicans see also nonallelic CaP19.2244 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania braziliensis prostaglandin f synthase, putative Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus multilocularis aldo keto reductase Get druggable targets OG5_126583 All targets in OG5_126583
Echinococcus granulosus aldo keto reductase family 1 member B4 Get druggable targets OG5_126583 All targets in OG5_126583
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase Get druggable targets OG5_126583 All targets in OG5_126583
Trichomonas vaginalis aldo-keto reductase, putative Get druggable targets OG5_126583 All targets in OG5_126583
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Neospora caninum aldo/keto reductase family oxidoreductase, putative Aldose reductase   315 aa 291 aa 21.3 %
Onchocerca volvulus Aldose reductase   315 aa 324 aa 39.8 %
Onchocerca volvulus Multiple coagulation factor deficiency protein 2 homolog Aldose reductase   315 aa 323 aa 40.2 %
Mycobacterium tuberculosis Conserved protein Aldose reductase   315 aa 323 aa 25.4 %
Mycobacterium ulcerans hypothetical protein Aldose reductase   315 aa 322 aa 24.8 %
Candida albicans similar to putative aryl alcohol dehydrogenase family Aldose reductase   315 aa 314 aa 18.2 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 310 aa 20.0 %
Candida albicans see also nonallelic CaP19.6816 Aldose reductase   315 aa 279 aa 29.7 %
Toxoplasma gondii aldo/keto reductase family oxidoreductase Aldose reductase   315 aa 294 aa 24.8 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 19.7 %
Onchocerca volvulus Aldose reductase   315 aa 316 aa 36.7 %
Candida albicans putative aryl alcohol dehydrogenase Aldose reductase   315 aa 326 aa 20.9 %
Trypanosoma cruzi aldo/keto reductase, putative Aldose reductase   315 aa 304 aa 29.3 %
Candida albicans aryl alcohol dehydrogenase Aldose reductase   315 aa 319 aa 18.2 %
Leishmania mexicana aldo/keto reductase, putative,aldo/keto reductase family-like protein Aldose reductase   315 aa 349 aa 25.2 %
Candida albicans D-arabinose dehydrogenase, NADP-dependent Aldose reductase   315 aa 294 aa 35.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0217 0.3538 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0202 0.0571
Toxoplasma gondii aldose reductase, putative 0.0038 0.0318 0.3734
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0038 0.0318 0.5941
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0038 0.0318 0.0583
Echinococcus multilocularis aldo keto reductase 0.0038 0.0318 0.09
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0339 0.0957
Schistosoma mansoni hypothetical protein 0.018 0.2876 0.8127
Trypanosoma brucei aldo-keto reductase, putative 0.0038 0.0318 0.5941
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Echinococcus granulosus aldo keto reductase 0.0038 0.0318 0.09
Brugia malayi jmjC domain containing protein 0.0038 0.0306 0.0847
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0128 0.1927 0.5286
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0306 0.0865
Brugia malayi Thioredoxin reductase 0.005 0.0536 0.1482
Leishmania major trypanothione reductase 0.005 0.0536 1
Mycobacterium tuberculosis Hypothetical protein 0.0217 0.3538 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0318 0.09
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Echinococcus granulosus jumonji domain containing protein 0.0043 0.0407 0.1151
Echinococcus granulosus Transglutaminase 0.0217 0.3538 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.1696 0.4612
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0039 0.0339 0.0957
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0102 0.1459 0.4124
Onchocerca volvulus 0.0038 0.0318 0.0132
Trypanosoma cruzi aldo-keto reductase 0.0038 0.0318 0.5941
Trypanosoma brucei trypanothione reductase 0.005 0.0536 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0318 0.088
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0318 0.0764
Giardia lamblia PHD finger protein 15 0.0031 0.0189 0.0533
Loa Loa (eye worm) hypothetical protein 0.0038 0.0318 0.088
Toxoplasma gondii thioredoxin reductase 0.005 0.0536 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0181 0.0512
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0318 0.0764
Brugia malayi MH2 domain containing protein 0.0116 0.1709 0.4727
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0318 0.09
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Echinococcus multilocularis peregrin 0.0031 0.0189 0.0533
Onchocerca volvulus 0.0038 0.0318 0.0132
Loa Loa (eye worm) oxidoreductase 0.0038 0.0318 0.088
Mycobacterium ulcerans transglutaminase family protein 0.0217 0.3538 1
Trypanosoma cruzi aldo/keto reductase, putative 0.0038 0.0318 0.5941
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0318 0.088
Leishmania major aldo-keto reductase-like protein 0.0038 0.0318 0.5941
Trypanosoma brucei prostaglandin f synthase 0.0038 0.0318 0.5941
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0306 0.0865
Echinococcus granulosus hypothetical protein 0.0038 0.0318 0.09
Trichomonas vaginalis peptide N-glycanase, putative 0.0217 0.3538 0.8492
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0536 0.1515
Giardia lamblia Aldose reductase 0.0038 0.0318 0.09
Mycobacterium tuberculosis Long conserved protein 0.0217 0.3538 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0189 0.0533
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0318 0.088
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0339 0.0813
Loa Loa (eye worm) hypothetical protein 0.0031 0.0189 0.0522
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0306 0.0847
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Echinococcus multilocularis Transglutaminase 0.0217 0.3538 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0339 0.6318
Mycobacterium tuberculosis Probable reductase 0.0115 0.1696 0.4793
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0039 0.0339 1
Giardia lamblia Hypothetical protein 0.0217 0.3538 1
Brugia malayi Bromodomain containing protein 0.0031 0.0189 0.0522
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0202 0.0571
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0102 0.1459 0.4124
Echinococcus multilocularis aldo keto reductase 0.0038 0.0318 0.09
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0202 0.0571
Schistosoma mansoni aldo-keto reductase 0.0038 0.0318 0.09
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Entamoeba histolytica aldose reductase, putative 0.0038 0.0318 0.9403
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0202 0.0571
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Loa Loa (eye worm) jmjC domain-containing protein 0.0064 0.0783 0.2166
Echinococcus multilocularis geminin 0.018 0.2876 0.8127
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0339 0.6318
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0536 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0318 0.09
Onchocerca volvulus 0.0038 0.0318 0.0132
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0202 0.0571
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0536 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0039 0.0339 0.0957
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0039 0.0339 0.0957
Echinococcus multilocularis aldo keto reductase 0.0038 0.0318 0.09
Giardia lamblia Transglutaminase/protease, putative 0.0217 0.3538 1
Brugia malayi PHD-finger family protein 0.0031 0.0189 0.0522
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.1696 0.4793
Plasmodium vivax SET domain protein, putative 0.0032 0.0202 0.0385
Plasmodium falciparum glutathione reductase 0.005 0.0536 1
Schistosoma mansoni hypothetical protein 0.0031 0.0189 0.0533
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0318 0.0764
Schistosoma mansoni hypothetical protein 0.018 0.2876 0.8127
Loa Loa (eye worm) oxidoreductase 0.0038 0.0318 0.088
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0189 0.0533
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0039 0.0339 0.6318
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0128 0.1927 0.5445
Loa Loa (eye worm) hypothetical protein 0.0053 0.0588 0.1625
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0038 0.0318 0.5941
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0128 0.1927 0.5445
Echinococcus multilocularis jumonji domain containing protein 0.0043 0.0407 0.1151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0202 0.0571
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0536 0.1515
Entamoeba histolytica aldose reductase, putative 0.0038 0.0318 0.9403
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.1696 0.4793
Onchocerca volvulus 0.0252 0.4167 0.4055
Echinococcus multilocularis ubiquitin specific protease 41 0.0039 0.0339 0.0957
Loa Loa (eye worm) hypothetical protein 0.0039 0.0339 0.0936
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0536 0.1515
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0039 0.0339 0.6318
Echinococcus granulosus aldehyde reductase 0.0027 0.0119 0.0337
Echinococcus granulosus aldo keto reductase 0.0038 0.0318 0.09
Loa Loa (eye worm) oxidoreductase 0.0038 0.0318 0.088
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0306 0.0865
Echinococcus multilocularis aldehyde reductase 0.0027 0.0119 0.0337
Brugia malayi glutathione reductase 0.005 0.0536 0.1482
Mycobacterium ulcerans hypothetical protein 0.0217 0.3538 1
Mycobacterium leprae Conserved hypothetical protein 0.0217 0.3538 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0128 0.1927 0.5445
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0318 0.0764
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0202 0.0571
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Mycobacterium tuberculosis Conserved protein 0.0217 0.3538 1
Onchocerca volvulus 0.0038 0.0318 0.0132
Brugia malayi Thioredoxin family protein 0.0217 0.3538 0.9785
Loa Loa (eye worm) glutathione reductase 0.005 0.0536 0.1482
Echinococcus granulosus peregrin 0.0031 0.0189 0.0533
Plasmodium vivax glutathione reductase, putative 0.005 0.0536 1
Entamoeba histolytica aldose reductase, putative 0.0038 0.0318 0.9403
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0318 0.09
Loa Loa (eye worm) oxidoreductase 0.0038 0.0318 0.088
Echinococcus granulosus geminin 0.018 0.2876 0.8127
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0039 0.0339 0.0957
Onchocerca volvulus 0.0032 0.0202 0.0014
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0306 0.0865
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1709 0.4727
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0318 0.09
Mycobacterium tuberculosis Conserved hypothetical protein 0.0217 0.3538 1
Schistosoma mansoni pol-related 0.0038 0.0318 0.09
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0038 0.0318 0.0764
Plasmodium falciparum thioredoxin reductase 0.005 0.0536 1
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1709 0.4727
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0039 0.0339 0.0936
Mycobacterium ulcerans putative transglutaminase-like protein 0.0217 0.3538 1
Mycobacterium ulcerans hypothetical protein 0.0217 0.3538 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0202 0.0385
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Trichomonas vaginalis aldo/keto reductase, putative 0.0038 0.0318 0.0764
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.1696 0.4793
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.1696 0.4793
Loa Loa (eye worm) oxidoreductase 0.0038 0.0318 0.088
Schistosoma mansoni jumonji domain containing protein 0.0081 0.1083 0.3061
Echinococcus multilocularis aldo keto reductase 0.0038 0.0318 0.09
Schistosoma mansoni aldo-keto reductase 0.0038 0.0318 0.09
Onchocerca volvulus 0.0038 0.0318 0.0132
Mycobacterium tuberculosis Conserved hypothetical protein 0.0217 0.3538 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0189 0.0533
Onchocerca volvulus 0.0038 0.0318 0.0132
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0339 0.0813
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0318 0.09
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0536 0.1482
Echinococcus granulosus aldo keto reductase 0.0038 0.0318 0.09
Leishmania major prostaglandin f synthase, putative 0.0038 0.0318 0.5941
Brugia malayi Pre-SET motif family protein 0.0222 0.3616 1
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0318 0.09
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0339 0.0957
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0222 0.3616 1
Mycobacterium leprae Conserved hypothetical protein 0.0217 0.3538 1
Echinococcus granulosus ubiquitin specific protease 41 0.0039 0.0339 0.0957
Giardia lamblia Aldose reductase 0.0038 0.0318 0.09
Brugia malayi Pre-SET motif family protein 0.0032 0.0202 0.0559
Brugia malayi jmjC domain containing protein 0.0102 0.1459 0.4035
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.1696 0.4793
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0039 0.0339 0.0957
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0038 0.0318 0.088
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0038 0.0318 0.09
Trichomonas vaginalis set domain proteins, putative 0.0252 0.4167 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0039 0.0339 0.0813
Mycobacterium ulcerans oxidoreductase 0.0038 0.0318 0.09
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0318 0.09
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Loa Loa (eye worm) hypothetical protein 0.0032 0.0202 0.0559
Mycobacterium tuberculosis Probable oxidoreductase 0.0038 0.0318 0.09
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0189 0.0522
Trichomonas vaginalis aldo-keto reductase, putative 0.0038 0.0318 0.0764
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0038 0.0318 0.09

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 3 uM Inhibition of bovine lens aldose reductase ChEMBL. 20452228

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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