Detailed information for compound 1150954

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 595.71 | Formula: C30H37N5O6S
  • H donors: 6 H acceptors: 8 LogP: 1.16 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 3
  • SMILES: CSCC[C@@H](C(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C(C)C)NC(c1ncccc1O)c1ncccc1O
  • InChi: 1S/C30H37N5O6S/c1-18(2)24(35-27(25-22(36)11-7-14-31-25)26-23(37)12-8-15-32-26)29(39)34-21(17-19-9-5-4-6-10-19)28(38)33-20(30(40)41)13-16-42-3/h4-12,14-15,18,20-21,24,27,35-37H,13,16-17H2,1-3H3,(H,33,38)(H,34,39)(H,40,41)/t20-,21-,24-/m0/s1
  • InChiKey: SEGGQCYIUSJDOQ-HFMPRLQTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus sodium:myo inositol cotransporter 0.008 0.0194 0.0126
Brugia malayi Protein kinase domain containing protein 0.0551 0.2129 0.2129
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.008 0.0194 0.0126
Brugia malayi polk-prov protein 0.0043 0.004 0.004
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0332 0.0466
Echinococcus multilocularis sodium:glucose cotransporter 2 0.008 0.0194 0.0126
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0652 0.2546 0.2516
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0206 0.0713 0.0648
Loa Loa (eye worm) hypothetical protein 0.0079 0.0188 0.0148
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0193 0.0836
Plasmodium falciparum protein kinase 5 0.0551 0.2129 1
Brugia malayi beta-lactamase family protein 0.0223 0.078 0.078
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.0905 0.0905
Onchocerca volvulus 0.0223 0.078 1
Trypanosoma brucei DNA polymerase eta, putative 0.0079 0.0188 0.0815
Entamoeba histolytica hypothetical protein 0.0076 0.0176 0.0448
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0054 0.0085 0.0044
Schistosoma mansoni hypothetical protein 0.0076 0.0176 0.0092
Entamoeba histolytica cell division protein kinase 2, putative 0.0551 0.2129 1
Echinococcus granulosus MAP kinase activated protein kinase 2 0.2465 1 1
Giardia lamblia Kinase, CMGC CDK 0.0551 0.2129 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0547 0.183
Loa Loa (eye worm) hypothetical protein 0.0086 0.0218 0.0179
Loa Loa (eye worm) hypothetical protein 0.0074 0.0169 0.013
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0551 0.2129 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0584 0.202
Echinococcus multilocularis short transient receptor potential channel 6 0.0145 0.0461 0.0395
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0223 0.078 0.1258
Trichomonas vaginalis D-aminoacylase, putative 0.0223 0.078 0.3034
Echinococcus multilocularis cyclin dependent kinase 0.0551 0.2129 0.2074
Schistosoma mansoni sodium/solute symporter 0.008 0.0194 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0905 0.3679
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0075 0.0186
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0085 0.0085
Schistosoma mansoni transient receptor potential channel 0.022 0.0767 0.0688
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0193 0.0836
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.0385 0.1168
Echinococcus multilocularis solute carrier family 5 0.008 0.0194 0.0126
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0551 0.2129 1
Mycobacterium tuberculosis Conserved protein 0.0223 0.078 0.1258
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0069 0.0029
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0547 0.183
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0193 0.0836
Loa Loa (eye worm) hypothetical protein 0.0223 0.078 0.0743
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.037 0.0331
Trypanosoma brucei trypanothione reductase 0.005 0.0069 0.0251
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0223 0.078 0.1258
Schistosoma mansoni hypothetical protein 0.0446 0.1698 0.1627
Brugia malayi MH2 domain containing protein 0.0123 0.037 0.037
Echinococcus granulosus transient receptor potential ion channel A 0.0212 0.0737 0.0672
Trichomonas vaginalis CMGC family protein kinase 0.0551 0.2129 1
Schistosoma mansoni serine/threonine protein kinase 0.0551 0.2129 0.2062
Echinococcus granulosus dna polymerase kappa 0.008 0.0193 0.0124
Giardia lamblia Kinase, CMGC CDK 0.0551 0.2129 1
Brugia malayi hypothetical protein 0.0086 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0085 0.0214 0.0174
Brugia malayi Thioredoxin reductase 0.005 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0206 0.0713 0.0633
Loa Loa (eye worm) hypothetical protein 0.0729 0.286 0.2831
Mycobacterium tuberculosis Conserved protein 0.0223 0.078 0.1258
Schistosoma mansoni DNA polymerase eta 0.0079 0.0188 0.0104
Brugia malayi ImpB/MucB/SamB family protein 0.0079 0.0188 0.0188
Schistosoma mansoni hypothetical protein 0.0206 0.0713 0.0633
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0905 0.3679
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.102 0.0957
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0111 0.0361
Echinococcus granulosus GPCR family 2 0.0206 0.0713 0.0648
Brugia malayi glutathione reductase 0.005 0.0069 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.102 0.0957
Plasmodium vivax hypothetical protein, conserved 0.0223 0.078 0.3452
Leishmania major hypothetical protein, conserved 0.0223 0.078 0.3556
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0223 0.078 0.1258
Trypanosoma brucei hypothetical protein, conserved 0.0223 0.078 0.3616
Mycobacterium ulcerans esterase/lipase LipP 0.0223 0.078 1
Echinococcus granulosus TRP transient receptor potential channel 0.0082 0.02 0.0131
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0111 0.0075
Mycobacterium leprae Probable lipase LipE 0.0223 0.078 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0905 0.3679
Brugia malayi hypothetical protein 0.0076 0.0176 0.0176
Echinococcus granulosus short transient receptor potential channel 6 0.0145 0.0461 0.0395
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0075 0.0028
Echinococcus multilocularis geminin 0.1196 0.4783 0.4746
Loa Loa (eye worm) hypothetical protein 0.0652 0.2546 0.2516
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0054 0.0085 0.0016
Echinococcus granulosus beta LACTamase domain containing family member 0.0223 0.078 0.0716
Onchocerca volvulus 0.0223 0.078 1
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0905 0.3679
Loa Loa (eye worm) glutathione reductase 0.005 0.0069 0.0029
Mycobacterium tuberculosis Conserved hypothetical protein 0.0054 0.0085 0.0027
Trypanosoma cruzi DNA polymerase eta, putative 0.0079 0.0188 0.0728
Loa Loa (eye worm) hypothetical protein 0.0223 0.078 0.0743
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.102 0.0943
Trypanosoma cruzi cdc2-related kinase 1 0.0551 0.2129 1
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.2465 1 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0075 0.0186
Echinococcus multilocularis dna polymerase eta 0.0079 0.0188 0.012
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0206 0.0713 0.0648
Loa Loa (eye worm) hypothetical protein 0.008 0.0194 0.0154
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0111 0.0451
Loa Loa (eye worm) beta-lactamase 0.0223 0.078 0.0743
Echinococcus multilocularis transient receptor potential ion channel A 0.0212 0.0737 0.0672
Loa Loa (eye worm) hypothetical protein 0.0223 0.078 0.0743
Loa Loa (eye worm) hypothetical protein 0.0539 0.2079 0.2047
Schistosoma mansoni transient receptor potential channel 0.0145 0.0461 0.038
Schistosoma mansoni hypothetical protein 0.1196 0.4783 0.4738
Brugia malayi Sodium:solute symporter family protein 0.008 0.0194 0.0194
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0551 0.2129 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0652 0.2546 0.2546
Brugia malayi beta-lactamase family protein 0.0223 0.078 0.078
Schistosoma mansoni inositol transporter 0.008 0.0194 0.011
Mycobacterium tuberculosis Probable hydrolase 0.0223 0.078 0.1258
Echinococcus granulosus cyclin dependent kinase 5 0.0551 0.2129 0.2074
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0166 0.0709
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.078 0.3556
Brugia malayi cell division control protein 2 homolog 0.0551 0.2129 0.2129
Mycobacterium tuberculosis Probable esterase LipL 0.0223 0.078 0.1258
Loa Loa (eye worm) hypothetical protein 0.0051 0.0075 0.0035
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.0385 0.0558
Trichomonas vaginalis CMGC family protein kinase 0.0551 0.2129 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0075 0.0186
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.102 0.0943
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0193 0.0836
Echinococcus granulosus dna polymerase eta 0.0079 0.0188 0.012
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0905 0.3679
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0547 0.183
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0332 0.0466
Schistosoma mansoni eyes absent homolog 0.0086 0.0218 0.0135
Leishmania major trypanothione reductase 0.005 0.0069 0.0159
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0193 0.075
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0223 0.078 0.0743
Echinococcus granulosus solute carrier family 5 0.008 0.0194 0.0126
Trypanosoma brucei cdc2-related kinase 3 0.0551 0.2129 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.078 0.0743
Entamoeba histolytica hypothetical protein 0.0076 0.0176 0.0448
Trichomonas vaginalis D-aminoacylase, putative 0.0223 0.078 0.3034
Mycobacterium tuberculosis Probable reductase 0.0114 0.0332 0.0466
Echinococcus multilocularis beta LACTamase domain containing family member 0.0223 0.078 0.0716
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.004 0.0115
Trypanosoma brucei DNA polymerase IV, putative 0.008 0.0193 0.0836
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.0385 0.0558
Echinococcus granulosus geminin 0.1196 0.4783 0.4746
Mycobacterium ulcerans lipase LipD 0.0223 0.078 1
Brugia malayi hypothetical protein 0.0051 0.0075 0.0075
Echinococcus multilocularis high affinity choline transporter 1 0.0729 0.286 0.281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0281 0.102 0.0957
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0547 0.183
Trichomonas vaginalis penicillin-binding protein, putative 0.0223 0.078 0.3034
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0193 0.0836
Echinococcus granulosus high affinity choline transporter 1 0.0729 0.286 0.281
Trypanosoma cruzi cdc2-related kinase 3 0.0551 0.2129 1
Trichomonas vaginalis D-aminoacylase, putative 0.0223 0.078 0.3034
Echinococcus multilocularis sodium:myo inositol cotransporter 0.008 0.0194 0.0126
Echinococcus multilocularis GPCR, family 2 0.0206 0.0713 0.0648
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.0905 0.3679
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0551 0.2129 0.2074
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0075 0.0278
Trypanosoma cruzi cdc2-related kinase 3 0.0551 0.2129 1
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0547 0.183
Echinococcus granulosus sodium:glucose cotransporter 0.008 0.0194 0.0126
Echinococcus granulosus cyclin dependent kinase 0.0551 0.2129 0.2074
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0551 0.2129 0.2097
Onchocerca volvulus 0.0223 0.078 1
Echinococcus granulosus sodium:glucose cotransporter 2 0.008 0.0194 0.0126
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0223 0.078 0.0702
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.037 0.0331
Mycobacterium leprae conserved hypothetical protein 0.0223 0.078 1
Leishmania major hypothetical protein, conserved 0.0051 0.0075 0.0186
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0082 0.02 0.0131
Mycobacterium tuberculosis Probable lipase LipE 0.0223 0.078 0.1258
Mycobacterium tuberculosis Probable lipase LipD 0.0223 0.078 0.1258
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0069 0.0159
Loa Loa (eye worm) hypothetical protein 0.0223 0.078 0.0743
Echinococcus granulosus short transient receptor potential channel 6 0.0145 0.0461 0.0395
Trypanosoma brucei cdc2-related kinase 1 0.0551 0.2129 1
Trichomonas vaginalis esterase, putative 0.0223 0.078 0.3034
Plasmodium vivax protein kinase Crk2 0.0551 0.2129 1
Brugia malayi Transient-receptor-potential like protein 0.0082 0.02 0.02
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0281 0.102 0.0957
Schistosoma mansoni serine/threonine protein kinase 0.0551 0.2129 0.2062
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0547 0.6022
Trichomonas vaginalis penicillin-binding protein, putative 0.0223 0.078 0.3034
Entamoeba histolytica hypothetical protein 0.0076 0.0176 0.0448
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0551 0.2129 0.2097
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0076 0.0176 0.0108
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0193 0.075
Brugia malayi Latrophilin receptor protein 2 0.0206 0.0713 0.0713
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0547 0.183
Schistosoma mansoni hypothetical protein 0.0206 0.0713 0.0633
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.008 0.0194 0.0126
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.0905 0.0868
Toxoplasma gondii ABC1 family protein 0.0223 0.078 0.3556
Schistosoma mansoni serine/threonine protein kinase 0.2465 1 1
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0551 0.2129 0.2097
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0223 0.078 0.0702
Toxoplasma gondii thioredoxin reductase 0.005 0.0069 0.0159
Echinococcus multilocularis cyclin dependent kinase 1 0.0551 0.2129 0.2074
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0075 0.0028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0076 0.0176 0.0108
Schistosoma mansoni transient receptor potential channel 4 0.022 0.0767 0.0688
Echinococcus granulosus transient receptor potential gamma protein 0.022 0.0767 0.0703
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0127
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0223 0.078 1
Loa Loa (eye worm) hypothetical protein 0.0223 0.078 0.0743
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1424 0.5719 1
Brugia malayi beta-lactamase 0.0223 0.078 0.078
Mycobacterium tuberculosis Conserved protein 0.0223 0.078 0.1258
Trypanosoma cruzi hypothetical protein, conserved 0.0223 0.078 0.3556
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0193 0.0836
Brugia malayi latrophilin 2 splice variant baaae 0.0446 0.1698 0.1698
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0206 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.0446 0.1698 0.1664
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0547 0.183
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0332 0.0466
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0193 0.0836
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.0385 0.0558
Loa Loa (eye worm) hypothetical protein 0.022 0.0767 0.0729
Echinococcus multilocularis cyclin dependent kinase 1 0.0551 0.2129 0.2074
Mycobacterium ulcerans beta-lactamase 0.0223 0.078 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0652 0.2546 0.2546
Echinococcus multilocularis cyclin dependent kinase 5 0.0551 0.2129 0.2074
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0223 0.078 0.078
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0193 0.0836
Schistosoma mansoni hypothetical protein 0.1196 0.4783 0.4738
Echinococcus multilocularis short transient receptor potential channel 6 0.0145 0.0461 0.0395
Loa Loa (eye worm) hypothetical protein 0.0206 0.0713 0.0675
Schistosoma mansoni hypothetical protein 0.0206 0.0713 0.0633
Leishmania major DNA polymerase eta, putative 0.0079 0.0188 0.0728
Schistosoma mansoni transient receptor potential channel 0.0145 0.0461 0.038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0281 0.102 0.0983
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.0584 0.202
Loa Loa (eye worm) hypothetical protein 0.0138 0.0431 0.0392
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.2465 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0332 0.0466
Echinococcus granulosus cyclin dependent kinase 1 0.0551 0.2129 0.2074
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0214 0.0631
Schistosoma mansoni high-affinity choline transporter 0.0729 0.286 0.2799
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0127
Echinococcus multilocularis transient receptor potential gamma protein 0.022 0.0767 0.0703
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0193 0.075
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0054 0.0085 0.0016
Brugia malayi GH02984p 0.0729 0.286 0.286
Schistosoma mansoni inositol transporter 0.008 0.0194 0.011
Entamoeba histolytica cell division protein kinase 2, putative 0.0551 0.2129 1
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0085 0.0214 0.0631
Leishmania major DNA polymerase kappa, putative 0.006 0.0111 0.0361
Schistosoma mansoni transcription factor LCR-F1 0.0076 0.0176 0.0092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0206 0.0713 0.0648
Trypanosoma brucei unspecified product 0.0073 0.0166 0.0709
Loa Loa (eye worm) hypothetical protein 0.0086 0.0218 0.0179
Mycobacterium ulcerans hypothetical protein 0.0223 0.078 1
Trypanosoma cruzi cdc2-related kinase 1 0.0551 0.2129 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0075 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.004 0.0115
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0043 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0193 0.0836
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0332 0.0466
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.008 0.0194 0.0756
Trypanosoma cruzi DNA polymerase kappa, putative 0.008 0.0193 0.075
Echinococcus multilocularis dna polymerase kappa 0.008 0.0193 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0193 0.0836
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0281 0.102 0.0943
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0206 0.0713 0.0648
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0281 0.102 0.102
Loa Loa (eye worm) hypothetical protein 0.0082 0.02 0.016
Entamoeba histolytica hypothetical protein 0.0076 0.0176 0.0448
Loa Loa (eye worm) latrophilin receptor protein 2 0.0206 0.0713 0.0675
Trichomonas vaginalis CMGC family protein kinase 0.0551 0.2129 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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