TDR Targets

Basic information

Technical information

TDR Targets ID: 1144211
Name: (3E,5E)-1-[4-(2-diethylaminoethoxy)benzoyl]-3 ,5-bis(phenylmethylidene)piperidin-4-one
MW: 494.624 | Formula: C32H34N2O3
H donors: 0 H acceptors: 2 LogP: 5.49 Rotable bonds: 10
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCOc1ccc(cc1)C(=O)N1C/C(=C\c2ccccc2)/C(=O)/C(=C/c2ccccc2)/C1)CC
InChi: 1S/C32H34N2O3/c1-3-33(4-2)19-20-37-30-17-15-27(16-18-30)32(36)34-23-28(21-25-11-7-5-8-12-25)31(35)29(24-34)22-26-13-9-6-10-14-26/h5-18,21-22H,3-4,19-20,23-24H2,1-2H3/b28-21+,29-22+
InChiKey: XNUPNZBLCDYURW-XXGIQBRXSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(3E,5E)-1-[4-(2-diethylaminoethoxy)benzoyl]-3,5-bis(phenylmethylene)piperidin-4-one
(3E,5E)-1-[[4-(2-diethylaminoethoxy)phenyl]-oxomethyl]-3,5-bis(phenylmethylene)-4-piperidinone
(3E,5E)-3,5-bis(benzylidene)-1-[4-(2-diethylaminoethoxy)benzoyl]-4-piperidone
(3E,5E)-1-[4-(2-diethylaminoethoxy)phenyl]carbonyl-3,5-bis(phenylmethylidene)piperidin-4-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	hypothetical protein	0.0171	0.1749	0.4945
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0092	0.0744	1
Onchocerca volvulus		0.0109	0.0962	0.3105
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0362	0.0949
Leishmania major	trypanothione reductase	0.0097	0.0813	0.2231
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0272	0.305	0.8138
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0109	0.0962	0.1136
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0194	0.2054	0.5635
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0362	0.1024
Brugia malayi	Fli-1 protein	0.0232	0.2536	0.6769
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0043	0.0112	0.0281
Brugia malayi	beta-lactamase family protein	0.0109	0.0962	0.2568
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.005	0.021	0.0543
Loa Loa (eye worm)	beta-lactamase	0.0109	0.0962	0.2554
Brugia malayi	Pre-SET motif family protein	0.0214	0.2305	0.6153
Echinococcus multilocularis	peptidase Clp (S14 family)	0.006	0.0339	0.0339
Loa Loa (eye worm)	hypothetical protein	0.0065	0.0404	0.1062
Echinococcus granulosus	thioredoxin glutathione reductase	0.0097	0.0813	0.3127
Echinococcus granulosus	expressed conserved protein	0.0093	0.0759	0.2918
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0109	0.0962	0.272
Plasmodium vivax	hypothetical protein, conserved	0.0109	0.0962	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0256	0.0725
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0092	0.0744	0.2863
Mycobacterium tuberculosis	Conserved protein	0.0109	0.0962	0.1136
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.003	0.0115
Echinococcus granulosus	ATP dependent DNA helicase PIF1	0.0194	0.2054	0.79
Brugia malayi	Calcitonin receptor-like protein seb-1	0.005	0.021	0.0561
Mycobacterium tuberculosis	Probable lipase LipD	0.0109	0.0962	0.1136
Brugia malayi	Probable ClpP-like protease	0.0092	0.0744	0.1987
Loa Loa (eye worm)	hypothetical protein	0.0092	0.0744	0.1971
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0362	0.0949
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0109	0.0962	0.0962
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0109	0.0962	0.2554
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0109	0.0962	0.2568
Leishmania major	mitochondrial DNA polymerase beta	0.0319	0.3644	1
Mycobacterium tuberculosis	Conserved protein	0.0109	0.0962	0.1136
Schistosoma mansoni	patched 1	0.0043	0.0112	0.0318
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0045	0.0142	0.039
Trypanosoma cruzi	hypothetical protein, conserved	0.0109	0.0962	0.264
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0247	0.2723	0.3216
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0092	0.0744	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0256	0.0256
Trypanosoma brucei	DNA repair and recombination helicase protein PIF6	0.0194	0.2054	0.5635
Brugia malayi	beta-lactamase	0.0109	0.0962	0.2568
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0092	0.0744	0.7737
Schistosoma mansoni	hypothetical protein	0.0036	0.003	0.0085
Onchocerca volvulus		0.0109	0.0962	0.3105
Schistosoma mansoni	hypothetical protein	0.0034	0.0007	0.0021
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0092	0.0744	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0222	0.2407	0.2842
Echinococcus granulosus	sterol regulatory element binding protein	0.0043	0.0112	0.0432
Echinococcus multilocularis	ATP dependent DNA helicase PIF1	0.0194	0.2054	0.2054
Schistosoma mansoni	hypothetical protein	0.0048	0.0187	0.0529
Schistosoma mansoni	hypothetical protein	0.0171	0.1749	0.4945
Onchocerca volvulus		0.0109	0.0962	0.3105
Mycobacterium ulcerans	esterase/lipase LipP	0.0109	0.0962	0.3042
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0109	0.0962	0.1136
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.006	0.0339	0.0401
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0097	0.0813	0.096
Loa Loa (eye worm)	glutaminase	0.0281	0.3162	0.8439
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0235	0.0608
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0109	0.0962	0.3042
Giardia lamblia	Rrm3p helicase	0.0194	0.2054	1
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0362	0.1024
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0187	0.0529
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0256	0.0725
Mycobacterium leprae	Probable lipase LipE	0.0109	0.0962	0.2612
Loa Loa (eye worm)	hypothetical protein	0.0099	0.0835	0.2215
Schistosoma mansoni	gabp alpha	0.0076	0.0546	0.1544
Mycobacterium leprae	conserved hypothetical protein	0.0109	0.0962	0.2612
Brugia malayi	glutaminase DH11.1	0.0281	0.3162	0.8442
Brugia malayi	Thioredoxin reductase	0.0097	0.0813	0.217
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.2305	0.6145
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0092	0.0744	0.0744
Toxoplasma gondii	ABC1 family protein	0.0109	0.0962	1
Plasmodium vivax	glutathione reductase, putative	0.0097	0.0813	0.8451
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0092	0.0744	0.1699
Brugia malayi	RNA binding protein	0.0062	0.0362	0.0967
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0092	0.0744	0.7737
Trichomonas vaginalis	penicillin-binding protein, putative	0.0109	0.0962	0.3042
Loa Loa (eye worm)	fli-1 protein	0.0232	0.2536	0.6763
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0962	0.2554
Schistosoma mansoni	hypothetical protein	0.0041	0.0093	0.0262
Echinococcus granulosus	geminin	0.0171	0.1749	0.6727
Brugia malayi	CHE-14 protein	0.0043	0.0112	0.03
Toxoplasma gondii	hypothetical protein	0.0051	0.0226	0.2352
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0092	0.0744	1
Leishmania major	hypothetical protein, conserved	0.0109	0.0962	0.264
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0054	0.0256	0.0684
Mycobacterium tuberculosis	Probable hydrolase	0.0109	0.0962	0.1136
Echinococcus multilocularis	geminin	0.0171	0.1749	0.1749
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0092	0.0744	0.7737
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0256	0.0986
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0055	0.0267	0.0733
Echinococcus multilocularis	protein patched	0.0043	0.0112	0.0112
Echinococcus multilocularis	sterol regulatory element binding protein	0.0043	0.0112	0.0112
Mycobacterium tuberculosis	Probable lipase LipE	0.0109	0.0962	0.1136
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0222	0.2407	0.2842
Toxoplasma gondii	thioredoxin reductase	0.0097	0.0813	0.8451
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0109	0.0962	0.1136
Echinococcus multilocularis	survival motor neuron protein 1	0.0237	0.2599	0.2599
Mycobacterium tuberculosis	Conserved protein	0.0109	0.0962	0.1136
Mycobacterium ulcerans	glutaminase	0.0281	0.3162	1
Trichomonas vaginalis	esterase, putative	0.0109	0.0962	0.3042
Schistosoma mansoni	glutaminase	0.0281	0.3162	0.8943
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0962	0.2554
Mycobacterium ulcerans	hypothetical protein	0.0109	0.0962	0.3042
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0187	0.0499
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.006	0.0339	0.0401
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0151	0.1498	0.411
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0327	0.3746	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0142	0.1379	0.5305
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0362	0.1024
Echinococcus granulosus	Protein patched homolog 1	0.0043	0.0112	0.0432
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0327	0.3746	1
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0319	0.3644	1
Echinococcus multilocularis	Niemann Pick C1 protein	0.0099	0.0835	0.0835
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0092	0.0744	0.9156
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.0112	0.0355
Loa Loa (eye worm)	glutaminase 2	0.0281	0.3162	0.8439
Trypanosoma brucei	hypothetical protein, conserved	0.0109	0.0962	0.264
Echinococcus granulosus	Niemann Pick C1 protein	0.0099	0.0835	0.3214
Loa Loa (eye worm)	glutathione reductase	0.0097	0.0813	0.2155
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0362	0.1024
Brugia malayi	follicle stimulating hormone receptor	0.0272	0.305	0.8142
Brugia malayi	latrophilin 2 splice variant baaae	0.0034	0.0007	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0962	0.2554
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0319	0.3644	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0222	0.2407	0.2842
Trypanosoma brucei	DNA repair and recombination helicase protein PIF7	0.0194	0.2054	0.5635
Echinococcus multilocularis	Niemann Pick C1 protein	0.0142	0.1379	0.1379
Trypanosoma cruzi	hypothetical protein, conserved	0.0109	0.0962	0.264
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0054	0.0256	0.0725
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0962	0.2554
Brugia malayi	TAR-binding protein	0.0062	0.0362	0.0967
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0222	0.2407	0.2842
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0151	0.1498	0.411
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0076	0.0546	0.1441
Trichomonas vaginalis	conserved hypothetical protein	0.0194	0.2054	0.6493
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0962	0.2554
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0222	0.2407	0.2842
Echinococcus granulosus	survival motor neuron protein 1	0.0237	0.2599	1
Loa Loa (eye worm)	hypothetical protein	0.0327	0.3746	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0247	0.2723	0.3216
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0962	0.2554
Echinococcus multilocularis	GA binding protein alpha chain	0.0076	0.0546	0.0546
Loa Loa (eye worm)	thioredoxin reductase	0.0097	0.0813	0.2155
Mycobacterium ulcerans	lipase LipD	0.0109	0.0962	0.3042
Leishmania major	PIF1 helicase-like protein, putative,DNA repair and recombination protein, mitochondrial precursor, putative	0.0194	0.2054	0.5635
Schistosoma mansoni	ets-related	0.0232	0.2536	0.7171
Trichomonas vaginalis	glutaminase, putative	0.0281	0.3162	1
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0112	0.0281
Echinococcus multilocularis	expressed conserved protein	0.0093	0.0759	0.0759
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0247	0.2723	1
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0362	0.0362
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.005	0.021	0.0561
Brugia malayi	hypothetical protein	0.0237	0.2599	0.6939
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0362	0.1024
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0362	0.0967
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.003	0.0085
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF6, putative	0.0194	0.2054	0.5635
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0142	0.039
Loa Loa (eye worm)	hypothetical protein	0.005	0.021	0.0543
Trichomonas vaginalis	D-aminoacylase, putative	0.0109	0.0962	0.3042
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.0045	0.0142	0.039
Schistosoma mansoni	hypothetical protein	0.0041	0.0093	0.0262
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0054	0.0256	0.0986
Brugia malayi	hypothetical protein	0.0036	0.003	0.008
Plasmodium vivax	thioredoxin reductase, putative	0.0097	0.0813	0.8451
Brugia malayi	Niemann-Pick C1 protein precursor	0.0099	0.0835	0.223
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0362	0.1394
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0319	0.3644	1
Brugia malayi	glutathione reductase	0.0097	0.0813	0.217
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0097	0.0813	0.0813
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0054	0.0256	0.0256
Schistosoma mansoni	peptidase Clp (S14 family)	0.0092	0.0744	0.2105
Brugia malayi	Ets-domain containing protein	0.0076	0.0546	0.1458
Loa Loa (eye worm)	MH2 domain-containing protein	0.012	0.1099	0.292
Plasmodium falciparum	glutathione reductase	0.0097	0.0813	1
Mycobacterium ulcerans	hypothetical protein	0.0168	0.1716	0.5425
Schistosoma mansoni	hypothetical protein	0.0041	0.0093	0.0262
Loa Loa (eye worm)	transcription factor SMAD2	0.012	0.1099	0.292
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0151	0.1498	0.411
Brugia malayi	MH2 domain containing protein	0.012	0.1099	0.2933
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0092	0.0744	0.2353
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0247	0.2723	0.3216
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.003	0.003
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0362	0.0949
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0194	0.2054	0.5635
Trichomonas vaginalis	D-aminoacylase, putative	0.0109	0.0962	0.3042
Trypanosoma cruzi	DNA repair and recombination helicase protein PIF7, putative	0.0194	0.2054	0.5635
Loa Loa (eye worm)	hypothetical protein	0.0237	0.2599	0.6933
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0696	0.8469	1
Brugia malayi	Ets-domain containing protein	0.0076	0.0546	0.1458
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0168	0.1716	0.2026
Onchocerca volvulus		0.0244	0.2683	1
Entamoeba histolytica	hypothetical protein, conserved	0.0194	0.2054	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0093	0.0262
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0092	0.0744	0.2353
Trichomonas vaginalis	set domain proteins, putative	0.0244	0.2683	0.8483
Trichomonas vaginalis	D-aminoacylase, putative	0.0109	0.0962	0.3042
Schistosoma mansoni	hypothetical protein	0.0194	0.2054	0.5807
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0099	0.0835	0.398
Mycobacterium ulcerans	beta-lactamase	0.0109	0.0962	0.3042
Echinococcus granulosus	peptidase Clp S14 family	0.006	0.0339	0.1306
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0222	0.2407	0.8672
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0101	0.0855	0.2418
Entamoeba histolytica	DNA repair and recombination protein, putative	0.0194	0.2054	1
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0054	0.0256	0.0666
Echinococcus multilocularis	protein dispatched 1	0.0049	0.0189	0.0189
Mycobacterium tuberculosis	Probable esterase LipL	0.0109	0.0962	0.1136
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0109	0.0962	0.272
Echinococcus granulosus	GA binding protein alpha chain	0.0076	0.0546	0.2101
Plasmodium falciparum	thioredoxin reductase	0.0097	0.0813	1
Trichomonas vaginalis	penicillin-binding protein, putative	0.0109	0.0962	0.3042
Echinococcus granulosus	beta LACTamase domain containing family member	0.0109	0.0962	0.3701
Trypanosoma brucei	trypanothione reductase	0.0097	0.0813	0.2231
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.0045	0.0142	0.039
Trypanosoma cruzi	trypanothione reductase, putative	0.0097	0.0813	0.2231
Brugia malayi	beta-lactamase family protein	0.0109	0.0962	0.2568
Mycobacterium tuberculosis	Probable reductase	0.0222	0.2407	0.2842

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1186460

Bibliographic References

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Detailed information for compound 1144211