Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Angiotensin II receptor (AT-1) type-1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | 0.2489 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0142 | 0.053 | 0.053 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2489 | 1 | 1 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0926 | 0.3693 | 0.3692 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.2489 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0001 | 0.5 |
Brugia malayi | protein kinase C II. | 0.0018 | 0.0031 | 0.003 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0018 | 0.0031 | 0.003 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.2489 | 1 | 1 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0018 | 0.0031 | 0.003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0031 | 0.003 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0926 | 0.3693 | 0.3692 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0018 | 0.0031 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0501 | 0.05 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0001 | 0.5 |
Toxoplasma gondii | fructose-bisphospatase II | 0.2489 | 1 | 1 |
Echinococcus granulosus | protein kinase c iota type | 0.0018 | 0.0031 | 0.003 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0501 | 0.05 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0018 | 0.0031 | 0.003 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0926 | 0.3693 | 0.3692 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Onchocerca volvulus | 0.0134 | 0.0501 | 0.5 | |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.2489 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0001 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0031 | 0.003 |
Echinococcus multilocularis | protein kinase c iota type | 0.0018 | 0.0031 | 0.003 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0031 | 0.003 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.2489 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0018 | 0.0031 | 0.003 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.2489 | 1 | 1 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.2489 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0018 | 0.0031 | 0.003 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.001 | 0.0001 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0543 | 0.0542 |
Entamoeba histolytica | protein kinase, putative | 0.001 | 0.0001 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.0501 | 0.05 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.59 uM | Inhibitory concentration was evaluated by measuring displacement of [3H]-AII from rat liver Angiotensin II receptor, type 1 | ChEMBL. | 8667363 |
IC50 (binding) | = 0.59 uM | Inhibitory concentration was evaluated by measuring displacement of [3H]-AII from rat liver Angiotensin II receptor, type 1 | ChEMBL. | 8667363 |
Inhibition (functional) | = 27.8 % | In vivo inhibitory percentage of pressor response induced by exogenous submaxilmal dose of angiotensin -II (3 mg/kg) administered iv to pithed rats | ChEMBL. | 8667363 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.