Detailed information for compound 1146752

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 2012.18 | Formula: C91H134N24O28
  • H donors: 31 H acceptors: 28 LogP: -9.37 Rotable bonds: 81
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CC(C)C)CO)Cc1c[nH]c2c1cccc2)C(C)C)CC(=O)O)[C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H]([C@H](O)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2c1cccc2)NC(=O)[C@H](CO)N)Cc1ccccc1)C)CO)CCCNC(=N)N)CC(=O)O)CO
  • InChi: 1S/C91H134N24O28/c1-9-46(6)73(89(141)108-63(35-71(125)126)83(135)113-72(45(4)5)88(140)107-61(33-51-37-98-56-25-16-14-23-53(51)56)81(133)111-66(42-118)85(137)109-64(90(142)143)30-44(2)3)114-78(130)58(26-17-18-28-92)103-84(136)65(41-117)112-82(134)62(34-70(123)124)106-77(129)57(27-19-29-96-91(94)95)102-69(122)39-99-68(121)38-100-87(139)74(48(8)120)115-86(138)67(43-119)110-75(127)47(7)101-79(131)59(31-49-20-11-10-12-21-49)105-80(132)60(104-76(128)54(93)40-116)32-50-36-97-55-24-15-13-22-52(50)55/h10-16,20-25,36-37,44-48,54,57-67,72-74,97-98,116-120H,9,17-19,26-35,38-43,92-93H2,1-8H3,(H,99,121)(H,100,139)(H,101,131)(H,102,122)(H,103,136)(H,104,128)(H,105,132)(H,106,129)(H,107,140)(H,108,141)(H,109,137)(H,110,127)(H,111,133)(H,112,134)(H,113,135)(H,114,130)(H,115,138)(H,123,124)(H,125,126)(H,142,143)(H4,94,95,96)/t46-,47-,48+,54-,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,72-,73-,74-/m0/s1
  • InChiKey: ZBSSLDYXMWVIJI-BGGTVVSQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni pyruvate kinase 0.0034 0.0796 0.0917
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0796 0.3089
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0343 0.0482
Loa Loa (eye worm) hypothetical protein 0.0301 0.8588 0.9964
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.053 0.2051
Plasmodium vivax importin-beta 2, putative 0.0028 0.0615 0.6696
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.2563 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.053 0.0843
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1192 0.1801
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0915 0.1066
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0915 0.1302
Toxoplasma gondii ABC1 family protein 0.0039 0.0915 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.053 0.5766
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0915 0.3557
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0305 0.3291
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0006 0.0007
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.2563 0.2559
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.053 0.0843
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0646 0.0743
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0915 0.1302
Mycobacterium ulcerans lipase LipD 0.0039 0.0915 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.053 0.5766
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.022 0.6231 0.6228
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0007
Mycobacterium leprae Probable lipase LipE 0.0039 0.0915 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0915 0.1056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.053 0.5766
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0007
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0396 0.1528
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0312 0.0439
Trichomonas vaginalis ran, putative 0.0021 0.0396 0.0593
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0396 0.4295
Trichomonas vaginalis set domain proteins, putative 0.0233 0.6596 1
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0796 0.1199
Schistosoma mansoni kinase 0.0049 0.1228 0.1419
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2563 0.3881
Leishmania major importin beta-1 subunit, putative 0.0023 0.0458 0.177
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.11 0.1276
Brugia malayi AMP-binding enzyme family protein 0.0025 0.053 0.0617
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0915 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0915 0.1381
Brugia malayi phosphoinositide-dependent protein kinase I 0.022 0.6231 0.7255
Loa Loa (eye worm) beta-lactamase 0.0039 0.0915 0.1062
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0915 0.1062
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0006 0.0007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0006 0.0007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0396 0.1528
Loa Loa (eye worm) hypothetical protein 0.0051 0.1282 0.1488
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0915 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0915 0.1062
Schistosoma mansoni pyruvate kinase 0.0034 0.0796 0.0917
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0915 0.3557
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0915 0.1302
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.2563 0.2985
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.2563 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0915 1
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0396 0.4946
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.2563 0.2969
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0615 0.061
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.053 0.5766
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0458 0.0687
Giardia lamblia Kinase, PLK 0.0095 0.2563 1
Onchocerca volvulus 0.0233 0.6596 1
Mycobacterium ulcerans hypothetical protein 0.0025 0.053 0.5766
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0646 0.7033
Entamoeba histolytica Ran family GTPase 0.0021 0.0396 0.0628
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0796 0.3089
Brugia malayi Pre-SET motif family protein 0.0029 0.0646 0.0752
Brugia malayi beta-lactamase family protein 0.0039 0.0915 0.1066
Schistosoma mansoni hypothetical protein 0.0302 0.8619 1
Brugia malayi AMP-binding enzyme family protein 0.0025 0.053 0.0617
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0915 0.1302
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0396 0.0405
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0006 0.0007
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.2563 0.4109
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0396 0.0462
Echinococcus multilocularis pyruvate kinase 0.0018 0.0305 0.03
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.8619 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.053 0.5766
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0305 0.3789
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0646 0.064
Trichomonas vaginalis esterase, putative 0.0039 0.0915 0.1381
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2563 0.3881
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.2563 0.2559
Loa Loa (eye worm) hypothetical protein 0.0019 0.0343 0.0397
Mycobacterium tuberculosis Conserved protein 0.0039 0.0915 0.1302
Plasmodium falciparum pyruvate kinase 0.0034 0.0796 1
Schistosoma mansoni ran 0.0021 0.0396 0.0454
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0008 0.0014 0.0032
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0796 0.0923
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2563 0.3881
Loa Loa (eye worm) hypothetical protein 0.0019 0.0343 0.0397
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0646 0.0743
Onchocerca volvulus 0.0039 0.0915 0.1381
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.053 0.5766
Loa Loa (eye worm) hypothetical protein 0.0039 0.0915 0.1062
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0915 0.3557
Mycobacterium ulcerans hypothetical protein 0.0039 0.0915 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0396 0.0391
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.11 0.1095
Brugia malayi Pre-SET motif family protein 0.0204 0.5769 0.6718
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0491 0.0779
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0491 0.0569
Entamoeba histolytica protein kinase, putative 0.022 0.6231 1
Echinococcus multilocularis pyruvate kinase 0.0034 0.0796 0.0791
Plasmodium vivax SET domain protein, putative 0.0029 0.0646 0.7033
Loa Loa (eye worm) hypothetical protein 0.0039 0.0915 0.1062
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0796 0.1131
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0396 0.1528
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0646 0.064
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.053 0.2051
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0646 0.0743
Leishmania major GTP-binding protein, putative 0.0021 0.0396 0.1528
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.2563 0.2974
Echinococcus multilocularis pyruvate kinase 0.0018 0.0305 0.03
Echinococcus multilocularis muscleblind protein 0.0301 0.8588 0.8587
Trichomonas vaginalis AGC family protein kinase 0.022 0.6231 0.9446
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0646 0.0743
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1192 0.1801
Echinococcus multilocularis snurportin 1 0.0302 0.8619 0.8618
Loa Loa (eye worm) hypothetical protein 0.0025 0.053 0.0615
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2563 0.3881
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0646 0.064
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0796 0.0923
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0614 0.0609
Loa Loa (eye worm) hypothetical protein 0.0024 0.0491 0.0569
Brugia malayi RNA, U transporter 1 0.008 0.214 0.2492
Loa Loa (eye worm) hypothetical protein 0.0039 0.0915 0.1062
Echinococcus granulosus pyruvate kinase 0.0018 0.0305 0.03
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.053 0.0843
Onchocerca volvulus 0.0039 0.0915 0.1381
Echinococcus granulosus pyruvate kinase 0.0034 0.0796 0.0791
Echinococcus multilocularis tumor protein p63 0.0349 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.11 0.127
Brugia malayi AMP-binding enzyme family protein 0.0025 0.053 0.0617
Trichomonas vaginalis AGC family protein kinase 0.022 0.6231 0.9446
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0615 0.2382
Mycobacterium tuberculosis Conserved protein 0.0039 0.0915 0.1302
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0019 0.0343 0.0397
Echinococcus multilocularis pyruvate kinase 0.0027 0.0583 0.0578
Loa Loa (eye worm) hypothetical protein 0.0301 0.8588 0.9964
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0796 0.0923
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.1282 0.1482
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0458 0.177
Echinococcus granulosus snurportin 1 0.0302 0.8619 0.8618
Loa Loa (eye worm) hypothetical protein 0.0039 0.0915 0.1062
Trypanosoma brucei polo-like protein kinase 0.0095 0.2563 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0915 0.1062
Brugia malayi beta-lactamase 0.0039 0.0915 0.1066
Loa Loa (eye worm) hypothetical protein 0.0025 0.053 0.0615
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0796 0.0927
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.11 0.1281
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0305 0.3291
Chlamydia trachomatis pyruvate kinase 0.0034 0.0796 1
Plasmodium falciparum importin beta, putative 0.0028 0.0615 0.771
Echinococcus granulosus pyruvate kinase 0.0018 0.0305 0.03
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0343 0.4264
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0796 0.1199
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0915 0.1381
Leishmania major pyruvate kinase 0.0034 0.0796 0.3089
Giardia lamblia Pyruvate kinase 0.0034 0.0796 0.2173
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0796 0.8684
Schistosoma mansoni importin beta-1 0.0028 0.0615 0.0707
Echinococcus granulosus pyruvate kinase 0.0034 0.0796 0.0791
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0915 0.1302
Loa Loa (eye worm) oxidoreductase 0.0007 0.0006 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.11 0.127
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0796 0.1199
Loa Loa (eye worm) hypothetical protein 0.0034 0.0796 0.0923
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0458 0.0687
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0796 0.8684
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0343 0.3703
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.11 0.1095
Onchocerca volvulus 0.0029 0.0646 0.0971
Loa Loa (eye worm) hypothetical protein 0.0019 0.0343 0.0397
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0312 0.0439
Schistosoma mansoni pyruvate kinase 0.0018 0.0305 0.0348
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0396 0.0391
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.053 0.2051
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2563 0.3881
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.11 0.1095
Onchocerca volvulus 0.0039 0.0915 0.1381
Loa Loa (eye worm) hypothetical protein 0.0019 0.0343 0.0397
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0396 0.046
Loa Loa (eye worm) hypothetical protein 0.0007 0.0006 0.0007
Brugia malayi Protein kinase domain containing protein 0.022 0.6231 0.7255
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0915 0.1302
Mycobacterium tuberculosis Conserved protein 0.0039 0.0915 0.1302
Mycobacterium ulcerans beta-lactamase 0.0039 0.0915 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0458 0.0687
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2563 0.3881
Loa Loa (eye worm) hypothetical protein 0.0029 0.0646 0.0749
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0312 0.0439
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.022 0.6231 0.7229
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0796 0.1199
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.2563 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0204 0.5769 0.6693
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.022 0.6231 0.6228
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0915 0.1381
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0915 0.1381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.11 0.1095
Loa Loa (eye worm) hypothetical protein 0.0028 0.0615 0.0713
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.2563 0.3881
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0796 0.3089
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0396 0.4295
Echinococcus multilocularis muscleblind protein 1 0.0301 0.8588 0.8587
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.053 0.5766
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.053 0.5766
Brugia malayi beta-lactamase family protein 0.0039 0.0915 0.1066
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0312 0.0439
Brugia malayi Muscleblind-like protein 0.0301 0.8588 1
Schistosoma mansoni serine/threonine protein kinase 0.022 0.6231 0.7227
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0796 0.3089
Brugia malayi Importin beta-1 subunit 0.0028 0.0615 0.0716
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.11 0.127
Echinococcus multilocularis pyruvate kinase 0.0018 0.0305 0.03
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.053 0.0751
Onchocerca volvulus 0.0025 0.053 0.0796
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0915 0.091
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.2563 0.3881
Schistosoma mansoni ran 0.0021 0.0396 0.0454
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0246 0.6994 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0915 0.091
Echinococcus granulosus importin subunit beta 1 0.0028 0.0615 0.061
Loa Loa (eye worm) hypothetical protein 0.0025 0.053 0.0615
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0796 0.8684
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.001 0.0093 0.0108
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0007
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0343 0.3703
Trichomonas vaginalis AGC family protein kinase 0.022 0.6231 0.9446
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.022 0.6231 0.7229
Entamoeba histolytica hypothetical protein 0.0023 0.0458 0.0727
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0796 0.1199
Onchocerca volvulus 0.0051 0.1282 0.1937
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.053 0.5766
Echinococcus multilocularis pyruvate kinase 0.0034 0.0796 0.0791
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0796 0.8684
Echinococcus granulosus muscleblind protein 0.0301 0.8588 0.8587
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0915 0.1302
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0915 1
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0915 0.1381
Leishmania major pyruvate kinase 0.0034 0.0796 0.3089
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0615 0.6696
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0615 0.2382
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0915 0.1056
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.053 0.0751
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0796 0.0927
Echinococcus granulosus pyruvate kinase 0.0018 0.0305 0.03
Leishmania major hypothetical protein, conserved 0.0039 0.0915 0.3557
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0006 0.0007

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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