Detailed information for compound 1146332

Basic information

Technical information
  • TDR Targets ID: 1146332
  • Name: N-methyl-1-[4-(trifluoromethyl)phenyl]methana mine
  • MW: 189.178 | Formula: C9H10F3N
  • H donors: 1 H acceptors: 0 LogP: 2.17 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNCc1ccc(cc1)C(F)(F)F
  • InChi: 1S/C9H10F3N/c1-13-6-7-2-4-8(5-3-7)9(10,11)12/h2-5,13H,6H2,1H3
  • InChiKey: YMSMEZAYZIYFGA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl-[4-(trifluoromethyl)benzyl]amine
  • 90390-11-7
  • MO 00896
  • AIDS107206
  • Benzenemethanamine, N-methyl-4-(trifluoromethyl)-
  • 90389-03-0 (HYDROCHLORIDE)
  • AIDS-107206

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0058 0.0043
Mycobacterium leprae Probable ionic transporter integral membrane protein ChaA 0.0026 0.0126 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0512 0.4594
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0593 0.0579
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0076 0.1205
Loa Loa (eye worm) hypothetical protein 0.0454 0.4391 0.4383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0193 0.0879
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0514 0.05
Echinococcus multilocularis transient receptor potential gamma protein 0.0098 0.0843 0.0829
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2198 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0593 0.0579
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.2648 0.2637
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0023 0.0008
Brugia malayi isocitrate dehydrogenase 0.0064 0.0512 0.1079
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0023 0.0008
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0194 0.0179
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0243 0.3022
Schistosoma mansoni hypothetical protein 0.0144 0.1301 0.1288
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0175 0.016
Brugia malayi MH2 domain containing protein 0.0032 0.0194 0.0389
Brugia malayi Transient-receptor-potential like protein 0.0036 0.0232 0.0472
Loa Loa (eye worm) nuclear factor I 0.0018 0.0049 0.0034
Echinococcus granulosus sodium:potassium:calcium exchanger 0.0026 0.0126 0.0111
Entamoeba histolytica hypothetical protein 0.0073 0.0593 1
Entamoeba histolytica hypothetical protein 0.0073 0.0593 1
Schistosoma mansoni hypothetical protein 0.0518 0.5028 0.5021
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0243 0.4571
Schistosoma mansoni na/ca exchanger 0.0026 0.0126 0.0111
Schistosoma mansoni smad1 5 8 and 0.0032 0.0194 0.0179
Onchocerca volvulus 0.0057 0.0443 0.1961
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0593 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0216 0.0981
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0194 0.0179
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0144 0.1301 0.1288
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.2648 0.2637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.013 0.059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0305 0.1386
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0243 0.3022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0193 0.0879
Schistosoma mansoni transient receptor potential channel 0.0065 0.0514 0.05
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0512 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0016 0.0001
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0243 0.2494
Echinococcus granulosus smad 0.0032 0.0194 0.0179
Loa Loa (eye worm) hypothetical protein 0.0018 0.0049 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0126 0.0573
Entamoeba histolytica hypothetical protein 0.0073 0.0593 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0043
Brugia malayi MH1 domain containing protein 0.0018 0.0049 0.0075
Brugia malayi hypothetical protein 0.0148 0.1345 0.2889
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0305 0.029
Onchocerca volvulus 0.0031 0.0175 0.0731
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0454 0.4391 0.4383
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0111
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0305 0.0629
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0064 0.0512 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0232 0.0218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0279 0.2648 0.2637
Echinococcus granulosus Smad4 0.0032 0.0194 0.0179
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.3925 0.3916
Loa Loa (eye worm) hypothetical protein 0.0098 0.0843 0.0829
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0514 0.05
Echinococcus multilocularis transient receptor potential ion channel A 0.0094 0.0811 0.0797
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0512 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0475
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.2648 0.2637
Echinococcus multilocularis sodium:potassium:calcium exchanger 0.0026 0.0126 0.0111
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0243 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0194 0.0179
Schistosoma mansoni sodium/calcium exchanger 0.1017 1 1
Echinococcus multilocularis Smad4 0.0032 0.0194 0.0179
Brugia malayi Latrophilin receptor protein 2 0.0144 0.1301 0.2794
Schistosoma mansoni ap endonuclease 0.0037 0.0243 0.0228
Loa Loa (eye worm) MH2 domain-containing protein 0.0477 0.4618 0.461
Brugia malayi Isocitrate dehydrogenase 0.0064 0.0512 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0105 0.0477
Echinococcus multilocularis GPCR, family 2 0.0144 0.1301 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0216 0.0981
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0243 0.3022
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0194 0.0179
Echinococcus multilocularis sodium calcium exchanger 0.1017 1 1
Onchocerca volvulus 0.0234 0.2198 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0243 0.1104
Brugia malayi K+-dependent Na+/Ca+ exchanger related-protein 0.0026 0.0126 0.0241
Echinococcus granulosus TRP transient receptor potential channel 0.0036 0.0232 0.0218
Onchocerca volvulus Sodium\/potassium\/calcium exchanger 0.0026 0.0126 0.0509
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0179 0.1657 0.754
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0127 0.0579
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0144 0.1301 0.2794
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0193 0.0879
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0072
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0243 0.4571
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0305 0.5821
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0144 0.1301 0.1288
Brugia malayi CXXC zinc finger family protein 0.0057 0.0443 0.093
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0023 0.0008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.013 0.059
Echinococcus granulosus GPCR family 2 0.0144 0.1301 0.1288
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0072
Schistosoma mansoni smad1 5 8 and 0.0032 0.0194 0.0179
Brugia malayi Pre-SET motif family protein 0.0205 0.1917 0.4131
Loa Loa (eye worm) hypothetical protein 0.0031 0.0175 0.016
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0305 0.3819
Onchocerca volvulus 0.0148 0.1345 0.6093
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0126 0.0573
Echinococcus granulosus short transient receptor potential channel 6 0.0065 0.0514 0.05
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0072
Brugia malayi Na/Ca eXchangers family member (ncx-4) 0.0026 0.0126 0.0241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0216 0.0981
Loa Loa (eye worm) isocitrate dehydrogenase 0.0064 0.0512 0.0498
Brugia malayi latrophilin 2 splice variant baaae 0.031 0.2961 0.64
Schistosoma mansoni hypothetical protein 0.0144 0.1301 0.1288
Loa Loa (eye worm) solute carrier family 8 0.1017 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0243 0.4571
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0194 0.0179
Loa Loa (eye worm) hypothetical protein 0.0148 0.1345 0.1332
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0064 0.0512 1
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.7855 0.7852
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0175 0.016
Schistosoma mansoni hypothetical protein 0.0144 0.1301 0.1288
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0126 0.0573
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0305 0.5821
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0216 0.4036
Toxoplasma gondii histone lysine methyltransferase SET1 0.011 0.0966 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0016 0.0002
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0243 0.1104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0216 0.0981
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0243 0.0495
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0305 0.3819
Brugia malayi Pre-SET motif family protein 0.0031 0.0175 0.0347
Schistosoma mansoni hypothetical protein 0.0407 0.3925 0.3916
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0056 0.0089
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0105 0.0477
Brugia malayi MH2 domain containing protein 0.0032 0.0194 0.0389
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0216 0.4036
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0243 0.5
Toxoplasma gondii isocitrate dehydrogenase 0.0064 0.0512 0.4594
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0216 0.0981
Echinococcus multilocularis cpg binding protein 0.0061 0.0475 0.0461
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0305 0.1386
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0023 0.0008
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0016 0.0001
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0026 0.0126 0.0111
Schistosoma mansoni smad 0.0032 0.0194 0.0179
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0144 0.1301 0.1288
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0036 0.0232 0.0218
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0194 0.0179
Toxoplasma gondii target of rapamycin (TOR), putative 0.0032 0.0193 0.0801
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0175 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0072
Echinococcus multilocularis tumor protein p63 0.0328 0.3135 0.3125
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0064 0.0512 1
Loa Loa (eye worm) Na/Ca eXchangers family member 0.0026 0.0126 0.0111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0454 0.4391 0.9507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0162 0.0735
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0016 0.0001
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.2648 0.2637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0193 0.0879
Echinococcus granulosus transient receptor potential gamma protein 0.0098 0.0843 0.0829
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0175 0.016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1917 0.1905
Schistosoma mansoni transient receptor potential channel 0.0065 0.0514 0.05
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0512 0.0498
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0305 0.029
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0443 0.0429
Loa Loa (eye worm) hypothetical protein 0.0144 0.1301 0.1288
Brugia malayi Calcitonin receptor-like protein seb-1 0.0454 0.4391 0.9507
Schistosoma mansoni Smad4 0.0032 0.0194 0.0179
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0305 0.5821
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0512 0.0498
Echinococcus multilocularis geminin 0.0518 0.5028 0.5021
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0194 0.0179
Echinococcus granulosus dnaJ subfamily B 0.0407 0.3925 0.3916
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0279 0.2648 0.2637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.013 0.059
Entamoeba histolytica hypothetical protein 0.0073 0.0593 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0175 0.016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0193 0.0879
Echinococcus multilocularis isocitrate dehydrogenase 0.0064 0.0512 0.0498
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0175 0.016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0144 0.1301 0.1288
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0243 0.0228
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0193 0.0879
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0175 0.016
Brugia malayi Smad1 0.0032 0.0194 0.0389
Toxoplasma gondii exonuclease III APE 0.0037 0.0243 0.1388
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0151 0.0137
Brugia malayi Sodium/calcium exchanger protein 0.0407 0.3922 0.8489
Brugia malayi MH1 domain containing protein 0.0032 0.0194 0.0389
Schistosoma mansoni cpg binding protein 0.0061 0.0475 0.0461
Echinococcus multilocularis smad 0.0032 0.0194 0.0179
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0305 0.5821
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0241 0.1097
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0179 0.1657 0.754
Schistosoma mansoni hypothetical protein 0.0026 0.0126 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0152 0.0692
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0064 0.0512 0.0498
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0279 0.2648 0.2637
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0279 0.2648 0.2637
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0064 0.0512 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0243 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0105 0.0477
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0175 0.016
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0064 0.0512 0.0498
Schistosoma mansoni ap endonuclease 0.0037 0.0243 0.0228
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0305 0.029
Echinococcus multilocularis sodium:potassium:calcium exchanger 6 0.0026 0.0126 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0104 0.0475
Schistosoma mansoni potassium-dependent sodium-calcium exchanger 3 4 0.0026 0.0126 0.0111
Echinococcus granulosus tumor protein p63 0.0328 0.3135 0.3125
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0064 0.0512 0.0498
Brugia malayi MH1 domain containing protein 0.0018 0.0049 0.0075
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0064 0.0512 1
Schistosoma mansoni cpg binding protein 0.0061 0.0475 0.0461
Loa Loa (eye worm) hypothetical protein 0.031 0.2961 0.295
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0279 0.2648 0.5719
Loa Loa (eye worm) hypothetical protein 0.0407 0.3922 0.3913
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0243 0.0228
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0144 0.1301 0.1288
Plasmodium vivax SET domain protein, putative 0.0031 0.0175 0.1258
Echinococcus multilocularis short transient receptor potential channel 6 0.0065 0.0514 0.05
Brugia malayi MH1 domain containing protein 0.0032 0.0194 0.0389
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0051 0.0701
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0016 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0193 0.0879
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0064 0.0512 1
Echinococcus granulosus cpg binding protein 0.0061 0.0475 0.0461
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0023 0.0008
Schistosoma mansoni hypothetical protein 0.0518 0.5028 0.5021
Giardia lamblia GTOR 0.0044 0.0305 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0126 0.0111
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0348 0.0334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0127 0.0579
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0243 0.4571
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0305 0.5821
Schistosoma mansoni transient receptor potential channel 0.0098 0.0843 0.0829
Schistosoma mansoni hypothetical protein 0.031 0.2961 0.295
Echinococcus granulosus sodium:potassium:calcium exchanger 6 0.0026 0.0126 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0305 0.1386
Schistosoma mansoni hypothetical protein 0.0073 0.0593 0.0579
Schistosoma mansoni hypothetical protein 0.0144 0.1301 0.1288
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0016 0.0001
Loa Loa (eye worm) hypothetical protein 0.0033 0.02 0.0185
Loa Loa (eye worm) hypothetical protein 0.0048 0.0348 0.0334
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0064 0.0512 0.0498
Brugia malayi hypothetical protein 0.0073 0.0593 0.1257
Brugia malayi MH2 domain containing protein 0.0477 0.4618 1
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0305 0.029
Schistosoma mansoni smad1 5 8 and 0.0032 0.0194 0.0179
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0043
Loa Loa (eye worm) hypothetical protein 0.0061 0.0481 0.0467
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0243 0.0228
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.1095 0.1082
Echinococcus granulosus transient receptor potential ion channel A 0.0094 0.0811 0.0797
Loa Loa (eye worm) transcription factor SMAD2 0.0477 0.4618 0.461
Onchocerca volvulus 0.0048 0.0348 0.1527
Loa Loa (eye worm) Smad1 0.0032 0.0194 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0105 0.0477
Schistosoma mansoni transient receptor potential channel 4 0.0098 0.0843 0.0829
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0216 0.4036
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0305 0.5821
Echinococcus granulosus geminin 0.0518 0.5028 0.5021
Schistosoma mansoni cpg binding protein 0.0057 0.0443 0.0429

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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